Conserved Protein Domain Family
HOOK

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pfam05622: HOOK (This model is not part of the current CDD release)
HOOK protein coiled-coil region
This family consists of several HOOK1, 2 and 3 proteins from different eukaryotic organisms. The different members of the human gene family are HOOK1, HOOK2 and HOOK3. Different domains have been identified in the three human HOOK proteins, and it was demonstrated that the highly conserved NH2-domain mediates attachment to microtubules, whereas this central coiled-coil motif mediates homodimerization and the more divergent C-terminal domains are involved in binding to specific organelles (organelle-binding domains). It has been demonstrated that endogenous HOOK3 binds to Golgi membranes, whereas both HOOK1 and HOOK2 are localised to discrete but unidentified cellular structures. In mice the Hook1 gene is predominantly expressed in the testis. Hook1 function is necessary for the correct positioning of microtubular structures within the haploid germ cell. Disruption of Hook1 function in mice causes abnormal sperm head shape and fragile attachment of the flagellum to the sperm head. This entry includes the central coiled-coiled domain and the divergent C-terminal domain.
Statistics
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PSSM-Id: 516894
Aligned: 17 rows
Threshold Bit Score: 516.168
Created: 14-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
B6MFW3       189 QRCHELDMQVQQLMEENTLMKVEKDELSDKVNQVD--------GYEDTSTP--AGRRYIQLTHQVEQLQEETYRLETGRD 258 Florida lancelet
XP_009247919 199 QRCEELDMQVTTLQDEKNSLVSENEMMNEKLDQLDg-------SFDDPNTV--VAKKYFHAQLQLEQLQEENFRLEAAKD 269
Q5TZ80       193 QRCQELDMQVTVLQEERNSLLAENDLLTDRSSQLE--------TFDDPSTP--SGRKHSQLQFQLEQLQEENFRLEAAKD 262 zebrafish
NP_115786    197 QRCHELDMQVAALQEEKSSLLAENQVLMERLNQSD--------SIEDPNSP--AGRRHLQLQTQLEQLQEETFRLEAAKD 266
2_pfamImport   1 QKCHELDQQLSLLQEEKAALMTENKKLQERLDEFE--------NP-ESCSI----FRHSGLRKQVEALKDELFKVETSRD 67 
XP_019696954 199 QRCHELDQQLSLLQEEKAALIVENKKLQERLDEFE--------NPEESGSI----LKYSGLRKQAEALKDELFKVETSRD 266
XP_025270490 196 QKCHELDQQLSLLQEEKAALIAENKKFQERLDEFE--------NPEESGSI----MKYSGLRKQVDALKDELFKMETSRD 263
B4I5P7       194 QKCFETEKKMLLLIDEKTNLQQELHKLQQEFARLEqhstvigdDGVSLGPVqtGSVRYNELRRQLDLLKEELLQSEGARE 273 Drosophila sech...
Q7PWT9       188 QKCHETNKKMLGLIEEKAALQQEIVKLQAIVGRYEnpnl-igdDGTSLGPIqlGSSRYNDLRKLVDSLKDELLQAETARD 266 African malaria...
XP_003225260 193 QRCHDLEQQISILVDEKNTLVLENKTLREQKSALE------------SDTAglTGKKLLLLQSQIEQLQEENFRLENGRD 260
B6MFW3       259 EYRLKCEEMEKEILDLAGKNEELMALAAETQLLKDEMDILRQSAEKTSKYEQTIETYKKKLEDLADLRRTVEQLQEET-- 336 Florida lancelet
XP_009247919 270 DYRVHCEELEKQLIEFQHRNDELTSLAEETRALKDEIDVLRATSDKANKLESTVEIYRQKLQDLNDLRKQVKTLQETNmm 349
Q5TZ80       263 DYRIHCEELEKQLVELQHRNDELTSLAEESRSLKDELDILRSCSDRAVKLEASVETYRKKLEDLSDLRRQMKALEEKNmt 342 zebrafish
NP_115786    267 DYRIRCEELEKEISELRQQNDELTTLADEAQSLKDEIDVLRHSSDKVSKLEGQVESYKKKLEDLGDLRRQVKLLEEKNtm 346
2_pfamImport  68 DYRLKIELLEKEVLELQSRQEDLQKAADEANNLKDEIDALRETADKVAKYEQTIESYKKKMEDLSDLRRQVKILEDKNle 147
XP_019696954 267 DYRLKVELLEKEVLELQLRQEDLQKAADEANHLKDEVDALRETVDKVAKYELTIESYKKKMEDMGDLKRQMKILEDKNle 346
XP_025270490 264 DYRLKAELLEKEVLELQSRQEDLQKAADEANHLKDEIDALRETADKVAKYEIMIESYKKKMEDLSDLKRQLKISEDKNve 343
B4I5P7       274 DLKIKAQQQDTDLLHMQMRIEELMKSSAEVTTLKDEVDVLRESNDKLKICEAQLDTYKKKLEDYNDLKKQVKILEERSad 353 Drosophila sech...
Q7PWT9       267 DLKMKSMIQEKEIGELQVKIDELHAATAEIAQLKDEIDILKEANEKLKICETQLQTYKKKLEDYNDLKKQIKLQEERSad 346 African malaria...
XP_003225260 261 DFRVRCEDLEREVQELQHRNEELTSLAEEAQALKDEMDVLRHSSDRVGRLEAMVDSYKKKLEDLGDLRRQVRLLEERNtv 340
B6MFW3       337 YRLETGLSHCELRKANTLRSQLDMYKKQVQELHGKVSEETKRADKAEFELKRSTEKLDTVQKEKQRIVNERDTLKETNEE 416 Florida lancelet
XP_009247919 350 YMHNTVSLEEELKKANAARTQLETYKRQVQDLHVKLSSESKRADTLAFEMKRLEEKHEALLKEKERLIEQRDTLKETNEE 429
Q5TZ80       343 YMHNTVSLEEELRKANAARAQLETYKRQVQELHKKLSDESRRADNLVFEMKKLQEKYDALVKERERISIERDTLRETNEE 422 zebrafish
NP_115786    347 YMQNTVSLEEELRKANAARSQLETYKRQVVELQNRLSEESKKADKLDFEYKRLKEKVDSLQKEKDRLRTERDSLKETIEE 426
2_pfamImport 148 YLQSKIDYEEESKRTTMLRNHLEVCKQQLAEAHHKLDEQTNKCDKLEFEGKKMEAQLSTLQRERDRLIVERDALKETNEE 227
XP_019696954 347 YLQVKLDYEEESKRTTMLRNHLEICKQQLTETQHKLDEMSGKYDRLVCEDKKKEARMNTLQRERDRLVIERDALRETNEE 426
XP_025270490 344 YLQAKLDYEEEVKRTMMLRNHLEACKQQLTEVHHRLDEQSNKYDRLEFEGKKMEAKLGALQRERDRLVIERDALKETNEE 423
B4I5P7       354 YVQQNAQFEEDAKRYANTKGQVELFKKEIQDLHAKLDAESSKNVKLEFDNKNLEGKNLALQRAKDSLLKERDNLREAVDE 433 Drosophila sech...
Q7PWT9       347 YLKQNLEYEEEAKKYAGLKGQVELYKKKIQDLHGMLDEEMGKTVRAEFEYNQLQGQLAVVQREKETLLSERDTLREALDE 426 African malaria...
XP_003225260 341 YMQRTCELEEELRRANAVRSQLEAHKRQVQELHSKHEKESLKSEKWQFEFKNLKEKFDALMKEKERLIEERDVLREANEE 420
B6MFW3       417 LHC-MQLQQGKamLYSTGslAGIGSNVespvGSPIPEVVPPEIKEKLIRLQHENKMLKLKAEGSDDERLAVSQAMLDDAQ 495 Florida lancelet
XP_009247919 430 LRC-SQVQQDH--LNQTD--ASATKSY----ENLAAEIMPVEYREVFIRLQHENKMLRLQQEGSENERIEELQEQLEQKH 500
Q5TZ80       423 LRC-TQAQQDQ--LLLAGkyQTGSPSH----DNLAAEMLPIEYREKFIRLQHENKMLRLQQEESEKQRITELQQQLEEAR 495 zebrafish
NP_115786    427 LRC-VQAQEGQ--LTTQGlmPLGSQESs---DSLAAEIVTPEIREKLIRLQHENKMLKLNQEGSDNEKIALLQSLLDDAN 500
2_pfamImport 228 LKC-TQLQAAE---------NITKPSTd---tVTNTEMIPLEIKEELLCLKHENKMLKLKQMGN-EDKLPTVQALLEDSE 293
XP_019696954 427 LKC-AQLQAAE---------NMAKPSTvdsnSVAGTEMIPLEVKEKLLCLQLENKMLKARQKGN-EEKLPSVQTLLDESE 495
XP_025270490 424 LKCnTQLQTAE---------NMAKPSAds-sGVAGTEMVPLEIKEKLLRLQLENKMLKMKQTGN-EDKLPSVQALLDDSE 492
B4I5P7       434 LKC-GQLSSNTal----------------tgTTVSRELQPSATVEKLQRLEAENKALREGQGGQ-----TALAQLLDDAN 491 Drosophila sech...
Q7PWT9       427 LKC-GQAVGAD-----------GVGHGgpggNTMSKELHSNDVCERIERLERENKALREGQGGQ-----TALSQLLDDAN 489 African malaria...
XP_003225260 421 LRC-AQVQQKF--LHQAD--TMLEEIPsp-vDNLAAEIMPAELKETIVRLQHENKML-CAQEQSYREQQAELQELLEESN 493
B6MFW3       496 ARTNELETENRLANQRILELQGQLEDMQTEQEEVGSPAKDqdSVALRKKLEEHMEKLKDADSQLQKKKEYIDNLEPKVSS 575 Florida lancelet
XP_009247919 501 RKMNELETEQRLSKERIRELQQQIEDLQKSLQEQGSKSEGesSSKLKQKLEAHMEKLTEVHEELQKKQELIEDLQPDINQ 580
Q5TZ80       496 RGRSQLDTDNRLNRERISELQQQVEDLQKALQTQGAKPDD---SHLKRKLDAHMVQLNEAQDEIMKKKELLEDLQPDATQ 572 zebrafish
NP_115786    501 LRKNELETENRLVNQRLLEVQSQVEELQKSLQDQGSKAED--SVLLKKKLEEHLEKLHEANNELQKKRAIIEDLEPRFNN 578
2_pfamImport 294 ERLNTLRGKNRKANQRIIELENRLEEALGNQSSGDNKTDN---INLGQKITQLQDEVRKIQSEKERLILQVEERENALQT 370
XP_019696954 496 ERLNTLREQNRKANQKIMEMEAKLEEVTMQSSNADGKSDS---GGLGQKAVQLQDELRKAQAEKERLTLQLEEREATLQV 572
XP_025270490 493 ERLNTLRGQNRKANQRIMELETKLEEVMGTQTSDDNKND----AGLNQKMSQLQDELRKMQAERERLTLQLEERESALQA 568
B4I5P7       492 KRCENLREQLKTANERILSLSHA------------SQSDD--PILKESEFGKQIKQLMELNEQ---KTLQLEE-AVTQST 553 Drosophila sech...
Q7PWT9       490 QRNEKLREQLKSANQKILLLSQH-------------HAED---GTTKSELEMQMKQTLELGEQRSSAQQQLDETTQHQLS 553 African malaria...
XP_003225260 494 RTKSQLEAQQRLSQQQISELKAQVEELQRALQEQGSKAED--SSLLKKKLEEHLEKLHEAHAELQKKKECLDELEPKIDS 571
B6MFW3       576 SA-EKIQQLQEMLNKKDDDMKAMEERYKRYLEKAKSVIRTLDPKQNQSSt-PEVQALKNQLTEKERLIDHLERD-HEKAK 652 Florida lancelet
XP_009247919 581 NV-QKINELEAALQKKDEDMKAMEERYKMYLEKARNVIKTLDPKLNPAS--AEIMLLRKQLAEKERRIEILESE-CKVAK 656
Q5TZ80       573 TS-VKMDELMAALKKKDEDMRAMEDRYKMYLEKARDVIRALDPKLNPAS--AEIQSLKVQLSDKDKKIIALERE-CEQAK 648 zebrafish
NP_115786    579 SS-LKIEELQEALRKKEEEMKQMEERYKKYLEKAKSVIRTLDPKQNQGAa-PEIQALKNQLQERDRLFHSLEKE-YEKTK 655
2_pfamImport 371 QK-QKVFALQEKLTRREYDNAALEERYKKYVEKAKSVIKSLDPKQNNSSp-NEVAVLRNQILEQRKIMEDMERS-LKESK 447
XP_019696954 573 QK-QKTATLQEKLTRKEYEDAAREEHYKKNVEKAKSVIKSLESSK--HSp-TEL-VLRNQLLEQRKAIEEMERT-VKESR 646
XP_025270490 569 QK-QKAFAIQEKLTRKEYENAALEERYKKYIEKAKSVIKSLDPKQNNSSp-SEVVVLRNQLLEQRKMIEDMERS-MKESR 645
B4I5P7       554 SLqCKVTQLETNLSAREQEILVYDAKYRKCVEKAKEVIKSIDPRI--------ASALDASVLE--KSADLVEAEpKPKMS 623 Drosophila sech...
Q7PWT9       554 NLhTKIANLEAALVVKDQELQAADVRYKKCVEKAKEVIKTLDAHAi-----SEALLM--------DKVDSASGTgVDATL 620 African malaria...
XP_003225260 572 TTaKKIDELQQSLKKKDEDMRAMEERYKRYMDKACTVIKKLDPKQQPHVvpLEIQALKNQLQEKDKKISHLESD-FEKTK 650
B6MFW3       653 Lt------------REQEEKLIVSAWYNMGAQLHRKAVEGRLANGG-Pm------qGGQSFLARQRQATSRRTTVS 709 Florida lancelet
XP_009247919 657 F-------------RDYEEKLIVSAWYNKSLAFQKLGMESRLVSGGgAcsdtgactPARSFLAQQRHITNTRRNLS 719
Q5TZ80       649 L-------------REYEEKLIVTAWYNKSLNFQKMAIESRLSGRAnSlv-----pPGQSFLAQQRQVTNARRTMS 706 zebrafish
NP_115786    656 Sq------------REMEEKYIVSAWYNMGMTLHKKAAEDRLASTG----------SGQSFLARQRQATSSRRSYP 709
2_pfamImport 448 Li------------KEMEEKLMISAFYRLGLTCHREAIDQRLAALSs--------gQGQSFLARQRQPSA-RRHPP 502
XP_019696954 647 Ll------------REMEEKLMVTAFYKLGLSAQRDAMDQRLATLSs--------gQGHSFLARQRQPSA-RRHSP 701
XP_025270490 646 Ll------------REMEEKLMVTAFHRLGLNCHREVIDQRLAALSs--------gQGQSFLARQRQPSA-RRHPP 700
B4I5P7       624 V---------------MEEQLMTSAFYRLGVNAQRDAIDSKLAILMg---------SGQTFLARQRQSAP-RKSLS 674 Drosophila sechellia
Q7PWT9       621 TtvgnggtaarapmGQQEEQLIATAFYRLGMVCHREAVDARL--LSg---------PGQSFLARQRQPAA-RKPLN 684 African malaria mos...
XP_003225260 651 Sq------------QEQEEKLIITAWYNMGLALHQRASEERSSTPA----------TVQSFLAQQRLATNMRRGHH 704
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