2Z1P


Conserved Protein Domain Family
Collagen_bind

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pfam05737: Collagen_bind 
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Collagen binding domain
The domain fold is a jelly-roll, composed of two antiparallel beta-sheets and two short alpha-helices. A groove on beta-sheet I exhibited the best surface complementarity to the collagen. This site partially overlaps with the peptide sequence previously shown to be critical for collagen binding. Recombinant proteins containing single amino acid mutations designed to disrupt the surface of the putative binding site exhibited significantly lower affinities for collagen.
Statistics
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PSSM-Id: 283410
Aligned: 12 rows
Threshold Bit Score: 117.848
Created: 14-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2Z1P_A  158 PFFYKVGDLAGESNQ--VRWFLNVNLNKSDVtEDISIADRQGSGQQlnKESFTFDIVNDKETKYISLAEF---------- 225  Enterococcus faecalis
Q9KBB4  793 NNGFKNGSYNAVTKE--ITWNIGVNYNLQEL-HDAVVEDFIQEGQHlvADSIEVFEMGLTGGANGVNQGDllt-----eg 864  Bacillus halodurans
Q8Y479  183 NAFEKKGSTVQNAQV--IDWEIKINQELATH-ENASVEDFPGNGQKilFDSFEVHEMNMHIDGTYEIGAKvd-------p 252  Listeria monocytogenes
Q9KFW0  372 HSIDKRGVVDQTFNAteIKWTVDFNKQLQPI-EQAILKDPIQTGQAlrAGSIKVYELNVQLDGSVVQGAE---------- 440  Bacillus halodurans
Q9KBB4  378 SMIDKQGIVDRGYNAteITWTVDFNKQMREI-DNAVLRDPIQLGQAlqAGSIEVYELNVQLNGSVVQGDL---------- 446  Bacillus halodurans
Q836L2  177 PFFYKVGDLAGESNQ--VRWFLNVNLNKSDVtEDISIADRQGSGQQlnKESFTFDIVNDKETKYISLAEF---------- 244  Enterococcus faecalis
Q8Y8L7  177 TIVFKQGRMDDKDLSi-LHWTVTLNNALTPI-DNAVYTDTLGSGQNllGSATIKYRDANKKV------------------ 236  Listeria monocytoge...
P11000  180 PDVNKVGYQDKSNPGl-IHWKVLINNKQGAI-DNLTLTDVVGEDQEivKDSLVAARLQYIAGDDVDSLDEaasrpyaedf 257  Streptococcus mutan...
Q9CHP4   99 EVLYKWGWVDENDSTl-IHWQVRINYAKENI-QKAIYTDIIGGNQNlvSGSISVANVTYSSDGENYNVD----------- 165  Lactococcus lactis ...
Q8YAG7  184 ETLFKYGWVDASNPSl-IHWVVRVNYAKVNI-PNAVFTDIIGAKQTlnFDSIKAFHGTYSADRVFTA------------- 248  Listeria monocytogenes
Q8YAG6  187 ESLYKYGWADAENPEl-IQWVVRVNYSKQNI-QNAVYEDFIGPKQVvdFNSIKAFHGEFDPDDNFTP------------- 251  Listeria monocytogenes
Q9CJ55  349 QAIDKSGHFDKTPNPseVIWEININRPLNTM-ENATLTDPMPEGTT--YESVEIYPETVGKNGEIISIDK---------- 415  Lactococcus lactis ...
2Z1P_A  226 -EQQGYGKIDFVTDNDFNLRFYRd-kARFTSFIVRYTSTITEAGQHQatfenSYDINYQLNNQDATNEKN 293  Enterococcus faecalis
Q9KBB4  865 vDYDLVMVQDGDGNPGFRVEFRD---TIDSPYWISFKTSLDERLIKQ-----TYQNEAILSSSNTDDFRL 926  Bacillus halodurans
Q8Y479  253 sEYTVTKINNTSGQTGFRLTFEN---PIDSAYQITYQTEITDFNKA------TFSNTATFNSDETEEVMD 313  Listeria monocytogenes
Q9KFW0  441 -VDPSSYTIEQVDGNDFQIVFGS----IDSAYRVEFITDITNRNAT------YYMNRATLTGENIDDLSA 499  Bacillus halodurans
Q9KBB4  447 -VDPSNYSIGQIDGDDFQINFGD----IDSAYRVVFKTDITDGDAT------SYQNVATLDGDNIDPMPA 505  Bacillus halodurans
Q836L2  245 -EQQGYGKIDFVTDNDFNLRFYRd-kARFTSFIVRYTSTITEAGQHQatfenSYDINYQLNNQDATNEKN 312  Enterococcus faecalis
Q8Y8L7  237 -IATNIQPIALDADRNFELSIGA---LNNQSVVITYDTKITTKQK-------SYTNKATLSGDNLDAVSR 295  Listeria monocytogenes EGD-e
P11000  258 sKNVTYQTNDLGLTTGFTYTIPG---SSNNAIFISYTTRLTSS---------QSAGKDVSNTIAISGNNI 315  Streptococcus mutans UA159
Q9CHP4  166 -SYYPQASILENGVNGFTVNLGD----ISNTIIIDYSTRATDGGLSQ-----QYENRGELTGENIEKQVV 225  Lactococcus lactis subsp. lactis
Q8YAG7  249 -GAPISSTNFSATSDGFSVALGN----LTDSVQISYTTTTTDGGKST-----QYDNTAKLAGTDFVTKQT 308  Listeria monocytogenes
Q8YAG6  252 -GAEVPSSAITQTTDGFKVDLGN----LTDSVKISYYTTSTDNGASP-----NYTNKGQLTGDNFIKQEI 311  Listeria monocytogenes
Q9CJ55  416 -EHPLVKGTDYTVDSNGKITFIGkyaTTDQAFNVVYTTTIDESSFPEkegavSFKNTATLNDGKTDTNES 484  Lactococcus lactis subsp. lactis
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