2NR7,2IKB


Conserved Protein Domain Family
Glyco_hydro_108

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pfam05838: Glyco_hydro_108 
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Glycosyl hydrolase 108
This family acts as a lysozyme (N-acetylmuramidase), EC:3.2.1.17. It contains a conserved EGGY motif near the N-terminus, the glutamic acid within this motif is essential for catalytic activity. In bacteria, it may activate the secretion of large proteins via the breaking and rearrangement of the peptidoglycan layer during secretion. It is frequently found at the N-terminus of proteins containing a C-terminal pfam09374 domain.
Statistics
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PSSM-Id: 399090
Aligned: 105 rows
Threshold Bit Score: 71.8143
Threshold Setting Gi: 284083955
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2NR7_A         11 LPYILKWEGGFVHDPADAGGATNKGVTIATWKRvgydkdgdgdidveDLKLLTDDDVLnRVLKPFYWDRWKADLIEs--Q 88  Porphyromonas ...
WP_013278181    9 FKKILDYEGGYSDEQKDHGGKTKYGITEKLARDygh---------egEMKDLELEKAK-EIYYREFWANHLYSWIEd--E 76  Acetohalobium ...
WP_015327762    9 LQEVLNYEGGYTDDEDDSGGPTKFGVTESTARRsdy---------kgDLKELTKKEAT-EIYYENYWANLKYNQIEd--D 76  Halobacteroide...
jgi:Lebu_1825  10 FNYILLVEGSYSNDKNDKGGETKYGITKERAREcgy---------kgSMKDLTKATAQ-KIYEEKYYKAKKLDKVKn--D 77  Leptotrichia b...
Q31HV3          7 FPKVIKVEGGDSDNKNDSGGKTRFGITQAVASMhg----------fdDVSKLTIQQAK-SIYKSDYWDLLHLDNIDllsD 75  Hydrogenovibri...
WP_012205902    7 FDRLLGHEGGYSNNSADPGGETMWGVTARVARAdgy---------lgEMRDLPRDRAK-SIYRRLYWTPVRADELP---E 73  Delftia acidov...
Q775E1          7 FDRLIGHEGGYSNNPADPGGETMWGVTAAVARAngy---------tgPMRDMPRDTAK-AIYRARYWTPVRGDMLP---P 73  Bordetella vir...
Q65WE5         11 FDRVVGHEGGYVNDPHDPGGETNWGITKYTAREngy---------tgSMKAMTREQAY-KIYEKAFWQRYHCEKLP---E 77  [Mannheimia] s...
2IKB_B          9 INRVLSHEGGYANHPKDPGGETNWGITKRTAQAngy---------ngSXRAXTREQAI-SIYRKAFWERYRADQXP---E 75  Neisseria meni...
ACL32506       14 FDRVIQHEGGYVNDPRDAGGETKFGITIHTARAngy---------tgSMFTMTRDDAK-QIYLKAFWQRYRCNEFP---P 80  Glaesserella p...
2NR7_A         89 KVANILVDWVWGSG 102 Porphyromonas gingivalis W83
WP_013278181   77 RIATEVFEQAVNMG 90  Acetohalobium arabaticum
WP_015327762   77 RIALEVLDQAINFG 90  Halobacteroides halobius
jgi:Lebu_1825  78 KMALSIFDFSVNAG 91  Leptotrichia buccalis C-1013-b
Q31HV3         76 KIAFELFDTAVNMG 89  Hydrogenovibrio crunogenus XCL-2
WP_012205902   74 VVRFDVFDGAVNSG 87  Delftia acidovorans
Q775E1         74 AVAFQVFDAAVNHG 87  Bordetella virus BPP1
Q65WE5         78 AVAFQFFDAAVNHG 91  [Mannheimia] succiniciproducens MBEL55E
2IKB_B         76 AVAFQFFDACVNHG 89  Neisseria meningitidis MC58
ACL32506       81 ELAFQFFDACVNHG 94  Glaesserella parasuis SH0165
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