Conserved Protein Domain Family
KAP
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pfam05804: KAP 
Kinesin-associated protein (KAP)
This family consists of several eukaryotic kinesin-associated (KAP) proteins. Kinesins are intracellular multimeric transport motor proteins that move cellular cargo on microtubule tracks. It has been shown that the sea urchin KRP85/95 holoenzyme associates with a KAP115 non-motor protein, forming a heterotrimeric complex in vitro, called the Kinesin-II. It includes kinesin-associated protein 3 (KAP3, also known as SMAP). In human and mouse, KAP3 is involved in tethering the chromosomes to the spindle pole and in chromosome movement. It binds to the tail domain of the KIF3A/KIF3B heterodimer to form a heterotrimeric KIF3 complex and may regulate the membrane binding of this complex.
Links
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Statistics
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PSSM-Id: 253396
Aligned: 3 rows
Threshold Bit Score: 1204.72
Created: 14-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q26626      13 VKGGSIDVHPTEKALVVNYELEATILGEMGDPMLGERKECQKIIRLRSLNSTTDIAALAREVVEKCKLIHPSKLPEVEQL 92   purple sea urchin
Q92845      13 VKGGNIDVHPSEKALIVHYEVEATILGEMGDPMLGERKECQKIIRLKSLNANTDITSLARKVVEECKLIHPSKLNEVEQL 92   human
NP_727512  107 WKGGSIEPHPTDKALIVNYQLEATVFGEPNNPMIEEKKHCQKIIRLRSLNAKTDPAALAREVVEKCDLIHKSQLNDVEQI 186  fruit fly

Q26626      93 LYYLQNRKE---------------------TTqkAGAKKGELTGKLK-----------------DPPPYEGTELNEVANI 134  purple sea urchin
Q92845      93 LYYLQNRRD---------------------SL--SGKEKKEKSSKPK-----------------DPPPFEGMEIDEVANI 132  human
NP_727512  187 IFYLKNRKDnasndipdnnthsrrsaalhtSHtrSSARSHSSVAAMTsstgsgggstgasngvsNALSAATPTAD--VSI 264  fruit fly

Q26626     135 NDIEDYIELLYEDNPEKVRGTALILQLARNPDNLEELQSNETVLGALARVLREEWKHSVELATNIVYIFFCFSSFSQFHS 214  purple sea urchin
Q92845     133 NDMDEYIELLYEDIPDKVRGSALILQLARNPDNLEELLLNETALGALARVLREDWKQSVELATNIIYIFFCFSSFSQFHG 212  human
NP_727512  265 NNIDEYVELLYEELGERIRGSAMILQMARNPDNLEELEKNEACLSALSRVLREDWRKSLDLSTNIIYIFFCFSTYTKFHP 344  fruit fly

Q26626     215 IVAHFKIGALVMGVVEHELKKHLSWNEELLKKKK---------------------------TAEENP------------- 254  purple sea urchin
Q92845     213 LITHYKIGALCMNIIDHELKRHELWQEELSKKKK---------------------------AVDEDP------------- 252  human
NP_727512  345 LIVQYKIGSLCMDVIDYELRRYETMRNELDVRKQpngsstphsakaskeklnrstddfldiMNEEKPkemepprrripel 424  fruit fly

Q26626     255 ------------------------AS---KRDFEKST-----------------------------------------KK 266  purple sea urchin
Q92845     253 ------------------------ENqtlRKDYEKTF-----------------------------------------KK 267  human
NP_727512  425 kqrpksgnwssfhgsmsssliksqIL---NSSYHESLcaggspggdtpavpaeqkaqsnesldrndpkvkkeeidrlnKQ 501  fruit fly

Q26626     267 YHGLLKKQEQLLRVSFYLLLNLSEDPKVELKMKNKNIIRLLIKTLERDNAELLILVVSFLKKLGIYVENKNEMAEQQIIE 346  purple sea urchin
Q92845     268 YQGLVVKQEQLLRVALYLLLNLAEDTRTELKMRNKNIVHMLVKALDRDNFELLILVVSFLKKLSIFMENKNDMVEMDIVE 347  human
NP_727512  502 LKIFAKKQEQLLRVAFYLLLNMAENVKLEEKMRRKHIVKMLVKALDRQNIDLLMLVSTFLKKLSIVGDNKDEMGALNIVA 581  fruit fly

Q26626     347 RLAKLVPCDHEDLLNITLRLLLNLSFDTDLRGKMIKLGMLPKFVELLANDNHRLVVLCVLYHVSQDDKAKSMFTYTDCIP 426  purple sea urchin
Q92845     348 KLVKMIPCEHEDLLNITLRLLLNLSFDTGLRNKMVQVGLLPKLTALLGNDNYKQIAMCVLYHISMDDRFKSMFAYTDCIP 427  human
NP_727512  582 KLPRLFQSTHTDLVQVTLKLVFNLSFDGGLRRKMIAAGYLPMLVMFINDEKHHGIAVKILYHMSLDDKVKGMFTQTECVQ 661  fruit fly

Q26626     427 MIMKMMLESPTERLEIELVALGINLACNKHNAQLICEGNGLRLLMRRALKFRDPLLLKMIRNISQHDGPSKAQFIEYISD 506  purple sea urchin
Q92845     428 QLMKMLFECSDERIDLELISFCINLAANKRNVQLICEGNGLKMLMKRALKFKDPLLMKMIRNISQHDGPTKNLFIDYVGD 507  human
NP_727512  662 MATDAIILNLNVKVDLDLIALCINLSLNRRNAQIMVEGQRLHSLMDRAFKYQDALLMKLLRNLSQHE-SLQLQFIDYVGD 740  fruit fly

Q26626     507 VARIIKESNDEELVVEALGIMANLTIPDLDYEMIINEFGLVPWIKEKLEPGAAEDDLVLEVVMLVGTVATDDSCAAMLAK 586  purple sea urchin
Q92845     508 LAAQISNDEEEEFVIECLGTLANLTIPDLDWELVLKEYKLVPYLKDKLKPGAAEDDLVLEVVIMIGTVSMDDSCAALLAK 587  human
NP_727512  741 LARILTICDDEAFIVECLGILGNLALTDLDYSQILQNFQLIPWIRQILLPCARMDDLVLDTIVYLGTCACDELCALLFCR 820  fruit fly

Q26626     587 SGIIQSLIELLNAKQEDDEIVCQIVYVFYQMVFHEATREVIIKLTQAPAYLIDLMHDKNSEIRKVCDNTLDIISEFDEEW 666  purple sea urchin
Q92845     588 SGIIPALIELLNAQQEDDEFVCQIIYVFYQMVFHQATRDVIIKETQAPAYLIDLMHDKNNEIRKVCDNTLDIIAEYDEEW 667  human
NP_727512  821 AKVVISLIELLKAKQEDDEIVLQIIFVFQQILRHESTREYMIKETESAAYLIDLMHDKNEEIRKVCDYCLDIIAISDSEW 900  fruit fly

Q26626     667 ARKIKLEKFRWHNSQWLEMVESQQIDDGEGGLmYGDESYS-----PYIQESDILDRPDL 720  purple sea urchin
Q92845     668 AKKIQSEKFRWHNSQWLEMVESRQMDESEQYL-YGDDRIE-----PYIHEGDILERPDL 720  human
NP_727512  901 AKRIKLEKFRNHNSQWLCMVESQQDQDNEQd--YADQEDEcdndlDTYLRSEYLDNCDL 957  fruit fly
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