8F2U


Conserved Protein Domain Family
CCDC22_CC

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pfam05667: CCDC22_CC (This model is not part of the current CDD release)
CCDC22 protein coiled-coil region
Human coiled-coil domain-containing protein 22 (CCDC22) is involved in regulation of NF-kappa-B signalling; the function may involve association with COMMD8 and a CUL1-dependent E3 ubiquitin ligase complex. It is part of the COMMD/CCDC22/CCDC93 (CCC) complex, which interacts with the multisubunit WASH complex required for endosomal deposition of F-actin and cargo trafficking in conjunction with the retromer. This entry also includes CCDC22 homologues from animals and plants.
Statistics
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PSSM-Id: 516914
Aligned: 30 rows
Threshold Bit Score: 290.813
Created: 14-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
8F2U_T        128 RAIGSQIRDQLALPWVPPHLrt---------------------pkLQHLQGSALQKPFHASrlvvpe-------lssrgE 179  human
XP_004995815  127 RAITAEIDKQLSCPWIPPAFhrdglc-------------wsnnrtAWHLISRRGVRSFRSTtlftsemda-antaraayE 192 
XP_001743975  580 AAVAADVRRRIELPFLPHAIyrdgai--------------aldakTTLQMNPRAQRPFRTNtleia--------dsngsQ 637 
Q01GI4        156 ARAMVARSTKAEAAW------------------------------------GRAAGALKGFagvaaaara-kkrtddttN 198  Ostreococcus ...
XP_001321323  115 KSVAVTSPSALAIKAAQDEFna---------------------------ckTLKVRSYVVQslkevlkp---agiedskK 164 
Q54MP2        124 DQICQYLQGCVKESWIPYFCp-----------------------fSKRIPGNYSTATLFTTtggnlripsrgrqlkvtpG 180  Dictyostelium...
XP_020436796  480 DLICNHLASSIKESWMPYFCp-----------------------fTKRIPGNYSTAKLFTVaplkipar--grqlkltpG 534 
XP_011270107  126 KAITDELEYRAEAPWTLPVAkrsgyarrvatipgptpkspptyvpHQQWEGLRGVHRLHASvvvipagag-dvtkplskE 204 
XP_026693321  124 RRIGQVLREKCAVLWMPFYCh-----------------------------tSPKKIPFRTQpiniskys---qgyknskS 171  vase tunicate
XP_002902835  139 SSIAEAAASVLASDRLANIFsswkrek------------tlhmlpNQNVQGLRGFQRLPLQtsplelpwsrpgksth--- 203  Phytophthora ...
8F2U_T        180 PREFQASplllpvptqv------------------------------------------------pqpvgrvasLLE--- 208  human
XP_004995815  193 TTnqqtipqqr------------------------------------------------------svatsslasILA--- 215 
XP_001743975  638 ERVAYETehmplvtaqp------------------------------------------------mrsanrltsLLA--- 666 
Q01GI4        199 AREFYTSrlttsssggffg--------------------------------------------nlsadtyavpsVLE--- 231  Ostreococcus ...
XP_001321323  165 IAEFSLMpkqpfieepilpnsgipfntqlkknslasllafndrevdidqfdfskekpsttklqniasrafqvssTPAevv 244 
Q54MP2        181 LEQYYSQylepltlqt-------------------------------------------------nrfediapsVFE--- 208  Dictyostelium...
XP_020436796  535 LEDFYIKhlrpinqqp-------------------------------------------------nrtddvapsVFE--- 562 
XP_011270107  205 LRKYYAGalpyltaqp-------------------------------------------------pvrqdvapsILE--- 232 
XP_026693321  172 ----QDEttydfvhrqi------------------------------------------------knrdqltpsLLE--- 196  vase tunicate
XP_002902835  204 -----------------------------------------------------------nlfekfssdsikatsLLEala 224  Phytophthora ...
8F2U_T        209 ---HHALQLCQQTGRDRPGDEDWV--HrtSR-LPPQEDTRAQ-------RQRLQKQLTEHLRQSWgllg------apiQA 269  human
XP_004995815  216 ---RNSRLLASERAREEELTAAGRdpA-----LPNEDFVRQK-------RTTTRRTISAKVKAALfnd--------akQE 272 
XP_001743975  667 ---KHAALQARRAVWQEEWSTLGM-----TSgKTEQQYRHDK-------QDSILKNMRQQLQKGIaadm-----tahrQR 726 
Q01GI4        232 --------YAARVRAEEEAEEDARrlK--FSgVVRAEFIGPDgkpfdlrKRGGLRGLVAEIFRLAleggfytepraiqAC 301  Ostreococcus ...
XP_001321323  245 avaMKPTILPSTKARSRIANQARFdyH--SQ------------------DTKIGQNAASTLTTAAvasttgiersaskDK 304 
Q54MP2        209 ---YNLSIYAEAQERDNEWNDKGV--S--SG-MNPIDYRKNK-------QKQVLSKMNDSIRQSIidggnnqissncnSG 273  Dictyostelium...
XP_020436796  563 ---YNLSIYAEAQERENEWNTKGS--Q--SG-LNPLEYKKNK-------SKTILSKMNDSIRSAMvdgss----adsrRN 623 
XP_011270107  233 ---KVSAEYTAAREWEEIWNKEGM--D--TG-LSEAEFRDRK-------RQFVRSKMAEYVRSSAlkgdga--gfgrnDA 295 
XP_026693321  197 ---LNSKQTVSVTSLDKAS------------------GQDSK-------RRKVQKEAFQWKHKSMi-----------tDK 237  vase tunicate
XP_002902835  225 vakRGSTMFLREDEFDDDVEEDNV----------DAQLKQGQ-------VEGLLTDATRAGESGFlspqeaeaeddefAT 287  Phytophthora ...
8F2U_T        270 RDLGELLQAW----------GAGAKTGa--PKGSRFTHSEKF-----TF-----HLE-------PQA---------QA-- 309  human
XP_004995815  273 VDMAKFLAKF---------------SGielGKMSMFRAKHKL-----QF-----AKE-------DE-----------A-- 307 
XP_001743975  727 QDIRTFLDGF---------------ANvqlGKKSLFRKREEL-----QF-----QSE-------A--------------- 759 
Q01GI4        302 AELEE----------------------------TQVVDEDKVvesanDV-----ENA----------------------- 325  Ostreococcus ...
XP_001321323  305 VDLAEKVEEA------------------------------------------------------APA---------AP-- 319 
Q54MP2        274 DSFLDIISEF---------------RGnslDVGGQFNRKKAF------------TNEl------NNNnnnnndsttNT-- 318  Dictyostelium...
XP_020436796  624 NTFDHVIGQF----------GMGSADDd----YGQFARKKAF------------TNE-------EVA---------SE-- 659 
XP_011270107  296 DSFASFLDSF----------SDRGLRN---AKGSRFTHAEKF-----QF-----TQD-------E--------------- 330 
XP_026693321  238 IPLDSSFDDV----------IQAVTGNsgnIKQSRFAHAKSL-----QF-----TTEeqksfrlRPTv-------pQKps 290  vase tunicate
XP_002902835  288 IEPQTFLSSAlpdvplslnnPSSGTTDtmaTEGATTDSTGSAsigasQFavlqtANDn---------------------- 345  Phytophthora ...
8F2U_T        310 --------------------------------------TqvsdVPAtSRRPEQVTwaaqEQELESLREQLEGVNRSIEEV 351  human
XP_004995815  308 --------------------------------------A----VAAtKTVTDEELkqqrEDELSALQGEVEDLESSLQAM 345 
XP_001743975  760 --------------------------------------S-----DApKAATQEELeqqrQAELEELETRLSDLMATMQSL 796 
Q01GI4        326 -----------------------------------------------AMDTLEDRikarERDLEDVHRRIDEAMSVVSTV 358  Ostreococcus ...
XP_001321323  320 --------------------------------------V----VPKlTVKQEKQIreeqSKEMVEIRELINRTESSAAEI 357 
Q54MP2        319 --------------------------------------N----KVEtEIETEEQRqlkrQAEIDALQSQIDEISESIQLH 356  Dictyostelium...
XP_020436796  660 --------------------------------------P----IEPkAKETEEERqqkqQEEIDQLQSVLEELANRMANA 697 
XP_011270107  331 --------------------------------------G----AAAaVADTEEELrkrrEEELRALQERLDALSAEVDRM 368 
XP_026693321  291 hlikhenkkkddaetdnqessedgvdgssagggedaviP----------EEPEEVkfkrEEE--EIKVKILDADAGEEKY 358  vase tunicate
XP_002902835  346 ----------------------------------------------------------eEQSLDEVQKQVDDTERRIAAM 367  Phytophthora ...
8F2U_T        352 EADMKTLGVSFVQAESECRHSKLSTAEREQALRLKSRAVELLp-D---GTANLAKLQLVVENSAQRVIHLAGQWEKHRVP 427  human
XP_004995815  346 RDNLASLQSTAEALAEQTARMQEENEALTKEQKVRKRVLDLLp-N---AEENMQLLKDKIDEVAAKLAALAERWEEHRVA 421 
XP_001743975  797 QGELSTFDKDAVKMDSKLAELKALAEELAANNAVRKRVLDLLp-N---ADENIERLGQAIDALARKLIAIGEKWEPHRRE 872 
Q01GI4        359 DDEIAACASKVKEAMEATDAKRALTAELESNYLLHKQAVGMVlaTdrpVEESEAELNKVLVAAKERLEQLSAEWNAAKTP 438  Ostreococcus ...
XP_001321323  358 ESQIESNKDEIKRINELLETVKEENTRLANEVDKATKMAEIAk-S---DPTQIRALQRDFVDSMASLLEIAREFEPKRSA 433 
Q54MP2        357 NKEMLDFLSLMRQSESENLEQDQQREVLEKQYKIKKKTFSLLd-D---AEGNMKELQSLCNQTSSNLLEMSGEWEKVRKP 432  Dictyostelium...
XP_020436796  698 TSEMDDWIQQIRQLEAQINEEDRKRAELEKEYKVKKKTFGLLe-N---AEENFAKLQELCQQTSASLIEMSGEWEKVRRP 773 
XP_011270107  369 EHEIRNFNVNTSQLESNLREEKSASATKEALYRSKVKVFELLp-E---ADKNIELLQGLVSTSTKRLVELATKWEAVRAP 444 
XP_026693321  359 KEELKMVELSIKQLMIKTEELETNNEEEVKNVKLKEKTLKLLp-N---AEENMEKLKSLVDASSKRLVELGRLWEEKRVP 434  vase tunicate
XP_002902835  368 RKVLDRERGHLQQVEQHVLETQSTGQELQKQLARQKQLLAMLp-Q---AQANILKLEAICQSNAEKKVEISQQMGSARGP 443  Phytophthora ...
8F2U_T        428 LLAEYRHLRKLQDCRELESSRRLAEIQELHQSVRAAAEEARRKEEVYKQL----------MSELETLPRDVSRLAYTQRI 497  human
XP_004995815  422 LIKEYRDLKVAAANKNSEARKQAESIQELRSQAKQIIADAKQKEQLFQQL----------VQDYERMNKDILRSSYTSRI 491 
XP_001743975  873 LLREYQQLKSAAADQMSEIKVQMAYVQEMRETTQGILAGAKAKEQRVAEL----------QAEYEKRNNATQRSWYVERI 942 
Q01GI4        439 LLAAIEAHAEGAREKRKKAKNQLEEIEKWRSEGKDTSSLLRIKEQEQRQL----------LDQYEAAPKSVHRPSFVRRV 508  Ostreococcus ...
XP_001321323  434 LINEYRSLSTAIRTRTDDYQRQMTKLAKLKRQIQEGEAKLATDAEAISNL----------EKAMENRGEQKPRSHYIDSI 503 
Q54MP2        433 IIEKYRSLKDKQNNQADETKSKLDRIKEMRILIKKLVSEVQQKDDQFQQL----------QDQYKQAPKDSNRSQYTRRI 502  Dictyostelium...
XP_020436796  774 IIEKYRQLKDEKANQSDEAKSKVERIKEIRALIKKMIADIRAKEELFTQL----------QDTYKAMPKDTNRSMYTRRI 843 
XP_011270107  445 LVLEYRTLKESQDGRMTESRRKLAQIKEFRESMKQIAEEARIKDELYRQL----------TAEYEKMTKDINRSIYTRRI 514 
XP_026693321  435 LIEDIRRLKQSKTESEFDAERKVEEIRMLRTRMKDVAEETKLKDQLTKQL----------KAELESVKRDISRQSYTRRI 504  vase tunicate
XP_002902835  444 LLLEYAALEGQKSSRKARCRQLIREMKAFRAEMLEISGIIQSKMESLKALervqerqlakLGQKKDADGPMTRNMYTSRI 523  Phytophthora ...
8F2U_T        498 LEIVGNIRKQKEEITKILSDTKELQKEINSLSGKLDRTFAVTDELVFKDAKK--DDAVRK--A----YKYLAALhenCSQ 569  human
XP_004995815  492 LEIVKSIDKQKREIQKILVETRGLQKDLGLLEGKIERTFTVAEEEIFKESKA--NPAARL--A----YKHLANLhaeCGR 563 
XP_001743975  943 LEIIKSINKQSADIETSILDIRAMQREINQISDRLSRQFTVVDEMVFKDAKK--DADIKR--A----YQLLASLhtgCED 1014
Q01GI4        509 NEIIKNIKKQEREIVKIVGDTRSVQSDINSAQACLERTYTVVEEILFREARS--DELCRA--A----YKHLHGMhagFAD 580  Ostreococcus ...
XP_001321323  504 FQIIKTIEKQEADVERIRSDIRNQHNTMNNTISKVKRTWMYIDEMVYTEAKTpnGEWAKM--M----YKTIVELlvlFEG 577 
Q54MP2        503 LETVKNIKKQKVDIDKVLLDTKNLQKEINTITDTAVRTFELVKDLLYNDAKK--DQTAKQ--A----IKSFAIIddkFQK 574  Dictyostelium...
XP_020436796  844 IESVKNIKKQKEDIDRILLDTRTLQKEINTITDTAVRTFDAVKDMLYADAKK--DQTAKT--A----IKSFAVIdekFQT 915 
XP_011270107  515 LEIVKNIKKQREDIDKVLIETRALQKEINHTSDVLNRTFSATDELIFKDAKK--DDACRR--A----YKYLASLhehCNV 586 
XP_026693321  505 LEIVASIHKQKQEIQRVIQDVKQVQKTMNRLKGRAERTFSAADEVIFKDAKH--DEGSKQ--A----YKYLVSLhdnCAT 576  vase tunicate
XP_002902835  524 MDIIKQVHKQKQDIAKILDDIKGLQKQLNTASERLKRTEAVAEDKLYSAASTskSTSSTKadAyvecYRKFAQVrelFEE 603  Phytophthora ...
8F2U_T        570 LIQTIEDTGTIMREVRDLEEQIETELGK 597  human
XP_004995815  564 LIDVVKSTGTVAREIRDLEDQIEVEQRK 591 
XP_001743975 1015 LIQCVENIGSLEKECRELDNAVHVEQAK 1042
Q01GI4        581 LIDKVEATGVARRSQTDLQRKLVEISKQ 608  Ostreococcus tauri
XP_001321323  578 ISEGIETSGKISAQIMELDTKIDRAETQ 605 
Q54MP2        575 LFKTIDETGNFQNNILNLNSKIEHVSQK 602  Dictyostelium discoideum
XP_020436796  916 LLTAIDETGTYQNNIFTLTSKIDYISQK 943 
XP_011270107  587 LIADVENTGKLLNEIRDFEEKLEQLNQQ 614 
XP_026693321  577 LLKTVEETGLIMREIRDFEGQIDIETGK 604  vase tunicate
XP_002902835  604 LIVVVGDVGKKENAARDLQNWISQLESR 631  Phytophthora infestans T30-4
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