Conserved Protein Domain Family
LuxC
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pfam05893: LuxC 
Acyl-CoA reductase (LuxC)
This family consists of several bacterial Acyl-CoA reductase (LuxC) proteins. The channelling of fatty acids into the fatty aldehyde substrate for the bacterial bioluminescence reaction is catalyzed by a fatty acid reductase multienzyme complex, which channels fatty acids through the thioesterase (LuxD), synthetase (LuxE) and reductase (LuxC) components.
Links
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Statistics
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PSSM-Id: 399113
Aligned: 7 rows
Threshold Bit Score: 466.148
Threshold Setting Gi: 81654098
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q8G6W7             65 LAAMSVNDILDIVADAAQLWADPdfelrrqaelliPAITGYEPDMVRIel-krYMRQFRRRELLRFLDSEI-GQPSMLDE 142 Bifidobact...
Q9KV99            423 LANQPLEAILGLINEARKSWSST------------PELDPYRHTGLNF-----LADWCEPNRLKNLLDSALnGQRAFLDN 485 Vibrio cho...
Q97GS8             45 VHDIKTEETIDLLDRCAKLWLDDnyskk--hietlAQITNQSFELVNYef-ksMMQMLLRENIQNTIKREL-GEVDILDS 120 Clostridiu...
jgi:Franean1_4697  68 LLNVPLKEIIDFLVETGERIRDPrntfmqdcidrmAGTHVLPRAVLEGqv-kgAAAYLDKRLLETVVEQNF-PDPRALDE 145 Frankia sp...
Q7N577             52 nNKLRLHNIVNFLYTVGQRWKNEeysrrrtyirdlKKYMGYSEAMAKleanwiSMILCSKGGLYDVVENEL-GSRHIMDE 130 Photorhabd...
Q7MZU4             30 ACPPSVQQVLACAERFVDDLDNV------------AVKLALDTAALTA-----LRHFCHRDSLEAKLRHELgEQPFSLRR 92  Photorhabd...
Q7NQ23             30 AAEPDVDAVLSCAERFADALAGA------------ERHPLLDEPGRAQ-----LAAFCRREALQAKLERELgERPFSLRR 92  Chromobact...

Q8G6W7            143 FR--PNKAg--GYSKYVGPALTYQVFSSNVPGIPVWSMAMTLLVKGAILGKSSFSEPVMPAFFARSIAMVNSD------- 211 Bifidobact...
Q9KV99            486 FL--PRKDishSSQKAMPRGIVSHWLSGNVPLLGMFALVQSILSKNANILKVSASESQALPVLLATFKGLSYTtpggyti 563 Vibrio cho...
Q97GS8            121 WH--KTNY---GYEHRQPRGIIFHNISGNAFVVIPMSISMGLLSKNCNLVKVSKDEPYFAYAFYKSLCELDEt------- 188 Clostridiu...
jgi:Franean1_4697 146 WVpkQDFTgrkSYIRAFAPRLI-HVLPGNSPGVAVKSIAQGALVKAVNLFKMSSSDPFTTVAVLRTMADIDPGh------ 218 Frankia sp...
Q7N577            131 WL--PQDE---SYIKAFPKGKSIHLLAGNVPLSGIMSILRAILTKNQCIIKTSSTDPFTANALALSFIDVDPNh------ 199 Photorhabd...
Q7MZU4             93 FD--YTQP---RFETWQPLGLVVHITPANAPLLPFMAVLESLLVGNVNWLRPSSSDHGLNAQILAEFLRHDLSg------ 161 Photorhabd...
Q7NQ23             93 PD--YREP---RFEAWRPLGLVLHVTPSNAALLPFMAALEGLLAGNVNWLRPSSSDQGLSSRLLAELLRHDASg------ 161 Chromobact...

Q8G6W7            212 ----LADAIAVVPW-KGGSQQLEDSAI--DAADAVIVYGSSQTTKLIAG-KVAGSKPCLGYGAKVGLAFIGREAlr-pdT 282 Bifidobact...
Q9KV99            564 hgddLLGTLAVVYF-DRHQTKIAEKFS--ANADVRIAWGGREAIESVSGlPKKYNSQDILFGPKLSMMVVGSDAldsdkA 640 Vibrio cho...
Q97GS8            189 ----VKDRLSVLYF-DSSKTEIYDTIV--KNSDGVIHWGGEYSSRIIGEmCAKYQKHMIMHGAKISFEVVDKCD-----D 256 Clostridiu...
jgi:Franean1_4697 219 ---pIVRSMSAVYW-RGGDNTVEQVLYrpQYFDKIVAWGGGDAINNVIK-YLGPGFQLVSFDPKTSISMVGREAfaseeA 293 Frankia sp...
Q7N577            200 ---pITRSLSVVYWpHQGDTSLAKEIM--QHMDVIVAWGGEDAINWAVE-HAPPYADVIKFGSKKSFCIIDNPV-----D 268 Photorhabd...
Q7MZU4            162 ---tLAPYISVL---PLPSDQLSELL---ACADAVSAWGSNSALTAIRS-QLRPGCRWIDWGHRISFAYFDPMA-----A 226 Photorhabd...
Q7NQ23            162 ---rLAARVAVL---PAPSDALPRLM---ADADGVSAWGGDAALSAIRA-RLPAGCRWIDWGHRVSFAYLDPAA-----A 226 Chromobact...

Q8G6W7            283 YADTVHRVAVDIATYDQQSCLAPQTVFVETDGALTPREVAQLLGGELENQQRKYPRSVLSDAENVAIQRARTDaemrALM 362 Bifidobact...
Q9KV99            641 IRKLIRRAATDSSVFDQFACASPHTIFVEKGGLITPKEFAEKLASAMDKALVRLPTQVPDIGQANKIRSKIAE----YAF 716 Vibrio cho...
Q97GS8            257 LNKVSEEIAKDIICWEQKACLSPRVVFLN--DKIDVDEFSHCLSASLRKITEVIPKAYLSEWNSVKTIQDRQYctlkYGM 334 Clostridiu...
jgi:Franean1_4697 294 LDTAAELAAGDVMVLNQEACVASRFVFVEAD-QAEADRFSERL------HARIVEKAAASGDARPLDADLREQidvlMML 366 Frankia sp...
Q7N577            269 LTSAATGAAHDICFYDQRACFSAQNIYYM---GNQYEEFKLALIEKLNLYAHILPNAKKDFDEKAAYSLVQKE-----SL 340 Photorhabd...
Q7MZU4            227 SDADYDALADDVCRFDQQACSSPQCLLVDSADENVLREVVSAVAAALARRATIWPALQTDIQEAAEISSQMAFlkldHTF 306 Photorhabd...
Q7NQ23            227 ADEALDALADDICRFDQQACSSPQALLVDSDDPAAIHEMARRLAAALARRAPLWPALTPDLQEAAEISARMAFhkldQAF 306 Chromobact...

Q8G6W7            363 GGKa--aVFaSGHSTAWSVLYRELdgsgadedvASLMSPL-NRTVNVVAVPDLLDAARRLTSC-RgwlQSCGVAVDSTRL 438 Bifidobact...
Q9KV99            717 IGE----YW-HDKHLRWTVLFDEG---------IELVEPTyQRVITVKAVDNVFDVVDSVHED-I---QTVGLAMNGEKR 778 Vibrio cho...
Q97GS8            335 KNErrfkVY-SSFNADYTVILSDGmp-----ekEDINKCF-YRFIFVCPYSSKSDVVNYVSENlKdylQTMG---YSGND 404 Clostridiu...
jgi:Franean1_4697 367 DDEf--gVW-GKTDGHGLVIRSDE---------PVDFHPI-NKTANVVRVNSLDEAMRYVNVAt----QTVGFYPFARMA 429 Frankia sp...
Q7N577            341 FAGl--kVE-VDVHQRWMIIESNAg--------VEFNQPL-GRCVYLHHVDNIEQVLPYVQKN-Kt--QTISIFPWESAF 405 Photorhabd...
Q7MZU4            307 AELr--gSV--EEGNGWRVAWIQRq--------ELAPSPL-YRTLQVRPAPRA-QLVEILLPW-RpylQSCALIVKEKEL 371 Photorhabd...
Q7NQ23            307 ADDq--gQV--LSGQGWRLAWSMEq--------ELAPSPL-FRTVELRPAPRA-ALARILRPW-RthlQSCGLIAPPARL 371 Chromobact...

Q8G6W7            439 FGLADTLAEVGVNRICPLGEMDRAKSgwHHDGGFNLIDLLRA 480 Bifidobacterium longum
Q9KV99            779 LRFANEIMLKGAMRCPDVGYMTHFDS--PWDGVVALDRMVRW 818 Vibrio cholerae
Q97GS8            405 EEFIEKMTLLGVSIVTKPGKMSLHEPgtSHDGIHNLKEFTFL 446 Clostridium acetobutylicum
jgi:Franean1_4697 430 DYRDR-LASGGAQRIVRLGEAGPSTIgnPHDAMYPLHRFVHW 470 Frankia sp. EAN1pec
Q7N577            406 KYRDA-LALRGAERIVEAGMNNIFRVggSHDGMRPLQRLVTY 446 Photorhabdus laumondii subsp. laumondii TTO1
Q7MZU4            372 PMLSRQLLAAGVSRICQAGVMHDGYEgePHDGVYALTRLARR 413 Photorhabdus laumondii subsp. laumondii
Q7NQ23            372 PELSRMLLAAGVSRVAPAGRMHDGYHgePHDGVYALQRLSRR 413 Chromobacterium violaceum
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