Conserved Protein Domain Family
Sarcoglycan_2
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pfam05510: Sarcoglycan_2 
Sarcoglycan alpha/epsilon N-terminal domain
Sarcoglycans are a subcomplex of transmembrane proteins which are part of the dystrophin-glycoprotein complex. They are expressed in the skeletal, cardiac and smooth muscle. Although numerous studies have been conducted on the sarcoglycan subcomplex in skeletal and cardiac muscle, the manner of the distribution and localisation of these proteins along the nonjunctional sarcolemma is not clear. This family contains alpha and epsilon members. This entry represents the N-terminal domain.
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Statistics
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PSSM-Id: 487805
Aligned: 5 rows
Threshold Bit Score: 154.994
Created: 14-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
O43556        49 NVYPSAGVLFVHVLEREYFKGEFppypkpgEISNDPITFNTNLMGYPDRPGWLRYIQRTPYSDGVLYGSPTAENVGKPTI 128 human
XP_002014839  24 TLQANVGELFTYKIEPHLFNWTH-------QVISEQFSYRPTMRNYPDLPTWMRYEYSHEYHAGFLYGTPPETEAGKALS 96 
XP_049544642  28 TDDVSVSELFSLRIEPRMFNWSY-------EGLSEQFHYRSSLEGYPDLPSWIRYMYSTEYHSGFLYGTPPPRTADTRVP 100
EDW04061      21 HLQANVGELFTYKIEPQLFNWTH-------QVISEQFRYRPSLENYPDLPSWMRYMYSHEYHAGFLYGTPPDSVAGKTLN 93 
Q9VLQ0        22 KLQANVGELFTYKIEPQLFNWTH-------QVISQQFRYRPSLKNYPDLPSWMRYMYSHEYHAGFLYGTPPASSAGKDLS 94  fruit fly

O43556       129 IEITAYNRRTFETARhnLIINIMS 152 human
XP_002014839  97 IEVIALNRQNFETRI--TDLAMSV 118
XP_049544642 101 IEIIALNRMSYETKR--LVLMLAV 122
EDW04061      94 LDLVALNRQNYETRQ--LIITMFV 115
Q9VLQ0        95 LDVVALNRQNYETRR--VVVTMFV 116 fruit fly
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