3LOT,3FA5,2Y7G,3E02


Conserved Protein Domain Family
BKACE

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pfam05853: BKACE 
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beta-keto acid cleavage enzyme
BKACE, beta-keto acid cleavage enzyme plays, a role in lysine degradation. In certain instances it catalyzes the conversion of 3-keto-5-aminohexanoate and acetyl-CoA into acetoacetate and 3-aminobutyryl-CoA. The family is found to have at least 14 slightly different potential new enzymatic activities, all of which can therefore be designated as beta-keto acid cleavage enzymes.
Statistics
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PSSM-Id: 399095
Aligned: 229 rows
Threshold Bit Score: 141.851
Threshold Setting Gi: 333488344
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
3LOT_A              8 VIVTCAITGAIHTPSXSPYLPVTPDQIVEEAVKAAEAGAGXVHIHAR--Dp-KDGR---P-TTDVEVFRYICREIKK-QS 79  Archaeoglo...
jgi:Psed_2557      10 LFIEVRCN-ESTMRGANPHLPYSTEEIVREAVRAHDAGAAIIHWHGR--Dp-DTGG---P-DNSVETYRAASEGIRG-AT 80  Pseudonoca...
jgi:Swit_1770       5 VIIEVALN-ETVVRRENPHVPLTPEEIAEDAYQCYREGASIIHFHNRvpDkpDDGSydsSlAGSAEHYAETMRLIRA-KC 82  Sphingomon...
MSJTU:JDM601_3736   9 VYLEVGVN-EVVSKDDNPNVPYGAEETARNLVDCIQHGATAVHFHAR--N--DDGT---QaWVDDEISRTVLASAAR-EV 79  Mycoliciba...
WP_002712792        4 VWIEAALNGP-WTRAKQPGIPVAVEAIVADGIACAEAGAAIIHAHAY--Dv-TTGR---Q-RDDWEIYARIIEGIRA-TV 74  Afipia cle...
jgi:Dshi_0339       4 ICLEVALNGP-WSRSLQPGMPITTDELIAQGIACARAGAAVVHVHVY--Dp-DTGR---Q-REDYDAYAKVIEGIRA-VE 74  Dinoroseob...
WP_014745677        9 VWIEAALNGP-WGRDRQPGIPVTEAEIIADGIAAARAGAGIIHVHAY--Dp-ETGR---Q-NDDGATYARIIEGIRA-TT 79  Tistrella ...
WP_015930015        3 VWIEAALNGP-WTRARQPRMPLAVDEIVADGIACARAGAAIIHVHAY--Dp-ATGR---Q-IDDPDTYAAIIEGIRG-VE 73  Methylobac...
AEV70721            4 VIIECAING-VTSKAANPHVPIAPSEITADALACMDAGAAIIHNHID-----LPGV---GvERAVERYLEAWRPVLDaRP 74  Mycoliciba...
jgi:Psed_3787      23 VIVELALNGP-TPRSVNRHVPRSPAEITAVALEGIELGASIVHNHND--DpmFTAD---G-VHAVEPYVRAWTPILDrYP 95  Pseudonoca...
3LOT_A             80 DVVINVTTGgggtlgiPV-EE------RAK---VVPA-----LKPEIATFNXGSXNFAIhpllkkykefkydwepeylex 144 Archaeoglo...
jgi:Psed_2557      81 DLITKPTLG--------YiSQtgv-edRVKh--LRALaddpwLRFDAAAVDFGSLNIDTwdgqr--------------ft 135 Pseudonoca...
jgi:Swit_1770      83 DVIPYPTYT-------YPgAAgreeaeRGMhphVKALrampdIGLETFVLHVGATNIGRydfka-------------grf 142 Sphingomon...
MSJTU:JDM601_3736  80 DPLAYPSYHg-----------------------SLEHiwslaERP-----PAGT-------------------------- 105 Mycoliciba...
WP_002712792       75 DVIVYPTIP-------SPgLGqeqntnRFG---HTLElakrgLI-EWAVIDPGSVHISRfdd-----------------l 126 Afipia cle...
jgi:Dshi_0339      75 DVIVYPTLPls---gsRDaATamtpeaRFA---VVEAlardgLL-EWAVVDPGCAILSSlseir--------------ag 133 Dinoroseob...
WP_014745677       80 DALVYPTIPla---gaALtGQaagpaaRFA---HIDFlasrgLI-EMAVIDPGTVCFIDrrdgp--------------aa 138 Tistrella ...
WP_015930015       74 DVIVYPTIPfv---qsADaFRpgavemRFA---AIESlgrrgLL-EWAVVDPGSINLATfdeaa--------------ra 132 Methylobac...
AEV70721           75 DALLYPTIH--------FdTDgscsyeHLV---ALAAag-----iRVGITDPGSVNLGVrdadg--------------lp 124 Mycoliciba...
jgi:Psed_3787      96 DVLLYPTMG--------AaARgipverRWA---HVEElarrrM--GMTLVDPGSVNLGLtsdgvl------------dpv 150 Pseudonoca...
3LOT_A            145 trDIVFR-------------------------------NTFKDLEALSRIFKENDTKPELECYDIGQIYNTAFXFHEGYL 193 Archaeoglo...
jgi:Psed_2557     136 pgDGVYV-------------------------------NSRNDIEAVLRILDDIDTYLTTVVWDIGQIRTAKCFREMGLA 184 Pseudonoca...
jgi:Swit_1770     143 vyDRVSS-------------------------------HTHEQMSQFLAWCLESGLQPGFIVREPGHVRHLLMYHEMGLL 191 Sphingomon...
MSJTU:JDM601_3736 106 --ELLLTpfdpvqhikrvlwledenrfgvvsfgpddpnNSNPPYPPELDRFAELGLVPNIAVFNAADMRWVTLAARIGIL 183 Mycoliciba...
WP_002712792      127 ahGGVYA-------------------------------NPHEDIMEGMRIARAHNVHPSYAVYEPGFT-------RLGAA 168 Afipia cle...
jgi:Dshi_0339     134 reGFVYH-------------------------------NSEAEVRHGLDLARTYGFHPSYAIYEPGFA-------RLGAA 175 Dinoroseob...
WP_014745677      139 laSFVYT-------------------------------NTEAEIRHGLALAATHRLVPSYAIYEPGFT-------RAGAL 180 Tistrella ...
WP_015930015      133 epGSVYL-------------------------------NPGEHVLRGLTLAAQHGFVPSYAVYEPGFL-------RLGAA 174 Methylobac...
AEV70721          125 sgGFVYR-------------------------------NSFDVIGRAFDICRDGALGPSLAIYEPGFLRATLAWWRAGRL 173 Mycoliciba...
jgi:Psed_3787     151 aaAEPYA-------------------------------NPHADTDHMITRTAALGAAPSISIFEPGYLRTVLTWHRTGRL 199 Pseudonoca...
3LOT_A            194 E-------PPLRLQFIHg-------iLGGIGTAVEDVL----FXKQTADRligr-enyT-WSLVGA---------GRFQX 244 Archaeoglo...
jgi:Psed_2557     185 Q-------APTFWELVFtgd----srPSGAGTNLLALQamvaELPPG-----------EpWQLMCY---------GGDVL 233 Pseudonoca...
jgi:Swit_1770     192 K-------EPIMVHLNMsd-----svPYGPMPDAAGVLslldMFPPHIRYe---------WFPHNYttfvhdpahGDTHR 250 Sphingomon...
MSJTU:JDM601_3736 184 R-------QPLNIKLFFsd-----rwVSNNDPDPDVID----FLISRIPQgidhetvvvpYAMSSA----------QRCE 237 Mycoliciba...
WP_002712792      169 LaaiappsPTPIYRFMFsd-----efAWGFPPREKYLDihldLLAETTPG--------ApWMIAGL---------GVDIT 226 Afipia cle...
jgi:Dshi_0339     176 LaaqvpgvPRPIYRFMFse-----gfTFGYPPRGYALDsylaLMAELDPG--------ApCMIAGL---------QVDIL 233 Dinoroseob...
WP_014745677      181 LagqtpglATPLYRFMFsd-----afAWGFPPRRYGLEahlaLLGEAAPA--------ApWMIAGL---------CVDLE 238 Tistrella ...
WP_015930015      175 LaravpgcPPPLYRFMFsd-----rfTFGFPPAAYALDayleLLERTTAG--------SpWMVAGL---------GVDVR 232 Methylobac...
AEV70721          174 P-------AGAMIKLYFstergylgaPFGLPPTERALDayleVLGDCEIP----------WAVSIV---------GGDLC 227 Mycoliciba...
jgi:Psed_3787     200 P-------AGAIVKLYFgg-----rlEFGLPPTPTALEayleLLAPSGLP----------WSVAVL---------GGDVV 248 Pseudonoca...
3LOT_A            245 P--LGTLAVIXGGDVRVGLEDSLYIerGKLAKSNAEQVEKXVRIVKELGKRPATPDEVREILGL 306 Archaeoglobus fulgidus
jgi:Psed_2557     234 P--LAAAAIVLGGHVAIGLGDHDYA--RFGTPHNGELVAKVVALAETIGRPVATPAQARELLGM 293 Pseudonocardia dioxanivora...
jgi:Swit_1770     251 E--LNVLAVAMGGHIRTGLGDKPEW--DGEQLSNVEMVRRMAAVARAVGREIATPDEARAMLGY 310 Sphingomonas wittichii RW1
MSJTU:JDM601_3736 238 Q--LWERALDRGLGIRVGVGDCPW---AYPYATNAEMVDRAVELITKRGLTPATQADLRARVGa 296 Mycolicibacter sinensis
WP_002712792      227 S--LIPHTVARGGHVRVGLEDALWG----DPRTNEALVKDAVKRVRAAGGEPATTAEVRRELke 284 Afipia clevelandensis
jgi:Dshi_0339     234 P--LIGAAVPAGVHVRVGLEDAPFG----TELSNIGWTEAAAQAIAQAGGTLARAAEIRRKiag 291 Dinoroseobacter shibae DFL...
WP_014745677      239 D--LLPHAVAAGGHVRTGLEDAPFG----TETGNAGLVARMVQMVEAAGGLPATPAEIRAGLGL 296 Tistrella mobilis
WP_015930015      233 P--LVPHAVARGGHVRVGLEDAPFG----TEIGNPALVEEMVQLVEAAGGRPATAAEIRRAcpa 290 Methylobacterium nodulans
AEV70721          228 AdrLAGLALERGGNLHVGLE--FYG--GDRTPTNVDLVTEAVALCQRFDRPVATPEEAAQILGL 287 Mycolicibacterium rhodesia...
jgi:Psed_3787     249 GcgLAELAVRRGGHVRVGLEDHA----GPGEPSNADLLRALGELLADMGRVPASIAETRAILGv 308 Pseudonocardia dioxanivora...
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