Conserved Protein Domain Family
CLPTM1

?
pfam05602: CLPTM1 (This model is not part of the current CDD release)
Cleft lip and palate transmembrane protein 1 (CLPTM1)
This family consists of several eukaryotic cleft lip and palate transmembrane protein 1 sequences. Cleft lip with or without cleft palate is a common birth defect that is genetically complex. The nonsyndromic forms have been studied genetically using linkage and candidate-gene association studies with only partial success in defining the loci responsible for orofacial clefting. CLPTM1 encodes a transmembrane protein and has strong homology to two Caenorhabditis elegans genes, suggesting that CLPTM1 may belong to a new gene family. This family also contains the human cisplatin resistance related protein CRR9p which is associated with CDDP-induced apoptosis.
Statistics
?
PSSM-Id: 516883
Aligned: 117 rows
Threshold Bit Score: 344.528
Created: 14-Feb-2025
Updated: 28-Apr-2025
Structure
?
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
CBN75944       39 AQLFIKLAVLYMSFMFFSkqFQTHqikeavaimkeseqdevsqvlkplpkgeesdvnWMKEAMGlQSSRIPQfpeydarg 118
16_pfamImport   1 AKLLLGVFVVYMLHTAWL--LYGF---------------------------------LNTKPCD--GGRGEP-------- 35 
10_pfamImport   1 AKLLLGVFVVYALHTAWL--LYGF---------------------------------LHTKPCD-----GSS-------- 32 
XP_013126123    8 TTLIVGVFVVYVLHTCWV--MYGI---------------------------------VYTKPCS--NPKGAN-------- 42 
Q6DHU1          8 TSLIVGVFLLYVLHTCWV--MYGI---------------------------------VYTKPCE--KRRAES-------- 42  zebrafish
1_pfamImport    1 TTLIVGVFVVYVLHTCWV--MYGI---------------------------------VYTKPCE-----KIQ-------- 32 
XP_002111968    7 GRATVVVFLSYMVYNFYA--LYLL---------------------------------FYPQQCSiVAKNENN-------- 43 
EDO33037        7 TTIALTVFGLYMLNSVYV--VYNL---------------------------------FYVPSCR-GNS--RE-------- 40 
XP_002637938    7 TKIVSTVFLSFMFYNFFQ--LYKL---------------------------------FTPELCA-DTDPDSN-------- 42 
XP_064409435    8 TSLIVGVFIVYVLHTCWV--MYGI---------------------------------VHTKSCDs--------------- 37  coelacanth
CBN75944      119 rqlsVHRCT---F---NRG--QKVD-LHVYMS--GsEDEasvwetqgEEAGergagpegeeGTANslpaRLLWHESNL-V 186
16_pfamImport  36 -------CIssyL---AAK--PRLQlMSVFTC--L-VPD--------NSQL------------------TLALRVDLFdP 74 
10_pfamImport  33 ----GEHCItsyL---TAR--ARLQ-MSVFTC--L-VPD--------NSQL------------------HLAVKIDPFdP 73 
XP_013126123   43 -------CItpfL---AGN--PKLQ-LSIYTA--LrSNA--------EGGH------------------TLIHKEENFdV 81 
Q6DHU1         43 -------CIspyL---AAK--PRLQ-LSVYT-----ALR--------PNA-----------DGGH----SLIHREEEFdV 81  zebrafish
1_pfamImport   33 ----NENCItsyL---AEK--PRLQ-LSIYTS--L-KPTg-------DGNQ------------------NLIFSMEDFeV 74 
XP_002111968   44 -------CLrpfL---KDD--AKLS-LQIYTSvkStKQS--------IRKL------------------SSIYTEEDF-H 83 
EDO33037       41 -------CLhphS---ILG--QNLE-LALYTStqPnARS--------IDSL------------------ELLWKKSNFdI 81 
XP_002637938   43 -------CYspiIrpnSEGlfDLLQ-LRVYFS----TKR----------------------DSLE----TLVTTVENVqI 84 
XP_064409435   38 ----NGNCIkpyL---AKK--PKLQ-LSIYTS--T-RSSis-----aESDV------------------SLILSVEDFdV 81  coelacanth
CBN75944      187 FAgEAGDmtrstTLKLDLP-PMlLNNGSAWAHVFLTKKGHSPnpnDPDYKDSGVSHQTAQ-LNRYLPKpkNKDGHYLVDS 264
16_pfamImport  75 HS-TFER-----QVSVSLPeET-QNNGSLYAVVYVHKAGVSP------LEDRREVHYAAQ-LTTYITP---------PST 131
10_pfamImport  74 DS-AFER-----QVNVSVPePT-RANGTLFAVVYVHRAGVSP------LEDSREVHYAAQ-LTTYITP-------AYRDG 132
XP_013126123   82 NS-KFER-----TINVSLPkKT-RNNGTLYALIFVHQAAHDP------WHDPRQVHSVAQ-LTTYMVP--KPPEISLISG 145
Q6DHU1         82 NT-KFEK-----LVNVSLPkKT-RKNGTLYAMVFLHQAGVSP------WQDPHQVHLVTQ-LTTYMLP--KPPEISLITG 145 zebrafish
1_pfamImport   75 FS-KFER-----KINVSIPkKT-RNNGTLYAFVFVHKAGVSP------WHDSKQVHHIAQ-LTTYMVP--KPQEINLIIG 138
XP_002111968   84 YHkAFTK-----SVNVTLPsAV-VKNGTLFAHIVIYPY-------LQMIDGHSLAYTIAP-LTRYAIP--KADTQHLLSS 147
EDO33037       82 FE-SFTE-----ILNASIPrRT-RNNGSLYVTVYVYPVGQTP------FRNNYMTSYASSaLTTYAVP--KDEVVNLLSG 146
XP_002637938   85 AD-AFQK-----ELKVKIPsSV-AKDGYLYAHTILLPHGFED---RNPMSAPWKVHVAAP-MIVFQEP--VAKTFQLLGE 151
XP_064409435   82 TS-KFER-----IINVTLPkKT-RNNGTLYAYIFLHHAGVLP------WHDSKQVHVVGQ-LTAYMIP--KPEEVNLITG 145 coelacanth
CBN75944      265 KKSAADAAVekerkel-----dekeaavALAGADRE-MINYWKPTLTLGQLDFTAIFQRNHIPSSFAGHITFQSST---G 335
16_pfamImport 132 KGQKASRK---------------------RESQRPV---SHWRPHLSITVMSEEFIFSKAGLPSDVRRYMRLSQEGr-rM 186
10_pfamImport 133 QRDTQKVKRystssp--------rsentV----------SHWRPHLAITLMSEDFTFNRAGLPSDVRRYMRVSQEGr-qM 193
XP_013126123  146 EDKTQGQKEgqqkkphdavpgggaragaTSVSDHPV---SHWRSRLTVNIVGDHFLFDREYLPNDVHRYLRVFQNGk-kV 221
Q6DHU1        146 QDEPEKPDQqkq--------------ssDSELDRPV---SHWRSRLTLNVVSENFLFDREALPGDVHRYMRVYQSGk-kM 207 zebrafish
1_pfamImport  139 EDTSQQSEPqk---------------ktNGLQDRPV---SHWRSRLTLNVLSEDFAFDREALPSDVHRYMRVIQYGk-rM 199
XP_002111968  148 SIQNRCSSPli----------------iLQTLNRPK---SHWKKTVSVRLMTEKFLFDMKQFPAEIFSLLRLTNGD---- 204
EDO33037      147 GKKSQPIK-----------------------DDLPV---SHWRPTLNFHVMSEKVAFNRYAIPGEIFSLLRYSRMMgknE 200
XP_002637938  152 DEAVVEKP---------------------KKAKKVVeLAAHFRTVLPVRIVSESSRFVKTKVSGELADFLTVQRQD---- 206
XP_064409435  146 KSNFQEEHTkse-------------rkeTKIPNKPV---SHWRARLTLNILADEFIFDGSALPSDVHRYMKIVTQGk-tV 208 coelacanth
CBN75944      336 NYHPVLYVNEFWLQQKHLLALNSTVESVDLELSISPISLWKFQTMSQLESQWAAQAkIGMAGdGEQDTFRELLAETNPIV 415
16_pfamImport 187 TYLPLLLVNELSCRVKDLMEINGSSMQLPLTVSYEGISLRTFRFWIHLHDI----------------------------- 237
10_pfamImport 194 IYLPLLLVNELSFRVRDLLEISSSTVQLPLTVSYEGISLRGFRFWVHLQDVVYSLRqFGFTE-ENIDEIKETLLGSNLYL 272
XP_013126123  222 VYLPLLFVDELSNRVKDLVEINSTTTELPLTISYDSISLGRLRFWIHMQDAVYSLQqFGFTE-KDADEIKGIFVDTNLYF 300
Q6DHU1        208 IYLPLLFVDELSNRVKDLMEINSSSTELPLTITYDSIALGKLRFWIHMQDAVYSLQqFGFTE-KDADEIKGIFVDTNLYF 286 zebrafish
1_pfamImport  200 LYLPILFIDELSNRVKDLMVINSSTTELPLTISYDTISLGKLRFWIHMQDAVYSLQqFGFTE-KDADEIKGIFVDTNLYF 278
XP_002111968  205 QYLPFLHVTEMSQTLRQAEVIDVNTTVKVLHIDYQPISVGALRFWVSMEESMKLIRkLGFSD-NDIDKVKGIFSSGNLKL 283
EDO33037      201 QYLPIVYIDELQVVYRHIQPLNKTSHQMPLNLKYSPISLGKLRIWSAVHQSMGMMKnLGFKD-KDLDEIRGLFTDTNLYL 279
XP_002637938  207 QYLPIMFVDEMSMRSKHLFELADFQKSVNLTINYEPTSVAKLLLLTSTARSTQQLMrHGFKD-KDIDELRGLFTETSIVL 285
XP_064409435  209 QYLPILFLDLLSNRVKDLMVINGSVTKLPLTISYDTISLGKLRFWIHMQDAVYSLQqFGFTE-KDVDEVKGIFVDTNLYF 287 coelacanth
CBN75944      416 LVITMIVSLLHSVFNFLAFKNDISFWKDKkRSLEGISVR----------GMLVNLFFQAVIFLSLADNDTTYMILVTNAI 485
16_pfamImport 238 -----------LICEFLALKNDICSWAKK-KSMVGMSRKnnltkhrlqmNVLWRCLGTLLIFLHLLEE-TSLLVLLPVGL 304
10_pfamImport 273 LVLTALITALQLICEFLALKNDFSSWRKK-KSMVGMSRK----------SVQWRSLSTLLIFLHLLQE-TSLLVLLPVGL 340
XP_013126123  301 LALTFFVAAFHLLFDFLAFKNDISFWKQK-KSMVGMSSK----------AVLWRCFSTIVIFLYLLDEQTSLLVLIPAGI 369
Q6DHU1        287 LALTFFVAAFHLLFDFLAFKNDISFWKHK-KSMVGMSSK----------AVLWRCFSTIVIFLYLLDEQTSLLVLVPAGI 355 zebrafish
1_pfamImport  279 LALTFFVAAFHFFFIF-CFLNDVXFFSHQ-KTQVKTTGN----------AVLWRCFSTIVIFLYLLDEQTSLLVLIPAGI 346
XP_002111968  284 LLLTFVISLVHVLLDFLAFKNDVNFWKGR-KTTAGLSPT----------TVIWHSFSYSVIFLYLLDEDASYLVIVPLGI 352
EDO33037      280 LGLTFLISIFHLLFDFLAFKNDVNFWQNA-DSMVGLSSR----------TVIWRCVCSIIIFLYLMDEKASLLVLFPQGI 348
XP_002637938  286 LMITFFVSTLHLLFDALAFKNDISFWKGR-KSMVGLSTK----------TLLWRCFSQTIIFFYLFDQETSLLVLIPSGI 354
XP_064409435  288 LALTFFVAAFHLLFDFLAFKNDISFWKGK-TTMVGMSTK----------AVLWRCFSTIVIFLFLLDEQTSLLVLVPSGI 356 coelacanth
CBN75944      486 GLAIEVWKVGRFMVGRLDWggeDGQprrwVPRMMFQAKESYRKS--KTKEFDDVATAHLLYLVGPLMVGYAAYSLLN 560
16_pfamImport 305 GACVEVWKVFKVFKIQITF---ESS----KPPLISSQTNKLDEEerKTVEYDTQASRYLSYLVYPLCISGAVFSLGY 374
10_pfamImport 341 GACVEVWKVFTVFKIQFQW---KSS------KLHV---NKLDEEerKTVEYDTQASRYLSYLVYPLCISGAIFSLAY 405
XP_013126123  370 GSMIEVWKVKKAFKIQVFW---KGG----KPTFLF---GKLDESerRTEEYDTLAMKYLSYLLYPLCIGGAVYALIF 436
Q6DHU1        356 GSLIEVWKVKKAFKIHVIW---RGL----TPTFLF---GKLDESekRTEEYDTLAMKYLSYLLYPLCVGGAVYALVF 422 zebrafish
1_pfamImport  347 GSIIEIWKVKKAFKIHVLW---KGL----KPTFQF---GKSDESerKTEEYDTQAMKYLSYLLYPLCIGGAVYSLIY 413
XP_002111968  353 STIIEIWKLAKVFKVTLERk-pEHW----LPSIQF---GQRSKAeqESESYDLEAIRYLSYFLYPLVLIGAIYCLIY 421
EDO33037      349 GSIIEMWKLTKALKVTIIW---RGA----KPTLKF---GERSTQekQTDEFDGEALYYLKYVMYPLVVASAVYSLLY 415
XP_002637938  355 ATVIEYWKVTIAYKVSISW---RGI--------KF---GKHSAEedETDSIDAQAMKYLSILLVPLVIGGAVYSLLY 417
XP_064409435  357 GALIEVWKVKKAFKMSILW---KGL----KPTFQF---GTYNESekKTEKYDTQAMHFLSYILYPLCIGGAVYSLLY 423 coelacanth
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap