5ONJ


Conserved Protein Domain Family
Gamma_PGA_hydro

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pfam05908: Gamma_PGA_hydro 
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Poly-gamma-glutamate hydrolase
This family consists of a number of bacterial and phage proteins that function as gamma-PGA hydrolase enzymes. Structurally the protein in this family adopted an open alpha/beta mixed core structure with a seven-stranded parallel/anti-parallel beta-sheet. This structure shows similarity to mammalian carboxypeptidase A and related enzymes.
Statistics
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PSSM-Id: 399122
Aligned: 26 rows
Threshold Bit Score: 156.259
Threshold Setting Gi: 698943846
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
5ONJ_A                   9 YQNFEELKNNEDPS-DYGVVTKET-GSPVLVLAIHGGGIEGGTSEVARELSK--EYSMYLFEGLKSAGN-SVLHITSTHF 83  Bacil...
WP_015903614             5 YTNYDELSQNERLNaDYAILHREV-DSKIVVISPHGGGIEPGTIDIGDAIAGc-DHTFYAFKGLKKSGN-KILHITSNSF 81  Desul...
WP_015903613             5 YSNYDELSQNERQDvDYTIFHRGT-DSQLAVMAIHGGGIEPGTLDIADAIAGc-DHTFYCFKALKKSWS-NLLHITSNGF 81  Desul...
Q5HQS8                  45 YADFTELKKDTIKNkDWRIKTKHRkNKDILVTAIHGGGIEPGTTEIARRISNvgKYNFYTFEGLRKSNN-DQLHVTSTHF 123 Staph...
EST26986                17 YSNFADLAAHEDEGlHWTRECRRVpGSDLAHIAIHGGHIEAGTTEAALACAGt-TDNYYSFKGIKTGAN-RTLHVTSTHF 94  Strep...
CCP43671               159 pqSLSELLS------QPGVIETSQlRSRFGFLAIHGGGLEQVTDLIAERSAEaaGASVYLLRHPDN----YPHHLPSARF 228 Mycob...
PRJNA261003:LJ00_27640 154 pQSLAELLA------DPAVRETSTlRSRFGFMAIHGGGLEQMTDVIAERAAAasDASVYVVRHPDR----YPHHLPSARY 223 Mycol...
CCG44148                45 fcTFTELSDVYEESeDWEIKKRQSpNSRVLVSAIHGGGIEQVTSQLADAVAGk-EYSFYTFKGKLSSGNfNNLHISSVNF 123 Halob...
Q8EL86                  31 YGSYEELKEHEEQNeDYEINYSQR-DSDITVIAIHGGGIEPGTSEVAKGLANrmDLSYYLFEGIKPTGN-MILHIESIRF 108 Ocean...
Q5HPQ0                   4 FKSMTELKELTKEGkDWEIECENR-SSIVTILALHGGGIEPATTELAYTIAHcgDYNYFSFKGMRSKGN-NELHVTSTHY 81  Staph...
5ONJ_A                  84 DEPRALKMTG---NHEYVISLHGYAEED--QQIEVGGTDRVRAADLVEKLQHAGFPAv----lLNMd-hPHAGVSPNNIA 153 Bacil...
WP_015903614            82 DEPLGIQVAQ---KALIVISVHGSRFRT--ETVHIGGRNQLLKQKILHALKAAGFNA------EISelpELQWISPENIC 150 Desul...
WP_015903613            82 DEPLGIQVAQ---KALTVISIHGARFKT--ETIHIGGRNQYLGQKIMHALIDAGFNA------KISkvpGLKGISPGNIC 150 Desul...
Q5HQS8                 124 NEPILDKLLK---NTKETLSIHGFSGDD--PIVYIGGKDKEMSHSITKELRKKDFTVk----eSPN---KIDAKSSDNIA 191 Staph...
EST26986                95 DEPQCVDLQS---GMARTVSWHGFSSGD--KITEVGGLDHDFSYWITASLQHAGFPVa----eATP---ERAGSSPKNIC 162 Strep...
CCP43671               229 DPAESARLAEfldHVDVAVSLHGYDRIGrsTQLLAGGRNRALAAHLARHIQLPGYRVvtdlaaIPE---ELRGLHPDNPV 305 Mycob...
PRJNA261003:LJ00_27640 224 LAAESQRLSEfleHVDVVVSLHGYGRMGrgTQLLAGGRNRTLAEHVARHVEIPGYTVvtdldaIPR---ELRGQHADNPA 300 Mycol...
CCG44148               124 DEPQARSMAN---EASIHISIHGAEGEM--KRTLLGGLNEDLRGLISEHLESSGFRVk----eAPE---HLDGDHPNNIV 191 Halob...
Q8EL86                 109 DEPIGRNMVQ---ESTSALSIHGYQGEE--PMIFLGGRNEVYREAIREALQDKGFAVe----dAPS---HISGMSEENIV 176 Ocean...
Q5HPQ0                  82 DDQIALDLVR---GSQRTVAIHGCEGNE--SVAYIGGSDDRLIELITESLEDIGISVr----eAPH---HISGTQENNIV 149 Staph...
5ONJ_A                 154 NKSKTGLSIQIEMSTGFRKSLFGIFSLKSRAVTq----NERFYEFTEV 197 Bacillus subtilis
WP_015903614           151 NRCKSGEGVHLEISRGLREKMFDNLDIRSLRKR-----TKCFYKFVNT 193 Desulfobacterium autotrophicum
WP_015903613           151 NRCKSREGIQLEISRGLREKMFDDLKFRNLRKR-----TVCFYKFVNT 193 Desulfobacterium autotrophicum
Q5HQS8                 192 NKNESNSGVQLELTTALRKQFFKHYKLDRHTRSdsdkyTKDFYKFANA 239 Staphylococcus epidermidis RP62A
EST26986               163 NRNLAGRGVQLELSRAQRAAFFTNNDMSGGNRTn---lTEEFHRYIEA 207 Streptomyces roseochromogenus subsp. ...
CCP43671               306 NRVRDG-GTQLELSIRVR----------GLGPRstlpgVGGMSPVTAT 342 Mycobacterium tuberculosis H37Rv
PRJNA261003:LJ00_27640 301 NRVA---GVQLELPSRVR----------GISPRsplpgADGLSPVTSA 335 Mycolicibacterium smegmatis MC2 155
CCG44148               192 NQTKTGEGVQLELTRAQRKAFFENGTISYSSRNdatnqTEAFTQYkaa 239 Halobacillus halophilus DSM 2266
Q8EL86                 177 NDTRLGEGVQLELTAGLRDSLFVNGDRSEAT-------TDVYAElmes 217 Oceanobacillus iheyensis
Q5HPQ0                 150 NMTQTQGGVQLELTAQLRKELFKNRKSSRKNREnkdnwDDLMYDFADA 197 Staphylococcus epidermidis RP62A
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