Conserved Protein Domain Family
Ceramidase

?
pfam05875: Ceramidase (This model is not part of the current CDD release)
Ceramidase
This family consists of several ceramidases. Ceramidases are enzymes involved in regulating cellular levels of ceramides, sphingoid bases, and their phosphates, EC:3.5.1.23. This family belongs to the CREST superfamily, which are distantly related to the GPCRs.
Statistics
?
PSSM-Id: 517014
Aligned: 144 rows
Threshold Bit Score: 155.03
Created: 14-Feb-2025
Updated: 28-Apr-2025
Structure
?
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
XP_006675514   19 GAPSSSVDWCEMNYEVTTFIAEYFNTISSFAMAVVGMLGVVLHPWAEM----RFHMAFQTTVAVGLGSVAFHCTLGKFSQ 94 
XP_004068052   15 AYESSDIDWCEDNYKYSEHVVEYFNTMSSFFFFIISPVMLYLLHPYAKernlAIHLVWILMIFVGLFSAYFHMTLSFVGQ 94 
XP_007489072    6 SYQSSEIDWCEKNFQYSELVAEFYNTISNVPFFIFGPLMIYLMHPYAQkrslKVHLALVLFILIGLFSSYFHMTLSFFGQ 85 
EHB15102        6 AYQSSEVDWCESNFQHSALVAEFYNTVSNVTFLIIGPLMGSLMHSYIQkrtrYIYCTLAFFVFTGLFSMYFHMTLSFLGQ 85 
14_pfamImport   1 GYQSSEVDWCESNFLHSPVVAEFYNTFSNVTFLIFGPLMAFLMRSYVHkrsrYIYSVLMLFVLTGLFSMYFHATLSFLGQ 80 
11_pfamImport   1 AYQSSEVDWCEVNFQHSELVAEFYNTFSNVSFLILGPLMTFLMHPYIQkrscGSYSTLFLFTVTGLFSMYFHMTLSFLGQ 80 
6_pfamImport    1 AYQSSEVDWCEPNFQYSQLVAEFYNTFSNVTFFIFGPLMTFLMRPYIQqrsrYLYVLFVLFTVTGLFSMYFHMTLSFLGQ 80 
XP_004771627    6 AYQSSEVDWCESNFQHSELVAEFYNTFSNVTFLIFGPLMMFLMHPYAQkrsrYVYITCVLFMVVGLFSMYFHMTLSFLGQ 85 
Q8R4X1         15 AYQSSEVDWCESNFQHSELVAEFYNTFSNVFFLIFGPLMMFLMHPYAQkrtrCFYGVSVLFMLIGLFSMYFHMTLSFLGQ 94  house mouse
XP_003978122    6 SYESSEIDWCEDNYKHSEQVVESFNTMSSFIFFIIAPIMLYLLHPYAKernlAIHLVWIMMIFVGLFSAYFHMTLSFVGQ 85  torafugu
XP_006675514   95 ALDEVPMLYSALAFTYIGIceryspsaRVRRFLAIGLtf--------hAIFTTLLVTMSEGfwQFFLFHVSFGTAQLFAI 166
XP_004068052   95 MLDELSIMWVLAVGYSMWF--------P-RKLFPSFIkdrtt-fsklvFTITVITSVSSFV--KPTVNAYVLNCFGLHLL 162
XP_007489072   86 ILDELAILWLLTTCYCLWF--------P-RCYFPAFLkknrslfsclvLVISIIVTFLAFI--KPVVNAYVLNGISLHIC 154
EHB15102       86 LLDEVSILWRVTRPPSVSV--------PGGCGAGSMgrsqf---tcmiLSGTVLVTFLSLV--RPTVNAYALNSIAIHIV 152
14_pfamImport  81 LLDEVAILWMLSSCYSIWM--------P-RCYFPSFLrgsrfqftrmmLWGTTIVTFLSVV--RPILNAYALNSIAIHVL 149
11_pfamImport  81 LLDEIAILWLLASGYSIWM--------P-RCYFPAFLgg-------nrWGRLAVCHLLSFL--RTTVNDYALNSIASTSS 142
6_pfamImport   81 MLDEIAILWLLASGYSIWL--------P-RCYFPAFLgqnrsryssliIIISLVSTFLSFL--RPTINAYALNAIGLHII 149
XP_004771627   86 LLDEIAILWLLASGYSIWM--------P-RCYFPTFLgenrpqficlvVITTVVSTFLSFL--RPVINAYALNSIAVHIL 154
Q8R4X1         95 LLDEISILWLLASGYSVWL--------P-RCYFPKFVkgnrfyfsclvTITTIISTFLTFV--KPTVNAYALNSIAIHIL 163 house mouse
XP_003978122   86 MLDELSILWVLAAGYALWF--------P-RRLFPPFIkdrst-fstlvLVVTVVTTASSFV--KPTANAYALNCFGLHLL 153 torafugu
XP_006675514  167 VQVICIY-RDReiphqfksgiiqrseitesskhrkhthdrkislenailsetkqllnthhdcadsisdhsvydnqracAN 245
XP_004068052  163 YTLAVEM-RYC-------------------------------------------------------------------TD 174
XP_007489072  155 YFTRLEY-KK--------------------------------------------------------------------NH 165
EHB15102      153 YIVRLEY-KKT-------------------------------------------------------------------CN 164
14_pfamImport 150 YIVCSEYrKKL-------------------------------------------------------------------RC 162
11_pfamImport 143 TSSTRSTrSAT-------------------------------------------------------------------SN 155
6_pfamImport  150 YIVVQEY-KKT-------------------------------------------------------------------KN 161
XP_004771627  155 YIVFQEY-KKT-------------------------------------------------------------------SN 166
Q8R4X1        164 YIVRTEY-KKI-------------------------------------------------------------------RD 175 house mouse
XP_003978122  154 YVLAVEM-KHC-------------------------------------------------------------------TD 165 torafugu
XP_006675514  246 DPVALTFQRGILSYGVATFCWLTDMLFCE-LVNPhykgailpfnPQLHAWWHIFVSIGLYHLALLTLAARVDSKYGAgRA 324
XP_004068052  175 QKVLRLAKLSVALWVLAITCWISDRFSCSfWQQLn--------fCYLHGIWHILIVMAVAHATTLIAYLDANNEIPYsLP 246
XP_007489072  166 PKVNHMIRVALMLWAMAISTWICDRLFCPfFQRIn--------fTYLHSFWHILISMAFPYIITILILLDGHYEMQNvPL 237
EHB15102      165 KQLRHMIEISVLLWASALISWISDLFFCSfWQRIr--------fFYLHSIWHVLISITFPYGMVTLALMDATYEMPGqTL 236
14_pfamImport 163 VRLRHIIHVSTILWASAVISWVSDRLFCSfWQRIh--------fFYLHSIWHVIISITFPYGFVTMALVDATYEMPGeTL 234
11_pfamImport 156 KELRHLIEVSVVLWAIALTSWISDRFLCNfWQWIk--------fFYLHSIWHVVISITFPYGMVTMALVDASYEMPGqTL 227
6_pfamImport  162 KELQHLIEVSTVIWALAFTSWISDRLLCSfWQWIn--------fSYLHSIWHVLISFTFPYGMVILALVDSEYEMPNkTL 233
XP_004771627  167 KELRHIMEVSVVLWAFALTSWISDRLLCSfWQQIn--------fFYLHSIWHVLISITFPYGMVTMALVDARYEMPGqTL 238
Q8R4X1        176 DDLRHLIAVSVVLWAAALTSWISDRVLCSfWQRIh--------fYYLHSIWHVLISITFPYGIVTMALVDAKYEMPDkTL 247 house mouse
XP_003978122  166 EKALRLAKFSVVLWVLAISCWISDRFGCSfWRKLn--------fCYLHGFWHILIAIAVAYGSTLIAYLDANYEIPYsLP 237 torafugu
XP_006675514  325 VLRFW---Fn--iIPYIK 337
XP_004068052  247 GLQYWpsdKwtigLPHIV 264
XP_007489072  238 EIHYWprdEwivgLPYVT 255
EHB15102      237 KVRYWprdSwpvgLPYIE 254
14_pfamImport 235 KVRYWprdSwpvgLPYIE 252
11_pfamImport 228 KVRYWakgHla---cgAA 242
6_pfamImport  234 KVRYWprdTwpmgLPYVE 251
XP_004771627  239 KVRYWprdTwpvgLPYVE 256
Q8R4X1        248 KVHYWprdSwvigLPYVE 265 house mouse
XP_003978122  238 GLQYWpcdKwavgLPHIV 255 torafugu
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap