5CA8


Conserved Protein Domain Family
RHD3_GTPase
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pfam05879: RHD3_GTPase 
Root hair defective 3 GTP-binding protein (RHD3) GTPase domain
This is the GTPase domain of several eukaryotic root hair defective 3 (RHD3) like GTP-binding proteins, including RHD3 from Arabidopsis and Sey1 from yeast, which are involved in homotypic membrane fusion of the endoplasmic reticulum. This domain binds GTP and forms dimers with other molecule for membrane tethering.
Links
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Statistics
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PSSM-Id: 461768
Aligned: 9 rows
Threshold Bit Score: 401.447
Created: 14-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
5CA8_A  64 FGSQSTGKSTLLNRLFNTNFDVMDE-LNRQQTTKGIWLAYSPVVS--------TtlghttSKSNILVMDVEGTDGRERGE 134 Candida albicans SC5314
Q9C0L9  64 FGSQSTGKSTLLNRLFNTNFDVMDE-SNRQQTTKGIWLAYSPVVSttl--ghtT------SKSNILVMDVEGTDGRERGE 134 Candida albicans SC5314
Q99287  43 FGSQSSGKSTLLNVLFNTNFDTMDAqVKRQQTTKGIWLAHTKQVNtti--eidN------DRPDIFVLDVEGSDGSERGE 114 Saccharomyces cerevis...
Q9P5X6  62 FGSQSTGKSTLLNHLFGTQFSVMSE-RERRQTTKGIWMSKNKNEG--------K------MADNILVMDVEGTDGRERGE 126 Neurospora crassa OR74A
Q9SSN0  48 MGPQSSGKSTLLNHLFGTNFMEMDAfKGRSQTTKGIWLARCAGI-----------------EPCTLVMDLEGTDGRERGE 110 thale cress
Q9FKE9  46 MGPQSSGKSTLLNHLFKTSFREMDAfAGRSQTTKGIWMARCVGI-----------------EPFTIAMDLEGTDGRERGE 108 thale cress
P93042  43 MGPQSSGKSTLLNHLFGTNFREMDAfRGRSQTTKGIWIARCAGI-----------------EPCTVVMDLEGTDGRERGE 105 thale cress
Q9UTE0  45 LGSQSTGKSTLLNNLFGTSFSVMDA-SKRQQTTKGIWLSKANN-------------------SPILVMDVEGTDGRERGE 104 Schizosaccharomyces p...
Q8TGG5  58 FGSQSTGKSTLLNHLFGTHFSVMSD-SERRQTTKGIWMSKNKREGeatvdptlR------MADNILVMDVEGTDGRERGE 130 Aspergillus fumigatus...

5CA8_A 135 DQD-FERKAALFALSTSEVLIINIWETQVGLYQGANMGLLKTVFEVNLSLFGKSKletHNDHKVLLLIVIRDHVGVTPVE 213 Candida albicans SC5314
Q9C0L9 135 DQD-FERKAALFALSTSEVLIINIWETQVGLYQGANMGLLKTVFEVNLSLFGKSKletHNDHKVLLLIVIRDHVGVTPVE 213 Candida albicans SC5314
Q99287 115 DQD-FERKAALFAIAVSEVLIVNMWEQQIGLYQGNNMALLKTVFEVNLSLFGKN----DNDHKVLLLFVIRDHVGVTPLS 189 Saccharomyces cerevis...
Q9P5X6 127 DQD-FERKSALFALATSEVLIVNIWEHQVGLYQGANMGLLKTVFEVNMQLFLKDK---QNQTRSLLFFVIRDHIGVTPLA 202 Neurospora crassa OR74A
Q9SSN0 111 DDTaFEKQSALFALAISDIVLINMWCHDIGREQAANKPLLKTVFQVMMRLF--------SPRKTTMLFVIRDKTR-TPLE 181 thale cress
Q9FKE9 109 DDTtFEKQSALFAIAVADIVLINMWCHDIGREQAANKPLLKTVFQVMLRLF--------SPRKTTLLFVIRDKTK-TPIE 179 thale cress
P93042 106 DDTaFEKQSALFALAVSDIVLINMWCHDIGREQAANKPLLKTVFQVMMRLF--------SPRKTTLMFVIRDKTR-TPLE 176 thale cress
Q9UTE0 105 DQD-FERKSALFSISTSEVIIVNMWENQVGLYQGSNMALLKTVLEVNLQLFHNKK------ERCLLQFVIRDFLGNTSME 177 Schizosaccharomyces p...
Q8TGG5 131 DQD-FERKSALFALATSEVLIVNIWEHQVGLYQGANMGLLKTVFEVNLQLFLKDK---NTTHRSLLFFVIRDFVGTTPLK 206 Aspergillus fumigatus...

5CA8_A 214 SLAKTFTLDLQNMWSSLAKPAELEHLQFADFFDVTFHALNHKVLQPKEFGEGINRLGDRLVVS---------------NE 278 Candida albicans SC5314
Q9C0L9 214 SLAKTFTSDLQNMWSSLAKPAELEHLQFADFFDVTFHALNHKVLQPKEFGEGINRLDDRLVVS---------------NE 278 Candida albicans SC5314
Q99287 190 SLSDSVTRELEKIWTELSKPAGCEGSSLYDYFDLKFVGLAHKLLQEDKFTQDVKKLGDSFVMkg------------teNY 257 Saccharomyces cerevis...
Q9P5X6 203 NLRNTLIQDLTHIWSSISKPAGLENSKIEDYFDFAFAALPHKILQPDKFISEVQNLGSRFIAGhrnkdsdatddqeltGG 282 Neurospora crassa OR74A
Q9SSN0 182 NLEPVLREDIQKIWDSVPKPEAHKETPLSDFFNVEVVALSSYEEKEEQFKEQIASLRQRFMHSi-------------aPG 248 thale cress
Q9FKE9 180 LLERALREDIQKIWDSVRKPEAHKNTPLNEFFNVMIVALSSYEEKEKQFEQEVAELRQRFFHSi-------------sPG 246 thale cress
P93042 177 NLEPVLREDIQKIWDSVPKPQAHKETPLSDFFNVEVVALSSYEEKEEQFKEQVYNLRQRFFQSv-------------aPG 243 thale cress
Q9UTE0 178 NLADTIMTDLNNIWASLSKPEGFENSVINDFFDVGFTGLPHKILCSDAFSEAVDSLRERFVDNnn------------sDY 245 Schizosaccharomyces p...
Q8TGG5 207 NLQKTLMEDMARLWESISKPPGLESSSVHDYFDFQFYGLPHKSYQPEQFVAETKKLSLRFREGqrdpsmdarrgefseGG 286 Aspergillus fumigatus...

5CA8_A 279 LFKPEYHHDVPIDGWTMYAERCWEQIETNKDLDLP 313 Candida albicans SC5314
Q9C0L9 279 LFKPEYHHDVPIDGWTMYAERCWEQIETNKDLDLP 313 Candida albicans SC5314
Q99287 258 YFKPQYHHRLPLDGWTMYAENCWDQIERNKDLDLP 292 Saccharomyces cerevisiae S288C
Q9P5X6 283 VFLPEYHRRIPADGLSIYAEGIWDQIVSNKDLDLP 317 Neurospora crassa OR74A
Q9SSN0 249 GLAGDRRGVIPASGFAFSADQIWRVIKENKDLDLP 283 thale cress
Q9FKE9 247 GLAGDRRGVVPASGFSFSSQQIWKVIKENRDLDLP 281 thale cress
P93042 244 GLAGDRRGVVPANAFAFSAKQMWQVIKDNKDLDLP 278 thale cress
Q9UTE0 246 IFNVSYHKKIPADGFSLYTREIWDTIENNKDLDLP 280 Schizosaccharomyces pombe 972h-
Q8TGG5 287 VFLPEYHRRIPADGFSRYAEGIWDQIVNNKDLDLP 321 Aspergillus fumigatus Af293
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