Conserved Protein Domain Family
FbpA

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pfam05833: FbpA 
Fibronectin-binding protein A N-terminus (FbpA)
This family consists of the N-terminal region of the prokaryotic fibronectin-binding protein. Fibronectin binding is considered to be an important virulence factor in streptococcal infections. Fibronectin is a dimeric glycoprotein that is present in a soluble form in plasma and extracellular fluids; it is also present in a fibrillar form on cell surfaces. Both the soluble and cellular forms of fibronectin may be incorporated into the extracellular tissue matrix. While fibronectin has critical roles in eukaryotic cellular processes, such as adhesion, migration and differentiation, it is also a substrate for the attachment of bacteria. The binding of pathogenic Streptococcus pyogenes and Staphylococcus aureus to epithelial cells via fibronectin facilitates their internalisation and systemic spread within the host.
Statistics
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PSSM-Id: 399087
Aligned: 75 rows
Threshold Bit Score: 229.813
Threshold Setting Gi: 74561463
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q8TSZ2            6 SSADVAAVVAELSAGprsIIDAKIGKIYQPASE---EIRINLYvFHQGR-DnLVIEA---GKRLHMT--KY-VRASPTLP 75  Methanosarci...
Q8YP27            5 DFTTLTATCSELHAH---WLPSRLEQVYQRDRY---TIAIALR-TLDKRgW-LQISWhpqATHICIG--DPpPR--TPDT 72  Nostoc sp. P...
Q110R4            5 DYTTLIASCSQLRSQ---WLPARLEHVIQRDRF---TISLALR-TLKKRgW-LDISWhpqAARICIG--DPpPR--IPDT 72  Trichodesmiu...
Q8DHA1            5 DLTTLRAVCADLQH----WLPARLETVYQRDRH---TIALAVR-TLKKQaW-LTLSWhpqAARIALE--PPpPR--QPDT 71  Synechococcu...
Q31PG3            5 DYTTLVAVCRELQTA---VVPARLEQVYQRDRF---SLSLGLR-TMSDRpW-LLLSWhpeAARLHLD--TPpPR--DPDT 72  Synechococcu...
Q7NK58            5 DFTALSAARAEIQSA---WIPARVEQIRQDDYQ---TIKLQLK-TFAAQrW-LVASChpqAARLHMG--EAsRG--KGAR 72  Gloeobacter ...
jgi:OSTLU_52043  47 DYTALVASVREINAL---STPVKIDACAQVDAH---SMTLDAR-AADGRrS-VRVSWhpvTAHVAMS--ARgAKVEKGMN 116 Ostreococcus...
Q2NGY7            2 SNVDIHRMVNELNKE---LINTRIDKAYQPDVD---TIRIKLRkAGEGR-KdLVIQA---GVRIHLT--NY-PQPNPTIP 68  Methanosphae...
Q59020            6 TNVDVCCVVDELQN----LINGRLDKAFLIDNEqnrELILKIHvP-EGGsReLVISI---GKYKYITltNY-EREKPKLP 76  Methanocaldo...
Q18J82            8 TSVDIAALVTELRR----YTGAKVDKTYRYGDD---LLRFRMRdFDRGR-LeLLIEVg-tQKRIHTAdpDH-VPDAPERP 77  Haloquadratu...
Q8TSZ2           76 QAFPMLLRKYLMGGRIISVEQ-HDFDRIIKIGIERA---GVRSTLIVELFAR-GNVLIVDSEN--KIILPMNPVTLK--- 145 Methanosarci...
Q8YP27           73 FTFSQQLVHQLGGLALVAIEAiAPWERVIDLQFARRpgdAALYHIYGEIMGKySNVILTDANN--LIITAAHQVSQQqss 150 Nostoc sp. P...
Q110R4           73 FTFSQQLKHQLNGLALIAIAEvSPWERVLDFQFAKRpgeKPLWHLYVEVMTKySNVILTTVDN--LVITCARQINIQqss 150 Trichodesmiu...
Q8DHA1           72 FTFSQQLHAQLNRLALVRVGLiNPWERVVVLEFAPRpqeATQWRLYAEIMGKySNVILVNAAG--EIVTAAHQVSPQqsr 149 Synechococcu...
Q31PG3           73 FTLSQQLQAVLKGFALIDLHIpQPWERIVTLSFGDRpgdPPRFRLLLEVMGKySNLVLVNGDS--EIVTVAHQVSDRqsr 150 Synechococcu...
Q7NK58           73 FSFASTLHQYLGGRVLVHCVQ-PQWERIVRLGFARRpeqEPEVELHVEVMGKySNIVLTDPSG--QILALAHSVSAAqsr 149 Gloeobacter ...
jgi:OSTLU_52043 117 LSFGESANALLKGKVLLDARVgTAWERACRLRFGDRpggEAEYELLCEVMGRySNAFLLDSKNndEVLACGYQVGEKqts 196 Ostreococcus...
Q2NGY7           69 PNFPMLLRKHLSGGSITSIEQ-HNFDRIIKIKVQKK----EEYTILVELFSK-GNIILLDKDN--NIISPLKHKTWH--- 137 Methanosphae...
Q59020           77 PSFAMLLRKYLKNAKLIKIEQ-VNFDRVVIFHFETR---DGIYKLVAELFGD-GNIIFLNNED--TIIAPLRVERWS--- 146 Methanocaldo...
Q18J82           78 PNFAMMLRNRLSGADLVNVEQ-FEFDRIMILSFERG---EEMTRIIVELFGD-GNVAVVDSAG--EVIQSLETVRLK--- 147 Haloquadratu...
Q8TSZ2          146 DRRLRSGEIYELPEA--QLSPLeaKVSDlMeAFSKS-------------TADIVRTIATRF-NLGGVLAEEACVRAGVDK 209 Methanosarci...
Q8YP27          151 VRPILTGQPYEAPPKltGTIPS--LQETqA-RWQERvsl---------vpGAIKRQLLKSYsGLSAVLVESMLLVANIAP 218 Nostoc sp. P...
Q110R4          151 VRQIQTGQPYELPPSltNSIPR--VSETqQ-HWQERisl---------vpGSLSRNVIKNYrGLSKALVEPMIKTAGLDP 218 Trichodesmiu...
Q8DHA1          150 LRPILTGQPYVPPPPltAALPS--GEIPfE-QWQQQvsv---------ipGRLRQQLLKAYrGLSPALVQQLLADAALPP 217 Synechococcu...
Q31PG3          151 LRTVRTGEPYEWPPAltTPIPD--LDEPfD-RWCERlql---------vpGRLDRQLIQCYrGLSSRLVQQLCRQADLDP 218 Synechococcu...
Q7NK58          150 VRPLLLGEIYQSPPPlsGPIPN--PDEPfA-SWCARlsv---------vpGPFAPTLFKAYrGVSQTLAQQMLAEAHLPT 217 Gloeobacter ...
jgi:OSTLU_52043 197 VRRLAIGYAYEPPPSapGIDPTtgVEGGvD-GWTAVlrdvargrsgdmgEARLDECMVRAFrGVSPALAKALIRGAGVAD 275 Ostreococcus...
Q2NGY7          138 DRKITAHEEYKYPPEk-GININncRFEDlKtVINTS-------------DRDITRTLATN--GLGGLYAEEVISYTSINK 201 Methanosphae...
Q59020          147 TRNIVPKEKYKFPPQk-PLNPYnlEFSIaYeVFKDYfln--------nkGVECVRLISRVF-GIGGLYAEEICERAEIDK 216 Methanocaldo...
Q18J82          148 SRTVAPGAQYEFPDS--RVNPLqvTYDRfIsLMNES-------------DTDIVRTLATQL-NLGGLYAEEVCARAGIDK 211 Haloquadratu...
Q8TSZ2          210 AKPAKEATVEDAEGLRDALQDLFSPLFigraagegkgeaeagvgtepatgvEaeaPKLRPQHVKKEIngkIETFDVV-Pf 288 Methanosarci...
Q8YP27          219 ETTTDTLHPEDWQRLFARWQEWLHTLD------------------------S---GKFQPAWm-------ANGYTVM-Gw 263 Nostoc sp. P...
Q110R4          219 QQLTNSLNNSDWEKLFQLWQKWLQALD------------------------K---LIFNPGWt-------STGYTVT-Gw 263 Trichodesmiu...
Q8DHA1          218 ECCTTDLSAEEWRRLFDHWQHWLECLE------------------------R---GHFGPQFt-------ATGYRVIpPl 263 Synechococcu...
Q31PG3          219 QQNTAAIAPAAWQQLYGAWQDWLRGLQa-----------------------E---TAFQPQLq-------ESGYRLL-Pt 264 Synechococcu...
Q7NK58          218 KVHIAELAEIDWRRLWELWRQWLACLG------------------------E---GSYRPGWt-------TGGYTVL-Gw 262 Gloeobacter ...
jgi:OSTLU_52043 276 GERVETASASDWVAVYDEFMRWIASVS------------------------S---D----ADs-------AGTLANA-Tw 316 Ostreococcus...
Q2NGY7          202 EKLAKELTDDEITQLNNAINELFNKIE----------------------------TNPQPQIILDEN---DKNKDLV-Pi 249 Methanosphae...
Q59020          217 KK--RDLSEEEIKKLFEASKNLFDEIF----------------------------NNRKPQIVLKD----NEYFDVV-Pi 261 Methanocaldo...
Q18J82          212 TTQITNTSDKIYRAIYTALESLGTQLQ------------------------S---GDFEPRLYTDD----DAVIDAT-Pf 259 Haloquadratu...
Q8TSZ2          289 dlIRYs--EFEKEYFDSFNTALDEFFGKKALEQVAEvK--AAEKKEKTlgvYERRLLQQEESLAKFGKEIEKNNTLaeiv 364 Methanosarci...
Q8YP27          264 gaV---------APVQDIQTLINEYYTKQLNQQLFA-Q--LRHQLTQK---LSNILGKLRNKAQTFSDRLQQSDRA---- 324 Nostoc sp. P...
Q110R4          264 kaI---------ECVDSVGELLNHYYTQQLNQQEFT-Q--LHHQISQK---VNSITAKLQLKAQTFTQRLEQSDGA---- 324 Trichodesmiu...
Q8DHA1          264 gaQA--------PSTLSIHEILATYYQNQLQQQQTQ-Q--LQQQLHQS---LEAQRQKLIAKIEGFRERLAAAAGG---- 325 Synechococcu...
Q31PG3          265 g----------pDSANSVNAVIATYYDRQLLSQQFQ-Q--LRQQLSQR---LQQQQQKLQQKQQDFQGRLLAAEDA---- 324 Synechococcu...
Q7NK58          263 dlR---------APERSVHTLLDRYYTAQLQADLLR-A--RRSRLQQI---LKATLAKAVKRRAALEQMLAGAAEG---- 323 Gloeobacter ...
jgi:OSTLU_52043 317 ceEFGq-----fVAGGPIGALFGAVYGEAGETDVFE-R--ERSRILQA---VRARLKKLASKDVGFRKQLEAASGH---- 381 Ostreococcus...
Q2NGY7          250 tlNKYa--QFKSKSFETFNMAADEFYSKKIVSDIKN-K--EEKLWAKRigkFEKRLKMQEETLEGFYKTIEDKQHKgdti 324 Methanosphae...
Q59020          262 dlKKYk--GLEKKYYNSFLEAVDDYFAKFLTKVVVK-K--EKSKIEKEierQENILRRQLETLKKYKEDAEKNQIKgdli 336 Methanocaldo...
Q18J82          260 plEERkqqNLDVTTYDSFNGALDVYFREVDRNPAAEeSgqTRPDFAAEiakKQRIIEQQEGAIDDFEQRAEAERSRaell 339 Haloquadratu...
Q8TSZ2          365 yANYQLIEELFSVLNGAR-AKGYSWDEIRSILKQakKTvpaaqkitnid---qktgtvtvdldGR----NVNLDIRKTVP 436 Methanosarci...
Q8YP27          325 -DEYRQKADLLMAHLQNW-QPGMKEISIPDFET---GE-------------------------PV----AIALLPDKNAV 370 Nostoc sp. P...
Q110R4          325 -ELLRSQADLLMANLQEW-QPGMKNISLPDFET---GE-------------------------II----FIKLDPEKNAV 370 Trichodesmiu...
Q8DHA1          326 -DRQRYLADLLMAHAHLW-QPGMTELIVTDFTT---QE-------------------------PL----TIALSPEKSAI 371 Synechococcu...
Q31PG3          325 -DRWRQQGDLLMASLDQW-QPGMESLTLPDFET---GK-------------------------PQ----QLQLDPALNAV 370 Synechococcu...
Q7NK58          324 -ERHKQMADLLMAYLHQGaEPGARRVVLEDFES---GE-------------------------PV----TIPLDPTKDLV 370 Gloeobacter ...
jgi:OSTLU_52043 382 -EEIQLLADALMAYSYNY-KPGSSELEGQDFTT---GE-------------------------TV----MFKVDPEKGPV 427 Ostreococcus...
Q2NGY7          325 yAHYNEIQQIINVIHQAR--ENYSWKEIGSIIKKskKEgkipelemiesi--dkmgvinlkldDT----HVQIDSNIGIP 396 Methanosphae...
Q59020          337 yANYQIVEELLNAIRQAR--EKMDWARIKKIIREnkEHpilglieninenigeiiirlksevdDKvieeRVSLDIRKNAF 414 Methanocaldo...
Q18J82          340 yANYELVNEIIETIQTAR-AEDTSWDEIRETFAMgaERgidaaaavvsvd--gaeamvtieidDM----RVPVNVDVGVE 412 Haloquadratu...
Q8TSZ2          437 QNAQEYYEKVKKFSKKRDGALKAIEETKKAMEKKAASKAAKA---------------------GRKLQAF------RKKH 489 Methanosarci...
Q8YP27          371 QNAQNLYKQHQKLKRARIAVEPLLQEVQAEIDYLEQVEAAISqidnyqtaedlqaleeirdelIGQKYLEele-yrSRNN 449 Nostoc sp. P...
Q110R4          371 QNAQSIYKKYQKLKRAHTIVKPLLAEVQNEIHYLEQVEAFLSqlnnyrspedlqtleeireelIQQGILNapehhqQNNR 450 Trichodesmiu...
Q8DHA1          372 QTAQELYRQHQKLKRAQQHITPLLTAAEGELAYLDQVAATLAtatsldvl------eeiraelIQQGYLIapdyyrPPTT 445 Synechococcu...
Q31PG3          371 QNAQRFYRRHQKAKRSRQAVLPLLAEVEAELRYLDSIATALAplqtaqtradwlalqdireelAQQGYWPykt-drPRPT 449 Synechococcu...
Q7NK58          371 ANAQAYYRLHRKAKRARQAVTPLLEQAREEVAYLEQVGATVEllgestdle---alleveeelVQQKYVEa-----KEKP 442 Gloeobacter ...
jgi:OSTLU_52043 428 GTAEALYKKTRKLRRTADAVEPLIEQNASEIEYLEGVEFSILevsefksrddl-lfieeigaelKGGGAKpkt-gkQARK 505 Ostreococcus...
Q2NGY7          397 ESTEKYYNKGKKAKRKIDGVNKAIENTKSEIKKLEDKKEVAIellrq-------------------------kqekREKR 451 Methanosphae...
Q59020          415 ENAESYYEKAKKLRNKIEGIENAIELTKKKIEELKKKGEEELkekesm----------------------qmkkkiRKER 472 Methanocaldo...
Q18J82          413 KNADQRYTEAKRIEEKKEGALTAIENTREELNAVKQRRDAWDredak------------------------pdtedNADN 468 Haloquadratu...
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