8J07,8SNB,9CPC,8TO0,8IYJ,7UNG


Conserved Protein Domain Family
RIB43A

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pfam05914: RIB43A (This model is not part of the current CDD release)
RIB43A
This family consists of several RIB43A-like eukaryotic proteins. Ciliary and flagellar microtubules contain a specialised set of protofilaments, termed ribbons, that are composed of tubulin and several associated proteins. RIB43A was first characterised in the unicellular biflagellate, Chlamydomonas reinhardtii although highly related sequences are present in several higher eukaryotes including humans. The function of this protein is unknown although the structure of RIB43A and its association with the specialised protofilament ribbons and with basal bodies is relevant to the proposed role of ribbons in forming and stabilising doublet and triplet microtubules and in organising their three-dimensional structure. Human RIB43A homologues could represent a structural requirement in centriole replication in dividing cells.
Statistics
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PSSM-Id: 517029
Aligned: 62 rows
Threshold Bit Score: 224.385
Created: 14-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
8J07_5A       13 DLRQDANLAKRRHAELCRQKRVFNARNRIIGGDTEAWDVQVHDQKIKEATEKARHETFAAEMRQNDKIMCILENRKKRDR 92  human
5_pfamImport   2 DHAEVAKHVKARLFDEERKKRIFNPTTRTIGIDKDALDRQVQEKKILRDQEQARHQAYSNKLLQDCATSLQLDEQNKKKQ 81 
XP_001607133  11 DLKAAAAIERKRRIEEERKPRIFNPRIRRIGIDKEYLDRQVEEKKRLQDLQREQECRLDEALLRSSQLAIVQEKRLDEER 90 
4_pfamImport   2 ELKLAAAVQRRRQIEAERKERIFNARFRKIGIDKEFLDKQVEEKKQQRELEEARESELDEILLQSCKIGLLLEKQQEEER 81 
XP_011140007  12 DLKIAASIERKRRLEEARKQRIFDPRVRKIGIDKAFLDKQVEEKRRQRECEQAEECQLNEALVHSSQLAAHLERQREEER 91 
EFN62279      12 DLKIAASIERKRQLEEARKLRIFNPRVRKIGIDKAFLDKQVEEKQRQHEWEQAKECQLDEALIRNSELAVHLERQQEEER 91 
XP_006677976   9 DTLHNAAIQRRQRLDEERKQRIFNPKVRILGIDLQALDEQIQIKNELKEIDKQRNDALDKSSKLNNDILQLMDEQVQKAR 88 
XP_002678969   8 ETKERLAIEKRRQAEEERRKRILDPKARTMGLDVAGIQSQIEEKEQIKKREQDRDRYFDQASLVHAKVANIMEKEMHQTK 87 
XP_002286823   8 QDQEEQRLFALRQRLEDRSKRFVNAKARTIGVDKDALDKQVEEKRQQQLAEREEKLADAQRIQALVTCLDQKEAAEQEAK 87 
XP_067741733  13 EDKEELRIEARRQREIERLKKLGPGRLRFIGADIAGMKNQVEERQRQDATDREAKRASEEEDAAIRRYLLQVESEDAFAK 92 
8J07_5A       93 KNLCRAINDFQQSFQKPETRREFDLSDPLALKKDLPARQSD--N-DV-RNTISGMQKFMGEDLNFHERKKFQEEQNREWS 168 human
5_pfamImport  82 KEIDLEILEYRKKYQAPETRREFDIYDPLQCRKGQPNRIGD--D-DP-RITLSSVQRFEGEEGTTKEQKAEQIKQQRVWL 157
XP_001607133  91 RKLNKELNTFRQTHQKPEFRRDFDLYDPELLKKSKPPGEDG--V-DP---GLASAQKFEGEDENLVARLREQREQMQSWI 164
4_pfamImport  82 RKIHKEIEHYRQQYQQ---RQECDL-----------SKKGD--R-DL-SFG----ELLKSEEEDFKEKSRAKKEEMRWWI 139
XP_011140007  92 RRIREGIESFRREHQRAEDRRDYDLYDPEALKKSLPPRADD--D-DP-SLGLASAQKFEGEDPNLQERLKAQKRQMRWWI 167
EFN62279      92 RTVNKEIEHFRRVHQRIEDRRDYDLYDPETLKKSLPSRVDD--D-DP-SLGPASAQKFEGEDRNLRERLKVQREQMRWWI 167
XP_006677976  89 RHCLQQTNQYRRDHQQPHQRRDYDLYDPKALQKDVSTRVTNgqSkDH-PIGISSLQRFEGEDLAAEKRTMLQKDQMRVWA 167
XP_002678969  88 KQVYKEVNDFRKNEQLPHTRREFDLNDPDELKKSRPIRVGD--Y-DP-SLTISGGQIMHGEDLGREERLKAQQDQLKCWV 163
XP_002286823  88 KLSLGELKRTLDAQARQPKNNALRMDDPINV------------D----RCGPSSLQRLSGEDRSYEIRKKEQQEQVQFWC 151
XP_067741733  93 RRELLTL------------RNDWDQQSAEACQGRARYAATRalGiDPdNCAPGAAQKFEGEDAARLERIRLQALQMKQWS 160
8J07_5A      169 LQQQREWKNARAEQKCAEALYTETRLQFDETAKHLQKLESTTRKAVCASVKDFNKSQAIESVERKKQEKKQEQEDNLAEI 248 human
5_pfamImport 158 EMQIREKNMTREENKNVERTWQETEHTTVQRAMALATLENECRRKLIEANYRYNQALASEQKMNKSIMEAESNEDKMAEV 237
XP_001607133 165 MQQVQERRLAEREKRDTEQAYQEALLSRDRRALALEHMELECRRRLSEATARFNRALAEEKAERKRCRALQDNEAARAEI 244
4_pfamImport 140 EKQMQEHISAESERKEFEKAQEAAILSRDKHAMKIAQMEQDCRRKLNEATARFNQAMAEEQEYRRRCEALREEEDKKADI 219
XP_011140007 168 RRQKEEREAVEKVQREIEEAYQEVVLSRDKRAATLARMEEECRRRLNEATAKFNCALATERQQRRQCEAIQEEEDNKAEI 247
EFN62279     168 QRQKEEREAVEKARRDTEEAYQEVVLSRDKRAMMLARMEEECRRRLNEAMATFNRALAEEQQQRRHCEAIQDEEDKKAEI 247
XP_006677976 168 NEQVFEKERRRQEELDEKKRYEEFQKSIGDKMAALQSSVEQAQREQARLDSEYNQSLAAEKRLREQQQKEYDNNLNTYEI 247
XP_002678969 164 SEQVNEKQMVKEKEDLERKLFEQKELEIQRLTYELREKENMIKLEKERERKEFNVEQWNDKEEKEKLQREKEELDKLEEI 243
XP_002286823 152 AKDTLEKKRALEEERRREQEYAEYVLEQDRIRAELEAAAKKRRDEENRRTQFENVELARRAREMKMQESKAEKLAQAEQS 231
XP_067741733 161 IQKMAEDAQRNANESEDQAAYMAQLFEIERLMEELHRGNERERAAAAAEISRFNQSLLAQQRQGESDRHRREQEENSREI 240
8J07_5A      249 TNLLRGDLLSENPQQA-ASSFGPH---RVVPDRWKGMTQEQLEQIRLVQKQQIQEKLRLQEEKRQRDLDWDRRRIQGARA 324 human
5_pfamImport 238 YNAITGDFLTENPELGfNSALGPG---KISKSLYKGLTPAMKQAIYDEQASQRAELKLRKEAYDKQEKDWADLLNILARC 314
XP_001607133 245 YNHVTGDFLTEPKDQA-ESVHGPK---KLLVTRYKGMTSEQLKVIRDEQARQMEEIQRMRAEENEKNEEWNRLMNGNARA 320
4_pfamImport 220 YNHVTGDFLTEAKEQA-ESTHGPH---KPLASRYKGMTADELKVFREAQARQLKEMKEMKIEEKRRDEEWDRLMTTQAEI 295
XP_011140007 248 YNHVTGDFLTEAREQA-ESTRGPQ---RPLASRYKGMTEDELKVFRDAQLEQMKELERIKQGEKRTDEEWDRLMTSHLQV 323
EFN62279     248 YNHVTGDFLTEAREQA-ESTRGPY---RPLADRYKGMTADELKVFRDAQLEQMEEIRKIKLQEKNMNEDWDRLMNSHLQA 323
XP_006677976 248 VSHINSTFLTEASGTS-ASRQSS----KMRADLFKGITTEQRKEILDTQERQRMEQQKRLDEKIKEEERWAIQETMNNRA 322
XP_002678969 244 QNQLNSHLLNEAFHTT-LNVNDPN---RFRPDHFKHMRPDQYEHIEQVRQEQLRELQQKRDTESLNQQYWDKKRLLETKM 319
XP_002286823 232 HYLQTCPLLTEDKSLT-MNVNAPDh--RFRPDHFKGYQQDKVIEMYKENDTVVEEKRDLLIGEAQTEADWAKRHMEMIQQ 308
XP_067741733 241 QLTLQSNFVSENPLQA--ALPGMSfdhRVRVDHWKGFSGEQTKYYLRQNDDILDDKARRKQQEREQAEQDARAQKELQRT 318
8J07_5A      325 TLLFERQQWRRQRDLRRALDSSNLSLAKEQHLQKKYMNe-VYTNQPTGDYFTQFNTGSR 382 human
5_pfamImport 315 GTLNDQEMQKKKRNLEDGIKDFNLDLANEQKNKEEFLNnvLYRTKATNEFFDQFNKTSR 373
XP_001607133 321 AESYQRELDRRRAELNRQIAEENLRLAEQQRSQQDYLNrhVYKNKPGPEFYAQFNKSTR 379
4_pfamImport 296 ADSYQREIDRKKAEIKKKIAKENLELAEQQKSHQEYLNcvLYKNKATAAFYEQFNKDAR 354
XP_011140007 324 AYSHARELDQRKSELNKKIAEENLQLAERQKSHQDYLNrvLYKNMPTADFYEQFNKSTR 382
EFN62279     324 AYSYEHELNKKKSDLNKKIAEENLQLAEQQKLHQEYLNrvIYRNQPTAAFYEQFNKGTR 382
XP_006677976 323 LNLLERERVRNSREKAIQIRRENEAKAIEDKKRRTYIDkvLYTNAPQDAYFMQFNTTSR 381
XP_002678969 320 AGLQLREQERAKKQQAAELLELHKRQAEEKKQKEKFVNq-VYANEVTEDFFNRFGTSSR 377
XP_002286823 309 MAEVEDQKQRRIAEESRRQREILDVQKAELDVRRKELEkaRL-HEISSEFFSRFGQ-CR 365
XP_067741733 319 LAHEEYLAQQRRAQMEMDVRATREQQRQQ-AADREKSSaeRGRGKIEPSFFQKFGQSYR 376
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