1U5T


Conserved Protein Domain Family
ESCRT-II

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pfam05871: ESCRT-II 
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ESCRT-II complex subunit
This family of conserved eukaryotic proteins are subunits of the endosome associated complex ESCRT-II which recruits transport machinery for protein sorting at the multivesicular body (MVB). This protein complex transiently associates with the endosomal membrane and thereby initiates the formation of ESCRT-III, a membrane-associated protein complex that functions immediately downstream of ESCRT-II during sorting of MVB cargo. ESCRT-II in turn functions downstream of ESCRT-I, a protein complex that binds to ubiquitinated endosomal cargo.
Statistics
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PSSM-Id: 399106
Aligned: 139 rows
Threshold Bit Score: 97.2351
Threshold Setting Gi: 159113646
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1U5T_D                     7 VYSFPPLYTrQPNSLTRR---QQISTWIDIISQYCKTKKIWYMSVDgtvindneldsgstdnddSKkiskNLF--NNEDI 81  bak...
WGS:AAFB:cds.EHI_137860A   8 faKFPPFYTiQLVDKTKN---QQLQLWSQLILKYCECIKKPIMKQS-------------------EfnklPIF--HNEEL 63  Ent...
XP_001323916              18 FYDYPPFWTlQTNSQTKK---QQLDLWASFICAYTKFYKKTEIDMI-------------------QaldaPLF--NNQKL 73  Tri...
GAC74800                  34 VHAFPPFYTlQPNPVSRS---QQLSQWRTLILDFCRYHRIFTLAPLpttdap-------tghgeAAdphkSLF--ANRAI 101 Moe...
XP_011390365              39 IHAFPPFFTlQHNPVSRA---QQLSQWSTLILDYCRHHRLFTISPLagtsdp-------asgsvAAdphtSLF--ANQSI 106 Ust...
EKD02948                  35 IWSFPPFFTiQPNPTTQQ---HQLALWTELVLAWAKHDRVFSVNAD-------------------SpepgDVF--NNKTI 90  Tri...
KDE05109                  49 LYSFPPFFTqQPTESTWS---HQRSQWTTLILAYARHHRIFRFDIS------------------EAtcthELF--NNTAI 105 Mic...
XP_014569795              24 IFSFPPFFTlQPHEATRD---AQLLQWKDLIIAYARHFRLFELELSl-----------------TAsrngELW--TNPAC 81  Mix...
XP_001707049              12 LWYFPPFFTlQQKIEQADvctEQLKQWDALLMKWC--YEVKSREIPk-----------------DNylekAIF--KNTKI 70  Gia...
A0DIH4                    14 lLKYPPFYTlQDHKETRK---KQITQWSEIVHLYFQSHKILESSIS-------------------EilnfPIFqdSSSGI 71  Par...
1U5T_D                    82 ----QRSVSQVFIDEIWSQMTKEG-------KCLPIdqsgrr-----ssnttTTRYfILWKSLDSWASLILQWFEDSGKL 145 bak...
WGS:AAFB:cds.EHI_137860A  64 ----HRTLSENGIELVKEFMVNNNkiidlnkSSKLI---------------------LLYKPLREWGKELYEYGNSKGLI 118 Ent...
XP_001323916              74 ----GRRVSQQMMTEIIDYMVQSE-------NAKWLes------------tkTRAR-IIWRTTQQIGDMVRQYLDNIGSL 129 Tri...
GAC74800                 102 ----QRSLSPEAIRTILSDLVDHK-------QAAWDdasgkknagsaaadtnAKAL-IYWKSPAQWGDTIYDWVFATGQN 169 Moe...
XP_011390365             107 ----QRSLSAESIRVVLTHLVDHK-------QAAWEeqltgaatkskrsnanSKAF-IYWKTPVQWADSIYDWVMQTGQN 174 Ust...
EKD02948                  91 ----GRKLQPPALKQLLAHMAAEG-------NAAADppk-----------qtTTYL-LYWRKPEEWGQLIYDWVSDNGFL 147 Tri...
KDE05109                 106 ----KRRVNISMLRAIFNFMTSSG-------TAEYDtkplk-------gqlpTGAL-VYWKTSDEWALAIYTWVKDKGLT 166 Mic...
XP_014569795              82 atgqQRRVTPELQQAIISYLISQD-------LASYPvegslvqp-vksaiahDRLL-IYTRTPAEWATVIYDFITRNGLN 152 Mix...
XP_001707049              71 ----NRKVSDELFREIIDWFKRKG-------RLVEI----------------NKSYyLLSAPEDTIPDSLLRLLKNNNFT 123 Gia...
A0DIH4                    72 ----IKKLDSSEIKEILNQMAQLG-------SIEWKn---------------DQNFtVNLVSPFELADAIYAWAKEKKLI 125 Par...
1U5T_D                   146 -NQVITLYELSE-GDETVN-W 163 baker's yeast
WGS:AAFB:cds.EHI_137860A 119 -GQSDTFFSIEN-DKE----S 133 Entamoeba histolytica HM-1:IMSS
XP_001323916             130 -NTMMTYEELIN-GDETEG-E 147 Trichomonas vaginalis G3
GAC74800                 170 -KSIMTLFELSH-GDLVQG-Q 187 Moesziomyces antarcticus T-34
XP_011390365             175 -KSIMTLFELNQ-GDLVQA-Q 192 Ustilago maydis 521
EKD02948                 148 -NTIMTFYEIVD-GDLAHT-T 165 Trichosporon asahii var. asahii CBS 8904
KDE05109                 167 -NSIMTFWELTE-ANEVET-A 184 Microbotryum lychnidis-dioicae p1A1 Lamole
XP_014569795             153 -GSIMTAYELVKgGDLAHT-T 171 Mixia osmundae IAM 14324
XP_001707049             124 vGCIITVLELKK-TMDKDA-S 142 Giardia lamblia ATCC 50803
A0DIH4                   126 -GYTETLRGITE-GSQTDEsK 144 Paramecium tetraurelia
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