Conserved Protein Domain Family
ECM1

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pfam05782: ECM1 (This model is not part of the current CDD release)
Extracellular matrix protein 1 (ECM1)
This family consists of several eukaryotic extracellular matrix protein 1 (ECM1) sequences. ECM1 has been shown to regulate endochondral bone formation, stimulate the proliferation of endothelial cells and induce angiogenesis. Mutations in the ECM1 gene can cause lipoid proteinosis, a disorder which causes generalised thickening of skin, mucosae and certain viscera. Classical features include beaded eyelid papules and laryngeal infiltration leading to hoarseness.
Statistics
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PSSM-Id: 516975
Aligned: 10 rows
Threshold Bit Score: 785.182
Created: 14-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_003498694  45 VGYAAPPSPP--QTRGLRVdDHFETSLHDSL-FEGQREVE-PPASPEvpfvQEEEWPASPKSVKSEV---GPPTPQEAIP 117
2_pfamImport   1 VGYAAPPSPP--LTRARPR-DHPEISLHDPD-FEGQSEVQ-PFSSFD----QEEQLFSPQLLVRSGSqaeDPTGPGRVVP 71 
XP_012667220  45 VGYAAPPSPP--LSQSLPM-DHPDASQHGPL-LEGQSEVQ-PLPPQEaipvQEEEMPPPQVPLEK-T---DLPHPQEAIP 115
Q16610        41 VGYAAPPSPP--LSRSLPM-DHPDSSQHGPP-FEGQSQVQ-PPPSQEatplQQEKLLPAQLPAEKEV---GPPLPQEAVP 112 human
3_pfamImport   1 VGYAA-------MTQTLPM-DKPDTSQHGPR-FEGQREAQ-TPPSQEaipvQTEELPPRQLPVERKA---DHPLPHGAIP 67 
4_pfamImport   1 VGYAAPPAPP--RPQEPSL-QDPVTPQHI---FVGQETVD---YLFEdfpvQ-QAQSPQRIPLET-----GKSTPNEAIP 65 
Q61508        45 VGYAAPPSPP--QTRRLRV-DHSVTSLHDPPlFEEQREVQ-PPSSPEdipvYEEDWPTFLNPNVDKA---GPAVPQEAIP 117 house mouse
XP_003478933  45 VGYAEPPSPPvsRSRGLPAgPH-DSSQRDPS-FEGQMEVNfPYVSQEeiplQ-KEVPPLQHPNAKRV---DTPGPQEEIP 118
XP_013216683  41 AGYAAPPSPP--QARGFPV-YHLDPSQYDLP-FEGQREVQ-SPPSPEaipvQ-EELPPPHLSNGKKV---DPPLPPEAIP 111
XP_001370788  46 VGYAAPPAPSspQKPDL---QDLVISHRA---FEGQTEaqd---------------------------------ffEDFP 86  gray short-tail...
XP_003498694 118 LQEK-QPPPQVSIEQK----------------------------------------------------EID-PYaQQQEe 143
2_pfamImport  72 VQEE-LLPPPGPIEQK----------------------------------------------------ELDaPPlPAQEe 98 
XP_012667220 116 AQEEnLPPPQLSIEQK----------------------------------------------------EVE-PA-LSQAe 141
Q16610       113 LQKE-LPSLQHPNEQK---------------------------------------------------------------- 127 human
3_pfamImport  68 IQEE-LPPPQLPVEQK----------------------------------------------------EVD-PPfPQQEe 93 
4_pfamImport  66 LQKE-VHAPQLPIEQK----------------------------------------------------EVD-F------- 84 
Q61508       118 LQKE-QPPPQVHIEQK----------------------------------------------------EID-PPaQPQEe 143 house mouse
XP_003478933 119 LQQE-VTPLRHPTGQK----------------------------------------------------QMGsPVtHQKE- 144
XP_013216683 112 LQEE-LPPPHPRTEQK----------------------------------------------------EIS--------- 129
XP_001370788  87 LQQA-QSPQKLSLGKKepspsravpiqkevepprhlpmdqreaqssspaleseeiphqeqkevipsqfGELpP------- 158 gray short-tail...
XP_003498694 144 fIh-TGQK-EEKPAPSVVQGspgp--rswnPAQHCQQGR-RGGWGYRLDGFPPGRPSPDNLNQICLSERQHVVYGPWNLP 218
2_pfamImport  99 rTspPKQG-EEKPAPTSQHG----------PGQHCQQGGpQRCWGQRLDGFPPGRPSPDNLDQICLPTRQHVVYGPWDLP 167
XP_012667220 142 mIfqPKQR-EGKPAALVSQShpep--etwnPAQHCQRGRsRGGWSHRLDGFPPGQPSSDNLNQICLPDRQHVLYGPWNLP 218
Q16610       128 ---------EGTPAPFGDQShpep--eswnAAQHCQQDRsQGGWGHRLDGFPPGRPSPDNLNQICLPNRQHVVYGPWNLP 196 human
3_pfamImport  94 iTfgSKQR-QKKPAHSLGQGhpep--eswnPAQHCQRGRpRGGWGHRLDGFPPGRPSPDNLNQICLPGRQHVVYGPWNLP 170
4_pfamImport  85 -----SQD-EEHPNGQREMEhpnpgsspynQPRHCPQDPrFGGWGHRLDGFPPGRPSPDNIDQICLPDRKHVVYGPWNLP 158
Q61508       144 iV----QK-EVKPHTLAGQLppep--rtwnPARHCQQGR-RGVWGHRLDGFPPGRPSPDNLKQICLPERQHVIYGPWNLP 215 house mouse
XP_003478933 145 -IfpSGQT-EEKSGPLTGQGpsdp--qswnPAQHCQRGRfRGGWGHRLEGFPPGRPSADNLNQICLPDRQPVLYGPWNLP 220
XP_013216683 130 ------QS-EEKPAPPMRQDppep--hswnPAQHCQQGRfRGGWGYRLDGFPPGRPSPDNLNQICLPERQHVVYGPWNLP 200
XP_001370788 159 ----ALGEeHQQP-------------------RRCRPEGrPVGWGHRLDSFPPGRPSPKNMHQICHPERKHVVYGPWNLP 215 gray short-tail...
XP_003498694 219 QTGYSHLSRQGEALNLLETGYSRCCRCRSHTNRLDCAKLVWEDTMTRFCEAEFSVKTRPHRCCKQRGEERFSCFQEEAPQ 298
2_pfamImport 168 QSGYSHLSRQGETLNMLETGYSRCCRCHYYAKRMDCAKLVWENAMNQYCEAEFSVKTRPHWCCKQQGEARFSCFQEEAPR 247
XP_012667220 219 QSGYSHLTRQGETLNFLETGYSRCCRCRSHTQRLDCAKLVWEDAMTRFCEAEFSVKTRAHWCCKQQGEARFSCFQKEAPQ 298
Q16610       197 QSSYSHLTRQGETLNFLEIGYSRCCHCRSHTNRLECAKLVWEEAMSRFCEAEFSVKTRPHWCCTRQGEARFSCFQEEAPQ 276 human
3_pfamImport 171 QTGYSHLIRQGEALNLLETGYSRCCRCSSHTNRLDCAKLAWEDAMTQFCEAEFSVKTRAYGCCKQQGEARFSCFQEEAPW 250
4_pfamImport 159 QTGHSHLSRQGNALNFLETGYTRCCHLK--MGRLDCAASVWADALFRFCESEFSVKTRAYSCCWLRGEARLSCFQENAPL 236
Q61508       216 QTGYSHLSRQGETLNVLETGYSRCCRCRSDTNRLDCLKLVWEDAMTQFCEAEFSVKTRPHLCCRLRGEERFSCFQKEAPR 295 house mouse
XP_003478933 221 QTGYSHLSRQGETLNLLETGYSRCCRCQSTTHRLECAKLVWENSMTQFCEAEFSVKTRPYSCCKQQGEARFTCFQEGALR 300
XP_013216683 201 QSGYSHLSRQGETLNLLETGYSRCCRCRSHTNRLDCARLVWEDAMTRFCEAEFSVKTRPHWCCRQQGEARYSCFQEAAPQ 280
XP_001370788 216 QTGYSHLSRQGNALNFLETGYTRCCHLP--KDQLDCAEFVWADALFRFCESEFSVKTRAYSCCWLRGEARLSCFQERAPQ 293 gray short-tail...
XP_003498694 299 PHYLR--QPCPTHQTGMSSGPQLPFPPGLPTLDNVKNICLLRRFRSVPRNLPATDPIQRQLQALTRLEMAFQRCCRQSHN 376
2_pfamImport 248 PHYQL--QAGPSPQPVISTGLELPFPPGLPTLDNIKNICHARRFRSVPRNLPPTDGLQRQLQALTRLEGELQRCCRRGSN 325
XP_012667220 299 PHYRL--RACPNHQSGISSGLELPFPPGVPTLDNVKNICHLRRFRSVPRNLPATDPIQRQLQVLTWLEGEFQRCCRQGDN 376
Q16610       277 PHYQL--RACPSHQPDISSGLELPFPPGVPTLDNIKNICHLRRFRSVPRNLPATDPLQRELLALIQLEREFQRCCRQGNN 354 human
3_pfamImport 251 PQYQP--RACPSQQPGISSGPELPFPPGVPTLDNVRNICLLRRFHSVPRNLQATGHIERQLQALTQLERAFQRCCRQEHN 328
4_pfamImport 237 PDYKLlqGPCPGHPPRPSSGLAVSFPPGVPTQGNIRNICRFRRYRAVPRGLQILDHLVPQLRAVAQLEGKFKRCCHQGDN 316
Q61508       296 PDYLL--RPCPVHQNGMSSGPQLPFPPGLPTPDNVKNICLLRRFRAVPRNLPATDAIQRQLQALTRLETEFQRCCRQGHN 373 house mouse
XP_003478933 301 PHYQL--QAYPSHQPGISVGLEVPFPPGLPTLDNVNNICHLKRLRYMPRNLPATDTIERQLQVLMQLEVEFQRCCRQGND 378
XP_013216683 281 PHYQL--RACPTHQPGISLGLELPFPPGMPTLDNFKNICHLRRFRSVPRNLPATDPIQRQLHALTQLEMEFQRCCRQGNN 358
XP_001370788 294 ADYERlhEPCPPPTPRPAPGLELSFPPGVPSPDNVRNICRLRRFRSVPRGLPTMDHVQRQLRALTQLEGKFRRCCHQGDN 373 gray short-tail...
XP_003498694 377 HTCLRNAWEDTLDEYCDRELAIKTHPHSCCHYPPSPARDECFSRRAPYPNYDRDILTLDLSRVTPNLMGHLCGNRRVLTK 456
2_pfamImport 326 HTCAWKAWEDSLDGYCERELAIKTHHHSCCRYPPSPQRDECFAQKAPYPNYDRDLLTIDLSRITPNLMDYLCGNQRVISK 405
XP_012667220 377 HTCTWKAWEDSLDRYCDQEHAVKTHPYSCCHYPPSPARDECFARRAPYPNYDRDILTVDISRVTPNLMGYLCGKQRVLTK 456
Q16610       355 HTCTWKAWEDTLDKYCDREYAVKTHHHLCCRHPPSPTRDECFARRAPYPNYDRDILTIDIGRVTPNLMGHLCGNQRVLTK 434 human
3_pfamImport 329 HTCAQKAWEDALDRYCDKEQAIKTHQHSCCRHPLSPARDECFARWAPYPNYDRDILTLDVSQVTPNLMGHLCGNQRVFTK 408
4_pfamImport 317 YTCARQAWEDVLDNYCDEELAIKTHHHVCCHRSPISARDECFARHAPYPNYDRDILTVDLSRITPDVMNQLCGHQKVLTK 396
Q61508       374 HTCTWKAWEGTLDGYCERELAIKTHPHSCCHYPPSPARDECFAHLAPYPNYDRDILTLDLSRVTPNLMGQLCGSGRVLSK 453 house mouse
XP_003478933 379 HTCARKAWEDALDRYCDQEQAVKTHHHMCCHYPPSPIRDECFAQRAPYPNYDRDILTLDLSRVTPNLMGHLCGNGRIITK 458
XP_013216683 359 LTCIWKAWEDTLDGYCDKEQATKTHHHSCCHYPPSPARDECFAHQAPYPNYDRDILTLDLGRVTPNLMGHLCGNRRVLTK 438
XP_001370788 374 YTCARQAWEEALDSYCDEELAIKTHHHVCCQHPASPARDICFARHAPYPNYDRDILTVDLSRITPDTMAQLCGHRKVLTk 453 gray short-tail...
XP_003498694 457 HKQIPGLIQNMTARCCVLPFPEQACCGEEEKLAFIEDLCGPRKNSWKDPALCCNLSPGDEQANCFNTNYLRNVALVSGDT 536
2_pfamImport 406 YKQIPGLIRNITARCCDLPLPEQACCAEEEKTSFISYLCGPQRNIWRDPAFCCRMNPGDEQTNCFNINYLKNVALVAADS 485
XP_012667220 457 HKQIPGLIQNMTASCCELPFPEQACCAEEEKLAFISDLCGPRRNFWRDPAFCCDLNPGDEQVNCFNTNYLRNVALVAGDT 536
Q16610       435 HKHIPGLIHNMTARCCDLPFPEQACCAEEEKLTFINDLCGPRRNIWRDPALCCYLSPGDEQVNCFNINYLRNVALVSGDT 514 human
3_pfamImport 409 HKQIPGLIQNMTARCCDLPFPEQACCAEEEKSAFIENLCGPRHNSWQDPARCCDLSPGDKQTNCFNIQYLRNVAVVAGDT 488
4_pfamImport 397 HKQIPGLIRNMTARCCKLPAAEQGACAEEEKSAFIEDLCGSRRDSWRDSDYCCDEKPGDEQTNCFNIHYLRNVALVAGVA 476
Q61508       454 HKQIPGLIQNMTIRCCELPYPEQACCGEEEKLAFIENLCGPRRNSWKDPALCCDLSPEDKQINCFNTNYLRNVALVAGDT 533 house mouse
XP_003478933 459 YQHIPGLIRNMTARCCELPFPEQACCAEEEKLAFIEDLCGPRRNFWRDSASCCDRKPEDEQTKCFNLNYLRSVALVTGDT 538
XP_013216683 439 HKQIPGLIQNMTARCCNLPFPEQACCAEEEKSAFVEDLCGPRRNFWRDSAFCCDLSPGDEQTNCFNINYLRNVALVAGDT 518
XP_001370788 454 HKHIPGLIRNMTARCCELAPPEQGFCAEEEKSAFIRDLCGSRRDSWRDTESCCDHSPGDEQTCCFNTHYLRNVALVAGVP 533 gray short-tail...
XP_003498694 537 GDATGQREQDPTGETNVNPAPGSKEE 562
2_pfamImport 486 GDAKGQGKHDPTQATNTSPPSEPQEK 511
XP_012667220 537 ENAKGQGEQGPTGGTKIGSTLEPKAE 562
Q16610       515 ENAKGQGEQGSTGGTNISSTSEPKEE 540 human
3_pfamImport 489 GDAKDPGEQDPNQETNISPTQKPSEE 514
4_pfamImport 477 QKPKDQQETGTTELPPASPTPEHKGE 502
Q61508       534 GNATGLGEQGPTRGTDANPAPGSKEE 559 house mouse
XP_003478933 539 GDARG--EQVPTRGTNVSPAPESKEE 562
XP_013216683 519 GDARGQGEQVPTGGTNISPTPESKEE 544
XP_001370788 534 QKPRGQQGTGTTELPLVTPTPEHKGE 559 gray short-tailed opossum
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