Conserved Protein Domain Family
TROVE

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pfam05731: TROVE (This model is not part of the current CDD release)
TROVE domain
This domain is found in TEP1 and Ro60 proteins, that are RNA-binding components of Telomerase, Ro and Vault RNPs. This domain has been named TROVE, (after Telomerase, Ro and Vault) and binds RNA. It consists of HEAT repeats that form a ring with a central hole as described in Ro proteins. The ring is closed by a von Willebrand factor A domain.
Statistics
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PSSM-Id: 516952
Aligned: 22 rows
Threshold Bit Score: 287.869
Created: 14-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_047287691   226 TSGDSESHPEPTDHVLQEKKMALLSLLCST---LVSEVNMNNTS-------DPTLAAIFEICREL-----ALLEPEFILK 290 
11_pfamImport    1 TSGVSESCPELVDHVLKEKKMALMSLLCST---LATKVNMKDAA-------DPTGASILEVCSEL-----APLEPEFILK 65  
12_pfamImport    1 TSGESKSLPDFMDQTLQEKKMALMSLLCST---VASNVNMKDPD-------DPTRASILEVCSEL-----APLEPEFILK 65  
Q231I6          27 NQND-----IQVRVKIDDPKQYLVNVTAAC---LLQEGSYYQDK-------DERRYIITKALLEV-----AESDPEFICQ 86   Tetrahymena ...
WP_011727486    23 VRNAAGGYTFPVDDWARVHRFLTLGTDGGTyytADRELTRDNAEvvl-rvaATDPVGLVNRIVEVseagrAPKANPALFA 101  Mycolicibact...
Q27274          63 VENNAGGFVFPVSDETQVRRFLILGSDKGSyhqSSEKITIDNAQriikiieQGNGHMVLKELALInaenrNPKMNAMIFT 142  Caenorhabdit...
EGT55430        64 VKNNAGGYVFQTSDETQVRRFIIIGSDKSSyyqSAEKMTMENAQriieiveSGKGHMVLEQLARInaenrNPKMNSMLFT 143 
KAF8360018      57 KKNSEGYVTLALSDENRIRRFLILGATGGTfyaKEQKLTMENVQalkeiiiRGGASTILETLREVsiagkSQKQEAILLA 136 
XP_013221194   206 TSEDSESHLEPTDQVLQEKKMALMSLLCST---LASNVNVKDAY-------DPTQVSILEVCTEL-----APLEPVFILK 270 
P97499         230 TSGDSGFHPETTDQVLQEKKMALLTLLCSA---LASNVNVKDAS-------DLTRASILEVCSAL-----ASLEPEFILK 294  house mouse
XP_047287691   291 ASLYARQQLNVRNVAN----------------NILAIAAFLPACRPHLRRYFCAIVQLPSDWIQVAEl------------ 342 
11_pfamImport   66 ASLYARQQLNVRDVAN----------------KVLAIAAFLPVCRPHLRRYFCAIVQLPSDWIQVAEf------------ 117 
12_pfamImport   66 ASLYTRQQLNIRDAAN----------------KVLAIAAFLPACRPHLRRYFCAIVQLPSDWIQVAEf------------ 117 
Q231I6          87 LAVYIRNELYIRTTTN----------------YIVAFCVVHKNTQPFIEKYFNKAVLLPNDLLEVCEfaqvlyifdatef 150  Tetrahymena ...
WP_011727486   102 LAIAASSEDVDGRRAA--------------------LAALPRVAR------------TATHLFLFAG------------- 136  Mycolicibact...
Q27274         143 LAICARISTHDTTKKTecpmlnay-sdyiralHDSALDLIPEVCR------------TPTHLFEFVD------------- 196  Caenorhabdit...
EGT55430       144 LAICARIATHDTSKKNrecpvidaysqyirelHAAALRLLPDVCR------------TPTHLFEFVD------------- 198 
KAF8360018     137 LGLCSRFGVSSLSSAPsdlaahpf-yvylremHKEATGLVNTICR------------TATHLFSYVA------------- 190 
XP_013221194   271 AALYTRQQLNIRDLAN----------------KVVAIAAFLPVCRPHLRRYFCAIVHLPSDWIQVAE------------- 321 
P97499         295 ASLYARQQLNLRDIAN----------------TVLAVAALLPACRPHVRRYYSAIVHLPSDWIQVAEf------------ 346  house mouse
XP_047287691   343 ---Y-QSLAEGDK-------------------------------------NKLVPLPACLRTAMTD----KFAQFDEYQL 377 
11_pfamImport  118 ---Y-QSLAERDE-------------------------------------NKLVPLPACLRAAMTD----KFAQFDEYQL 152 
12_pfamImport  118 ---Y-QALAEGDE-------------------------------------NKLVPLPACLRAAMTD----KFAQFDEYQL 152 
Q231I6         151 knlYlDRILSQDI-------------------------------------RKELTFRKCLQRCVRS----KFSEFNEYQL 189  Tetrahymena ...
WP_011727486   137 ---YvEQFR---------------------------------------------GWGPTLRRAVSRwyteRPVDALAYQL 168  Mycolicibact...
Q27274         197 ---YcQTISESTKag---------------------------------gaKSSTGWGRSMRNAISKwyttKTTEKLAMLL 240  Caenorhabdit...
EGT55430       199 ---YcQTISESTKag---------------------------------gsKSSTGWGRSMRNAISNwyksKTPKNLAMLL 242 
KAF8360018     191 ---YcEMVAADIIithdeevekrheepghqarkrktremlekkekesapvRKSTGWGRVMRKCIQNwylsKTPEELAVAV 267 
XP_013221194   322 ---FyQSLAEGDQ-------------------------------------TKLVPLPACLRAAMTD----KFAQFDEYQL 357 
P97499         347 ---Y-QSLAEGDE-------------------------------------KKLVSLPACLRAAMTD----KFAEFDEYQL 381  house mouse
XP_047287691   378 AKYNPRKHRAKRHPRRPPR--SPGmeppFSH-----RCFPRYIGFLREEQRKFEKAGDTVSEKK---------------- 434 
11_pfamImport  153 AKYNPRKHRAKRRPCPPPR--PPKmgypFSE-----RCFPGHLWFLKEEQIKFEKSYNALPKKK---------------- 209 
12_pfamImport  153 AKYNPRKHRAKRCPRRPPR--SPKterpFSEk---hRYFSGGLQALKDEQIKFEEAYNPVSERT---------------- 211 
Q231I6         190 GKYCTESQR-KKTMFRYLS-------------------------------VTNKQKWDQTKKKRkenlltklqaikesed 237  Tetrahymena ...
WP_011727486   169 VKYRQRGGWSHRDMLRLAR--PSGvvdpARRmafnwAAGKGLGDYAEAparltdvelkvgqrt----------------- 229  Mycolicibact...
Q27274         241 TKYPQREGWSHRDLFRLAH--PNLmdsrSHGqsedrLEREQLFRFAVK---------GDLVKRKrkmsveevaevekvwd 309  Caenorhabdit...
EGT55430       243 TKYPQRDGWTHRDLFRLAH--PNL----KKNdgedsYEREYLFRFAAT---------GDLKDRKrkaaadekstkesek- 306 
KAF8360018     268 TKYRARNGWSHKDLLRLSHpiP--------RndhqrIVFEHIFYYATK---------GECQPRKrlfpadtcwaetv--- 327 
XP_013221194   358 AKYNPRKHRAKRRPNRPPR--PPRteplFSEq---kRYFAKSLWPLEREQLEFEATYNAVPEKK---------------- 416 
P97499         382 AKYNPRKHRSKRRSRQPPR--PQKterpFSEr---gKCFPKSLWPLKNEQITFEAAYNAMPEKN---------------- 440  house mouse
XP_047287691   435 ------------------------------------------------NPPRFTLKKLVQRLHIHKPAQHVQALLGYRYP 466 
11_pfamImport  210 ------------------------------------------------NQPQFTLKKLVQRLHIHKPAENVQALLGCRYP 241 
12_pfamImport  212 ------------------------------------------------SQPKFTLKKLVQRLHIREPAQHVHALLGYRYP 243 
Q231I6         238 kskretgdimnvedaikalkpavmkkiakrqnamkkhmkapkipnstlESKYLTFKDLIKFCHISEPKERVYKILGKKYP 317  Tetrahymena ...
WP_011727486   230 --------------------------------------avrppvraevvpdeLAIIADFEDAQAASAAARWIEIIGRGH- 270  Mycolicibact...
Q27274         310 k-------------------------------kalklpyteeqlikeeQSRALNLVEAYLKLKNEQSEEVIVAAI-KKH- 356  Caenorhabdit...
EGT55430       307 ----------------------------------dkndqsdvpmdteeQSSVVGLVEAYLRLKNEQNEELIVAAI-KKH- 350 
KAF8360018     328 -----------------------------------rmkyteaqlveedISEGLLYLERVSSLSPYTSEEEMIWSI-RHF- 370 
XP_013221194   417 ------------------------------------------------NQPRFTLKKLVQRLHIHEPAHHVQALLGYRYP 448 
P97499         441 ------------------------------------------------RLPRFTLKKLVEYLHIHKPAQHVQALLGYRYP 472  house mouse
XP_047287691   467 Snlq---lfsRSRLPGPWDSSRA------GKRMKLSRPETWERELSLRGNKASVWEELIEN-GKLPFMaMLRNLCNLLRV 536 
11_pfamImport  242 Snlq---lfsRSRLPGPWDSSRA------GKRMKLPRPETWERELSLRGNKAAVWEELIEHgFKVSFI-LLKNTCGLKII 311 
12_pfamImport  244 Snlq---lfsRSRLPGPWDSSRA------GKRMKLPRPETWERELSLRGNKAAVWEELIDN-GKLPFMaMLRNLCNLLRV 313 
Q231I6         318 KteeeykaafGDSASAPFNPELA------GKRMKIEISKTWENELSAKGNTAEVWDNLISS-NQLPYMaMLRNLSNILKA 390  Tetrahymena ...
WP_011727486   271 ------------GL-------------------------SWEMLPDAALAQPAVWEALIDR--GMPQTaLMRQLPRLTRL 311  Mycolicibact...
Q27274         357 ------------GL-------------------------VREHLPTTSLNSKLVWETLFDV--SMPMTaMIRNLAKMTVV 397  Caenorhabdit...
EGT55430       351 ------------GL-------------------------VREHLPTSSLNSKLVWETLYDV--RMPMTaMIRNLAKMTVV 391 
KAF8360018     371 ------------RL-------------------------TWEQVPSKHLNSLEVWKAIVE---RMPMLaMIRNLAKMQNV 410 
XP_013221194   449 S---------NLQLFSRSGLPGPwdssraGKRMKLSRPETWERELSLRGNKASVWEELIDN-GKLPFMaMLRNLCNLLRV 518 
P97499         473 Atle---lfsRSHLPGPWESSRA------GQRMKLRRPETWERELSLRGNKASVWEELIDN-GKLPFMaMLRNLCNLLRT 542  house mouse
XP_047287691   537 GISSRH-----HE-LILQRLQHAKSVIHSRQFPFRFLNAHDAIDALEAQLRNQALPFPSNitlmrril------------ 598 
11_pfamImport  312 LLAPQG-----DEkVILQRLQHAKSVIHSRQFPFRFLNAHDSINNLEVQLKNKELPFPSNtqlmwrivtr---------- 376 
12_pfamImport  314 GISARH-----HE-LILQRLQHAKSVIHSRQFPFRFLNAHDSIDKFEAQLKNKGXXXXXXxxxxxssdscllslsenkgd 387 
Q231I6         391 GVSDTT-----HS-IVINKICEPKAVENSKMFPLQFFSAIEAVNEAVTKGFKAKKRENMN-------------------- 444  Tetrahymena ...
WP_011727486   312 GVLSGA-----VGdTVAEQLADRDRLVKARVHPVNVLVAQ---------------------------------------- 346  Mycolicibact...
Q27274         398 GALDEK-----RVdNIVKRLTDQEELRRSRIHPINLLTAR---------------------------------------- 432  Caenorhabdit...
EGT55430       392 DALDEK-----RVdDIVKRLTNQDELRRARIHPLNLLTAR---------------------------------------- 426 
KAF8360018     411 GLFKGEkkegdKIaHVVAHLANIEAIKKARIHPIQILLAK---------------------------------------- 450 
XP_013221194   519 GISARH-----HG-LILQRLQHEKSVINSRQFPFRFLNAHDSIDNLEAQLRNRALPFPSNinlmrrimi----------- 581 
P97499         543 GISARH-----HE-LVLQRLQHEKSVVHSRQFPFRFLNAHDSIDKLEAQLRSKASPFPSNttlmkrimi----------- 605  house mouse
XP_047287691   599 -----------------------------------------------------------------------trneknrPR 607 
11_pfamImport  377 ---------------------------------------------------------------------vvkntrgsgHF 387 
12_pfamImport  388 sntdtlsllpcslrvwagqrsgtchpgagtqdtrqnkmrvyslpdsdfpshhtalplpsntflmkrilvrysrkvkrpAI 467 
Q231I6         445 ------------------------------------------------------------------------------LK 446  Tetrahymena ...
WP_011727486       --------------------------------------------------------------------------------      Mycolicibact...
Q27274             --------------------------------------------------------------------------------      Caenorhabdit...
EGT55430           --------------------------------------------------------------------------------     
KAF8360018         --------------------------------------------------------------------------------     
XP_013221194   582 ---------------------------------------------------------------------rkskkvrrpAR 592 
P97499         606 ---------------------------------------------------------------------rnskknrrpAS 616  house mouse
XP_047287691   608 RRFLCHLSRQQLRMAMRIPVLYEQLKREKLRVHKARQWKYDGEMLNRYRQALETAVNLSVKHSLPLLPG 676 
11_pfamImport  388 VPKHIYSTSRQVRSAMKIPVMYEHLMREKLKIHKARQWKYDSEILNRYRQALEIAVNLSVKHSLPPLPG 456 
12_pfamImport  468 KRQLCNLNRRGLRMAMRIPVLFEQLKLEKLKIQRARQWSYDSEMLDQYRQALETAVNISVKHSLPPLPG 536 
Q231I6         447 GQIEAVKEVVEKTDEEKKD--MELEQTEEGEFVKV-----NEGIGKQYINSIELAIKIAVNKNLDEIKG 508  Tetrahymena thermophila...
WP_011727486   347 -------------------RTYTRGCGARGQ----AVWTPVAKI----SDALDAAFYAAYG-AVRPAYK 387  Mycolicibacterium smegm...
Q27274         433 -------------------AVYAQGRGDKGS----LTWEPNQKI----CDALEAGFYKAFV-NAPPTGK 473  Caenorhabditis elegans
EGT55430       427 -------------------AVYAQGRGDKGS----LKWEPNQKI----VKALEDGFYKAFV-NAPPTGK 467 
KAF8360018     451 -------------------TVYDVGTGDRGS----LTWTPKPEL----SAALEKAFYLAF--SLMPKTE 490 
XP_013221194   593 WKHLCKLSRRELRAAMKIPAIYEELQREKLKIHKARQGNYDLEILDQYRQALEAAVNLSVKHSLPPLPG 661 
P97499         617 RKHLCTLTRRQLRAAMTIPVMYEQLKREKLRLHKARQWNCDVELLERYRQALETAVNLSVKHNLSPMPG 685  house mouse
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