Conserved Protein Domain Family
Synaphin
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pfam05835: Synaphin 
Synaphin protein
This family consists of several eukaryotic synaphin 1 and 2 proteins. Synaphin/complexin is a cytosolic protein that preferentially binds to syntaxin within the SNARE complex. Synaphin promotes SNAREs to form precomplexes that oligomerise into higher order structures. A peptide from the central, syntaxin binding domain of synaphin competitively inhibits these two proteins from interacting and prevents SNARE complexes from oligomerising. It is thought that oligomerisation of SNARE complexes into a higher order structure creates a SNARE scaffold for efficient, regulated fusion of synaptic vesicles. Synaphin promotes neuronal exocytosis by promoting interaction between the complementary syntaxin and synaptobrevin transmembrane regions that reside in opposing membranes prior to fusion.
Links
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Statistics
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PSSM-Id: 487991
Aligned: 21 rows
Threshold Bit Score: 57.4764
Created: 14-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_006639899   1 MSFLLKTMVGSPMKNLSGGgg----ggGGEEEKKVEgdgketaeskgMTREEFEEYQRQLVEEKIERDKQFAQKKAERAS 76 
Q6DHG4         1 MNFLLKAAMGGGPPDVGKMlg----geE-DKDPEAE-------------KEKEEERQEALRQEEEERKAKHAKMEAEREN 62  zebrafish
Q4RJ93         1 MNFVMKAALGGGPPDVGKMlg----geEKEQDPDAA--------------KKEEERQEALRQQEEERKAKYAKMEAERER 62  spotted green p...
XP_015788879   2 AAFIAKQMVGNQLSAVKDig------gGGDSAEDKE-----------KLEELERERLEALREAEERRREKHRKMEEEREK 64 
XP_015023546   2 AAFIAKQMVGNQLSAVKGAvg----gdGGDDGDDKE-----------KAEEEERERQEAIREAEERRKEKHRKMEEEREK 66 
XP_046450530   2 AAFVAKQMLGSKMNAVKGlg-----gnDSEDGDTKD-----------KDDEAERERLEAIKEAEDRRKEKHRKMEVEREN 65 
1_pfamImport   1 AAFVAKQVVGNKLNAVKGAvg-----dGGESAEDKE-----------KNAEAERERLEAIREAEERRKEKHRKMEEEREK 64 
XP_003142100   2 ASFIMKQMVGGKLNEMKGGidkltgdkDGEGGEKTE-------------SGEDPEVVAARLEQEERRKERHRKMEREREK 68 
XP_011417713   2 AAFIAKQMVGNQLKSVKGAig----ggDKEGEGENKed--------aGGGGEDPEVEEMRREAERKRKEKHEKAEAEREE 69 
XP_009015915   2 vsLLGGGLFGNPLSGVTNAlg----dkDEKDDKNAE--------------EEDPEIAEAKREAEEKRNEKYRKMEEEREA 63 

XP_006639899  77 LRMHMRGKYRLPQSEKDDAQV----QIV-----------GGDVDLPEDLAKMVEQDEEEEEANDSLLGKIQNMe-lDFDV 140
Q6DHG4        63 IRQGIRDKYGIKKREVAEAEE----AAAmeqac--egsmTRPKK-----AVPSGCGDDDEEE--NIMDTVMKYlpgPLQD 129 zebrafish
Q4RJ93        63 MRQGIRDKYGLKKREEAEAEA----AAAaeepa--agslTRPKK-----AVPAGCGDEEEEE--SIMDTVMKYlpgPLQD 129 spotted green p...
XP_015788879  65 MRQGVREKYGIKKKEEKEEEMrkqqEALmggst--dgglNRAKKTPEELAAEAAAQEQDE------FTKIKTTietQVNE 136
XP_015023546  67 MRQDIRDKYNIKKKEEIV-------EAApqee---pnplMRKKKTPEELAAEAEQEELDD------FTKLKNQietQVNE 130
XP_046450530  66 MRQDIRDKYNIKKKEEAP-------EAEtqkep--dnplMRKKKTPEELAKEAEEADQDE------LTKLKNTletQVNE 130
1_pfamImport  65 MRQEIRDKYNIKKKEELP-------EPVqeep---anplMRKKKTPEELAKEAEMEEEDE------FTKLKNTietQVNE 128
XP_003142100  69 MRQDIRSKYNIQKKEDGIS------GIPfdtstdgrivgPSMKKTPQQIAQEME-DDDSLIGQLG-LTEQVEKaktAVNE 140
XP_011417713  70 LRQSIRDKYGLKKKVPEEE------NMMlnndd--ggrvGRKKKTPAELAAEANADSDDDEFT---MPKNMDElknKVQD 138
XP_009015915  64 MRQTIRDKYHIQKKE----------IPKedpgl--egrlGRKKKTPEELAMESDPNYDPSGNN-SVFPKNLDEltsRVKE 130

XP_006639899 141 IKT 143
Q6DHG4       130 MLK 132 zebrafish
Q4RJ93       130 MLK 132 spotted green pufferfish
XP_015788879 137 LKS 139
XP_015023546 131 LKT 133
XP_046450530 131 WKS 133
1_pfamImport 129 LKS 131
XP_003142100 141 Ale 143
XP_011417713 139 IPQ 141
XP_009015915 131 LPN 133
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