6PTN,2EHO,5U8T,3JC5,3ANW


Conserved Protein Domain Family
Sld5

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pfam05916: Sld5 
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GINS complex protein
The eukaryotic GINS complex is essential for the initiation and elongation phases of DNA replication. It consists of four paralogous protein subunits (Sld5, Psf1, Psf2 and Psf3), all of which are included in this family. The GINS complex is conserved from yeast to humans, and has been shown in human to bind directly to DNA primase.
Statistics
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PSSM-Id: 399129
Aligned: 166 rows
Threshold Bit Score: 31.3133
Threshold Setting Gi: 124461120
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
6PTN_A        27 VNLPMY---HEDIIr-nILKEVSNLRKNteYLKEQQQLGMLDDKVakc-----------------------qyfVT-LLC 78  baker's yeast
Q55EA2        34 PNLLNY----EDVIikeVMEKIEEKESL--CASAISNINLQFTAN-----------------------------IY-EME 77  Dictyostelium d...
Q6CKF3        76 PELLPYphhLMTRTlirIQERIELIETL--SMGYLEDNQELTVDS-----------------------------KLpLLC 124 Kluyveromyces l...
Q6FT85        81 PELLPLpklLVSRMlkrIQDQMEHIENI--SMGFLEHEILEKDGEeaigqney-------------qnnalnngKLpLLC 145 [Candida] glabr...
XP_001644149  78 PELMPYphyLMTRIlrrIQEQMEHIENI--SMGFLEESMNQISHGsgnvtgdgddeddefgmgrgnnvinnnnkLP-LLC 154 Vanderwaltozyma...
KOH51924      74 PELLPYphqLMKRLlnrISMQSQLIENI--SMGFLDMQNASNANPpmpnes------------------klpllCM-ETE 132 Saccharomyces s...
A0D3B1        15 PELLPY-------FdvsKIQDALKGQLD--SIQDLKKDLSKHNKQrdtqy-----------------------ltlhVIE 62  Paramecium tetr...
CAM69806      91 PEVLPY---PATTIs--TVVHLIQR-----TQERVEAMVAEEKREgaersllp-----------------frpsdimGLE 143 Leishmania infa...
Q582Q4        81 PDILPY----PEAIvdsVVAQIVAQNEQ------IRLLGTDERQKaagsdsgvs------------llpfkpsdIM-ALE 137 Trypanosoma brucei
Q4E684        61 PDILPYpeaIVDGVaaqIAAQNEQIRLL--SVEEKQQTAEKDPGAsllpfk---------------------psdimALE 117 Trypanosoma cruzi
6PTN_A        79 MERn----kRCLLAYQRLRTDILDSMAWNNNGLDlms-sitFSQQDTNNLSHQEQ 128 baker's yeast
Q55EA2        78 IERl----kYIIKCYLVQRIKKIDKFYSSILLEIe-----nDEYDSYKLLSEFEI 123 Dictyostelium discoideum
Q6CKF3       125 MEAelerlkFLVRSFIRCRLSKIDKYSIYLRQQSelp--nnAGLSRLDLLMSKEE 177 Kluyveromyces lactis NRRL Y-1140
Q6FT85       146 MEAelervkFVMRSYLRCRLNKIDKYSLYLRQLGdq---giNLISLDELMSEQEL 197 [Candida] glabrata CBS 138
XP_001644149 155 MEAelervkFVIRSFIRCRLNKIDKYSLYLKQIEdd---smNFLPINELLSKEEM 206 Vanderwaltozyma polyspora DSM 70294
KOH51924     133 LERl----kFVIRSYIRCRLSKIDKFSLYLRQLNed---enSLISLTDLLSKDEI 180 Saccharomyces sp. 'boulardii'
A0D3B1        63 LERi----qYFYQQYLRTRMLKLISNAFYYYNNIgeyqislKEKEFLKALVEKKL 113 Paramecium tetraurelia
CAM69806     144 MQRi----qFFLCELLRCRLRKIEHLATSIYYEGla---vgQSSMSQSRLGQADE 191 Leishmania infantum JPCM5
Q582Q4       138 VQRa----qFFLCELLRCRLRKIEALALTINYESqsg--aeAHTQLREHLSHNEI 186 Trypanosoma brucei
Q4E684       118 VQRa----qFFLSELLRCRLRKIEALALSLFYEGqlh--sdAPTQLRGMLSHNEV 166 Trypanosoma cruzi
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