Conserved Protein Domain Family
PAXNEB

?
pfam05625: PAXNEB 
PAXNEB protein
PAXNEB or PAX6 neighbor is found in several eukaryotic organisms. PAXNED is an RNA polymerase II Elongator protein subunit. It is part of the HAP subcomplex of Elongator, which is a six-subunit component of the RNA polymerase II holoenzyme. The HAP subcomplex is required for Elongator structural integrity and histone acetyltransferase activity. This protein family has a P-loop motif. However its sequence has degraded in many members of the family.
Statistics
?
PSSM-Id: 398965
Aligned: 69 rows
Threshold Bit Score: 239.424
Threshold Setting Gi: 0
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
?
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
XP_002006649   9 VQKPIR-GTRTSPHTGQVITSSGNPSLDLILGGGLPIGSICLIEEDRFMTHAKVLAKYFLAEGLLSKQELFLGSLdd-lP 86  Drosophila moja...
EFH61096      20 SSPQIP-GLKSGP-NGTAFISTGIRDLDRILGGGYPLGSLVMVMEDPEAPHHMDLLRTFMSQGLVNNQPLLYASPsk-dP 96  Arabidopsis lyr...
XP_006593446  18 VTSQNH-GLKHGP-NGTMFISSGIPDLDKILGGGFSLGSLVMVMEDPEAPHHMLLLRNFMSQGLVQKQPLLYASAsr-dP 94  soybean
XP_010646438  19 PAPQAP-GLKSGP-NGTIFLSSGIPDLDKILGGGFPLGSLVMVMEDTEAPHHMLLLRNFMSQGLVHNQPLLYASPsk-dP 95  wine grape
XP_002438727  24 SSSGAA-GVRIGP-NGAAFVSSGIPDLDRILGGGFLLGSVVMIMEDADAPHHLLLLRCFMSQGVVHKQPLLFSGAmk-eP 100 sorghum
XP_002316217  19 SAPQLP-GIKCGP-NGTFFVSSGIPDLDKILGGGFPLGSLVMIMEDAEAPHHMLLLRNFMSQGLVQNQPLLYASPak-dP 95  black cottonwood
XP_015166714  19 ATTQIP-GVKLGP-NGTSFLSSGIPDLDQILGGGFTLGSLVMVMEDAEAPHHMLLLRNFMSQGLIHKQTLLYASPer-dP 95  potato
XP_004993576  13 ARKPPP-ATKPSLANGQLLTSTGMDAIDHLLGGGVAVGSVFLIEAQAKSPYADVVLKYFLSQGICHNHHVTLMSAdt-dP 90  Salpingoeca ros...
1_pfamImport   1 GGIVIP-GTHPSLHNGLLLVSSGIPSLDVVLGGGLPVGSIMMIEEDSGRRFSKIIMKYFLAEGVMSTHSLFVASYde-kP 78 
Q54XS0        42 AAKKLPnGCKISIKNSNLLTSTGLTDLDDIIGGGIPIGSILMIEEDINSSYYMFLLKYFLAEGVLQQQGVFFSSLigidP 121 Dictyostelium d...
XP_002006649  87 EEMLRRLPKPLTd-------eEVEQEQRLEQEQQAdk-----ngLRIAFRYND-----LPLVNS--EQATA-----KIGH 142 Drosophila moja...
EFH61096      97 RGFLGTLPHPASs-------kEDKSTAPDPDqg---------esLRIAWQYRKy-------------LESQknsidDYSN 147 Arabidopsis lyr...
XP_006593446  95 KSFLGTLPSPASp-------kGDNKSSDLShe----------kdLRIAWQYKKy----FGEPQL--NLNTNnggqhDYCN 151 soybean
XP_010646438  96 RAFLGTLPSPVLs-------kDDRSHNRDPEQLqe-------kgLRIAWQYKKy----FGEHRP--NFDSHrdtkhEYCN 155 wine grape
XP_002438727 101 RLFLGTLPAPVSs-------sKEDGRHRAMGAAASsdgrandegLRIAWQYKKy----FGDD----SRAEHkdnkqEFSN 165 sorghum
XP_002316217  96 RGFLGTLPCPSSs-------kDDKSRNHDTEqe---------kgLRIAWQYKKy----FSENQK--NIDDHkdsnqEFCN 153 black cottonwood
XP_015166714  96 RGFLGTLPSPMAs-------kEEKSHERPAEqd---------anLRIAWQYKKy----FGEQ----NSEGQrggkaEYCN 151 potato
XP_004993576  91 SKFLKSCPRSVDtlnipesasVEKpe----------------kdMKIAWRYKN-----LPKVSSvvGTASRttfstKFCH 149 Salpingoeca ros...
1_pfamImport  79 QEIVEHLPKPVCk-------dTVSASkt--------------ddMKIAFRYRD-----LSTASN--SLDAPp----KYGH 126
Q54XS0       122 FEILNKLPARITkeeeieadkNDTTNNINTNINTNnnnkqptdeLKIAWRYQQyvsneLSKQQQ--QQSAStimnqTFCH 199 Dictyostelium d...
XP_002006649 143 HFNLMEHMDAMMLS-YAHATIWNdkktnqedyedfdvandseqpragggeslpdpsesmlysyaqvvgskadpdqegeqS 221 Drosophila moja...
EFH61096     148 DFDMRKPLERQFLS-----------------------------------------------------------------G 162 Arabidopsis lyr...
XP_006593446 152 DFDLRKPLDRHFFS-----------------------------------------------------------------G 166 soybean
XP_010646438 156 DFDLRKPLERYFLT-----------------------------------------------------------------A 170 wine grape
XP_002438727 166 DFDLRKPLERHLLN-----------------------------------------------------------------G 180 sorghum
XP_002316217 154 DFDLRKPLEKHFYS-----------------------------------------------------------------G 168 black cottonwood
XP_015166714 152 DFDLRKPLERHFYS-----------------------------------------------------------------G 166 potato
XP_004993576 150 TFNLSQQVEEKDLS-----------------------------------------------------------------N 164 Salpingoeca ros...
1_pfamImport 127 FYDISQTMDEKDLE-NCEIETLNln----------------------------------------------------etS 153
Q54XS0       200 SYDFTRKMNVQSMNpELIHTLSHda----------------------------------------------------qsQ 227 Dictyostelium d...
XP_002006649 222 PPpdaaptqaaaaaaetdeatpmeqsdgqktapninnnnnnnmdnstannttsttgttttttptaspptgKPQFFYNArY 301 Drosophila moja...
EFH61096     163 RPi------------------------------------------------------------------dCVSLLDSSdL 176 Arabidopsis lyr...
XP_006593446 167 NNv------------------------------------------------------------------dCVSIKDSPnL 180 soybean
XP_010646438 171 QNi------------------------------------------------------------------cCLSIQDPPnL 184 wine grape
XP_002438727 181 QNi------------------------------------------------------------------eCVSIQDADtL 194 sorghum
XP_002316217 169 QRv------------------------------------------------------------------dCVSIKDSPnL 182 black cottonwood
XP_015166714 167 QRv------------------------------------------------------------------dCISLRDSPnL 180 potato
XP_004993576 165 DTi------------------------------------------------------------------hTADLRISKsG 178 Salpingoeca ros...
1_pfamImport 154 D---------------------------------------------------------------------TDFPLLNTsL 164
Q54XS0       228 A----------------------------------------------------------------------EG---TSpY 234 Dictyostelium d...
XP_002006649 302 DRLLNYIQLLLNDsifEPGANmqe----knLCRVCLTSLGSPLWy--------------------dDHFAEDLLKFLTIL 357 Drosophila moja...
EFH61096     177 SVAQDHCSTFLSKfsrSSSNIa-------sIGRIAIQSFSSPLCe--------------------ySDKESDMLSFIRLL 229 Arabidopsis lyr...
XP_006593446 181 TALQDCCAGFLAKfsrNEGSIs-------sAGRIAIQSFCSPQCk--------------------ySNEEWHMLSFIRSL 233 soybean
XP_010646438 185 AAFRDCCAKFLAQfsrNNSSIs-------cAGRVAIQSFCAPQCe--------------------ySNMEWDMLSFIRSL 237 wine grape
XP_002438727 195 SSLQDCCSAFLSKlprKDGGSl-------tAGRIAIQSLCAPQCr--------------------yFEKDWDMVSFIRSL 247 sorghum
XP_002316217 183 ATLHDRCATFLAQfprNDGSFs-------cMGRIAIQSLCAPQCe--------------------lSKMDWDMLSFIRSL 235 black cottonwood
XP_015166714 181 APLLERCSTFSAQiakSDDNIt-------cAGRIAIQSLCSPQCd--------------------fSDKDWEMLSFIRSL 233 potato
XP_004993576 179 NTFADAMQLILEAvepFRMVPqpgplvsaaVHRIGVHRLGSSAWdlgatdkdddggggynddqysvEERVQAACAFLHQL 258 Salpingoeca ros...
1_pfamImport 165 QTILTKLKKMVSNskfTAPKIldpt-trlnVLRVTIPNLGSPVWcd------------------nsNTSVSAITRFLHAL 225
Q54XS0       235 RNLFLEIQNLVYKynkEAAMNpdq----trVLRLCIQSFSSPLW----------------------SNDEEGVIEFLHAL 288 Dictyostelium d...
XP_002006649 358 RGSVRSCTAVCFITMPMHLIAkYDSSLVPKIRQLVDYAIELESFAGSERETHpa---fkEYSGLLHLHKMSAINTLAVHM 434 Drosophila moja...
EFH61096     230 KSMLMVSNAVAIVTFPPSLL---SPSSSKRLQHMADTLLSIKAIPDGDKELEklltgykDINGFLNIHKVARINTQVPVI 306 Arabidopsis lyr...
XP_006593446 234 KGMARSSNAVIVVTFPPSLL---PPSCSKRLQHMADTLLSVKAIPDEDKELAklltgyqDMIGLLNVHKVARLNTQVPVI 310 soybean
XP_010646438 238 KGMIRDSNAVAVITFPPSLL---SPSSSKRWQHIADTLLSVKAIPDEDKELAnlltgyqDMVGLLNVHKVANVNTQVPVI 314 wine grape
XP_002438727 248 KAMVRSSNSVAVITFPSTVL---SNSFCKRWQHLADTLLSIKAIPDEDKDLAklltgyqDMVGFLHVHKVAQTNSQVPVI 324 sorghum
XP_002316217 236 KSMLRSANAVAIITFPSSLL---SPSFCKRWQHMADVLLSVKAIPDEDKELGklltgyqDMVGFLNVHKIARINTQVPMI 312 black cottonwood
XP_015166714 234 KGMVRSSGAVAVISFPPSLV---SPAFLKRWQHLADTLISVKAIPDEDKELAklltgyqDMLGLLSVHKVARINTQVPAI 310 potato
XP_004993576 259 RGIARRSCAVVFVTVPSSLLS-SSPHHRHRIHLLADAVVRMEGFAGTSNEHHpa---lkEYHGFFKVLRMPQLNSLVAAT 334 Salpingoeca ros...
1_pfamImport 226 RSLARNCLMTCLITVPTHLY---TPQQVTHIRHMVDCSIHLESFTG--EKTNpv---fiQFHGLLKIQKLPCLNSLVPYI 297
Q54XS0       289 KGLLRSSVATCVISVPTYIY---SGAFVKKIAHLCDTVVSINSFSGLGGETPeq---faEYLGLFNIRKIARLNTLSLSF 362 Dictyostelium d...
XP_002006649 435 -PETTDLAFKLRRKK-FVIEKLHLPPDLQESSeqtaksadvlpipncG--------VNSNVSMDF 489 Drosophila mojavensis
EFH61096     307 lE-AKTFSMSLKKRRfLALECLNQAPVDGssg-------------tsYgts--gscSSKSGALDF 355 Arabidopsis lyrata subsp. lyrata
XP_006593446 311 lE-ATTFSIKLQKRRfLVLECLNQAPVDGssg-------------ssYgtsggcsgSTKAGPLDF 361 soybean
XP_010646438 315 lE-ATTFSIKLQKRRyLVLECLNQAPVDGssg-------------ssYastgscsgSTKTGTLDF 365 wine grape
XP_002438727 325 lE-ASTLSLKLRKRRlLVLERLNQAPVDGstg-------------psSaas--sscSSQGSQLDF 373 sorghum
XP_002316217 313 lE-ATTFSIKLHKRRfLVLECLNQAPIDGssg-------------tsYgtsggcsgSSRSGALDF 363 black cottonwood
XP_015166714 311 lE-ATTFSMKLRKRRaLVLECLNQAPVDGssg-------------ssYgtsgscsgSSKTGNLDF 361 potato
XP_004993576 335 -PDTADLVFKLKKKQ-FVIEKFHLPPELSDMPsrpqeda-----------pvtpssSSSSSSSSS 386 Salpingoeca rosetta
1_pfamImport 298 -PESLDLGFELKKTK-FLIKCLHLPPDMSETAlddrkt---qksspcDg-------TTLHKKLDF 350
Q54XS0       363 hPDMLTFVFKMKRRK-MCIETIHLPPESSrag-------------dsKpdnndsnkNKSDQNNIV 413 Dictyostelium discoideum
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap