Conserved Protein Domain Family
IER

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pfam05760: IER (This model is not part of the current CDD release)
Immediate early response protein (IER)
This family consists of several eukaryotic immediate early response (IER) 2 and 5 proteins. The role of IER5 is unclear although it play an important role in mediating the cellular response to mitogenic signals. Again, little is known about the function of IER2 although it is thought to play a role in mediating the cellular responses to a variety of extracellular signals.
Statistics
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PSSM-Id: 516967
Aligned: 17 rows
Threshold Bit Score: 238.257
Created: 14-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q99J55         1 MECALDAQSLISISLRKIHSSRTQRGGIKLHKNLLVSYVLRNARQLYLSERYAELYRRQQQQQQqqpphhqhq------- 73  house mouse
1_pfamImport   1 MECAVDAQSLISISLRKIHNSRTQRGGIKLHKNLLVSYVLRNARQLYMNEKYAEIYRMQQYEEV---------------- 64 
XP_005993309   1 MECAVDAQTLITISLRKIHNSRTQRGGIKLHKNLLVSYVLRNARQLYLNERYAEIYRRQQYEEV---------------- 64 
XP_011615873   5 AECAVDAESLISISLMKIHNSRTQRGGIKLHKNLLVSYVLRNARQVYIKEKYAEVYRIQQYEEV---------------- 68 
5_pfamImport   1 MECAVDAQSLISISLMKIHNSRTQRGGIKLHKNLLVSYVLRNARQVYIKEKYAEIYRMQQYEEV---------------- 64 
Q6NYT3         1 MECAVDAQSLISISLRKIHNSRTQRGGIKLHKNLLVSYVLRNARQVYMNEKYAEIYRMQQYEEV---------------- 64  zebrafish
XP_006635330   1 MEYKVEAHRIMSISLGKIYNSRVQRGGIKLHKNLLVSLVLRSARQVYLSEYYQGVCLNAQHMDTapqwgegaivdstqdk 80 
XP_003785699   1 MEFKLEAHRIVSISLGKIYNSRVQRGGIKLHKNLLVSLVLRSARQVYLSDPCPGLYLAGPAGTPapppqqpgepaa---- 76 
Q5VY09         1 MEFKLEAHRIVSISLGKIYNSRVQRGGIKLHKNLLVSLVLRSARQVYLSDPCPGLYLAGPAGTPapppqqqpgepaa--- 77  human
XP_007257047   5 AECAVDAQSLISISLRKIHNSRTQRGGIKLHKNLLVSYVLRNARQVYMNEKYAEIYRMQQYEEV---------------- 68 
Q99J55        74 ------hlayaapgMPASA-------ADFGPLQLgggg---daeAREPVARHQLHQLHQLHQLHLqqql-hqhQHpaprg 136 house mouse
1_pfamImport  65 --------------MTVCSe-----iQELNPLEL----------GEDGAEPSAECGAGPSSSSSSssggdpapVC----- 110
XP_005993309  65 --------------MAVCSe-----iQELNPLEL----------VEEVAVDNEDCGGGGGSLLEVss-----pVC----- 105
XP_011615873  69 --------------MAVCNe-----iEELNPLETaae-----dmDNGDQARGGCCSEESSLCGS---------AChr--- 112
5_pfamImport  65 --------------MAVCNe-----iQELDPLELeag-----daDDGDQARGVCCGEESSPCGS---------AChr--- 108
Q6NYT3        65 --------------MTVCNe-----iQELNPLDLae------dcED----QTADCCGSASESAS---------LC----- 101 zebrafish
XP_006635330  81 agsdpagsaqgspdSGSTLppe-----ssHPLPAat-------------------------------------------- 111
XP_003785699  77 --vppagwgeppppAARAAwretepqPQPQPQPErtavldaqwvGGAEPATSVTRVGDALQGREAdaaeaawgSVegprg 154
Q5VY09        78 --gppagwgeppppAARASwpe------tePQPErssvsdaprvGDEVPVATVTGVGDVFQGGEAdateaawsRVegprq 149 human
XP_007257047  69 --------------MTVCNe-----iQELDPLDVvaggaaadecEDAGVAEQQQCCAGGMAGGQA--------SL----- 116
Q99J55       137 ctAAApva------vaGAPAGCAGALSELPGCAalqpphgaPHRGQHL--EPlQPGpaplpppapaalcprdprvpaacs 208 house mouse
1_pfamImport 111 --AAL-----------LAGAGGHTAVSPPPPSP--------ALHGEDAgkDT-DASfyrs-------------------- 148
XP_005993309 106 --GAL-----------IPAPQQQEAAAAAAGDPt------lQLQNQEIckDS-DSAfyrs-------------------- 145
XP_011615873 113 -dAA-----------------HARALSALPCCP----------RLEDVskEP-ENPyyrs-------------------- 143
5_pfamImport 109 -dAA-----------------HARAASALPGCP----------RLEDAnkEP-ESAyyrs-------------------- 139
Q6NYT3       102 --GAL-----------LPAVGHQTSPAAQHIQPasacsvplALQSEEVckAApEPSfyrs-------------------- 148 zebrafish
XP_006635330 112 ---------------aLESPAAGRQPETAEPGEqsapsapsSP--ACCcrPTgEPLg----------------------- 151
XP_003785699 155 aaAAGagdpvrgsdvfPEGP--ARRPSACPPGGedqrgaaaASPGADCccAP-RPVv----------------------- 208
Q5VY09       150 aaAREaegtaggwgvfPEVSRAARRPCGCPLGGedppgtpaATPRAACccAP-QPAe----------------------- 205 human
XP_007257047 117 ---------------------CGAQPCSLPSAP------------EEAckTS-ETLfyrs-------------------- 142
Q99J55       209 apsvlpgaapstvaassppastapssstgfyrGAYPAPs-----------------------------dFGVHCsSQTTV 259 house mouse
1_pfamImport 149 -----------------------------ccaEAYPVPscdf------------------------lpaGGAHC-NKTTV 174
XP_005993309 146 -----------------------------cclGAYPVTncdf------------------------tagNGTHC-AKTTV 171
XP_011615873 144 -----------------------------cfmQPYPLSncaq-----------------------fvtnGSAQC-TKTTV 170
5_pfamImport 140 -----------------------------ccaQPYPAShcaqv----------------------taggGSAQC-TKTTV 167
Q6NYT3       149 -----------------------------ccaEAYPVSncdf------------------------spvNNMHC-NKTTV 174 zebrafish
XP_006635330 152 --------------------------------EPVPAPadlpcapvapfparshgaetppykeatppeeGAGGC-GEAEV 198
XP_003785699 209 --------------------------------DESPAPpavc-----------------------prkrGAAGV-G---- 228
Q5VY09       206 --------------------------------DEPPAPpavc-----------------------prkrCAAGV-G---- 225 human
XP_007257047 143 -----------------------------ccaEPYPPPppsp------------------------cdfSPAHC-NKTTV 168
Q99J55       260 LDLDTHVVTTVENGYLHQD--CCASAHCPCcgQGAPGPgla-saAgCKRKYYP----GQEEE-DDEEDAgDlgaeppggt 331 house mouse
1_pfamImport 175 LDLDTHVVTTVENGYLHQD--CCGAAGPPCc-QGAPAP------A-KKRKADF----GYYAAgGAEEVA-D--------- 230
XP_005993309 172 LDLDTHVVTTVESGYIQQD--CCAS---QChcQGAQAA------AnKKRKFDF----NYYAS-ETEESH-D--------- 225
XP_011615873 171 LDLDTHVVTTVENGYVHED--CFCDS-PQCg-QNTQSTt-------KKRKVEF----SCCVS-DAVDVS-D--------- 224
5_pfamImport 168 LDLDTHVVTTVENGYLHQDccCCCDA-PQWg-QIAQSP------T-KKRKVEF----GGCAP-DAEEVS-D--------- 223
Q6NYT3       175 LDLDTHVVTTVENGYLHQD--CC-ASLQQCc-QGAQSP------A-KKRKLDF----GYYVS-EIEEAP-D--------- 228 zebrafish
XP_006635330 199 KGGESESSETRLNHSAAAS--CCRKRS------AEKAPhaespvKkTKQTSPS--------------------------- 243
XP_003785699 229 -GGP-------------AG--C-------------QAPgat-plKkPRRNLEEq---------QPGRg--E--------- 258
Q5VY09       226 -GGP-------------AG--C-------------PAPgst-plKkPRRNLEQ----------PPSGg--E--------- 254 human
XP_007257047 169 LDLDTHVVTTVENGCLHQD--CCCTPLQPC-----SSP------SsKKRKVSDysgcGYYAP-ELEDVSvD--------- 225
Q99J55       332 pFAPC-KRARFEDfCPDSSP---DASNISNLISIFGSGFSGLVSRQPDs-SEQPppLN----------------GQL-CA 389 house mouse
1_pfamImport 231 -FAPC-KRSRFEE-CACPSPeplDSSNISNLISIFGSGFTGLVSKQAD--LEQS--LN----------------GQF-CS 286
XP_005993309 226 -FSPC-KRARFED-FASQNLeqsDTSNISNLISIFGSGFTGLVSRQAD--CELS--LN----------------GQL-CS 281
XP_011615873 225 -FIATrKRLKRDD-CPFSNPdytDASNITNLISIFGSGFSGLLSRQSD--MEQI------------------------CS 276
5_pfamImport 224 -FTATrKRPRRED-GPFSGPdhaDASNITNLISIFGSGFSGLLSRQSD--MEQI------------------------CS 275
Q6NYT3       229 -FTPC-KRAKFED-SSYAITeplDTSNISNLISIFGSGFSGLVSRQAD--LEQA--LN----------------GQF-CS 284 zebrafish
XP_006635330 244 --------------EEAEREeemDTSNVSSLITIFGSSFSGLLSK------------DsapqaeppagdsdsasGQIcCE 297
XP_003785699 259 ----------------DDDPedmETGNVANLISIFGSSFSGLLRKSPGggREEEegAEsgpe--------aaepGQIcCD 314
Q5VY09       255 ----------------DDDAeemETGNVANLISIFGSSFSGLLRKSPGggREEEegEEsgpe--------aaepGQIcCD 310 human
XP_007257047 226 -PAPC-KRAKLED-CCSDCLvdlDTANISNLISIFGSGFSGLVSRQAD--FEQA--FN----------------GQF-CS 281
Q99J55       390 KQALASLGAWTRAIVAF 406 house mouse
1_pfamImport 287 KQALASLSGWTRAIVAF 303
XP_005993309 282 QQALASLGAWTRAIVAF 298
XP_011615873 277 KQVLASLGAWTRAIVAF 293
5_pfamImport 276 KQVLASLGAWTRAIVAF 292
Q6NYT3       285 KQALASLGAWTRAIVAF 301 zebrafish
XP_006635330 298 Q-MLKNMNPWSTAIVAF 313
XP_003785699 315 KPVLRDMNSWSTAIVAF 331
Q5VY09       311 KPVLRDMNPWSTAIVAF 327 human
XP_007257047 282 KQALASLGAWTRAIVAF 298
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