Conserved Protein Domain Family
Noggin

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pfam05806: Noggin 
Noggin
This family consists of the eukaryotic Noggin proteins. Noggin is a glycoprotein that binds bone morphogenetic proteins (BMPs) selectively and, when added to osteoblasts, it opposes the effects of BMPs. It has been found that noggin arrests the differentiation of stromal cells, preventing cellular maturation.
Statistics
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PSSM-Id: 399070
Aligned: 13 rows
Threshold Bit Score: 305.112
Threshold Setting Gi: 1028664958
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_008112580   9 CALAASVALRAERGQCQH----YLHIRPAPSDNLPLVDLIEHPDPLFDPKEKDLNDTLLRGLLGSHFDPAFMAAALPnEE 84  green anole
AFJ70365      12 YALVVVLGLRATPAGGQH----YLHIRPAPSDNLPLVDLIEHPDPIFDPKEKDLNETLLRSLLGGHYDPGFMATSPP-ED 86  Rhesus monkey
Q6BA00        11 YALMVFLGLRIDQGGCQH----YLHIRPAPSENLPLVDLIEHPDPIYDPKEKDLNETLLRTLMVGHFDPNFMAINLP-EE 85  tropical clawed...
XP_006000006  11 YALIVLLGLRIEEGVCQH----YLHLRPVPSENLPLVDLIEHPDPVFDPKERDLNDTMLRTILGSNFDPNFMSFSLP-DE 85  coelacanth
Q6B9Z9        10 FLLCSWLFLVHHQGSCQP----YLRLRPSPSENLPVKDIIEHPDPEQDPKEQDLDERTLRKKLGSNFDPNFMSVVLPnSV 85  tropical clawed...
XP_006006152   7 FLICCCLVL-VHEGSCQP----YLRLRPSPSDSLPVMDIIEHPDPEYDPREQDLDERTLRKKLGSNFDPNFMSITTPvQV 81  coelacanth
XP_023804931   6 TLLVYAL-LCVHLGLSQH----YLRLRPSPSDHLPVPDLREDPDPEYDPREQDLAERTLRKKLGSNFDPNFMSISSPlQV 80  Japanese medaka
Q9W740         8 LPLLLLLLLCAHGTASQH----HLRLRPLPSEGLPVPDLIENPDPEHDPREQDLSEKTLLKKLGSNFDANFMSIHLPaQL 83  zebrafish
1_pfamImport   1 LLCVAIIGSGISSVIGQH----FKHIRPQPNNNLPLQDIPENPDPIYNPRPADIDPRKLRAKLGVDYLPRFMSHRDPgDR 76 
XP_001948741   9 VLVALTCCSNRHTVMCTSvrldHLPLRPVPSNDPGVIDLIEMPNPALDPRPSDINATALLAKLAAKFDPNCMSMTAPeN- 87  pea aphid
XP_015211513  11 YVLVLSLGLTIEEGMCQH----YYHLRPIPSDNLPIVELIEHPDPVFDPKERDLNETELRSILGSNFDSHYMSVSPP-ED 85  spotted gar
Q9W741        11 YLLLLSF------AQCQH----YYLLRPIPSDTLPLLELKEDPDPIYDPREKDLNETELRSALG-DFDSRFLSVGPP-QD 78  zebrafish
XP_005816302  11 CLLMLSLGLLTDRAICQH----FFLLRPIPSDSLPVVDLKEDPDPAFDPKERDLNETELRSILG-DFDGRLLSVSLPvED 85  southern platyfish
XP_008112580  85 Rp-----nGGGGEDLA-EMDLLLRQRPSGAMPGEIKGLDFYDPAgGGgggggpasskKHHRLSKKLRRKLQLWLWSQTFC 158 green anole
AFJ70365      87 RpgggggaAGGAEDLA-ELDQLLRQRPSGAMPSEIKGLEFSEGLaQG----------KKQRLSKKLRRKLQMWLWSQTFC 155 Rhesus monkey
Q6BA00        86 R-------L-GVEDLG-ELDLLLRQKPSGAMPAEIKGLEFYEGL-QG----------KKHRLSKKLRRKLQMWLWSQTFC 145 tropical clawed...
XP_006000006  86 R-------LAGNEDLA-ELDLTLRQKPTGVMPSEIKLLEFYDAL-HG----------KKHRLSKKLRRKLQMWLWSHTFC 146 coelacanth
Q6B9Z9        86 N-------MSTQDSLT-------KMKTLGSVPLELKKLDLSETP-YG----------GRIRMGKKARRKFLQWLWAYTYC 140 tropical clawed...
XP_006006152  82 N-------LSTQDPLS-------KFKPPGPIPNDIKKLDLSETP-YG----------MRMKIGKKAKRKFLQWLWSYTYC 136 coelacanth
XP_023804931  81 N-------LSASDYQV---------KLQGPMPNEIKKLDLTETP-YG----------KRVKVGKKARRKFLQWLWTYTHC 133 Japanese medaka
Q9W740        84 N-------ASAPPELP-------RL----PMPAELKKLDLTETP-YG----------RRVKVGKKARRKFLQWLWMYTHC 134 zebrafish
1_pfamImport  77 G-------LRSPVKPP-------KPRPTAEIRQVFRRLTKSKFPrRG------------IRRYFKQRRLIQGWLWQATAC 130
XP_001948741  88 --------LVPATEIPfRRNRRGRLVPTGKMPTEIRELDTKYFFlSDgr-------rLRTRITGQLRRKIQQYLWGRTAC 152 pea aphid
XP_015211513  86 K-------YTGNDELA---DLELRQKPTGAMPKEIKSMEFFDFL-HG----------KKHKPSKKLRRRLQLWLWSYAFC 144 spotted gar
Q9W741        79 R-------YAGNEDLD-EQELQLNL--AGMMPKDIKNLDF-DAP-WG----------KKRKASKKLKRRLQMWLWSYSFC 136 zebrafish
XP_005816302  86 K-------HSGSDESD-HFDI---LKAGGVLPKEIRAVDF--DVqIG----------KKHKPSKKLKRRLQQWLWAYTFC 142 southern platyfish
XP_008112580 159 PVLYTWNDLGSRFWPRYVKVGSCFS-KRSCSVPEGMLCKPAKSAHLTILRWRC-QRR----------------------- 213 green anole
AFJ70365     156 PVLYAWNDLGSRFWPRYVKVGSCFS-KRSCSVPEGMVCKPSKSVHLTVLRWRC-QRR----------------------- 210 Rhesus monkey
Q6BA00       146 PVLYTWNDLGTRFWPRYVKVGSCYS-KRSCSVPEGMVCKAAKSMHLTILRWRC-QRR----------------------- 200 tropical clawed...
XP_006000006 147 PVLYTWDDLGTRFWPRYVKVGSCYT-KRSCSVPEGMVCKPAKSVHLTILRWRC-QRR----------------------- 201 coelacanth
Q6B9Z9       141 PVMYTWKDLGVRFWPRFIKEGHCFS-EKSCSFPEGMYCKPIKSVTKTFLRWYCqGWT----------------------- 196 tropical clawed...
XP_006006152 137 PVVYTWKDLGVRFWPRYIKEGNCFN-EKSCSFPEGMTCKPVNTVYKTFLRWYCqGWS----------------------- 192 coelacanth
XP_023804931 134 PVVYTWKDLGVRFWPRYIKEGKCFS-ERSCSFPEGMSCKPAKSINKIFLRWYCqGFL----------------------- 189 Japanese medaka
Q9W740       135 PVLYTWKDLGLRFWPRYIKEGNCFS-ERSCSFPEGMSCKPVKAVTKTFLRWYCqGFM----------------------- 190 zebrafish
1_pfamImport 131 QVHYRWKDLGIRYWPRYIKEGYCDT-SQSCSIPAGMHCHQSGQTGLKILRWFCqGIS----------------------- 186
XP_001948741 153 PMHRQWKDLGQRFWPRWLLEGHCPKgETSCSVPAGMYCRATSSQYKTLLRWHCrSPNgpssvlqqynslpgakstgsvvn 232 pea aphid
XP_015211513 145 PVVYTWNDLGNRFWPRYVKVGSCYS-KRSCSVPEGMVCKPAKSAHFTILRWRClQRK----------------------- 200 spotted gar
Q9W741       137 PVLYAWNDLGSRFWPRFVRAGSCYT-KRSCSVPEGMVCKPAKSTHITLLRWRCvARR----------------------- 192 zebrafish
XP_005816302 143 PVVHTWTDLGCRFWPRYVRVGGCVS-KRSCSVPEGMVCRPANSTHLTVLRWRCvQRK----------------------- 198 southern platyfish
XP_008112580 214 GGQRCAWIPIQYPIISECKCSC 235 green anole
AFJ70365     211 GGQRCGWIPIQYPIISECKCSC 232 Rhesus monkey
Q6BA00       201 VQQKCAWITIQYPVISECKCSC 222 tropical clawed frog
XP_006000006 202 GGQKCTWIPVQYPIISECKCSC 223 coelacanth
Q6B9Z9       197 RQRYCTWIPVQYPIISECKCSC 218 tropical clawed frog
XP_006006152 193 RQKYCTWIPIRYPIISECKCSC 214 coelacanth
XP_023804931 190 RQKYCTWIQVQYPIISECKCSC 211 Japanese medaka
Q9W740       191 RQKYCTWIQVQYPIISQCKCSC 212 zebrafish
1_pfamImport 187 EQKYCLWREMHYPIISECRCQC 208
XP_001948741 233 QIKVCQWIKVEYPVVTECGCGC 254 pea aphid
XP_015211513 201 TGQKCAWIPIQYPIISECKCSC 222 spotted gar
Q9W741       193 GALKCAWIPVQYPIITECKCSC 214 zebrafish
XP_005816302 199 SGLKCAWIPVQYPVITDCKCSC 220 southern platyfish
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