Conserved Protein Domain Family
L6_membrane

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pfam05805: L6_membrane (This model is not part of the current CDD release)
L6 membrane protein
This family consists of several eukaryotic L6 membrane proteins. L6, IL-TMP, and TM4SF5 are cell surface proteins predicted to have four transmembrane domains. Previous sequence analysis led to their assignment as members of the tetraspanin superfamily it has now been found that that they are not significantly related to genuine tetraspanins, but instead constitute their own L6 family. Several members of this family have been implicated in human cancer.
Statistics
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PSSM-Id: 516985
Aligned: 88 rows
Threshold Bit Score: 118.822
Created: 14-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_003766182    2 TCTEGFTSCNGFSLMVLALLAVVLNTIPLISYKLQSDelsKNPISCFEWWYPGIIGAGVLVIPATIMSLAARKRaCC--- 78 
XP_006638044    2 TCCEGFTSCNGFFLISLCILAIAFNLLPLFADYSMDGrlfQKPVSCFEWWLPGVLGGGILVLPAVAMTFAAKKRgSC--- 78 
XP_004917870    2 TCTERWSSCNGFFLLILSLLAIAFNLTPLIADYVEDGrlfVSPISCYEWWLPGLVGGGLLVLPAVSMTLAARKKgSC--- 78 
XP_001507415    2 TCCEGLTSCNGFSLLILVLISVGLNMVPLISDYAQDGlllHNSISCYEWWLPGIMGAGFLGLPAVAVSLAARKRgSC--- 78 
14_pfamImport   1 TCCEGWTSCNGFGLLVLLLLGVILNAIPLVMNLLEQDqffQNPISCFEGWFPGIIGAGLMRGGANRSSWSAKGAlCClsn 80 
XP_023422811    2 TCCEGWTSCNGFSLLALLLVGVVLNAVPLGINLVEQDrifQNPISCYEWWFPGIIGAGLMVIPATTMSLAARKRgCC--- 78 
XP_004868053    2 TCCEGWTSCNGFSLLALLLAGVILNAIPLGINLVEADkvfQNPISCFEWWFPGIIGAGLMVIPATTMSLAARKRaCC--- 78 
Q9CQY8          2 TCCEGWTSCNGFSLLILILLGVVINCIPLGISLVEADstsQNPISCYEWWFPGIIGAGLMAIPATTMSLAARKRaCC--- 78  house mouse
XP_005326520    2 TCCEGWTSCNGICLLILLVIGVVLNAIPLGIDLVEQDkdfQNPISCYEWWFPGIIGAGLMVIPATTMSLAARKRgCC--- 78 
EFB17910        2 TCCEGWTSCNGFSLLVLLLLGIVLNAIPLIVNVVDEGqffHNPISCFEWWLPGIIGAGLMVIPATTMSLAARKRaCC--- 78 
XP_003766182   79 NNRLGMILSSFLSLVTIGGAVYCILVSALALSEGPLiCNYNGNSTFnceFS--MKNlsdihdqlqqpitLRWFFSPTC-E 155
XP_006638044   79 NSRTGMLLSAFFCIISIVGAIYCVLISLIALASGPLiCQDPDAGLSsctFS--LGNissls---tlnfdIGWYLQFDGcH 153
XP_004917870   79 NSRGGMLASALLSVLSIIGAVYCTIISLFAVAKGPLvCETGSHELSs--CDytLANlssnsf-kelrfdLAWLLNSTCsP 155
XP_001507415   79 NSRTGMLFSSFLSSVSIIGASYCLVVSLHALSEGPLiCNPNGNDLSncvFS--LKNlsnfq---eqafqLDWFFKGNCgL 153
14_pfamImport  81 QNRQFMFLSSLFSVITILGAVYCMVVSLQALSEGPLvCSLPANSSAqceFS--FKNltnih---pesftLQWFYNNSClL 155
XP_023422811   79 NNKTGMFLSSLLNVITIIGAVYCVLVSVQALSEGPLiCNSQVNGTVkceFS--LKNlsnih---sksfnLQWFLNDSCvS 153
XP_004868053   79 NNKTGMFLSSLLNVITVIGAAYCMLVSIQALSEGPLvCNSQVNGTAnckFS--WKNltdih---lqplfLQWFWNDSCvS 153
Q9CQY8         79 NNKTGMFLSSLFSVITVVGAVYCMLVSLQALLEGPLiCNTQANSTVtceFS--LKNlskfd---pesfnLLWFFNGTCvS 153 house mouse
XP_005326520   79 NNRTGMLLSSLLNAITVIGAVYCLLVSIQALSEGPLiCNSPSNSTTtceFS--LKNltdfh---pksfnLQWFFNDSCvP 153
EFB17910       79 NNRTGMLLSSLLNVLTVIGAAYCMLVSTQALLEGPLiCNSPENSTPs--CEfsFSNlsdih---pesfnLQWFFSEACvS 153
XP_003766182  156 PEipnnsvpdnstnlfqrtntltvsseenRYKIIHLTVFVGLFLVGILEILFSISQIVIGLFGCLCGVSK 225
XP_006638044  154 NStggegngtwvp-----lghsftnldesQIVNLHLITFSGLSVVALLEIIFSLLQIVAGICGCLCGTSK 218
XP_004917870  156 TVdlgitaaqgiip----kkdlsielnedTQKIIHITVFVALAIIGLVEALVAISQAAAGLFGFICGTSK 221
XP_001507415  154 TIpdnfitnndimglhrskssrsfgsdenEPKILHLSVFIGLFTTGVLEILFSISQIMVGIFGCICGTSA 223
14_pfamImport 156 PVlnnptf----------------sdttsQHTVIHFSVFLGLLLVGILEVLFGLSQIVIGFLGCLCGVSK 209
XP_023422811  154 PTghknsnpsdnmga--swkipssgseedRYRIVHFAVFLGLLLVGALEILCGLSQIVIGLFGCMCGVSK 221
XP_004868053  154 PTgstklntnnnmst--swkipssnseedRYRIFHFSVFLGLLLVGILEALFGLSQIVIGFLGCLCGVSE 221
Q9CQY8        154 PTdfknptinnmvs---nwkipnsnseedRHRIFHFSVFMSLLLVGILELLFGLSQILIGFLGCLCGVSQ 220 house mouse
XP_005326520  154 PTgfpnsainnmhs---nwripnsnseedRQRIFHFSVFLSLFLVGVLELLFGLSQIVIGFLGCLCGVSG 220
EFB17910      154 PTdvtdpttngitagdwrkhtlhfdskenKYRVIHFSVFLGLLLVGILELLFGLSQMVIGFLGCLCGVSK 223
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