2D8R,2JTG


Conserved Protein Domain Family
THAP

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pfam05485: THAP 
THAP domain
The THAP domain is a putative DNA-binding domain (DBD) and probably also binds a zinc ion. It features the conserved C2CH architecture (consensus sequence: Cys - 2-4 residues - Cys - 35-50 residues - Cys - 2 residues - His). Other universal features include the location of the domain at the N-termini of proteins, its size of about 90 residues, a C-terminal AVPTIF box and several other conserved residues. Orthologues of the human THAP domain have been identified in other vertebrates and probably worms and flies, but not in other eukaryotes or any prokaryotes.
Statistics
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PSSM-Id: 398893
Aligned: 517 rows
Threshold Bit Score: 37.445
Threshold Setting Gi: 0
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2D8R_A          13 AAAGCATtynkH--In------ISFHRFPLDPkr-rkEWVRLVRRKnfvPgk---htFLCSKHFeascf----------- 69 
XP_005464564     6 AALGCSN----Qr-NantkqqgITFHRFPKDKvk-rqLWKMALKRR---DfepndrsVVCSCHFkaedfd---------- 66  Nile tilapia
XP_003977975     6 AAYGCSNernaQtkSr-----gITFHRFPKDStl-rkQWELAVKRKdfvAsg---rsLLCSEHFrphef----------- 65  torafugu
XP_003200143     6 VAVGCKNryttAnkAr-----gITFHKFPKNIes-rkQWELAVKRGv-sAsr---ysVLCSEHFrpedf----------- 64  zebrafish
XP_009013824     6 AAYGCKSgyksNaaIdae--nkVSFHSYPVNDpelcaKWNKANPRR---DfipsrhsKMCSLHFrpsdfvdkysdtnstr 80  Helobdella ro...
157_pfamImport   1 ---QCRE----------------RWHNHLDPSvn-knSWTEDed------------lIICSAHK---------------- 32 
XP_420555      349 RALGVRIn---PqrIr------CAFHHPPSSAhc-iaYFFDVCH----------------ALHLi--------------- 387 chicken
EEC02950        14 AVSRCKPsdrdAkyI--------SSHGVPEDKnl-raSWLEAIGRSpsdKff-----rVCSRHFaadafk---------- 69  black-legged ...
XP_003968654   227 KITICGD-----------------THGQYYDL-------LNIFKLNglpSet---npYLFNGDFv--------------- 264 torafugu
XP_007250950     6 VAFGCYNrrntEtrSr-----gITFHKFPSNIdl-rrQWEFAIKRErfvAsq---ssKLCSEHFepdd------------ 64  Mexican tetra
2D8R_A          70 --------dltgqTRrLKMDAVPTIF 87 
XP_005464564    67 --------rtgqtTR-IREGVIPSVF 83  Nile tilapia
XP_003977975    66 --------dstgqTVrLRHGVKPSVF 83  torafugu
XP_003200143    65 --------drtgqTVrIRDGVKPSIF 82  zebrafish
XP_009013824    81 yknktsnsesrikQE-LKPGTIPTIF 105 Helobdella robusta
157_pfamImport  33 -------------RLgTRWAKIARLL 45 
XP_420555      388 -------------RN--------TLQ 392 chicken
EEC02950        70 --------prtgaRLqLKPGVIPTLF 87  black-legged tick
XP_003968654   265 ------------dRGsFSLEVILTLF 278 torafugu
XP_007250950    65 ---------fdrtGQiVRlrdgaips 81  Mexican tetra
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