Conserved Protein Domain Family
Hikeshi-like_N

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pfam05603: Hikeshi-like_N (This model is not part of the current CDD release)
Hikeshi-like, N-terminal domain
This domain is found at the N-terminal end of Protein Hikeshi from humans and its orthologues OPI10 from other eukaryotes. Hikeshi is an specific nuclear import carrier for HSP70 proteins following heat-shock stress, which is required to protect cells from heat- shock damages. The N-terminal domain shows a jelly-roll/beta- sandwich fold with two layers of beta-sheets consisting of three and five and five antiparallel beta-strands.
Statistics
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PSSM-Id: 516884
Aligned: 66 rows
Threshold Bit Score: 111.538
Created: 14-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_003668244   5 IASGNPLQFS-EEVaNSNGLQHTIvlsstkPK--SYSHISLFVLPNVTFPEDYIATVYFKLS-----PLEDFKMFGYLSA 76 
EFX70651       5 IVSGRLVQTNfQQI-TDSQFVITI------PDadSINHLVVFLTGASPFPEGFGGSVYFRWPepdlsAPPVWQLLGNLTN 77 
1_pfamImport   1 IVSGRLVHTDfSPI-AETRFLTTI------TEadSINHVAVFLTGAVPLPPGTAAMVYWSWPdp--aAPPNWQLLGHISN 71 
7_pfamImport   1 LASGRMVQTNyDRV-GENQFLITI------PEadNINHIVVFLTGNIAFPDGYAGLVYFSWPdp--dAPPNWQLLGTLSN 71 
XP_002426491   5 ILSGQLVQTDfQLV-GKKQFLINV------PNadNVNHIVVFLTGTMPFPEGCGGLVYFSFPdp--nSPPCWHLLGFISN 75 
XP_001600692   8 IVSGRLVQTDfQLV-GENKFLITI------PDadSINHVVVFLTGTVPFIDGMGGAVYFSWPdp--nAPPNWQFLGYVSN 78 
NP_001294457   8 IVSGR-TPIEvVPV-SDTEFTCEI------VNadAINHVVVFLTGAQPFPDGIGGSVYIRWPtqd---ggnWHYLGFICN 76 
XP_004349770   5 LASGRLVQTEpVAV-DPARVVFTI------DDadKINHLVVFLLGHIPFDEGFGGAVYFGWPs---aEGPVWQYLGFISN 74 
XP_001628400   8 VVSGRLVQTDaQQV-GPTQVVFNL------ADaeSIHHVVVFLTGTVPFPDGMGGAVFYCYPst---eGPAWQLLGFLSN 77 
KAL1231236     5 LVPGRAVQTNlTQI-DDTHCVFSL------DDaeHVNHIIVLLTGQVAFPQGYGGAVYLCYPss--dGQQAWLYLGYVSN 75  Trichinella pse...
XP_003668244  77 EKPSAIFKVklqSTNN-NNnlnntdtrtsrdgiqYGEGLGEIDMDEdedqsfp----hknsmnFHNISQLIIGISIEPRM 151
EFX70651      78 NKPSSIYKI---TGLKkNP---------------GSYSPSMFGVHQ-----------------GEIHHHAQIGISIEPLS 122
1_pfamImport  72 IKPSAIFKI---SNLKkLHel-----------tnENKFMGTFGQQQ-------------------ICHNAQIGISIEPEA 118
7_pfamImport  72 EKPSSIFKI---SNKRkTEelr----------tlQEAGLMQFTQTK-------------------ISHVAQVGISIETVA 119
XP_002426491  76 EKPSAIFRI---SNLKnTTkya----------lnADGSTFMFGQGE-----------------IRLT--AQVGIAVENMA 123
XP_001600692  79 NKPSAIFKI---SNLKknh-------------efENNNLGIFGATS-----------------TTISHVAQIGISVEPLS 125
NP_001294457  77 EKPSAIYKV---AQLHks---------------dASHSFSQFDNQMq----------------LYSSGSAQIGINAESLS 122
XP_004349770  75 LKPSAIFRV---SKTRpTQseaaap---fasmyqNAAPMGGFQQNFggsmmdseqaqypaymyDASSIQAQVGISIEPLD 148
XP_001628400  78 AKPSAIFKI---AKVKp-----------------EEVVQNPFSFQQ-----------------NQDHTIAQIGISLEPLD 120
KAL1231236    76 EKPSAIFRV---TKLKsmi-------------vpQTNVPGGFvg------------------fNKSSTVVQLGISVEPLT 121 Trichinella pse...
XP_003668244 152 EGMAKLEAWKHEM 164
EFX70651     123 LISNQSPSAITEP 135
1_pfamImport 119 NV--QLLASSVAL 129
7_pfamImport 120 VVEQQKQLLNAEV 132
XP_002426491 124 NIQQQCINTPAEN 136
XP_001600692 126 ILEQQAAVATANA 138
NP_001294457 123 DITGRQAADGTQA 135
XP_004349770 149 DIAQQTPLADEAS 161
XP_001628400 121 QLAQMTPASGATP 133
KAL1231236   122 SITSLTPVGDLDP 134 Trichinella pseudospiralis
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