Conserved Protein Domain Family
MRVI1
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pfam05781: MRVI1 (This model is not part of the current CDD release)
MRVI1 protein
This family consists of mammalian MRVI1 proteins which are related to the lymphoid-restricted membrane protein (JAW1) and the IP3 receptor associated cGMP kinase substrates A and B (IRAGA and IRAGB). The function of MRVI1 is unknown although mutations in the Mrvi1 gene induces myeloid leukaemia by altering the expression of a gene important for myeloid cell growth and/or differentiation so it has been speculated that Mrvi1 is a tumour suppressor gene. IRAG is very similar in sequence to MRVI1 and is an essential NO/cGKI-dependent regulator of IP3-induced calcium release. Activation of cGKI decreases IP3-stimulated elevations in intracellular calcium, induces smooth muscle relaxation and contributes to the antiproliferative and pro-apoptotic effects of NO/cGMP. Jaw1 is a member of a class of proteins with COOH-terminal hydrophobic membrane anchors and is structurally similar to proteins involved in vesicle targeting and fusion. This suggests that the function and/or the structure of the ER in lymphocytes may be modified by lymphoid-restricted resident ER proteins.
Links
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Statistics
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PSSM-Id: 516974
Aligned: 8 rows
Threshold Bit Score: 635.782
Created: 14-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q9N1F0       325 VESELGKPLAKTAKEGNPLPRGPTQGS----------------GGVAPQASQGKSTVGE-----PAGSKVGSKAELWPPT 383 domestic cattle
2_pfamImport   1 GEIKDGALDVTRGQKCPGPPGGPHPGTdlsgcirmsddlsmeeNGVEHLNSENLPQSREyptlpLPGHTSSTDSTVTSSD 80 
Q12912        23 GEVKDGALDVKRQHKCPGPTSGPSPGTnlsgcirmnddpsmeeNGVERVCPESLLQSREysslpLPRHTSSTDGTITSSD 102 human
5_pfamImport   1 EEIEDCALAVTERHRCPGRSAGPHPGTdlsgcirmnndlsmeeNGVEYLCSESQPQPREystlpSPGHTSSTESTVTSSD 80 
4_pfamImport   1 KEKKDDALYVTRGQKCPGPTEGPEHRPdlsdcirmngdlsmeeNGVERLHSENLSQSREhlvlpSPEHASSPESTVTSSD 80 
Q60664        10 QEPEDGALDVTRGCQCPLPTEDSILGQelldctrmnedqstdeNGAGHFYSESPSQLREyltqpSSEQTSSSESTVTSSE 89  house mouse
XP_056658072 200 GEKDPGKQLLKKPKESDHLLKGQLQGP-----------------GTTPQGPQGKGPAWE-----PPNSKTPSKADLKPPG 257 gray short-tail...
XP_046798220 311 CENEFGKSFLKKAKENDVPLRTCLPGP-----------------GIGNIDSKLKSPIPE-----MRDHKVSFKPEFKLCG 368 chicken

Q9N1F0       384 SRPPLLRGVSWDSGPEEPGPRlqkvlaklplaEEEKRFT-GKAGSKLAKAPGLKDFQIQVQpvrmqkltklreehiLLRN 462 domestic cattle
2_pfamImport  81 ASSEILNMSSGDPACRSFCEK-----------EEDTRAA-STMIETQGTSPAPDNIPLPGS---------------MSED 133
Q12912       103 PGLEILNMASCDLDRNSLCKK-----------EEDTRSA-SPTIEAQGTSPAHDNIAFQDS---------------TSKD 155 human
5_pfamImport  81 SGSEILHMASGDPDCKPLCEK-----------EEDKRSA-STVTKIPGGSPAPENTELQGS---------------VTEE 133
4_pfamImport  81 AGSENLHMASDDLDCKSLCET-----------QQKAKSA-ST-------------------------------------- 110
Q60664        90 SGSDILHMASGDLDCKPLCEK-----------EEEARAA-SAMQGTSLAPAAYGDYT---S---------------VGVA 139 house mouse
XP_056658072 258 VRPPLQRGVSWDSGPMELGPKdkaia-klavaEEEKRFP-GKAANKLPKSSGFKDFQIQVQpvrmqkltklreehiLMRS 335 gray short-tail...
XP_046798220 369 LRPPLLRAVSWDS--LEPGQKdktpv--klpsEEDKSFVvGNKSSNQIKA--FKDLQIQVQpvrmqkltklreehiLMRN 442 chicken

Q9N1F0       463 QNLVGLKLPELSEAAEQEKGhpselssaieeeESKGGLDVMPNISDVLLRKLRVHKSLPGSApplTEKEVENVFVQLSLA 542 domestic cattle
2_pfamImport 134 KAILHLEAKEEPETMEEHRK------------ECAAGDTAVSPLPVTTVKSVNFRQSDNISA---NEKEVEAEFLRLSLG 198
Q12912       156 KTILNLEAKEEPETIEEHKK------------EHASGDSVVSPLPVTTVKSVNLRQSENTSA---NEKEVEAEFLRLSLG 220 human
5_pfamImport 134 KSMLIQEAKKEPETIDEHRK------------ECAAGGAALSSLP---VKSVNFRQSDNMLT---FFVSVEAEFLRLSLA 195
4_pfamImport 111 ------EAKEVPKTTEEHRK------------ECAAGETEVSSPPVATGRSVNFRQSDNTSA---NEKEVEAEFLRLSLA 169
Q60664       140 KAASQLEAGEELRTTENGGK------------GSAPGETEISMPPKASVKLVNFQQSENTSA---NEKEVEAEFLRLSLG 204 house mouse
XP_056658072 336 QNLVGLKLPDLSEAVEQERGhpselspgieeeESKSGCDVMPNISDVLLHKLRVHKALPGSApplTEKEVENVFVQLSLA 415 gray short-tail...
XP_046798220 443 QNLVGLKLPELSEAAEQEKGpsplps-pteeeETKNSSDVMPGIPDILLRKLRVHKSLPGSSpplTEKEVENVFVQLSLA 521 chicken

Q9N1F0       543 FRNDSYTLESRINQAERERNLTEENTEKELENFKASITSSASLwhhCEH----RETYQKLLEDIAVLHRLAARLSSRAEM 618 domestic cattle
2_pfamImport 199 FKCDWFTLEKRVKLEERSRDLAEENLKKEITNCLKLLESLTPL---CEDdsqaLEIIKKLEKGITFLSQCTVRMASRAEM 275
Q12912       221 FKCDWFTLEKRVKLEERSRDLAEENLKKEITNCLKLLESLTPL---CEDdnqaQEIIKKLEKSIKFLSQCAARVASRAEM 297 human
5_pfamImport 196 FKCDWFTLEKRVKLEERSRDLAEENLKKEITNCLKLLESLTSL---CEDdsqaQEIIKKLEKSITFLSQCTTRVASRAEM 272
4_pfamImport 170 FKCDWFTLEKRVKLEERSRDLAEENLKKEITNCLKLLESLTPL---CEEdnqaQEIIKKLESSITFLSQCTARVASRAEM 246
Q60664       205 LKCDWFTLEKRVKLEERSRDLAEENLKKEITNCLKLLESLTPL---CEEdnqaQEIVKKLEKSIVLLSQCTARVASRAEM 281 house mouse
XP_056658072 416 FRNDSYTLEARINQAERERNLTEENTEKELNNFKASITSSASLwqtCEH----RETYEKLLEDIAVLHRLAARLSSRAEM 491 gray short-tail...
XP_046798220 522 FRNDSYTLESRINQAERERNLTEENAEKELENFKTAITSSAHLwhhYEH----REAYQKLLEDIAVLRRLAARLSSRAEM 597 chicken

Q9N1F0       619 VGAVRQEKRMSKATEVMMQYVENLKRTYEKDHAELMEFKKLANQNsSRSCGP--SEDGVPRTARSMSLSlGKNMPRRRVS 696 domestic cattle
2_pfamImport 276 LGAINQESRVSKAVEVMIQHVENLKRMYAKEHAELEELKQVLLQN-ERSFNSlgDEDDCQIKKRSASLN-SKPSSLRRVS 353
Q12912       298 LGAINQESRVSKAVEVMIQHVENLKRMYAKEHAELEELKQVLLQN-ERSFNPleDDDDCQIKKRSASLN-SKPSSLRRVT 375 human
5_pfamImport 273 LGAINQESRVSKAVEVMIQHVENLKRMYAKEHAELEELKQVLLQN-ERSFNPleDEDDCQTKKRSSSVN-SKPSSLRRVT 350
4_pfamImport 247 LGAINQESRVSKAVEVMIQHVENLKRMYAKEHAELEELKQVLLQN-ERSFNPleDEDDCQIKKRSASLN-SKPSSLRRVT 324
Q60664       282 LGAINQESRVSRAVEVMIQHVENLKRMYAKEHAELEDLKQALLQN-DRSFNSlpDEDDCQIKKRSSSLN-SKPSSLRRVT 359 house mouse
XP_056658072 492 VGAVRQEKRMSKAAEVMMQYVENLKRTYEKDHAELMEFKKLANQNsSRSYGP--SEDGVPRATRSMSLTlGKNMPRRRVS 569 gray short-tail...
XP_046798220 598 VGAVRQEKRMSKATEVMMQYVENLKRTYEKDHAELMEFKKLANQNsSRNYGA--SEDGVPRSSRSMSLTvGKNMPRRRVS 675 chicken

Q9N1F0       697 VAVVPKfnilNLpGQSPSSSPIPSLPALSE-SSNGKgnppvssalpaLLENGKTNGDPDCE----ASASVPTPSCLEGIS 771 domestic cattle
2_pfamImport 354 IASLPR----NI-GNVGTMAGMENNDRLSRrSSSWR-----------ILGSKQSEHRPSLH----RFISTYSWTDAEEEK 413
Q12912       376 IASLPR----NI-GNAGMVAGMENNDRFSRrSSSWR-----------ILGSKQSEHRPSLP----RFISTYSWADAEEEK 435 human
5_pfamImport 351 IASLPR----NI-GNAGMLAGMENNERFSRrSSSWR-----------ILGSKQSEHRPSLH----RFISTYSWADAEEEK 410
4_pfamImport 325 IASLPR----NI-GNAGMAAAME-NDRFSRrSSSWR-----------ALGTKQSEHRPSLH----RFISTYSWPDAEDEK 383
Q60664       360 IASLPR----NL-GNVGLVSGMENNDRFSRrSSSWR-----------ILGTKQGEHRPSLH----RFISTYSWADAEDER 419 house mouse
XP_056658072 570 VAVVPKfnalNIpGQSPSTSPIPSLPSLAE-TTNGKgnpsaslapsaLLENGKSSGDQDCEgptpSAPPALTQSGFEEIS 648 gray short-tail...
XP_046798220 676 VAVVPKfnslNIpGQSPTASPIPSMPSLSEsPSNGKsnltsnpvlpaVLENGKTNGEPDCE----TSTSTVTQGGLEEIN 751 chicken

Q9N1F0       772 QEAKARMEEEAYNkgyQEGLKKTKElQGLREEEEEQKSE--------------------SpeepeevaeteeeekeqRS- 830 domestic cattle
2_pfamImport 414 CEVKTKDDSEPPG---EEIVEQTRK-PSLSEKRNNPSKW--------------------D-----------------VS- 451
Q12912       436 CELKTKDDSEPSG---EETVERTRK-PSLSEKKNNPSKW--------------------D-----------------VS- 473 human
5_pfamImport 411 CELKTKDDLEPPE---EETVEKTRK-PSLSEKKTNPSKW--------------------N-----------------VS- 448
4_pfamImport 384 CDPKTKDDSESPG---EEIVERTRK-TSLSERKNNPSRW--------------------G-----------------IS- 421
Q60664       420 SDVKARDAPEPQG---EEAVERTRK-PSLSERRSSTLAW--------------------D-----------------RG- 457 house mouse
XP_056658072 649 QEIKAKIEEEAYNkgyQEGLKKTKE-LQE------LKEEeeektneslegpesedeekeL-----------------KN- 703 gray short-tail...
XP_046798220 752 PETKAKIEEEAYNkgyQEGLKKTKElQDLKEEDEETPKE--------------------Glhdehees-endseiknLKs 810 chicken

Q9N1F0       831 SKLEELVHFLQVMYPKLCQHWQVIWMMAAAMLVLTVVLGLYGS--HNSCVEQADGSLGKSTCSAAQRdSWWSSGLQHEQP 908 domestic cattle
2_pfamImport 452 SIYDTIASWAANLKTSFGKANKALWISVAFIVLFAALMSFLTGlfFQKPVDAAPIRNGDSWMSLEHA-LWPFTKLQHNGP 530
Q12912       474 SVYDTIASWATNLKSSIRKANKALWLSIAFIVLFAALMSFLTGqlFQKSVDAAPTQQEDSWTSLEHI-LWPFTRLRHNGP 552 human
5_pfamImport 449 SIYDTLASWATNLKTSIREANKMLWLSVAFIVLFAALMSFFTGrfFQKSVDAAPTQDADPWMSLEHI-LWPFTRLRHNGP 527
4_pfamImport 422 SIPDTLASWVTHLGTSVRKANKTLWLSVALIVLFAALMSLLAGrfFQKSVEAAPTQEGDSWISLEHI-LWPFTGLQHNGP 500
Q60664       458 TICSSVASWVTHLQASFRRANRALWLTGLIIILIAALMSFLTGqlFQTAVEAAPTQEGDSWLSLEHI-LWPFTRLGHDGP 536 house mouse
XP_056658072 704 SKLEALIHFLQILYPKLCQHWNVIWMVAAAILVFTVVLGLYNS--YHSCAELSEGTSGKATCSASQRdTWWSSGLQQEQP 781 gray short-tail...
XP_046798220 811 SRLEVVINYLYILYPKLCKHWNVVWLIVAAIIIFAVLLGIYHS--YSSCDEVSERPEGKASCSAAHQySWWNSGFQHEQR 888 chicken

Q9N1F0       909 TEQ 911 domestic cattle
2_pfamImport 531 PPV 533
Q12912       553 PPV 555 human
5_pfamImport 528 PPV 530
4_pfamImport 501 PPV 503
Q60664       537 PPV 539 house mouse
XP_056658072 782 TEQ 784 gray short-tailed opossum
XP_046798220 889 TE- 890 chicken
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