3DWB,7K1V,4XBH


Conserved Protein Domain Family
Peptidase_M13_N

?
pfam05649: Peptidase_M13_N (This model is not part of the current CDD release)
Peptidase family M13
M13 peptidases are well-studied proteases found in a wide range of organisms including mammals and bacteria. In mammals they participate in processes such as cardiovascular development, blood-pressure regulation, nervous control of respiration, and regulation of the function of neuropeptides in the central nervous system. In bacteria they may be used for digestion of milk.
Statistics
?
PSSM-Id: 516909
Aligned: 647 rows
Threshold Bit Score: 77.7224
Created: 14-Feb-2025
Updated: 28-Apr-2025
Structure
?
Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
3DWB_A         21 PCHDFFSYACGGWIKA-NPVPDGHSRWGTFSNLWEHNQ-AIIKHLLENstas---vseAeR-KAQVYYRACMN------- 87  human
90_pfamImport   1 PCDDFYKFACGGWLDR-HTIPEDRTSVSVFSAIQDDLN-NKLRVLV-Eseaep-neprFyT-MLRSMYKSCMN------- 68 
XP_015787619  108 PCDDFYDFACGGWIKK-KFISEDQTGITQFGAIRDDLN-RKLRELV-EndgdnsneaiYfK-MMRTVYKQCMN------- 176
XP_031782017   65 PCHDFYKFACGGFINN-SVIPTNRQSVDHLDSVKEKVL-TEIRQLV-Nkkfkp-keprIfK-LVKNYFRACKR------- 132
37_pfamImport   1 PCDDFYAFTCGGLSRNrKEIPPASTK--------EVLN-FMVGEMVqst-------dsKpFiMEKSFYLACSN------- 57 
38_pfamImport   1 PCDNFYDFVCGNFLKK----PKVSNEITPLSALEAVTL-QQFNSLITEpine---tlpKsWaLQRKYYNTCMN------- 65 
93_pfamImport   1 PCDDFYEFACGNWIKK-NPCPDLYPYVSVIDTLNSKPIeQ-IKSLL-Enesds-ndelItN-ITRSYYKMCMNagkftcf 75 
XP_042938013  111 PCDDFYEYACGNYPIN-RHLPSNKAIRHTLSDMQNRLNkQ-IRKLL-Qapvtd-tdkpWnR-LAKQYYQKCLN------- 178
XP_003116150  108 PCEDFYEFACGNYGLN-KNLPANKPLRHTISDVQSRLNkQ-VKSML-Qspisq-neksWdK-LAKGYYQKCLD------- 175
EFA05165       39 PCDNFYQFTCGNFAKI-HPRPSTLNVLDHFTLLENELIqV-GQEIL-Sspvke-ndpkAvK-KAKTAYKSCVQ------- 106
3DWB_A         88 --------------------ETRIEE-LRAKP-LMELIERLGG--Wni-tgP---WA-KD--NFQDTLqVV-TAH-YRts 134 human
90_pfamImport  69 --------------------LTEIER-VGNEP-VLETLNELGGwpVle--qDk-wNAsSF--NWLDSL-IK-FRK-AGfs 118
XP_015787619  177 --------------------LSEINE-QSKGE-VIKDIVDLGGwpLie--gPt-wREaEF--DWIEAL-KK-MRA-KGyd 226
XP_031782017  133 --------------------ETTKAKnNSLKA-LLGYIDQLGGwpVia--gDs-wDAgKF--DVFKTD-YK-LRE-IGyr 183
37_pfamImport  58 --------------------LAGIEL-DDDEW-LLDQFFSLGD--WpvlrgSnwdGS-YF--EWTEIV-KK-SRR-LGmk 107
38_pfamImport  66 --------------------TSAIEE-NNSES-FLEMLKFLGD--WpllhgRfwdER-KF--DWLNSM-VL-CRK-VG-- 113
93_pfamImport  76 lfilsqliisfsnihnlysfSEAISK-KSNQS-IHKIIEQIGDwpMat--nKq-wNPvDF--DWMEAT-VK-LRW-LG-- 143
XP_042938013  179 --------------------EEELEA-TGASS-MRKLLRDLGGwpVle--gHn--WK-PWdnSWEKQL-AHiMNR-TGvn 229
XP_003116150  176 --------------------EEELEA-TGVEA-MRDISKRIGGwpTle-gdKw-qEW-TH--SWEEQL-ALvLNL-TGvn 226
EFA05165      107 --------------------SQVLNN---VVPeLRTV-KEFGGmpLls-ssNn-qTI-SF--SWNEVG-K--LVSeYG-- 152
3DWB_A        135 --pF--FS--V----YVS---ADS-KNS-NSN-VIQ---VD-QS--Gl-gLPsRDYYln--ktE--NEKVLTGY-LNYMV 186 human
90_pfamImport 119 hdiL--MD--L----SVN---TDY-RN--NTRhVID---LD-QA--Tl-gMPdRSYLlrglndS-----AVQGY-YKLMV 171
XP_015787619  227 hniF--LS--I----YVS---PDV-KN--NSRhIIE---ID-QA--Yl-gVPdRKYLlkgmndS-----TVKAY-YKAIV 279
XP_031782017  184 pksI--LN--L----YVF---NDL-FNT-SRN-FLY---VG-PPeaEi----kSEILk-----RgfMNEVVQAY-YNYMV 235
37_pfamImport 108 --iDwfVD--F----SIY---EDV-NDT-RVN-VLK---ID-IP--AltqLKeSEVF------------PRQKL-LTKIA 154
38_pfamImport 114 ---Ft-FE--Y----FLKigaKDA-ANE-TGTiVLS---IN-PP--AvtdLP----F------H-----LRNFY-VELMA 159
93_pfamImport 144 ------ISsdA----FIK---IQPvIDVfN-N-TIYrigIN-EP--Kl-sLd-RNQLign-------ssVIKHY-INFMK 195
XP_042938013  230 -aiI--LE--L----AVS---HDP-LNS-SRF-IIE---VD-QP--Kw-gVGsRWPYlggiddL-----VIQNY-TSLMV 281
XP_003116150  227 -avI--LE--M----AVT---HDP-SNS-SRS-VIE---LD-QP--Kw-gAGsRYPYlsgandP-----MLRNY-TTLMK 278
EFA05165      153 ------VP--LifvySVA---QKS-QN--ESMiVLSwdtLNnPTlfRq--VLqKTYd------HvlEED-FAKFgTSRVT 209
3DWB_A        187 QL-----GKllGggdE-EAIRP-QM--QQILDF---ETALANIT--IP-QEKRrDEELIYHKVTAAE--LQ--T-LAP-- 244 human
90_pfamImport 172 ES-----AVmlGa----DRQKA-EKdmLEALAF---ETILANFS--IP-REERrNISLLYNLMTVKE--IE--T-IAP-- 228
XP_015787619  280 DS-----ASyiGq----NSKEAiEKgaSEIIDF---ETQLAKYS--LP-SEERrNFTKMYHKIQLID--LK--R-IGP-- 337
XP_031782017  236 DV-----AVilGa--DrVRATR-DL--RKALDL---ERDITFASs-FP--SIT-SAINLR---RLED--LE--KdA-A-- 288
37_pfamImport 155 VT-----LGapE-----KLAHY-ET--GRTIEF---EKELRMLAhvYR-SRKThMNANTLPKIPISE--VQ--K-LCP-- 210
38_pfamImport 160 NI-----SIelGa--PpYLVTH-EF--NRVLQF---EDEIKAAV--VD-EVQNgQEIIT----TIDT--LE--N-QFP-- 212
93_pfamImport 196 KT-----AStyGg----QREMI-EHdvYEVLEF---ERELS-LLt-MP-EEAVrESIMFYRSMTVAD--LS--T-LAP-- 252
XP_042938013  282 QTa----INi-Ga--DpTQAKH-DM--KKAIEF---ELRLVNFS--AD-EMTRrNPERGNNRFQLWQ--LG--SiF-P-- 338
XP_003116150  279 LT-----AValGa----DPAVA-DRemNEAMEF---ELKLVNFS--ADdMIRR-DPERGNNRFELWQ--LK--S-VFP-- 335
EFA05165      210 RStspqpFDi---------fLEtVA--KNLLKYtnpEKPEGEVL------DEL-DEMATFMR-TLYKggIKgsTiL-Plp 269
3DWB_A        245 -------------------AINWLPFLNTi--fY--PVeiN-----ESEPIVVY--DKEYLEQIS-TLIn-------tTD 286 human
90_pfamImport 229 -------------------NVNWSRFFNYllndP--IP--------PNELVLVN--VPTYLKKLD-KLLv-------eTD 269
XP_015787619  338 -------------------NIDWPNIVRSmm----vVN--Vs----DNEEINVK--VPRFLRSVD-TLIa-------nTD 378
XP_031782017  289 -------------------FVPWLEYINA----I--TS--PvvsfeIFEAVNVP--DLGYLKSLD-YFLr-------kTP 331
37_pfamImport 211 -------------------HISWLDLINA----Vt-GV--Nm----QETDVVIFdeMVDYIKDLN-KLIy-------gTP 252
38_pfamImport 213 -------------------SIPWVHFLTN----ItmNS--Nni--sSSSWIHFR--AGRYLRNLQ-TLLh-------rTP 255
93_pfamImport 253 -------------------SIPWVEFLSGl---I---------------GREIS--DDQFLLFLPfSFIn---------- 283
XP_042938013  339 -------------------HIDLITYIHTm---F--GG--Lek-lsPNDTVIIR--EPEYFHRIQ-EVMr-------rSS 381
XP_003116150  336 -------------------FINFEKYLKTv---F--KE--Lvd-lsPNHTVIVR--EIDYFVGIQ-HVLq-------sTP 378
EFA05165      270 sevtlgqlqewtyqqfgeaVIDWVQYLGLv---F--Q----------KSGVKITpmTKLYHQDIE-RIYgilnlvkktDP 333
3DWB_A        287 RCLLNNYMIWNLVR-KTSSFLDQRFQDADEKFME--VMY--GTKkt-slPRWKFCVSD-T----E--NnLGFALG--PMF 351 human
90_pfamImport 270 GRIVANYMMWRIVLqCYTT-LGKRWRELAQEYNK--VIT--GQDre--ePRWEQCMSS-L----T--GsLGVALS--SLY 333
XP_015787619  379 KRILANYMIWRAVF-SALPSAEEPLRKISEAYSR--VIS--GRKte--kPRWDTCMKR-L----Y--SsFGTPLS--ALY 442
XP_031782017  332 KKVMANYMIWKMIA-ESAIYLTDEIRDRAFEYQRmkSQT--AVPkp-rkPRWQECIEL-L----TdrG-RGLMLGvsSMY 401
37_pfamImport 253 KRIVADYMMWKVVE-ENWQFLTQPVRQKFEEYYE--EQH--QIQpe--lDRQKFCINA-S----R--KqFPLIVE--SEY 316
38_pfamImport 256 KSIQANYIVWKIIE-HFRNYLKESVRSLYESFLI--HLNp-NLAfv--nNRHLYCLQK-S----K--FyFPSVTE--LAY 320
93_pfamImport 284 -RVLANYLSWTVVR-ALLPYLGPKYDQLEVEFWD--ALY--DKHse--tPRWVKCVDE-V----S--NyLGPALQ--SMY 346
XP_042938013  382 KQTIANYVLWRVIQ-GYSPFLSPVMREPFYAFKA--NQT--GLPsipipDRWEDCVFL-A----T--VmIDMPVG--RLY 447
XP_003116150  379 KRVLANYISWRLVQ-GFSPFLPPTAREPFYQFKAn-QTGmfNSPp---pDRWEDCVTLsVi-------mMDMPVG--RLF 444
EFA05165      334 -KVLKNFALLRVFL-FQAPDSGSATRQAFEKYYQ-------AKNnq-lyPRWEYCTRK-IldvvDt-AsLSYAVT--YNY 399
3DWB_A        352 VKATFA-EDS----K-SIATEIILEIKKAFEESLSTLKWMDEETRKSAKEKADAIYNMIGYP 407 human
90_pfamImport 334 VKNHFK-EGS----K-YMALEMVNYIHKEFLTILDEVDWMDANTTQRAREKANAIVSYIGYP 389
XP_015787619  443 VSRNFD-EKS----R-KQAASMVDYIRGQFIASLKKIDWMDEATRAKAIEKAEEMFVQIGYP 498
XP_031782017  402 VRKHFS-EDT----K-EDVKEIVTNVVDGFKDILENVTWMDAATKIAASRKNEFMKQIIAYP 457
37_pfamImport 317 IRRHVT-LQK----R-QLVKEMLINIQRNYRRLLHSATWMNRKRRELALGKLDELKFLIGGP 372
38_pfamImport 321 VRTFLK-PQS----R-ENIKDMALEIKYRLWKKITANEWLDKNSKIFLLNKVAKIENIIGAS 376
93_pfamImport 347 ARAFYS-ESV----K-ETATRLAISIEQIFNESLSQNKWMDNDTKIRAMDKLDNLNMFIAYP 402
XP_042938013  448 VANHF---DQlrsmK--KMNDLTKHFKNELIKQLQNVDWMDEETRRRAVIKAQHINYKSGFP 504
XP_003116150  445 VENFFEkERA----M-NKMTELTSYLKNEFIKQLHVLDWMDETTRRRAISKANMIEYKSGFP 501
EFA05165      400 LQYHF---STe---KlAQVTQMIENIREVFSETLNASDWMDEESREQALKKATNMLVLLGYP 455
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap