Conserved Protein Domain Family
PAXNEB

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pfam05625: PAXNEB (This model is not part of the current CDD release)
PAXNEB protein
PAXNEB or PAX6 neighbour is found in several eukaryotic organisms. PAXNED is an RNA polymerase II Elongator protein subunit. It is part of the HAP subcomplex of Elongator, which is a six-subunit component of the RNA polymerase II holoenzyme. The HAP subcomplex is required for Elongator structural integrity and histone acetyltransferase activity. This protein family has a P-loop-like motif and adopts a RecA-ATPase-like fold, lacking the conserved sequence signature of ATPases.
Statistics
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PSSM-Id: 516896
Aligned: 63 rows
Threshold Bit Score: 236.73
Created: 14-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_002006649   9 VQKPIR-GTRTSPHTGQVITSSGNPSLDLILGGGLPIGSICLIEEDRFMTHAKVLAKYFLAEGLLSKQELFLGSLdd-lP 86 
XP_002438727  24 SSSGAA-GVRIGP-NGAAFVSSGIPDLDRILGGGFLLGSVVMIMEDADAPHHLLLLRCFMSQGVVHKQPLLFSGAmk-eP 100
XP_020888279  20 SSPQIP-GLKSGP-NGTAFISTGIRDLDRILGGGYPLGSLVMVMEDPEAPHHMDLLRTFMSQGLVNNQPLLYASPsk-dP 96 
NP_001241905  18 VTSQNH-GLKHGP-NGTMFISSGIPDLDKILGGGFSLGSLVMVMEDPEAPHHMLLLRNFMSQGLVQKQPLLYASAsr-dP 94 
XP_010646438  19 PAPQAP-GLKSGP-NGTIFLSSGIPDLDKILGGGFPLGSLVMVMEDTEAPHHMLLLRNFMSQGLVHNQPLLYASPsk-dP 95 
XP_015166714  19 ATTQIP-GVKLGP-NGTSFLSSGIPDLDQILGGGFTLGSLVMVMEDAEAPHHMLLLRNFMSQGLIHKQTLLYASPer-dP 95 
XP_024465466  19 SAPQLP-GIKCGP-NGTFFVSSGIPDLDKILGGGFPLGSLVMIMEDAEAPHHMLLLRNFMSQGLVQNQPLLYASPak-dP 95 
XP_004993576  13 ARKPPP-ATKPSLANGQLLTSTGMDAIDHLLGGGVAVGSVFLIEAQAKSPYADVVLKYFLSQGICHNHHVTLMSAdt-dP 90 
5_pfamImport   1 GGIVIP-GTHPSLHNGLLLVSSGIPSLDVVLGGGLPVGSIMMIEEDSGRRFSKIIMKYFLAEGVMSTHSLFVASYde-kP 78 
Q54XS0        42 AAKKLPnGCKISIKNSNLLTSTGLTDLDDIIGGGIPIGSILMIEEDINSSYYMFLLKYFLAEGVLQQQGVFFSSLigidP 121 Dictyostelium d...
XP_002006649  87 EEMLRRLPKPLTd-------eEVEQEQRLEQEQQAdk-----ngLRIAFRYND-----LPLVNS--EQATA-----KIGH 142
XP_002438727 101 RLFLGTLPAPVSs-------sKEDGRHRAMGAAASsdgrandegLRIAWQYKKy----FGDD----SRAEHkdnkqEFSN 165
XP_020888279  97 RGFLGTLPHPASs-------kEDKSTAPDPDqg---------esLRIAWQYRKy-------------LESQknsidDYSN 147
NP_001241905  95 KSFLGTLPSPASp-------kGDNKSSDLShe----------kdLRIAWQYKKy----FGEPQL--NLNTNnggqhDYCN 151
XP_010646438  96 RAFLGTLPSPVLs-------kDDRSHNRDPEQLqe-------kgLRIAWQYKKy----FGEHRP--NFDSHrdtkhEYCN 155
XP_015166714  96 RGFLGTLPSPMAs-------kEEKSHERPAEqd---------anLRIAWQYKKy----FGEQ----NSEGQrggkaEYCN 151
XP_024465466  96 RGFLGTLPCPSSs-------kDDKSRNHDTEqe---------kgLRIAWQYKKy----FSENQK--NIDDHkdsnqEFCN 153
XP_004993576  91 SKFLKSCPRSVDtlnipesasVEKpe----------------kdMKIAWRYKN-----LPKVSSvvGTASRttfstKFCH 149
5_pfamImport  79 QEIVEHLPKPVCk-------dTVSASkt--------------ddMKIAFRYRD-----LSTASN--SLDAPp----KYGH 126
Q54XS0       122 FEILNKLPARITkeeeieadkNDTTNNINTNINTNnnnkqptdeLKIAWRYQQyvsneLSKQQQ--QQSAStimnqTFCH 199 Dictyostelium d...
XP_002006649 143 HFNLMEHMDAMMLS-YAHATIWNdkktnqedyedfdvandseqpragggeslpdpsesmlysyaqvvgskadpdqegeqS 221
XP_002438727 166 DFDLRKPLERHLLN-----------------------------------------------------------------G 180
XP_020888279 148 DFDMRKPLERQFLS-----------------------------------------------------------------G 162
NP_001241905 152 DFDLRKPLDRHFFS-----------------------------------------------------------------G 166
XP_010646438 156 DFDLRKPLERYFLT-----------------------------------------------------------------A 170
XP_015166714 152 DFDLRKPLERHFYS-----------------------------------------------------------------G 166
XP_024465466 154 DFDLRKPLEKHFYS-----------------------------------------------------------------G 168
XP_004993576 150 TFNLSQQVEEKDLS-----------------------------------------------------------------N 164
5_pfamImport 127 FYDISQTMDEKDLE-NCEIETLNln----------------------------------------------------etS 153
Q54XS0       200 SYDFTRKMNVQSMNpELIHTLSHda----------------------------------------------------qsQ 227 Dictyostelium d...
XP_002006649 222 PppdaaptqaaaaaaetdeatpmeqsdgqktapninnnnnnnmdnstannttsttgttttttptaspptgKPQFFYNArY 301
XP_002438727 181 Qni------------------------------------------------------------------eCVSIQDADtL 194
XP_020888279 163 Rpi------------------------------------------------------------------dCVSLLDSSdL 176
NP_001241905 167 Nnv------------------------------------------------------------------dCVSIKDSPnL 180
XP_010646438 171 Qni------------------------------------------------------------------cCLSIQDPPnL 184
XP_015166714 167 Qrv------------------------------------------------------------------dCISLRDSPnL 180
XP_024465466 169 Qrv------------------------------------------------------------------dCVSIKDSPnL 182
XP_004993576 165 Dti------------------------------------------------------------------hTADLRISKsG 178
5_pfamImport 154 D---------------------------------------------------------------------TDFPLLNTsL 164
Q54XS0       228 A----------------------------------------------------------------------EG---TSpY 234 Dictyostelium d...
XP_002006649 302 DRLLNYIQLLLNDsifEPGANmqe----knLCRVCLTSLGSPLWy--------------------dDHFAEDLLKFLTIL 357
XP_002438727 195 SSLQDCCSAFLSKlprKDGGSl-------tAGRIAIQSLCAPQCr--------------------yFEKDWDMVSFIRSL 247
XP_020888279 177 SVAQDHCSTFLSKfsrSSSNIa-------sIGRIAIQSFSSPLCe--------------------ySDKESDMLSFIRLL 229
NP_001241905 181 TALQDCCAGFLAKfsrNEGSIs-------sAGRIAIQSFCSPQCk--------------------ySNEEWHMLSFIRSL 233
XP_010646438 185 AAFRDCCAKFLAQfsrNNSSIs-------cAGRVAIQSFCAPQCe--------------------ySNMEWDMLSFIRSL 237
XP_015166714 181 APLLERCSTFSAQiakSDDNIt-------cAGRIAIQSLCSPQCd--------------------fSDKDWEMLSFIRSL 233
XP_024465466 183 ATLHDRCATFLAQfprNDGSFs-------cMGRIAIQSLCAPQCe--------------------lSKMDWDMLSFIRSL 235
XP_004993576 179 NTFADAMQLILEAvepFRMVPqpgplvsaaVHRIGVHRLGSSAWdlgatdkdddggggynddqysvEERVQAACAFLHQL 258
5_pfamImport 165 QTILTKLKKMVSNskfTAPKIldpt-trlnVLRVTIPNLGSPVWcd------------------nsNTSVSAITRFLHAL 225
Q54XS0       235 RNLFLEIQNLVYKynkEAAMNpdq----trVLRLCIQSFSSPLW----------------------SNDEEGVIEFLHAL 288 Dictyostelium d...
XP_002006649 358 RGSVRSCTAVCFITMPMHLIAkYDSSLVPKIRQLVDYAIELESFAGSERETHpa---fkEYSGLLHLHKMSAINTLAVHM 434
XP_002438727 248 KAMVRSSNSVAVITFPSTVL---SNSFCKRWQHLADTLLSIKAIPDEDKDLAklltgyqDMVGFLHVHKVAQTNSQVPVI 324
XP_020888279 230 KSMLMVSNAVAIVTFPPSLL---SPSSSKRLQHMADTLLSIKAIPDGDKELEklltgykDINGFLNIHKVARINTQVPVI 306
NP_001241905 234 KGMARSSNAVIVVTFPPSLL---PPSCSKRLQHMADTLLSVKAIPDEDKELAklltgyqDMIGLLNVHKVARLNTQVPVI 310
XP_010646438 238 KGMIRDSNAVAVITFPPSLL---SPSSSKRWQHIADTLLSVKAIPDEDKELAnlltgyqDMVGLLNVHKVANVNTQVPVI 314
XP_015166714 234 KGMVRSSGAVAVISFPPSLV---SPAFLKRWQHLADTLISVKAIPDEDKELAklltgyqDMLGLLSVHKVARINTQVPAI 310
XP_024465466 236 KSMLRSANAVAIITFPSSLL---SPSFCKRWQHMADVLLSVKAIPDEDKELGklltgyqDMVGFLNVHKIARINTQVPMI 312
XP_004993576 259 RGIARRSCAVVFVTVPSSLLS-SSPHHRHRIHLLADAVVRMEGFAGTSNEHHpa---lkEYHGFFKVLRMPQLNSLVAAT 334
5_pfamImport 226 RSLARNCLMTCLITVPTHLY---TPQQVTHIRHMVDCSIHLESFTG--EKTNpv---fiQFHGLLKIQKLPCLNSLVPYI 297
Q54XS0       289 KGLLRSSVATCVISVPTYIY---SGAFVKKIAHLCDTVVSINSFSGLGGETPeq---faEYLGLFNIRKIARLNTLSLSF 362 Dictyostelium d...
XP_002006649 435 -PETTDLAFKLRRKK-FVIEKLHLPPDLQESSeqtaksadvlpipncG--------VNSNVSMDF 489
XP_002438727 325 lE-ASTLSLKLRKRRlLVLERLNQAPVDGstg-------------psSaas--sscSSQGSQLDF 373
XP_020888279 307 lE-AKTFSMSLKKRRfLALECLNQAPVDGssg-------------tsYgts--gscSSKSGALDF 355
NP_001241905 311 lE-ATTFSIKLQKRRfLVLECLNQAPVDGssg-------------ssYgtsggcsgSTKAGPLDF 361
XP_010646438 315 lE-ATTFSIKLQKRRyLVLECLNQAPVDGssg-------------ssYastgscsgSTKTGTLDF 365
XP_015166714 311 lE-ATTFSMKLRKRRaLVLECLNQAPVDGssg-------------ssYgtsgscsgSSKTGNLDF 361
XP_024465466 313 lE-ATTFSIKLHKRRfLVLECLNQAPIDGssg-------------tsYgtsggcsgSSRSGALDF 363
XP_004993576 335 -PDTADLVFKLKKKQ-FVIEKFHLPPELSDMPsrpqeda-----------pvtpssSSSSSSSSS 386
5_pfamImport 298 -PESLDLGFELKKTK-FLIKCLHLPPDMSETAlddrkt---qksspcDg-------TTLHKKLDF 350
Q54XS0       363 hPDMLTFVFKMKRRK-MCIETIHLPPESSrag-------------dsKpdnndsnkNKSDQNNIV 413 Dictyostelium discoideum
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