Conserved Protein Domain Family
Chromadorea_ALT

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pfam05535: Chromadorea_ALT 
Chromadorea ALT protein
This family consists of several ALT protein homologs found in nematodes. Lymphatic filariasis is a major tropical disease caused by the mosquito borne nematodes Brugia and Wuchereria. About 120 million people are infected and at risk of lymphatic pathology such as acute lymphangitis and elephantiasis. Expression of alt-1 and alt-2 is initiated midway through development in the mosquito, peaking in the infective larva and declining sharply following entry into the host. ALT-1 and the closely related ALT-2 have been found to be strong candidates for a future vaccine against human filariasis.
Statistics
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PSSM-Id: 398919
Aligned: 6 rows
Threshold Bit Score: 108.802
Threshold Setting Gi: 393904558
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_001896178  42 ATFINTDGIQKLCTSHADCYDMREPIYWCRLKRN-QHWTEKGCYCDSVLRACIIER----MTDLgpaskirNYAYCTPRA 116 Brugia malayi
1_pfamImport   2 AHFERTAGIELSCSSDHDCSNTGEPNEWCNSDRRgYQWTTRSCHCDLKLGACTVQRydkrTNDV-------QWAYCTPRN 74 
XP_002643374  52 GHFVRTAGISMPCTADHDCMENMEPNEWCNSERNgFQWAASGCHCDLKLKTCIMQRfdrnYNEI-------QWAFCTPRN 124 Caenorhabditis ...
Q27GT6        52 GHFVRTAGIGMPCETDQDCIHNMEPNEWCNSERNgYQWTTAGCHCDMKLKSCIVQRfdksYNEI-------QWAFCTPRN 124 Caenorhabditis ...
EFO14886      41 ATFINTDGILNPCTSNVDCYKMREPVFWCRLAKI-QQWTDKGCYCDPILNACVIER----KTKLgpitiirNYAFCTWKE 115 eye worm
EFO18446      23 ASFISTDGIQKLCLTHADCYDMREPIYWCFLAQN-QQWTDKGCYCDPVLKACIIER----MTKLgpaskirNYAYCSPKA 97  eye worm
XP_001896178 117 FWNC 120 Brugia malayi
1_pfamImport  75 RFRC 78 
XP_002643374 125 RFRC 128 Caenorhabditis briggsae
Q27GT6       125 RFKC 128 Caenorhabditis elegans
EFO14886     116 SWEC 119 eye worm
EFO18446      98 FWEC 101 eye worm
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