2Y7E,3LOT,3CHV,3NO5


Conserved Protein Domain Family
BKACE
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pfam05853: BKACE (This model is not part of the current CDD release)
beta-keto acid cleavage enzyme
BKACE, beta-keto acid cleavage enzyme plays, a role in lysine degradation. In certain instances it catalyzes the conversion of 3-keto-5-aminohexanoate and acetyl-CoA into acetoacetate and 3-aminobutyryl-CoA. The family is found to have at least 14 slightly different potential new enzymatic activities, all of which can therefore be designated as beta-keto acid cleavage enzymes.
Links
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Statistics
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PSSM-Id: 517005
Aligned: 172 rows
Threshold Bit Score: 160.739
Created: 14-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
2Y7E_A          9 PLILTAAITGAETTRADQPNLPITPEEQAKEAKACFEAGARVIHLHIREd--DGRP-SQRLDRFQEAISAIREVvPEIII 85  Candidatus Clo...
WP_014075751    6 KIIITVAINGGMQQDREGAVIPKQPVEIGEAAARCYEAGAAMVHVHARDp--EGKN-SGDPAIYAQIIKEIRAr-SPILV 81  Sphingobium sp...
WP_013830661    8 KVYLEVGVN-EVVSKDDNPNVPYGAEETARNLVDCIQHGATAVHFHARNd--DGTQaWVDDEISRTVLASAARe-VDPLA 83  Mycolicibacter...
Q28MR0          3 nIIIEARVN-ELATRIGNPHVPFLPAEVIADAKACHDAGASIFHFHGRNe--DGTP-SHDPNFYLETNAGIRAq-SDILI 77  Jannaschia sp....
WP_013324303    6 PLIIECRCN-EITPRGDNPALPHSPKEIIREAIRAWEAGASIFHWHGRDp-dTGKP-RNDVELYLEVIQGIREh-TDLLI 81  Gloeothece ver...
jgi:Psed_3787  22 PVIVELALNGP-TPRSVNRHVPRSPAEITAVALEGIELGASIVHNHNDDpmfTADG-VHAVEPYVRAWTPILDRyPDVLL 99 
WP_372023683    9 pVWIEAALNGP-WGRDRQPGIPVTEAEIIADGIAAARAGAGIIHVHAYDp-eTGRQ-NDDGATYARIIEGIRAt-TDALV 84  Tistrella mobilis
WP_015930015    2 qVWIEAALNGP-WTRARQPRMPLAVDEIVADGIACARAGAAIIHVHAYDp-aTGRQ-IDDPDTYAAIIEGIRGv-EDVIV 77  Methylobacteri...
WP_012177018    3 qICLEVALNGP-WSRSLQPGMPITTDELIAQGIACARAGAAVVHVHVYDp-dTGRQ-REDYDAYAKVIEGIRAv-EDVIV 78  Dinoroseobacte...
WP_015748633   18 PVVIESHING-VRSKEMNPNTPVGYDEIAEDAIRCWEAGAGAIHAHNTSfdlLGEN-AF--KDYMRTWEKVLDKhPDITW 93  Nakamurella mu...

2Y7E_A         86 QISTG---GavgeSF-DK------RLA---PL-Al-----KP--EMATLNAGTLNFg------------DDIFI------ 126 Candidatus Clo...
WP_014075751   82 QTTNG---------IgVRrdpktgQLYwpsDEeRlgllgiEPqqDLFGIAAGSADFynpeg----gypgETPYV------ 142 Sphingobium sp...
WP_013830661   84 YPSYHg------------------------SLeHiwslaeRP-------PAGT----------------ELLLTpfdpvq 116 Mycolicibacter...
Q28MR0         78 HPTLG---------YvANdtdakgRFAa--IEqMmqsaetAP--DFAPMDTGSVNVdwwnpdegkydttELIYK------ 138 Jannaschia sp....
WP_013324303   82 HPTLG---------YiTQhrv-edRVKh--ILaVnddpllRV--DMVPVDFGSLNVdfwnpqtkeftttDQVYI------ 141 Gloeothece ver...
jgi:Psed_3787 100 YPTMG---------AaARgipverRWA---HVeElar----rrmGMTLVDPGSVNLgltsdgvldpvaaAEPYA------ 157
WP_372023683   85 YPTIPlagA----ALtGQaagpaaRFA---HIdFlasrglI---EMAVVDPGTVCFidrrdg--paalaSFVYT------ 146 Tistrella mobilis
WP_015930015   78 YPTIPfvqS----ADaFRpgavemRFA---AIeSlgrrglL---EWAVVDPGSINLatfdea--araepGSVYL------ 139 Methylobacteri...
WP_012177018   79 YPTLPlsgS----RDaATamtpeaRFA---VVeAlardglL---EWAVVDPGCAILsslsei--ragreGFVYH------ 140 Dinoroseobacte...
WP_015748633   94 YPTTCnn---------------lrLIGdehGLeHvallneHAhaEIACVDTGLTLFathtdd--egylvGPEFG------ 150 Nakamurella mu...

2Y7E_A        127 -------------------------NHPADIIRLAEAFKQYNVVPEVEVYESGMVDAVARLIKKGIIT-------QnPLH 174 Candidatus Clo...
WP_014075751  143 -------------------------NSPELLRSTIKAVYEKGSALEYEIVEASSLHRLMRYAEEGLFD-------R-HRE 189 Sphingobium sp...
WP_013830661  117 hikrvlwledenrfgvvsfgpddpnNSNPPYPPELDRFAELGLVPNIAVFNAADMRWVTLAARIGILR-------Q-PLN 188 Mycolicibacter...
Q28MR0        139 -------------------------NSTGTLMYFADRIRHYNLTPYLVSWNVSFTRQIEQFLKMGVLD-------A-PAY 185 Jannaschia sp....
WP_013324303  142 -------------------------NTRANLMAVLEVFKKHNLHVSSVCWDVGQMRTARCFQEMGLLP-------R-ETL 188 Gloeothece ver...
jgi:Psed_3787 158 -------------------------NPHADTDHMITRTAALGAAPSISIFEPGYLRTVLTWHRTGRLP-------A-GAI 204
WP_372023683  147 -------------------------NTEAEIRHGLALAATHRLVPSYAIYEPGFT-------RAGALLagqtpglA-TPL 193 Tistrella mobilis
WP_015930015  140 -------------------------NPGEHVLRGLTLAAQHGFVPSYAVYEPGFL-------RLGAALaravpgcP-PPL 186 Methylobacteri...
WP_012177018  141 -------------------------NSEAEVRHGLDLARTYGFHPSYAIYEPGFA-------RLGAALaaqvpgvP-RPI 187 Dinoroseobacte...
WP_015748633  151 -------------------------FNYARVGRQWRMLRERNVPMVYGVYEPGHLRHAMYYVNQGMSTp------G-SMW 198 Nakamurella mu...

2Y7E_A        175 IQFVLg----------vPGGMSGKP---KNLMym----mEHLKEeip---taT-WAVAGIG-RWHIP--TSLIAMVTGGH 230 Candidatus Clo...
WP_014075751  190 NMWLLh-----------GGGFGATPaiaRNVIfsideglRMFPK--------AiWGITGTG-RDMFK--MATLGVAMGCD 247 Sphingobium sp...
WP_013830661  189 IKLFFsd--------rwVSNNDPDP---DVIDfl----iSRIPQgidhetvvvpYAMSSA--QRCEQ--LWERALDRGLG 249 Mycolicibacter...
Q28MR0        186 ICFCMtde-------iiFAGHPGTE---AGLDahtaflpPEFETv---------WTVVNYK-GDLFQ--LTEKIIRTGGH 243 Jannaschia sp....
WP_013324303  189 WELVFtge-------vmPAGAAATI---PGLQafvaevpADNQ-----------WLALCWN-GDVMR--VAAWAITMGGH 244 Gloeothece ver...
jgi:Psed_3787 205 VKLYFgg--------rlEFGLPPTP---TALEaylellaPSGLP----------WSVAVLG-GDVVGcgLAELAVRRGGH 262
WP_372023683  194 YRFMFsd--------afAWGFPPRR---YGLEahlallgEAAPA--------ApWMIAGLG-VDLED--LVPHAVAAGGH 251 Tistrella mobilis
WP_015930015  187 YRFMFsd--------rfTFGFPPAA---YALDaylelleRTTAG--------SpWMVAGLG-VDVRP--LVPHAVARGGH 244 Methylobacteri...
WP_012177018  188 YRFMFse--------gfTFGYPPRG---YALDsylalmaELDPG--------ApCMIAGLQ-VDILP--LIGAAVPAGVH 245 Dinoroseobacte...
WP_015748633  199 DFYLIgdygltatepigTNGMKPSL---ESLYyylhmieEAKVK--------HpWYISIWGqGALDDthILRRAIELGGH 267 Nakamurella mu...

2Y7E_A        231 -IRCGFE---DNIFYHKGVIAeSNAQLVARLARIAKEIGRPLATPEQAREILAL 280 Candidatus Cloacimonas acidaminovorans
WP_014075751  248 lVRVGFE---DGIHLPDGTVGrDNSEMVRAAVDIAAFYGAQPATVEEARARFGL 298 Sphingobium sp. SYK-6
WP_013830661  250 -IRVGVG---DCPW---AYPYaTNAEMVDRAVELITKRGLTPATQADLRARVGa 296 Mycolicibacter sinensis
Q28MR0        244 -ISIGLG---DYAY-MDGSRHmTNAEVIAKVADQARRLGREPASVAETREILNM 292 Jannaschia sp. CCS1
WP_013324303  245 -VGIGLG---DYSYT--RFGKpHNGELVEKVAKMAHTLGREVATPAQAREILKM 292 Gloeothece verrucosa
jgi:Psed_3787 263 -VRVGLE---DHA----GPGEpSNADLLRALGELLADMGRVPASIAETRAILGv 308
WP_372023683  252 -VRTGLE---DAPFG----TEtGNAGLVARMVQVVEAAGGRPATPAEIRTGLGL 297 Tistrella mobilis
WP_015930015  245 -VRVGLE---DAPFG----TEiGNPALVEEMVQLVEAAGGRPATAAEIRRAcpa 290 Methylobacterium nodulans
WP_012177018  246 -VRVGLE---DAPFG----TElSNIGWTEAAAQAIAQAGGTLARAAEIRRKiag 291 Dinoroseobacter shibae
WP_015748633  268 -IKTGLElfyD------PARNpTNLELLQQAQEIAREVGRPIATHEQARALYQL 314 Nakamurella multipartita
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