3WX6,1Y12


Conserved Protein Domain Family
T6SS_HCP

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pfam05638: T6SS_HCP 
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Type VI secretion system effector, Hcp
HCP is a family of proteins which are expressed in up to 1000 copies in Gram-negative bacteria. Together these copies aggregate into a needle-like shaft or tube that will penetrate other bacteria via a puncturing protein attached to its head. Initially Hcp forms a hexameric structure with a central channel of 40 Angstroms. These hexamers pile up one on top of each other forming nanotubes resembling the gp19 tail phage tube.
Statistics
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PSSM-Id: 398972
Aligned: 171 rows
Threshold Bit Score: 74.1103
Threshold Setting Gi: 764090796
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
3WX6_A                  6 YLKVKGktqgeIKGSVVQEGHDGKIHILAFKNDYDXpaRLQEGLTPAAa----ARGTITLTKEXDRSSPQFLQALGKREX 81  Burkho...
jgi:AciX9_1277          6 YLELNG-----ITGESEVAAFKGQIQVQSYSFGGTN--VSSVGTNGGSgagkvNLGPLTITKHADSASGPLFLDMCKGTH 78  Granul...
jgi:AciX8_2875         10 YLNIPG-----CQGESQTSGATNQIKVNSFSFGGNS--VSSVDATSGSssgkvICGDLNLDLVMDKGGPLLFQGMTKGTH 82  Granul...
WP_013578711            6 FLELDE-----INGESKDAKHTDQITIQSFSWGARQ--HTSVSGTGGSgagraTLADLMVTKEYDASSGPIYKALLLGTH 78  Granul...
jgi:AciX9_4003          6 FFKLAD-----IPGESVDSKHPNEISVMSFSWGASQ--TTSVSGSGGSgagkaSLADLSIMKNYDVASGPMYKALLLGTH 78  Granul...
Q02CH0                  7 FLKIDG-----IDGESLQKGHEKEIEIMSFSWGESN--AGSFAGNLGGgsgkvSMQDFHFTVPVNKSSPKLFLACATGEH 79  Candid...
WP_015245969            6 FLKITD-----VKGESKDKSHSGEIEIESFSWGASQ--LGASSHGTGAgagkvSMNDFHFVMRNNSASPTLFLFCANGKH 78  Singul...
WP_002210479            8 FLHIEG-----VDGESPDQQYNGWIQVQAWQWAEEN--AGRWGLGGGGgsgkvEMKDFEFRMVSNKASPKLFLMCAIGEH 80  Yersin...
Q63MY0                  9 FLQIDG-----VEGESTDQQYPGLIQIQSWQWAEEN--SGRWGFGSGGgagkvEMKDFEFRMVSNKASPKLFLMCATGEH 81  Burkho...
calssnu:BYI23_D001620   7 YLKVDG-----IEGESKHKGAEGQIEVQTFDWDATN--SGSASVGGGSgqgkaHPGLFTFSHFYDKASPTLEKSCVSGKH 79  Burkho...
3WX6_A                 82 XEEFEITIHRPktdtTGGDLTelLFTYKFEKVLITHXDQYs-------------PtpHkddsngikeglLgYIEEIKFTY 148 Burkho...
jgi:AciX9_1277         79 IPKGMLSLVKS----GGGSTA--YITLEMTEVFVAGFTSS--------------AtgE-----------V-PVETVHLTY 126 Granul...
jgi:AciX8_2875         83 FATATLTGLKTa---GSSPGT--YFTLALTEAYVSSTQFS--------------GqsS-----------M-PNLGISLSY 131 Granul...
WP_013578711           79 IKTGVLSAVKS----GGDGSA--FLTISLGELFITSIQIG--------------AsnE-----------T-PTESVTFSY 126 Granul...
jgi:AciX9_4003         79 IATGVLTAVKS----GGDGSP--FLTISLGEVFITSVQVS--------------GssE-----------V-PMESVSFSY 126 Granul...
Q02CH0                 80 IKSAVLVCRKA----GKTQQE--FLKWKFTDLLISSYNTGgs-----------gGsdV-----------V-PIDQVSFNF 130 Candid...
WP_015245969           79 LKEAKLTCRKA----GGTQQN--FMVVTLSDVLISSYQTGgs-----------qAg------------eV-PMDQISLNY 128 Singul...
WP_002210479           81 IPQAKLVCRKS----GQGQQD--FLIVTFSNCLVSSFKTVgnmplg--kgdavfTdtV-----------L-PTDAISLNF 140 Yersin...
Q63MY0                 82 IQNAKLICRKS----GKGQQE--FLTISFASGLVSSFRTLgnmpisqlghasgeVdgV-----------L-PTDQIRINF 143 Burkho...
calssnu:BYI23_D001620  80 LASAKLTVSKA----GEGQKE--FLTVTMKQVTVTHVAVGgg-----------mGg--------------eLRETVSLMY 128 Burkho...
3WX6_A                149 SGYSLEH 155 Burkholderia pseudomallei K96243
jgi:AciX9_1277        127 KSILYTY 133 Granulicella tundricola MP5ACTX9
jgi:AciX8_2875        132 NQITITY 138 Granulicella mallensis MP5ACTX8
WP_013578711          127 NHIETAY 133 Granulicella tundricola
jgi:AciX9_4003        127 NTISTEY 133 Granulicella tundricola MP5ACTX9
Q02CH0                131 TKIEVSY 137 Candidatus Solibacter usitatus Ellin6076
WP_015245969          129 SKVEIDY 135 Singulisphaera acidiphila
WP_002210479          141 ARIEVEY 147 Yersinia pseudotuberculosis complex
Q63MY0                144 AQIEFEY 150 Burkholderia pseudomallei
calssnu:BYI23_D001620 129 ADIEFEY 135 Burkholderia sp. YI23
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