7XHO


Conserved Protein Domain Family
CENP-H

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pfam05837: CENP-H (This model is not part of the current CDD release)
Centromere protein H (CENP-H)
This family consists of several eukaryotic centromere protein H (CENP-H) sequences. Macromolecular centromere-kinetochore complex plays a critical role in sister chromatid separation, but its complete protein composition as well as its precise dynamic function during mitosis has not yet been clearly determined. CENP-H contains a coiled-coil structure and a nuclear localisation signal. CENP-H is specifically and constitutively localised in kinetochores throughout the cell cycle. CENP-H may play a role in kinetochore organisation and function throughout the cell cycle. This the C-terminus of the region, which is conserved from fungi to humans.
Statistics
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PSSM-Id: 516999
Aligned: 61 rows
Threshold Bit Score: 80.4225
Created: 14-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
7XHO_H         41 TLLLRLRAQTKQQ---LLEYKSMVDASE---EKTPEQimqekQIEAK---IEDLENEIEEVKVAFEIKKLALD--RMRLS 109 human
XP_007875413   41 RNVLLLYKKLEEL---RNKRKMLLFEE----EISVDNnildqELSEK---IKEAEFELLIANATNTTKDLIIE--NFIET 108
O94261          9 NLCLGALQLLADQ-----PISVISNEPS---EEQRNEhvlkkWENNVlrhWKILFSLFMQTCGDSVQGNAAFSilNFMTT 80  Schizosaccharo...
XP_011276039   42 QKQVRLYHKLIEL----LDKLMVQEEKV---GEFGYE-----EVKKE---LIQSEKLALLVKEGEIPNDDELL--RFLKQ 104
XP_012431424  141 CSLLRLRNQMKEQl-mEYKSAILTCQEN-----FLDQeieesVIQSA---TEHLENDIEEVKVSFHNKMLALQ--RTQIS 209
Q90ZF9         30 LEHLCARTHLKQL---VMEFDTACPPDE-----GCNSgaevnFIESA----KETLEEVGKVKSAFESKALVIK--RIQLM 95  chicken
11_pfamImport   1 THLLSMKHLLSNNfklCFPLAVFLEAELv---lLMSDfceinLIHKNi--LKDVRLKRFRVRILFF---------SMQVT 66 
NP_001107081   37 TSLLKMKEIMENQ---CFEMNVKV---------SMGKhrescEAEAD---LSKYESEIEQARLSHFNKTLVLN--RMQIW 99 
XP_005804100   33 ADMLRIKQQMANQ---CFEMTVQLNAGKskrPCSTS------QAERE---LPDCVSELEHVKTVHFNSTLALH--RIQMW 98 
8_pfamImport    1 VDMLRIKQQMSNQ---CFEMAVQLNAEKnkrSCSTS------EAERD---LPEYISELERVKTLHFNSTLTLH--RMQMW 66 
7XHO_H        110 TALKKNLE----KISRQSSVLMDNMKHLL-ELNKLIMKSQQESWDLEEKLLDIRKKRLQLKQASESKLLEIQTEKNKQKI 184 human
XP_007875413  109 NPILQAAYst-qDSTKQDKIIGLCLENCD-NIISNLLNLHNILLKNEKKIVPLQKEVLNLFLKNKEKVNKIMEIITNIKD 186
O94261         81 NSLVGQLYqrlyDESNSLGFISSPLNETE-HLSEENLKIESSITFTSEEIEKEKENIKSVLLPSVQSISSSLELYAs--- 156 Schizosaccharo...
XP_011276039  105 VQYIRRM--------VVDSGIGVKLEERD-DLIDDIIALENEVSARQSKLNKLNQEINLKFEKSKELTSKLIEKHKNQIS 175
XP_012431424  210 DALRNKLK----QGDEDSRLILETMKHLV-LLSQTIIDYQKKIHEKEQQLINIRRERLSLKVYGGQKLQQIQTMMKRQKe 284
Q90ZF9         96 DALRKRVK----ENDGCARLIVETMRDII-KLNWEIIQAHQQARVIRENLNDIRRKRYFLKQAEGEKALRIFTTVRKKk- 169 chicken
11_pfamImport  67 QAILENLK----RKGKEAELMMATINHTL-SLCSRIEKMKQESRETEEQLLEIQKKRLELKKLNNGKMKEIQELKMMCd- 140
NP_001107081  100 SAVIEKMI----QNGADAEELKELTNQNS-EICEKTIQILKETRELQDQITDVQKQRLDLKGQIKKKMQEINELKQe--- 171
XP_005804100   99 NAIVEKMK----QTDPDATDLKAVSARCM-ALCSQIKRLQMETRNLQDEITEIQKERLEIKRLTHEKMKETQELLSNKe- 172
8_pfamImport   67 HAIGEKL-----NWSDSEADALKAISDRCmGLCSHIKHLQQESKKLQDEITEIQKNRLEMKRVTHEKIKHMEEFSKk--- 138
7XHO_H        185 ---DLDSME-NSERIKIIRQNLQMEIKITTVIQHVFQNLILGSKVNWAEDPALKEIVLQLE 241 human
XP_007875413  187 reeKILSVL-EKQQKEKLIKEMNDIKNRAIIVKNCLQGIILESGIDWYGNEHWRNIMLKAG 246
O94261        157 ---KESD---YRSSIEGVLADLKLARARWEIVRNVTQILLLESGISFLENKKLAYIMDLCG 211 Schizosaccharomyces pombe 972h-
XP_011276039  176 n-nGIDNTK-LKIQLQE---KLKIAKNKSYNLSEEIQAFLVENGINWAKDKKLRELVLYCG 231
XP_012431424  285 ---KQASMD--VRKIEKMLANLEKEREMTTIIQNVFQNIIVGSKVNWAEDPSLKAIVLQLG 340
Q90ZF9        170 ---EVVRMK-IAEKLKFIHRNVQYERKVTTLVQNILQNIIVGCQINWAKDPSLRAIILQLE 226 chicken
11_pfamImport 141 ---HPERGK-YSEILKQGQKNLDKYLQMVAVVKNVFQGIIIASKVNWAADSKLKDVILGME 197
NP_001107081  172 ---KENQGEvQQKTKERAEAVLQKYQRITTILQNVLRGIILASKVNWREDPKLSDIVMKLE 229
XP_005804100  173 ---QPDSEK-YKALLEKGQVNVETYKKMIIMAQNVLRGILLACKVNWLDEPNLREIVMTLE 229
8_pfamImport  139 ---EYPDMEkYKAALEKGQANLEKYKKMAIMTQNVLRGILLACKVNWLDDPKLRDIAMTLE 196
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