5KL8


Conserved Protein Domain Family
zf-nanos
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pfam05741: zf-nanos (This model is not part of the current CDD release)
Nanos RNA binding domain
This family consists of several conserved novel zinc finger domains found in the eukaryotic proteins Nanos and Xcat-2. In Drosophila melanogaster, Nanos functions as a localised determinant of posterior pattern. Nanos RNA is localised to the posterior pole of the maturing egg cell and encodes a protein that emanates from this localised source. Nanos acts as a translational repressor and thereby establishes a gradient of the morphogen Hunchback. Xcat-2 is found in the vegetal cortical region and is inherited by the vegetal blasomeres during development, and is degraded very early in development. The localised and maternally restricted expression of Xcat-2 RNA suggests a role for its protein in setting up regional differences in gene expression that occur early in development.
Links
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Statistics
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PSSM-Id: 516957
Aligned: 58 rows
Threshold Bit Score: 63.3745
Created: 14-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
5KL8_B        32 CVFCENNN--------------EPEAVINSHSVRDnFN-------RVLCPKLRTYVCPICGASGDSAHTIKYCPK 85  fruit fly
4_pfamImport   1 CYHCAYYN--------------KPTEEISSHNIRKpNG-------DLWCEDLQKQKCQHCEATGEKGHHHLICPK 54 
EFO91655     287 CFRCAYYD--------------MSKEEIASHNIRKeNG-------DLWCEHMKKIACVHCDAIGEKGHHPLVCPK 340
KAF8362064   773 CVYCKGTLk-------------LSEEEYSSHTLHDpSRprcgperRVTCPRLRETGCQYCGLKGDLAHDQFFCER 834
EGT41018     119 CSFCFGTAtqragemgerlperDDWGTWSTHSCKE-RG-------IVTCPFLWQVTCPICGATGAAAHTRAEHVR 185
EGT48749     113 CSFCYGTAaqmareqgqpvpdkDDYGPWSSHSCKM-NG-------HVSCPFLWQVVCPLCGATGPVAHTRAEHLR 179
3_pfamImport   1 CSFCYGTYvtfarlsgnpilskDDSGPWSDHQCKT-NG-------IVSCPVLRRNKCTVCGATGDYAHTSKYHHE 67 
2_pfamImport   1 CSFCYGLAakkaeeagepiadrDDDGPWSNHQLKS-DG-------AVSCPVLRAVVCNICGATGETAHTTVYHST 67 
EGT48747     112 CSFCYKVAaqwaaeqevqvpskDDYGYWSSHSLMGrYG-------VVVCPVLRRVVCGHCGATGDHAHTTRFHEQ 179
EGT40897      90 CSFCWKRAarwaredgvpvpskNARGSWSTHSLKG-PGpn----rVVTCPVLRQVVCGHCGATGDHAHTTHHHET 159
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