7D8F,5CVE


Conserved Protein Domain Family
Methyltransf_PK
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pfam05891: Methyltransf_PK (This model is not part of the current CDD release)
AdoMet dependent proline di-methyltransferase
This protein is expressed in the tail neuron PVT and in uterine cells in C. elegans [worm-base]. In Saccharomyces cerevisiae this is AdoMet dependent proline di-methyltransferase. This enzyme catalyzes the di-methylation of ribosomal proteins Rpl12 and Rps25 at N-terminal proline residues. The methyltransferases described here specifically recognise the N-terminal X-Pro-Lys sequence motif, and they may account for nearly all previously described eukaryotic protein N-terminal methylation reactions. A number of other yeast and human proteins also share the recognition motif and may be similarly modified. As with other methyltransferases, this family carries the characteristic GxGxG motif.
Links
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Statistics
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PSSM-Id: 517018
Aligned: 9 rows
Threshold Bit Score: 330.494
Created: 14-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
7D8F_A      8 DSHIKYEDAIDYWTDVDATVDGVLGGY----GegtVVPTMDVLGSNNFLRKLKSRml---pQENNVKYAVDIGAGIGRVS 80  brewer's yeast
O13748      2 DPEKFYSDAIDYWNGVQPTVDGMLGGL----Gt-gRIPQTDVVGSRTFLNRLNYRi-----GKIENLVAADCGAGIGRVT 71  Schizosaccharomyce...
XP_961021  18 DASISKEHGLAYWESVSADENGMLGGIptfaGf-aNTSKIDLQGSRNFLAKFGIGsk---pGLRRCKRILEGGAGVGRIT 93 
Q5PP70     31 KKTQWYRDGVSYWEGVEASVDGVLGGY----G---HVNDADIIGSEVFLKTLLQErlvnnvGANQHLVALDCGSGIGRIT 103 thale cress
Q10CT5     61 KREEWYSKAIAYWQGVEASTEGVLGGY----G---CVNDVDVKGSDAFLRPLLAErf---gAARRHLVALDCGSGIGRVT 130 Japanese rice
Q8R2U4      8 DEKQFYSKAKTYWKQIPPTVDGMLGGY----G---HISNIDLNSSRKFLQRFLREg----pNKTGTSCALDCGAGIGRIT 76  house mouse
Q9N4D9     11 NGEDVYEKAEEYWSRASQDVNGMLGGF----E---ALHAPDISASKRFIEGLKKKn-----lFGYFDYALDCGAGIGRVT 78  Caenorhabditis ele...
P38340      6 DSHIKYEDAIDYWTDVDATVDGVLGGY----GegtVVPTMDVLGSNNFLRKLKSRml---pQENNVKYAVDIGAGIGRVS 78  Saccharomyces cere...
5CVE_A     28 DEKQFYSKAKTYWKQIPPTVDGMLGGY----G---HISSIDINSSRKFLQRFLREg----pNKTGTSCALDCGAGIGRIT 96  human

7D8F_A     81 KTMLHKHA-----------AKIDLVEPVKPFIEQMHVELAelk----dkgQIGQIYEVGMQDWTPD----AGKYWLIWCQ 141 brewer's yeast
O13748     72 ENVLLKIA-----------SHVDLVEPVENFISTAKKQLAt---------KPCSFINVGLQNWTPE----KNRYGLIWNQ 127 Schizosaccharomyce...
XP_961021  94 EGLLTDLLvvdeneggkgpGKVDVVEPIAKFTAKLQgk-----------kGVGKVYVMGLEEWVPEvgegENKYDLVWTQ 162
Q5PP70    104 KNLLIRYF-----------NEVDLLEPVAQFLDAARENLAsags---ethKATNFFCVPLQEFTPA----AGRYDVIWVQ 165 thale cress
Q10CT5    131 KNFLLRHF-----------NEVDLVEPVSHFLEAAQENLTecmevgedthKAANFYCVPLQDFTPD----EGRYDVIWIQ 195 Japanese rice
Q8R2U4     77 KRLLLPLF-----------RVVDMVDVTEDFLAKAKTYLGee------gkRVRNYFCCGLQDFSPE----PGSYDVIWIQ 135 house mouse
Q9N4D9     79 KHLLMPFF-----------SKVDMEDVVEELITKSDQYIGkh-------pRIGDKFVEGLQTFAPP----ERRYDLIWIQ 136 Caenorhabditis ele...
P38340     79 KTMLHKHA-----------AKIDLVEPVKPFIEQMHVELAelk----dkgQIGQIYEVGMQDWTPD----AGKYWLIWCQ 139 Saccharomyces cere...
5CVE_A     97 KRLLLPLF-----------REVDMVDITEDFLVQAKTYLGee------gkRVRNYFCCGLQDFTPE----PDSYDVIWIQ 155 human

7D8F_A    142 WCVGHLPDAELVAFLKRCIVGLQPNGTIVVKENNTPTDtDDFDETDSSVTRSDAKFRQIFEEAGLKLIASERQRGLPR-- 219 brewer's yeast
O13748    128 WCLSHLTDEDLIAYLSRCCEAIQEKGVICVKENVSSFE-DTFDPIDSSVTRCEQSLKSLFKKANLVVVAETLQHGFPE-- 204 Schizosaccharomyce...
XP_961021 163 WCVGHLTDEQLVAYLQRCKSALAEDGLIVIKENTTVLGnDEFDKEDSSVTRGEATFQKVFQKAGLKVVKAEFQKGFPQtr 242
Q5PP70    166 WCIGHLTDNDFVSFFNRAKGYLKPGGFFVVKENLAKNGf-VLDKEDHSITRSDPYFKQLFRQCGLHLYRTKDQKGLPQ-- 242 thale cress
Q10CT5    196 WCIGQLPDDDFISFFNRAKIGLKPNGFFVLKENIARNGf-VLDKEDNSITRSDAYFKELFKKCGLYIHSIKDQSDLPK-- 272 Japanese rice
Q8R2U4    136 WVIGHLTDQHLAEFLRRCKRGLRPNGIIVIKDNMAQEGv-ILDDVDSSVCRDLEVVRRIIRTAGLSLLAEERQENLPD-- 212 house mouse
Q9N4D9    137 WVSGHLVDEDLVDFFKRCAKGLKPGGCIVLKDNVTNHEkRLFDDDDHSWTRTEPELLKAFADSQLDMVSKALQTGFPK-- 214 Caenorhabditis ele...
P38340    140 WCVGHLPDAELVAFLKRCIVGLQPNGTIVVKENNTPTDtDDFDETDSSVTRSDAKFRQIFEEAGLKLIASERQRGLPR-- 217 Saccharomyces cere...
5CVE_A    156 WVIGHLTDQHLAEFLRRCKGSLRPNGIIVIKDNMAQEGv-ILDDVDSSVCRDLDVVRRIICSAGLSLLAEERQENLPD-- 232 human

7D8F_A    220 --ELYPVRMYALK 230 brewer's yeast
O13748    205 --ELFPVKMYALV 215 Schizosaccharomyces pombe 972h-
XP_961021 243 tmKLLPVRMYALK 255
Q5PP70    243 --ELFAVKMYALT 253 thale cress
Q10CT5    273 --ELFAVKMYALV 283 Japanese rice
Q8R2U4    213 --EIYHVYSFALR 223 house mouse
Q9N4D9    215 --EIYPVKMYALK 225 Caenorhabditis elegans
P38340    218 --ELYPVRMYALK 228 Saccharomyces cerevisiae S288C
5CVE_A    233 --EIYHVYSFALR 243 human
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