Conserved Protein Domain Family
4_1_CTD

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pfam05902: 4_1_CTD 
4.1 protein C-terminal domain (CTD)
At the C-terminus of all known 4.1 proteins is a sequence domain unique to these proteins, known as the C-terminal domain (CTD). Mammalian CTDs are associated with a growing number of protein-protein interactions, although such activities have yet to be associated with invertebrate CTDs. Mammalian CTDs are generally defined by sequence alignment as encoded by exons 18-21. Comparison of known vertebrate 4.1 proteins with invertebrate 4.1 proteins indicates that mammalian 4.1 exon 19 represents a vertebrate adaptation that extends the sequence of the CTD with a Ser/Thr-rich sequence. The CTD was first described as a 22/24-kDa domain by chymotryptic digestion of erythrocyte 4.1 (4.1R). CTD is thought to represent an independent folding structure which has gained function since the divergence of vertebrates from invertebrates.
Statistics
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PSSM-Id: 399118
Aligned: 13 rows
Threshold Bit Score: 114.144
Threshold Setting Gi: 405975706
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
PNI87256       10 EKNSLRVEGDNIYVRHSnlmlEI----------DGG-AGGDSGTLLTAQTITSESVSTTTTTHITKTVKGGISETRIEKR 78   chimpanzee
ELV12560      713 DVPLVHTETRTITYEAA----QT----------DDRsGDLDPGVLLTAQTITSETTSSTTTTQITKTVKGGISETRIEKR 778  Chinese tree ...
5_pfamImport    2 DVSIVFQKSEKLTYSSS----EA----------DAN-GDSNPGVFMSAQTITSEKNSTTTTTHITKTVKDGISETRIEKR 66  
XP_023413249  990 EVPIVQTETKTITYESP----QV----------DGG-XGDDSGTLVSAQTITSDSVSTTTTTHITKTVKGGISETRIEKR 1054 African savan...
EKC40255     1433 NVPIVKTQTRTVTYEKDgfpvVI----------E-------DGILISSQSHSTRTQTIETTT--YKTERDGKTETRVEKK 1493 Pacific oyster
XP_011674353  570 DVPYVKTENTTITYEKD----PE----------DAVdGDEDPGTLISAQTMTSETRSMTTTTHITKTVKGELTETRVEKK 635  purple sea ur...
XP_014342933  679 RKEAVTTSHTAITETRS-----V----------SPVtNSSGKQTATNVQAVAAETISTSTTTHVTKTAKGGYSETRIEKR 743  coelacanth
4_pfamImport    1 NLPSVHMNTSKYYVSQS----QV----------E---SDTPAGLLLSSQTFITETSNTTTTTHITKMAKGGISETRIEKR 63  
XP_026689974  787 QPPIVQTETKTITYESS----TVrsqnepaqaeSSR-TDEHQSELVSSQIISSETEYTVTTTEITKIVHGSVSETVMEKQ 861  vase tunicate
AAI52369       97 EVPVVHTETKTITYESS----QV----------DPG-ADLEPGVLMSAQTITSETTSTTTTTHITKTVKGGISETRIEKR 161  house mouse
XP_020014098   62 DVPIVHTETKTITYEAA----QT----------DDSnGDLDPGVLLTAQTITSETTSSTTTTQITKTVKGGISETRIEKR 127  American beaver
XP_031586914  550 DMPVIHTETKTITYEAA----EV----------ETN-GDADPGVLLSAQTITSETTSTTTTTHITKTVKGGISETRIEKR 614  Oreochromis a...
KAE8286975    185 EVPIVHTETKTITYEAA----QL----------DGN-GDGEPGVLMTAQTITSESLCTTTTTHITKTLKGGLSETRIEKR 249  large yellow ...
PNI87256       79 IVI--TGDGD-IDHDQA---------LAQAIREAREQHPDMSVTRVVVHKETE 119  chimpanzee
ELV12560      779 IVI--TGDAD-VDHDQV---------LVQAIKEAKEQHPDMSVTKVVVHQETD 819  Chinese tree shrew
5_pfamImport   67 IVI--SGDAD-IDHDQA---------LAQAIKEAKEQHPDMSVTKVVVHKETE 107 
XP_023413249 1055 IVI--TGDGD-IDHDQA---------LAQAIKEAREQHPDMSVTRVVVHKETE 1095 African savanna elephant
EKC40255     1494 VVIsqEENGDdIDHDAL---------LAEAIKSVTEMNPDLSVERIECMRQie 1537 Pacific oyster
XP_011674353  636 IVI--QADGD-LDHDKEmteaqvralLAETLAEEQLQNPDFQVTRIVIQKEGE 685  purple sea urchin
XP_014342933  744 III--TGDED-VDQDQA---------LALAIKEAKQQHPDMLVTKAVVYKEpm 784  coelacanth
4_pfamImport   64 IVI--SGDPE-VDHNQA---------LEIALIEVWQQHPEPFITWFIVRKETK 104 
XP_026689974  862 VVS--TGDASvDDHHKA---------MADMIRDA-QLNPNLSITKVVVHEErp 902  vase tunicate
AAI52369      162 IVI--TGDAD-IDHDQA---------LAQAIKEAKEQHPDMSVTKVVVHKETE 202  house mouse
XP_020014098  128 IVI--TGDAD-IDHDQV---------LVQAIKEAKEQHPDMSVTKVVVHQETE 168  American beaver
XP_031586914  615 IVI--TGDAD-IDHDEA---------LAQAIKEAKEQHPDMSVTKVVVHKETE 655  Oreochromis aureus
KAE8286975    250 IVI--TGDCD-IDHDEA---------LAQAIKEAKEQHPDMSVTRVVVHKETE 290  large yellow croaker
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