5WWL


Conserved Protein Domain Family
Mis12
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pfam05859: Mis12 (This model is not part of the current CDD release)
Mis12 protein
Kinetochores are the chromosomal sites for spindle interaction and play a vital role in chromosome segregation. Fission yeast kinetochore protein Mis12, is required for correct spindle morphogenesis, determining metaphase spindle length. Thirty-five to sixty percent extension of metaphase spindle length takes place in Mis12 mutants. It has been shown that Mis12 genetically interacts with Mal2, another inner centromere core complex protein in S. pombe.
Links
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Statistics
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PSSM-Id: 517008
Aligned: 92 rows
Threshold Bit Score: 129.336
Created: 14-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
5WWL_M         1 MLVELLEFTPLSFIDDVINITNQLLYKGVNGVDKAFSQTR-------FAKKAPQEIEEGLHKFEVLFESVVDRYYDGFEV 73  Schizosaccharom...
7_pfamImport   2 YEAQFFGFTPQTCMLRIYLAFQDYLLEMMAVVEGVVLKKLeas---pggRVSRLDVRKSTEKFLRFMKEHFDQLFGKMEE 78 
Q1T769         8 YETQFFGFTPQTCMLRIYLAFQDYLFEMMVVVESVILKKLea---lpAVQISRFEIRKSTEKFLHFMKARFDQLFEKMEE 84  chicken
XP_001101672   8 YEAQFFGFTPQTCMLRIYIAFQDYLFEVMQAVEQVILKKLdg---ipDCDISPVQIRKCTEKFLCFMKGHFDNLFSKMEQ 84 
Q9CY25         8 YEAQFFGFTPQTCLLRIYVAFQDHLFEVMQAVEQVILKKLed---ipNCEITPVQTRKCTEKFLCFMKGRFDNLFGKMEQ 84  house mouse
XP_007502551   8 YETQFLGFTPQTCMLRIYIAFQDYLFEVMVAVEKVILKKAas---lpDGGMSAVQLRGSTEAFLRFMRERFDRLFVKMEQ 84 
XP_003430460   8 YEAQFFGFTPQTCLLRIYVAFQDYLFEVMLTVERVILKRLeaa---pgsGVSPVQIRKGTEKFLRFLKERFDGLFGTMET 84 
XP_015222873  16 YEAQFFGFTPQTCMLRVYNAFQDSLYEIMLIVETVLVKKIrg---peAAGEVDSQTRQRTQKLLTFLQKRVSRLTGRMER 92 
XP_007245327  21 YEAQYFGFTPQTCMMRVNSAFQDCLYEMLAVVESVFVRKLsqg--kdPPEELQLKTRECTQKLLRFLQERFKKLSSRMEA 98 
3_pfamImport   2 YETQFFGFTPQTCMLRVYSAFQDCLYDILPVVEKVCVRQLgrgesaeSEELLRARARECSRKLQRFLDERFKLLAERMEA 81 

5WWL_M        74 YTLRNIFSYPPelkgYMRTFG-KDVD--YSITTEQDAA-MDQAIQEAAEKLVVKMQLRRDLRMRLSRKREKKTEIEKHLE 149 Schizosaccharom...
7_pfamImport  79 VLLQLVLSIPP----HVLLPEd-RVHrqYPYSREQFQA-LQDEASHLQQRCRAEAAAGQALRAELQEQKAVQAELERILQ 152
Q1T769        85 VLLQLVLSIPD----NVLLPEd-RVHqqYPYSQEEFCA-LQDEISQLQQQCRAEAAAGQALRAELEEQRAVQAELEKVVQ 158 chicken
XP_001101672  85 LFLQLILRIPS----NILLPEdKCKEtpYSE--EDFQH-LQKEIEQLQEKYKTELCTKQALLAELEEQKIVQAKLKQTLT 157
Q9CY25        85 LILQSILCIPP----NILLPEd-KCQetNPFSEEKLEL-LQQEIKELQEKYKVELCTEQALLAELEEQKTVKAKLRETLT 158 house mouse
XP_007502551  85 VLLQLVLSIPP----NVLLPEd-RCHekYPQS-KEELPlLQQEIGQLQAQYKAEVGAKQALLAELEVQKVIQAQLKKTLR 158
XP_003430460  85 VLLQLVLRVPD----HVLLPEd-RSHarHPRGPEELAR-LREEADRLRGRYEAEVRAGRALLAELEEQRAARAELEKTLR 158
XP_015222873  93 FLQSSVLQVPA----NVLLPEd-AAHrqHPQGRERLVK-LEAELAALQLRYQAEVGARQALLAELEEQEAVQAELAGLLK 166
XP_007245327  99 LLVNSVLCVPE----NLLLPEd-ESHrkYPQSQEQLLK-LEASITNLQSSYQAEVCARQALLAELEEQKQTQEQLDEVLR 172
3_pfamImport  82 LLTERCFSVPP----SVLLPEd-QLHktYPQHIQEVLR-LESSLADLQSAYEAEVCARQALLAELEEQREVQKQLDGILA 155

5WWL_M       150 RISFL-NKVPENWQVTLPETTDFLLDQLGNLQHAVKRvveasptvhsrevDERITYLEKGYERL 212 Schizosaccharomyces pombe 972h-
7_pfamImport 153 WFEGLeNTCREHGTSNVRESFTFLTQNSKKLQDVLRE-------------------VKEKSKKI 197
Q1T769       159 WFDGLeNVCREHGTGNFKESLVFLTQNCKKLQDVLRD-------------------VEEKSKKI 203 chicken
XP_001101672 158 FFDELqNVGRDHGTSDFRESLVSLVQNSRKLQNIRDG-------------------VEKESKRL 202
Q9CY25       159 FFDELeNIGRYQGTSNFRESLASLVQSCRKLQSIRDN-------------------VEKESRRL 203 house mouse
XP_007502551 159 WFDGLgD---AHGLVGLGEMTAFLIQHSDCRAPWTRPp------------SASETWAASAARKF 207
XP_003430460 159 WFDGLeNAWREHGSGDPRESLAFLIRSSDRLRAVVGD-------------------VERKGRRL 203
XP_015222873 167 CISEVrAAYARGGMGWVQESFTYVLKTARRIQDALKE-------------------IGSKAEGL 211
XP_007245327 173 WTEELrLAWKQEGMGNVRDSFRHMVETVNQLQSVMGK-------------------IRKKSKSL 217
3_pfamImport 156 WVRELqAAWVKEGNGSFHDSFQLVMESVKKLQDAVGE-------------------VNNANRIS 200
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