Conserved Protein Domain Family
TRAP_beta

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pfam05753: TRAP_beta 
Translocon-associated protein beta (TRAPB)
This family consists of several eukaryotic translocon-associated protein beta (TRAPB) or signal sequence receptor beta subunit (SSR-beta) proteins. The normal translocation of nascent polypeptides into the lumen of the endoplasmic reticulum (ER) is thought to be aided in part by a translocon-associated protein (TRAP) complex consisting of 4 protein subunits. The association of mature proteins with the ER and Golgi, or other intracellular locales, such as lysosomes, depends on the initial targeting of the nascent polypeptide to the ER membrane. A similar scenario must also exist for proteins destined for secretion.
Statistics
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PSSM-Id: 399046
Aligned: 17 rows
Threshold Bit Score: 168.676
Threshold Setting Gi: 145341320
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_001415761  21 CAlv-vVASFANPIVAQDDAdasdappgPARVLVRKRIVEDLVVEGSNVTVAVTLTNAGETEARKVKARD-DGFaNEDDF 98  Ostreococcus lu...
EDO33394       4 LAlvlgVLASLGHCAESESS--------SARLIVAKNILNQFAVEGKDLTVHYTIYNVGSSPAFAVTLTE-TAF-DENSF 73  starlet sea ane...
Q5E9E4         4 LAfa-vLALFA---VTQAEE--------GARLLASKSLLNRYAVEGRDLTLQYNIYNVGSSAALDVELSD-DSF-PPEDF 69  cattle
Q54VI6        13 LF----VSFVYC------EN--------GAELLFHKKIVEGPVV-GKELPIQFIIYNVGSEPAYDISFID-NDF-SNAEF 71  Dictyostelium d...
XP_001581623  12 TKmf-gLSLL----LTQIKS--------APFIVFDKKLSSVSGKVGEPINCYYVIINQGDSTVTDLSIVE-NGI-PSEAW 76  Trichomonas vag...
Q0DLG8        12 LL----LLLVPFAAAAGQDA--------PFVVAQKKVALSRPGPGVERLAVTLNLYNQGSATAYDVSLND-DSW-PQEAF 77  Japanese rice
Q94BY3        13 MA----VFMLVSASFATSEV--------PFMVVHKKATLNRLKSGAERVSVSYDIYNQGSSSAYDVTLTD-NSW-DKKTF 78  thale cress
Q01GX3        22 IA----IACLALGARASDDDla-----tTARVLARKTIAPAMAVEGQNLTVTVSLVNAGTAEARKVRVRD-DGL-DASAF 90  Ostreococcus tauri
CAP24314       1 MK----LIILVSAFLATVNA--------SARVLVGKEFISMYPVAQQENVFEYQIINIGDTAAINVDFSDrGSF-PTDKF 67  Caenorhabditis ...
Q21352         1 MQ----LVFLILSALAAADA--------SAKILIGKSFVTKYPVAQRENAFEYQIINIGLSPALKVELSDlKSF-PTDRF 67  Caenorhabditis ...
XP_001415761  99 ELITGkeSLSATYATIAPGESVEYSFVVVPKKSGSFPGGAVSVSYlgtsgRETTHGSSnVLGATpvYTTMQKNIFAALKV 178 Ostreococcus lu...
EDO33394      74 KVKHG--LTSIKWKSIVPGTNVSHTLILEPLKSGVFNFTSAMVTY-----KPSEDAPE-QVAFS--TAPGEGGVMSNKDY 143 starlet sea ane...
Q5E9E4        70 GIVSG--MLNVKWDRIAPASNVSHTVVLRPLKAGYFNFTSATVTY-----LAQED-GPvVIGFT--SAPGQGGILAQREF 139 cattle
Q54VI6        72 EFVSG--SSEGKWETLAPNSQVQTNLTVIPKKSGIYSLTSTVLNY-----RKTQTSSEfTVSSA--ASYSGMYVESQADY 142 Dictyostelium d...
XP_001581623  77 SFSGD--SSILSWKSLKPGENITHIFPITPTKSGNLQIMPSTMIY--------YDGNEkQKHLS--SMIPFIEIKGSRSI 144 Trichomonas vag...
Q0DLG8        78 QLISG--TTSKIVEKLDPGATASHNFILETKVQGKFQGSPAIITY-----RVPTK-AAlQEAYS--TPMFPLDILAERPP 147 Japanese rice
Q94BY3        79 EVVNG--NTSKSWERLDAGGILSHSIELEAKVKGVFYGAPAVVTF-----RIPTK-PAlQEAYS--TPLLPLDILADKPP 148 thale cress
Q01GX3        91 ELIGEkdALSATYATLAPGERVEYAYTVVPKTSGSFKASAASVSYlgtsgRETTRGTSnVLGDVlvYTKTQRNIFTALEV 170 Ostreococcus tauri
CAP24314      68 EIVSG--SLDAKYAVIPPHSSVSHHIVVVPRVPHAIEDKDVLVDY-----TDSESKISsRVSTLwfSKGRLTHFFHQDAL 140 Caenorhabditis ...
Q21352        68 EILKG--SATASFPVIPANSTIYHHIVVIPRVPQAIEDHDVTVNY-----TDSETGKRaRTSTVsyDKRGYTHFFAETAM 140 Caenorhabditis ...
XP_001415761 179 GKYLTLGacrtIEDWVKYGTIIGSVCGA-----LLLNWVALKV------KK 218 Ostreococcus lucimarinus CCE9901
EDO33394     144 QRKHSPH----LVDWGLFSLMSIPTMLI-----PFMVWYRSHSkyenikAK 185 starlet sea anemone
Q5E9E4       140 DRRFSPH----FLDWAAFGVMTLPSIGV-----PLLLWYSSKRkyd-tpKT 180 cattle
Q54VI6       143 EKRTSLL----IKEWITFFVLCAGAIAL-----PYSISTYYKKnye-ngIK 183 Dictyostelium discoideum
XP_001581623 145 GARAN------LQGYCLFIVAAASSVLV-----PLLLWWVSRKgvs-ttTK 183 Trichomonas vaginalis G3
Q0DLG8       148 QQKFELVkt-cGEIWVAGLRCFLCRCVYlpgckPVKIHCCKRKqe--eaLN 195 Japanese rice
Q94BY3       149 TKPLDVAkr-lLAKYGSLVSVISMVVCF-----IYLVATPKSNvsk-asSK 192 thale cress
Q01GX3       171 GKYLTLGacktMEDWVRYGTLFGGVAGA-----LALNWFALKV------KK 210 Ostreococcus tauri
CAP24314     141 KHIAGSK----YAHFFVFAAIATPVTGL-----SALLYWVSKSryt-lpKR 181 Caenorhabditis briggsae
Q21352       141 RKVEGVN----CTHFLGFGAIAFPLTAI-----PAILYWISKRrysnkkQD 182 Caenorhabditis elegans
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