Conserved Protein Domain Family
CNF1
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pfam05785: CNF1 
Rho-activating domain of cytotoxic necrotizing factor
This family consists of several bacterial cytotoxic necrotizing factor proteins as well as related dermonecrotic toxin (DNT) from Bordetella species. Cytotoxic necrotizing factor 1 (CNF1) causes necrosis of rabbit skin and re-organisation of the actin cytoskeleton in cultured cells. Bordetella dermonecrotic toxin (DNT) stimulates the assembly of actin stress fibres and focal adhesions by deamidating or polyaminating Gln63 of the small GTPase Rho. DNT is an A-B toxin which is composed of an N-terminal receptor-binding (B) domain and a C-terminal enzymatically active (A) domain.
Links
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Statistics
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PSSM-Id: 283449
Aligned: 3 rows
Threshold Bit Score: 383.526
Created: 14-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q2KUX5 1173 TLANTD---TGRLNHGDISVLRGRGAIGGK-RTVALPSALLIdyVRIDSDllmdrAERLTNEAFMRQGGvlhgfVQSWLG 1248 Bordetella avium 197N
Q87GJ5   88 NVKKADaksITALKSGDLHILKGKGIIGMKgGDNKLPFKCTI--VNDDKN-----GAHLSQGTNLATNG-----IKSMAG 155  Vibrio parahaemolyt...
Q7VTS2 1170 DYANTD---IGLLNHGDISPLRARPPLGGR-RDIDLPPGLDIsfVRYDRPvrmsaPRALDASVFRPVDGpvhgyIQSWTG 1245 Bordetella pertussis

Q2KUX5 1249 SEITSTT-TGGMRLGKWGPGQQ-------LSSNVRVLRVSNGNEGTIGLRI--SALPTGMPLILTAGELSGCTSIVASKD 1318 Bordetella avium 197N
Q87GJ5  156 DSVRAAQlIPGTPLGQFYNSAP-------LDDSFNVVHLPNGQRGVNGLKIplSEFYSEKKFLFSNGALSGCMTCTAIDK 228  Vibrio parahaemolyt...
Q7VTS2 1246 AEIEYAY------------GAPaaarevmLTDNVRIISIENGDEGAIGVRVrlDTVPVATPLILTGGSLSGCTTMVGVKE 1313 Bordetella pertussis

Q2KUX5 1319 GALYFYHFGRR-EGKGGWLTSREGvATVYRSHLAFGLPSVPNLEPNSYDDLVDMLAV-YDRAAVVYLGKEREGGGGrisr 1396 Bordetella avium 197N
Q87GJ5  229 NNLYIFHVGKDgNDTSPWKTNVDG-SSLIQKNMKMLLGQNSDSLNNGIQGLIDYCSKnFDKAIIQYCGHGEQYSGR---- 303  Vibrio parahaemolyt...
Q7VTS2 1314 GYLAFYHTGKS-TELGDWATAREGvQALYQAHLAMGYAPISIPAPMRNDDLVSIAAT-YDRAVIAYLGKDVPGGGStrit 1391 Bordetella pertussis

Q2KUX5 1397 ---slpANVHVLDYNAAtAAADSARLGLTFALVS-SDGTGVKWSLLAEDDAIALASAELNVLAS 1456 Bordetella avium 197N
Q87GJ5  304 ------KNIHLFDYNTP-QKNNPLRVGNNLTLIShSDNGSLSISTLCDDMIINSKTCETNSVNS 360  Vibrio parahaemolyticus
Q7VTS2 1392 rhdegaGSVVSFDYNAAvQASAVPRLGQVYVLIS-NDGQGARAVLLAEDLAWAGSGSALDVLNE 1454 Bordetella pertussis
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