4RM6


Conserved Protein Domain Family
TPS
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pfam05860: TPS (This model is not part of the current CDD release)
TPS secretion domain
Filamentous hemagglutinin (FHA), the major 230-kDa adhesin of the whooping cough agent Bordetella pertussis, is one of the most efficiently secreted proteins in Gram-negative bacteria. FHA is secreted by means of the two-partner secretion (TPS) pathway. A TPS system is composed of two separate proteins, with TpsA the secreted protein and TpsB its associated specific outer-membrane transporter. All TPS-secreted proteins contain a distinctive N-proximal module essential for secretion, the TPS domain. The TPS domain folds into a beta-helix. This domain is found in a wide variety of secreted proteins from bacterial pathogens.
Links
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Statistics
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PSSM-Id: 517009
Aligned: 35 rows
Threshold Bit Score: 122.857
Created: 14-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
4RM6_A          2 ARDLPQGSSVVVGeanv---stiGNKMTIDQKTPttQ-----IDWHSFDIGQNKEVEFKQPDA----------------- 56   Haemophilus i...
Q8RI19         27 LVVDPNSNYNTKld-------ksANGVPIVNISTpnKngisiNEFSEYNIDEKGQIINNADNIgrshlgglin--anpnl 97   Fusobacterium...
Q9I791         29 AGLALDKAAGGNTglg-----qaGNGVPIVNIATpnDaglsnNHFRDYNVGANGLILNNATGKtqgtqlggii--lgnpn 101  Pseudomonas a...
Q8P9Q5         37 AQVAPTPNPGGQQpgq----qvaANGVPVVDIVApnArgishNRYSNFNVGPNGLILNNSAQIsktelggyva--gnnnl 110  Xanthomonas c...
Q9K0S7         73 AQITTDKSAPKNQqvvi---lktNTGAPLVNIQTpnGrglshNRYTQFDVDNKGAVLNNDRNNnpfv------------- 136  Neisseria men...
Q7DDD8         78 SGIIADKSAPKNQqavi---lqtANGLPQVNIQTpsSqgvsvNRFKQFDVDEKGVILNNSRSNtqtqlggwiq---gnph 151  Neisseria men...
Q9CPH9        112 IKLDASNLAGNDKtki----yqaENKVLVIDIAKpnGkgisdNRFEKFNI-PNSAVFNNNGTEaqarstligyipqnqnl 186  Pasteurella m...
Q9CPI1        122 AHHDAKGDHQTKik-------htENHVIIVDIAKpnQngisdNRFKKFNI-PNGAVFNNSAKEkrsqlvgylp--gnqnl 191  Pasteurella m...
WP_010945061  108 KQTAVDERDPKNG----------KEKVVVINIAKpdEqgisdNHFSKFNI-PNSAVFNNSIKEgnsqlvgllg---enkn 173  [Haemophilus]...
Q7VLE8        104 GKVYVDSQHSSTRiyeqktndnsKDGIVVVEIANpeVdgvsdNRFKEFNI-PNSAVFNNSRTEstsqlvgkl----hani 178  [Haemophilus]...

4RM6_A         57 -----NSVAYNRVTGGNASQIQGKLTANGK----VYLANPNGVIITQGAEINVAGLFATTKDleriSENG-NGNGNKFt- 125  Haemophilus i...
Q8RI19         98 apnqaANLVILQVNGSNRSQIEGYLEALSRekidVILSNENGLYINNSGTINIKNFTATAGK----VNLK-DGDFIGI-- 170  Fusobacterium...
Q9I791        102 lkgqaAQVILNQVTGGNRSTLAGYTEVAGQsa-rVIVANPHGITCQGCGFINTPRATLTTGK----PIMD----GQRLer 172  Pseudomonas a...
Q8P9Q5        111 qrsgaASLILNEVTSAS-SRLQGYTEIAGAka-qLVIANPNGISCDGCGFLNTSRVTLTTGA----PNLGsDGALNGF-- 182  Xanthomonas c...
Q9K0S7        137 -vkgsAQLILNEVRGTA-SKLNGIVTVGGQka-dVIIANPNGITVNGGGFKNVGRGILTTGA----PQIGkDGALTGF-- 207  Neisseria men...
Q7DDD8        152 largeARVIVNQIDSSNPSLLNGYIEVGGKra-eVVVANPSGIRVNGGGLINAASVTLTSGV----PVLN-NGNLTGF-- 223  Neisseria men...
Q9CPH9        187 rggkeADVILNQVTGPQESKIVGALEVLGKka-dIVIANQNGITLNGVRTINSDRFVATTSE---------LIDPNQMm- 255  Pasteurella m...
Q9CPI1        192 tegaeAKAILNQVTGPDASKIEGALEILGQka-dLVIANQNGIVLNGVKTINANRFVATTSS----TIDPeQMQl----- 261  Pasteurella m...
WP_010945061  174 lgsqaAKTIFNQVTGDQESKISGGLEVFGEka-dLFIINPNGVTLNGVKTINTDRFVASTSEvv-ePHIKq--------- 242  [Haemophilus]...
Q7VLE8        179 qlqkeAKLILNQVTGDHESNIQGALEVAGKka-dLIIVNPNGITLNGVKTINTDRFVVSTSD-----IIPhRENGLl--- 249  [Haemophilus]...

4RM6_A        126 rKLKDGQVVKEGQVINKGKikaK-DFVVLNGDKVI------NEGEIDATNng---kVYLSSGYNFtFTL---SDSSisva 192  Haemophilus i...
Q8RI19        171 -DVEKGNIVIGPKGMDGTN---A-NYVEIIAKTLE------------------------LRGNVV--------------- 206  Fusobacterium...
Q9I791        173 fQVDGGDIVVEGAELNVGN---L-EQFDLITRSAK------LNAKLYAKN------LNIVTGRND-VQA---DSL----- 227  Pseudomonas a...
Q8P9Q5        183 -TVTGGALSIGSNGLDAFN---V-DRLDLLSRQLS------VGGSIWTKE------LVATAGTGR-INY----------- 233  Xanthomonas c...
Q9K0S7        208 -DVRQGTLTVGAAGWNDKG---GaDYTGVLARAVA------LQGKLQGKN------LAVSTGPQK-VDY----------- 259  Neisseria men...
Q7DDD8        224 -DVSSGKVVIGGKG-LDTS---DaDYTRILSRAAE------INAGVWGKD------VKVVSGKNK-LDFd---------- 275  Neisseria men...
Q9CPH9        256 lKVTKGNVIIDIDG-FSTD---GlKYLDIIAKKIEqkq-siTSGDNSEAKt----dVTLIAGSSE-YDL----------- 314  Pasteurella m...
Q9CPI1        262 -NVTQGTVTIGVDG-FATD---GlPYLDIIAKKIEqkq-aiTKERTGNSEt----dITFVAGNSK-YDL----------- 319  Pasteurella m...
WP_010945061  243 lNVQRGKVIIGKDG-VATN---GlSHFDVVAKNIEqqgkvsIEGDSKPAKla---nVTFAAGNLT-YDVntrDVNR---- 310  [Haemophilus]...
Q7VLE8        250 -SVRNGKVTIDKGGVATNG---L-SHFEVVARNIDqkg-kiTVAKTENQKsvnpanITFAAGSLN-YNL----------- 311  [Haemophilus]...

4RM6_A        193 lednAVQSIVQNEGIIKag--dITLNAKGRnqalDSLVMNNGVLEATKVSNKnGKVVLSaddvQLNNKSDIK 262  Haemophilus influenza...
Q8RI19        207 ----TNDLKVVTGSNSTtstnnIAIDAKELggmyANRIRIISTDKGAGVNSD-AFIVSKnsklEITADGKIK 273  Fusobacterium nucleat...
Q9I791        228 ----QATPRAADGSEKPq----LAIDSSALggmyAGAIRLVGTEQGVGVRLA-GDMAASggdiRIDASGKLS 290  Pseudomonas aeruginosa
Q8P9Q5        234 -----DGMLLDVLPGTDggapaIGIDVAQLggmyADRIRLIATEAGVGVVSR-GTLAAQsgdlQIDGAGQVS 299  Xanthomonas campestri...
Q9K0S7        260 -----ASGEISAGTAAGtk-ptIALDTAALggmyADSITLIANEKGVGVKNA-GTLEAAkq-lIVTSSGRIE 323  Neisseria meningitidi...
Q7DDD8        276 ---gSLAKTASAPSSSDsvtptVAIDTATLggmyADKITLISTDNGAVIRNK-GRIFAAtggvTLSADGKLS 343  Neisseria meningitidi...
Q9CPH9        315 -----SKHELKKTSGENvsndvIAITGSSTgamhGKNIKLIVTDKGAGVKHD-GIILSEndiqIEMNEGDLE 380  Pasteurella multocida
Q9CPI1        320 ----NTHQVTEKHTAEAqg--eIAISGASTgamyGKNIKLIVTDKGAGVKHD-GIILSEadiqIETHEGDVE 384  Pasteurella multocida
WP_010945061  311 ----NTNPKKPITDNTRkd--nIAISGESAgsmyGRNIKFIVTDKGAGVNHQ-GVIFAEddinILTDDGNSR 375  [Haemophilus] ducreyi
Q7VLE8        312 ----KTREATPISSGTSrtsdtPAISADSAgsmyGSNIKFVVTDKGAGVKHK-GIIFSEndinIKMDGGNAS 378  [Haemophilus] ducreyi
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