8SV7


Conserved Protein Domain Family
TANGO2

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pfam05742: TANGO2 (This model is not part of the current CDD release)
Transport and Golgi organisation 2
In eukaryotes this family is predicted to play a role in protein secretion and Golgi organisation. In plants this family includes Solanum habrochaites Cwp, which is involved in water permeability in the cuticles of fruit. Mouse Tango2 has been found to be expressed during early embryogenesis in mice. This protein contains a conserved NRDE motif. This gene has been characterised in Drosophila melanogaster and named as transport and Golgi organisation 2, hence the name Tango2.
Statistics
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PSSM-Id: 516958
Aligned: 99 rows
Threshold Bit Score: 151.619
Created: 14-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
8SV7_A         1 MCIIFFKf-DPRPvsknAYRLILAANRDEFYSRP---------SKLADFW----G-NNNEILSGLDMEeGkeGGTWLGIS 65  human
9_pfamImport   1 MCIAVFLw-QSHP----LYPFLLFLNRDEYLNRA---------TEALRWW------QDGETLGGRDLV-G--GGTWLGCT 57 
XP_002868841   1 MCIAVFLw-QSHP----LYPFLLFLNRDEYHNRA---------TEALRWW------EDGETVGGRDLV-G--GGTWLGCT 57 
XP_006361539   1 MCIAVFIw-KAHP----LYPFLLILNRDEYHNRP---------TKPLSWW------EDSDILGGRDEV-A--GGTWLACT 57 
XP_003631559   1 MCIAVFLw-QAHP----IYPFLLLLNRDEYHNRP---------TEALAWW------QGGEILGGRDGL-A--GGTWLACS 57 
XP_006855741   1 MCIATWAw-RAHP----LYPLILFLNRDEYYNRP---------TEPVSWW------GEPEIIGGKDCL-A--GGTWLACS 57 
XP_003580333   1 MCIAAWTw-QSHP----AYGLLLLFNRDEFLSRP---------TRPAGWWaaagE-EGEEILGGKDEL-G--GGTWLGCT 62 
EFH69360       1 MGIIAFDwaENR--------LTVLQNRDEQESRQvvfidlflnVNEAAWL------ENGNILAGLGNPd---GGTWLGCS 63 
NP_173496      1 MGIVAFQwgEGE------NILTLLQNRENWQSRS---------IGKAAW-----EwDESQVLSGRCAEt---DGTWLGIS 57 
NP_001185046   1 MGIVAFEwaEGK-----TNQLTLLMNRDNWENRV---------ISGASWS------RNGQILSGRCKAn---NGTWFGIT 57 
8SV7_A        66 TRGKLAALTN-Y---LQPQLDwq-----aRGR-GEL-----VTHFLttDVDslSYLKKV-SM--EGHLYNG--FNLIAAD 125 human
9_pfamImport  58 RHGRIAFLTN-F---RETSsip-----daKSR-GDL-----PLRFLqsHKSpaEFAQEI-EK--EASLYNG--FNLVVAH 117
XP_002868841  58 RHGRLAFLTN-F---REASsfp-----daKSR-GDL-----PIRYLqsRKSpaEFAEEI-QD--EISLYNG--FNLVVAH 117
XP_006361539  58 RTGRLAFLTN-V---REINsns-----htKSR-GDL-----PLRFLksVKSphDFSEQL-LK--EVGEYNG--FNLIVAD 117
XP_003631559  58 RDGRLAFLTN-V---REVHpip-----eaKSR-GDL-----IVRFLesKKNpmEFAEEV-MK--EADKYNG--FNLIIAD 117
XP_006855741  58 KHGRLAFLTN-F---REVDvtp-----daKTR-GEL-----PLRFLqsEKNpiEFAEEV-VK--EGHHYNG--FNLIMAD 117
XP_003580333  63 KGGKLAFLTN-V---REPSpra-----gaRSR-GEL-----PVRFLqgRLGplEYATEI-AK--EADQYNG--FNLILAD 122
EFH69360      64 KTGRVAFLLDsIpwpRHPT-----------RRgEHL-----TLDFIegTRTpdQFAEDV-IR--MQNKGLA--FHLVVAD 122
NP_173496     58 IRGRVAFLVEag----------------pVNRdRIIgaecrTLDFLksNLSpeDFADSL-AL--DSGRNTGiaYHLIVAD 118
NP_001185046  58 KGGRVAFLVN---------TSllldrvksYSGsELY-----PVRFLegNMSpeQFANEVkVHekETNERHA--YSLVVAD 121
8SV7_A       126 LStakgdVICYYGNRGe------------PDpIVLTPGTYGLSN-ALLe---------tPWRKLCFGKQLFLEAVErsqa 183 human
9_pfamImport 118 VFs---kSMFYVTNRPlshgdkqqqqqqqQLvTLVSPGIHVLSN-ANLd---------sPWPKCLRLRDGFNQLLTqh-- 182
XP_002868841 118 VLs---kSMIYITNRPphg---------hkLaTQVSPGIHVLSN-ANLd---------sPWPKCLRLRECFQQLLAen-- 173
XP_006361539 118 LCs---mTMLYITNRPkh---------tgMSvTEVSPGIHVLSN-ATLd---------sPWPKSQRLEYSFKQLLDey-- 173
XP_003631559 118 LCs---kTMIYITNRPre---------anVSvVEVSPGIHVLSN-ASLd---------sPWPKARRLGHNFKELLDky-- 173
XP_006855741 118 LWl---eSMVYVSNRPkd---------epATfKEVSPGLHVLSN-AKLd---------tPWPKATRLILSFEKLLKey-- 173
XP_003580333 123 VHs---gNMVYISNKPsg----------aPVvQTVSPGSHVLSN-AAId---------sPWPKALRLGQSFNRFLAth-- 177
EFH69360     123 VFgt--kSLVYICKKRrdsdhvt--------kthvpyGVHTITTn--------------gIDKGEEVRRKFAAVTEw--- 175
NP_173496    119 IVs---nSMFYIYKPSlsedgmvytepvgP-------GVHTLSS-AGLdsevghrdlrlK--------RYFSERINre-- 177
NP_001185046 122 MTs---sSMVHILKPSdtksdvv--------ietvpfGVHTLSSyEGLdstdsardlllR--------RLFTQMVGnlgn 182
8SV7_A       184 lpKDV--LI--ASLLD----VLNNEEa-qLP----------DPAIedqg--geyVQPMlskyAAVC-----VRc--P--- 232 human
9_pfamImport 183 prGEF--PV--KTMVEe---VMTDTVk--DQ----------Qphvf----ppetQYHL----SSIF-----VDi--Ptpa 228
XP_002868841 174 gsREF--PV--KTMVEe---VMTNTVk--DE----------ETELphvf-tpetEYHL----SSIF-----VDm--Qrpt 222
XP_006361539 174 geSEI--PI--GKAAEr---IMRDLAk--ED----------SN-Lpgiy-specEYQL----SSIF-----VDt--Emsm 221
XP_003631559 174 geGEI--PT--EEMVEk---LMKNTIk--DD----------EIVLpriy-pperEHQL----SSIF-----VDt--Dtpl 222
XP_006855741 174 drEEI--PE--KEMLHk---LMLDTMk--AD----------RENLpntgcdpdwDYNL----SSIF-----VEt--Dsek 223
XP_003580333 178 dsVEV--PL--EQMVEe---LMMDTVk--AD----------RSEVpdtgvdpdwEYQL----SSIF-----IDt--Ekgq 227
EFH69360     176 -tHSQslELpmELSLRqiilELPNVQrtmNRlqgiktpddhDPID------------L----TSFFkrdgpL-------- 230
NP_173496    178 -lPEPisGLaeEVMYDtveaINGDP--------------------------------L----SSIFvvdtlIEn------ 214
NP_001185046 183 vqQRQmeEIagRFMYDa-------------------------------------QAGR----DAVFyhsrdehpngklgt 221
8SV7_A       233 -GYGTRTNTIILVDAD------G-HVTFTERSMMD 259 human
9_pfamImport 229 gRYGTRSISALTIKSH------G-QVCFYERHLEP 256
XP_002868841 223 gRYGTRSISAISIKSHgdgdgdG-EVCFYERHLEE 256
XP_006361539 222 gRFGTRSTSSLAVRSS------G-DATFYEVYLEK 249
XP_003631559 223 gRYGTRSTSSVCVRAS------G-EVNFYEKHLEN 250
XP_006855741 224 gCYGTRSMVALSIRAS------G-EVSFYERYRDN 251
XP_003580333 228 aRYGTRSMVAIAVKLD------G-EVTFYERSLAS 255
EFH69360     231 ---QTNCSTVVVVVPRaa--ggGgRCIFHEKYMRN 260
NP_173496    215 eHYGTRCTTALVVRRT------M-QVRFFERYRAR 242
NP_001185046 222 qRFGTTSTTALVVKRT------R-EVMLFEKYMEQ 249
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