3CUQ,1XB4


Conserved Protein Domain Family
ESCRT-II

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pfam05871: ESCRT-II (This model is not part of the current CDD release)
ESCRT-II complex subunit
This family of conserved eukaryotic proteins are subunits of the endosome associated complex ESCRT-II which recruits transport machinery for protein sorting at the multivesicular body (MVB). This protein complex transiently associates with the endosomal membrane and thereby initiates the formation of ESCRT-III, a membrane-associated protein complex that functions immediately downstream of ESCRT-II during sorting of MVB cargo. ESCRT-II in turn functions downstream of ESCRT-I, a protein complex that binds to ubiquitinated endosomal cargo.
Statistics
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PSSM-Id: 517012
Aligned: 131 rows
Threshold Bit Score: 97.9835
Created: 14-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
3CUQ_C        10 QYRFPPFFTLQPNVDTRQ---KQLAAWCSLVLSFCRLHKQSSMTVMeaq----esPLF--NNVKL----QRKLPVESIQI 76  human
GAA95348      24 IFSFPPFFTLQPHEATRD---AQLLQWKDLIIAYARHFRLFELELSltas--rngELW--TNPACatgqQRRVTPELQQA 96 
KDE05109      49 LYSFPPFFTQQPTESTWS---HQRSQWTTLILAYARHHRIFRFDISeat---cthELF--NNTAI----KRRVNISMLRA 116
EKD02948      35 IWSFPPFFTIQPNPTTQQ---HQLALWTELVLAWAKHDRVFSVNADspe----pgDVF--NNKTI----GRKLQPPALKQ 101
XP_067527146   1 ------mYVRQVTESTWK---SQAFEWESIILSYARHKHLFRLELHnattansgyDIF--ENKKI----NRRLSFEALQD 65 
EPB89623      11 MFDFPPFFTRQVTESTWK---SQVMQWENLILAYTRQKHIFRLDLHqatt-pggnEIF--ENKKI----NRRLSFETLQD 80 
XP_001707049  12 LWYFPPFFTLQQKIEQADvctEQLKQWDALLMKWC--YEVKSREIPkdny--lekAIF--KNTKI----NRKVSDELFRE 81 
A0DIH4        14 lLKYPPFYTLQDHKETRK---KQITQWSEIVHLYFQSHKILESSISeil----nfPIFqdSSSGI----IKKLDSSEIKE 82  Paramecium tetr...
XP_001323916  18 FYDYPPFWTLQTNSQTKK---QQLDLWASFICAYTKFYKKTEIDMIqal----daPLF--NNQKL----GRRVSQQMMTE 84 
XP_654057      8 faKFPPFYTIQLVDKTKN---QQLQLWSQLILKYCECIKKPIMKQSefn----klPIF--HNEEL----HRTLSENGIEL 74  Entamoeba histo...
3CUQ_C        77 VLEELRKKG-------NLEWL-----DKs------kSSFL-IMWRRPEEWGKLIYQWVSRSGQN-NSVFTLYELTN-GED 135 human
GAA95348      97 IISYLISQD-------LASYPvegslvqpvksaiahDRLL-IYTRTPAEWATVIYDFITRNGLN-GSIMTAYELVKgGDL 167
KDE05109     117 IFNFMTSSG-------TAEYDtkplkGQl------pTGAL-VYWKTSDEWALAIYTWVKDKGLT-NSIMTFWELTE-ANE 180
EKD02948     102 LLAHMAAEG-------NAAADp----PKq------tTTYL-LYWRKPEEWGQLIYDWVSDNGFL-NTIMTFYEIVD-GDL 161
XP_067527146  66 IIEEMVKKG-------TAEWEgg--pKGs------kTEAY-LYWHTPEEWANLIWNWINETGQN-DQIVTYYEIAH-GEL 127
EPB89623      81 IIEEMARKG-------TAEWEgg--sKGp------kTEAL-IYWHTPEDWANLIWNWINETGQN-NQIVTYYEIAH-GEL 142
XP_001707049  82 IIDWFKRKG-------RLVEI---------------NKSYyLLSAPEDTIPDSLLRLLKNNNFTvGCIITVLELKK-TMD 138
A0DIH4        83 ILNQMAQLG-------SIEWKn--------------DQNFtVNLVSPFELADAIYAWAKEKKLI-GYTETLRGITE-GSQ 139 Paramecium tetr...
XP_001323916  85 IIDYMVQSE-------NAKWL-----ESt------kTRAR-IIWRTTQQIGDMVRQYLDNIGSL-NTMMTYEELIN-GDE 143
XP_654057     75 VKEFMVNNNkiidlnkSSKLI--------------------LLYKPLREWGKELYEYGNSKGLI-GQSDTFFSIEN-DKE 132 Entamoeba histo...
3CUQ_C       136 TED-E 139 human
GAA95348     168 AHT-T 171
KDE05109     181 VET-A 184
EKD02948     162 AHT-T 165
XP_067527146 128 AEG-Q 131
EPB89623     143 AEG-Q 146
XP_001707049 139 KDA-S 142
A0DIH4       140 TDEsK 144 Paramecium tetraurelia
XP_001323916 144 TEG-E 147
XP_654057    133 ----S 133 Entamoeba histolytica HM-1:IMSS
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