Conserved Protein Domain Family
Prominin

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pfam05478: Prominin (This model is not part of the current CDD release)
Prominin
The prominins are an emerging family of proteins that among the multispan membrane proteins display a novel topology. Mouse prominin and human prominin (mouse)-like 1 (PROML1) are predicted to contain five membrane spanning domains, with an N-terminal domain exposed to the extracellular space followed by four, alternating small cytoplasmic and large extracellular, loops and a cytoplasmic C-terminal domain. The exact function of prominin is unknown although in humans defects in PROM1, the gene coding for prominin, cause retinal degeneration.
Statistics
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PSSM-Id: 516831
Aligned: 27 rows
Threshold Bit Score: 786.047
Created: 14-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_002068992  105 TTHEQQGQVHWPPVEFTPYKSKANYTKDTWSSSTAMSPIYNFTHFLYDSILTYepALPPGYIVIKDKdtlalgpkveqND 184 
XP_002046099   57 TAHEKLGQLHFSTAEFTEYKSKANYTKEPKYSTKAMDPVYNFTRYFFGFILPDeaAIPPGYVVVKDGnylalgpkvenND 136 
XP_002046100   53 TTHEQLGQQHYPSADLTVYKSKIRYTIELNRTSWNIKPAFNLSQFFFDHTITDtpSLPRGYLAVKNGdtlvmgpkvvdND 132 
EDW31127       92 TTHEQVGQVHFPKPIYTKFNGFFNYSRDLSSTTKAVNPIYNFTHFIFGTVMTDepALPPGYIMVQQEkvlvlgknverNE 171 
EDW32791       39 TTHEQLGQDHWPSVEYSPYLGFGNYSLDLTSSQKALSPVNTLTHFALRLFLSD---LPPGYVTTTANnklvlgpkvwkND 115 
XP_002016054  101 TTHEQLGQDHWPSAEYSPYRGFGRYSRELASPRKALSPINTITHFILRSFLSD---LPPGYVTSTDNnklalgpkvwkND 177 
XP_001352734   95 TTHEQMGELHWAPVDYTPYKPTVNYTRPPTAPTTAMNPIFNFTHKLYDSIISDepALPPGYIVMQ-GdslalgpkfhnAD 173 
NP_001261352   76 TTHEQLGQPHWPPVQYTVYRPTTNYTKAPPPPTSAMNPIFNFTHFLYDKVLYRdePIPEGYIVVKNSdtlslgpkveeND 155 
XP_001957034  103 TTHEQLGQPHYAPVEYSAYTPTSNYTEEPGPPTSAMNSVYNFTHFLYDKIIYRnqPIPDGYIIIKNGdtlalgpkveqND 182 
4_pfamImport    1 PGATDCGSLSPAEHLVFTPAARARWLAPRVRPRGPLDPLYGTVRRFLSMVQLN--PFPAELVKALLN-----------EP 67  
XP_002068992  185 WAALLAE---YWL-ILAWVFFLLILIILIPFIAVCYCCf-C-CCRRCRQGCpPCTSKQDARRRCCCGILLLLLIIGLIFG 258 
XP_002046099  137 WRDLLTQ---YWM-VLIAVVILAILAVIMPIIAVCYCCf-C-CCRRCKEGCpPCDSQKDARRRCCCGLLLLLLIIGILFG 210 
XP_002046100  133 WSDLLGQ---YFL-LILWVIILVVLIILIPFLAVCYCCf-C-CCRRCKRGCgPCDEANDKRRALICAVILALLLVFILLG 206 
EDW31127      172 WSLLMSR---YWL-VLFFVIFLLAAIIVIPFIAVCYCCf-C-CCLRCKQGCiRCMAATDRRRRMCCGICLFLLIIGLIFG 245 
EDW32791      116 WAALLAQ---YWF-LLVVVISLLFCIIIIPFIGVCYCCf-C-CCLRCKQN----KRSNEFRRRCLCSVCLALLVIGLMLG 185 
XP_002016054  178 WAALLAQ---YWF-LVVVVIILLVCIIIIPFIGVCYCCf-C-CCLRCKQH----KISESFRRRRLYGVCLGLLVVSLMFC 247 
XP_001352734  174 FRDLIAR---YWL-VLLFILFLCVIIVVMPFVAVCYCCl-C-CCRRCRQGCpPCTSKQDAQRRLWCGVCLLILIVGLIFG 247 
NP_001261352  156 WRDLLAH---YWM-VLIWVVILVVLIIVIPFIAVCYCCf-C-CCRRCRQGCpPCTSKQDAQRRFCCGICLLILIIGLIFG 229 
XP_001957034  183 WRDLLRH---YWL-LFIIVFVLLLLIIIVPFIAVCYCCf-C-CCRRCRQGCpPCTTKQDAQRRFCCGICLLLLIIGLIFG 256 
4_pfamImport   68 ASVKVNEvvrYEAgYVVCAAIAALYLLVVPTAGLCFCCcrCrCRRRCGGRV-KMEHKAVAWERGTLMACLLLTTLVLLIG 146 
XP_002068992  259 IIIAFATNRMLNQGFEDTTTTIRRGSEDTCTFLRDVSNHIYHLFVYnYEEVETHLIDSLNNAHKHIFLDLADTSESS--- 335 
XP_002046099  211 VIIAFATNRLLDRGLEETTTTMRRGSQDTCTYLKDVSDHIHHLLVNnYGEMDKHLSDILTNAHTHIFLDLMDASEAN--- 287 
XP_002046100  207 AIIGYTSNRGLDRGLAETASTVRRGNEDTCRFLEDVNAHIHHIFVYnYEELEAHLTDMLNNAHHHIFLDLADTSESN--- 283 
EDW31127      246 LLIAFVTNKFLHRGLQESMVTMRRSSEDTCTFLRNVADHIHHLLVFnFQELEMHLIEQINDAHNHIFLDLADASDSN--- 322 
EDW32791      186 LFIMFIANKFVDRGLEDSNMTMKRASRDTCTFLKDVADHIYHLLVYnYQELEAHLEDQLNNAHDHIFLDLGDTSEST--- 262 
XP_002016054  248 LLIMFFANKFLDRGLADSNMTMKRAGQDHCTFLKEVADHIYHLMVYnYQELEAHLDEQLSTASNHIFLDLGDTSESN--- 324 
XP_001352734  248 IVIAFVTNRLLDRGFDQATVTMKRGSDDICLFLKDVADHVHHLMVYnYEEMQTHISDELSSAHKHIFLDLADTSEST--- 324 
NP_001261352  230 IIIAFVTNKMIDSGFAETSETMKRGSEDTCTYLKDVADHVHHLMMYnYEEMETHVLDQLTHAHRHIFLDLSDTSESN--- 306 
XP_001957034  257 IIIALVTNRMLDDGFAETTDTMQRGGQDTCTFLKDVSDHMYHLMVYnYEEFETHVTDQLNQAHKHILLDLADTSESN--- 333 
4_pfamImport  147 LVYAFVTNQRVHEEMQSGVEAVPETLLSLRGLVSDVPQELQSVAQQ-FSLPQERVLQELDGVGVSIGQAIHTQLRSTvyp 225 
XP_002068992  336 ALSELERILDNMPEALALMRQVDKLEKDLRFYGSQLRDGVRGLKRDINYNVAN-LCNt--QQCQNFLETSNIelIDTSKC 412 
XP_002046099  288 AVYDLKRILENMEEAQKLIKEVDKLEKDLRFYGTQLRDGVRGVKRDVNYACAV-LCGn--RECLHFLKKTEIefLDNSKC 364 
XP_002046100  284 AIEHLDRIFDNMKEARALMKQVVALDKDLRFYSTQLRDGVRGAKRDVNYACSN-LISn--NKCKQFLRNSELefVDTSSC 360 
EDW31127      323 ALIELERILDSMPLAHPKMKQLEYLEKELRFYMSNLRDSIRGLKRDMTYTVTH-YCGntkERCYKTMAEKSVlyMDTSTC 401 
EDW32791      263 ALAEMERILNNMPKALKIMLQVEALEKDIRFFGSQFRDGMRGQKRDLSYAAYA-LCHl--EKCYKFNHDMGVvtYDVSKC 339 
XP_002016054  325 ALIEMERILANMPRALMIMSQVDDLEKDIRLFGSQLRDGLRGQKRDLSYAAYA-LCHl--PKCYKFNHDMGIttYDVSKC 401 
XP_001352734  325 SLGELERILHNMPEARQLMEQVAKMETDLRFYGAQLRDGLRGMKRDINFAVAN-LCTt--QECQTFLSSSSIelIDTSKC 401 
NP_001261352  307 SLAEMERVLENMPEALELMRQVEKMEKDLRFYGSQLRDGVRGIKRDVNFAVAN-LCQl--QMCQKFLISSNIehIDSSQC 383 
XP_001957034  334 SLAELERILDNMPEALQLMREVEKLETDLRFYGAQLRDGVRGIKRDINFAVAN-LCQl--QACQKFLITSNIeyIDTSEC 410 
4_pfamImport  226 ALTSVLSLGQALQVSVDHLRVLNATSVELWKGQEELEPVLVESRERLLAVLQQpSCQ----GCSGAVSQARA--LELGAD 299 
XP_002068992  413 IhfDQIPNTTVYVENMAEIIQENYAIIPKMAIERLQTVNEKVRMVMSHVVPPLIRDVQAGKEIFQTQATNI--RNIIDAV 490 
XP_002046099  365 LqfDQLPDTTYYSKAIEYIIAKNSGKTTKEVIDRLQYVGKRIKAGIDPLIPPIIRDIHNGQEQFRTQANNI--RSMIDAA 442 
XP_002046100  361 LhlDNMPNTTLFLEGIEQIIKDDVAIIPKKALERFQDIASKIETAMNQVIPPLLHDINQGREKFRIQAANI--HRTIESV 438 
EDW31127      402 LhlDELPNTTVYVEAVEMIIKKRYNLIPKLALVRFNKVREKIKEQMELVGPPLKRTIATGHSIFDDRALKI--RNMIDAI 479 
EDW32791      340 LhlDLIPNTTIFVEAMKQIIEDKLYQIPIRGMARLKKVKDIILKQMKLVLPPIFRSLTRSRIMFLNEAIEI--RDLIDSM 417 
XP_002016054  402 LhfDLIPNSTVFVEGMKKIIMDKTYLIPLSGLARLKNIKDLIVKHMALAFPPVFKSLAGARLMLLDEATGI--RDLIDSM 479 
XP_001352734  402 LhfDTIPNATLYLEGLNIVVKENYIKIPTDGLTRMENVSLKVKEQLNSVTPSMIRDLNGGRDTFRSHARRI--RNQVDAV 479 
NP_001261352  384 LhfDNLPNTKEFVEGMENIVASEYYAIPQRGLSRLKKVSDKVKTQLSFVVPPMMRDLTKGRTIFREHATNV--RNIVEGV 461 
XP_001957034  411 LhfDKMPNTSSYVKGMEDIVNGNYHLIPQAALARMQKINGKVMEHMTNIIPPITQNLGKGRATFRDTATEL--RNKVDAV 488 
4_pfamImport  300 F--RQMPPVDNVLQRLKGVPEANFSSMVQEENSTFNILPFLAAQQTADVVRELKKTVAQEPEGLRTLAKEFpgSEAASRW 377 
XP_002068992  491 LSDIHlNTLRSTKSFDDVYEKFGEDRSLVSVIVCMLILLILFVLIIALLCGCFGRRRSGYG-DDCCSKATGATCLLLAIL 569 
XP_002046099  443 ISDIHlNTVRSTKAFEDVYDKYGADRSIINVIVCSVLLIILLFLIIALICGCCGRRRRGYR-DDCCSKGTGASCLLLAML 521 
XP_002046100  439 ISDIHmRTLRSTESFEDVYEKFGKSRSYINALVCIFLLVIVILMAVGLICGCTR------------SKPTGATCLLMGII 506 
EDW31127      480 ISDIHlNTMRSTKTFDDVYEKFGTDRRTINIICITLIFIIIVFLFTSLVCGVGGYSRTHPGpSGFCSKGMAASCLLIAII 559 
EDW32791      418 ISDIHlNTLRTARTFDDVYEKFGEDRRTINIVIFLLIFIIIVILISALVCGFLGPNRTMPGpPRVFSKGMAASCLFIAII 497 
XP_002016054  480 INDIHlNTLRTSRMFDDIHDKFGADRRAINIVICILIFIIIVILISALVCGCLGPSRTKPGpSGVFSKGMAASCLLLAII 559 
XP_001352734  480 LSQIHlKTSRSSRSFDDVYDKFGNNRSVISVIVCLLMIMILGILIVSLLCGCFGRRKTGYR-DDCCSKATAANCLFLAIL 558 
NP_001261352  462 LSDIHiKTLHSTKSFEDVYERFGHDRNVVSLIVCLLILLVLFILIFALLCGCFGRRRTGYG-DECCSKSTGATCLLLAIL 540 
XP_001957034  489 ISDIHlKTVRSSKSFDDIYERFGPDRSVMSLIACMLILLILFILVVALLCGCFGRRRTGYG-DDCCSKATGASCLLFAIL 567 
4_pfamImport  378 TQALE-DMEQDSRSYVQEVQRYERYRWIVGCVLCSVVLLVVACNLLGLGLGIWGLSAREDLsYLEAKGKTGARFLMTGMG 456 
XP_002068992  570 LIFCVFSFITLVGLLYFMIGLVTYQGGCAPWrdqDQNALFRQIDSV------IDLNRYLpketn--rdndeLVVPPFRMS 641 
XP_002046099  522 LIFCVFSIVVLVGLFYFVVGLATYQGACAPLrdqESNALFRQLNSI------IDLNQYLpkse----lkseTPLPPLRIS 591 
XP_002046100  507 LIFAVFSFLVLIGLFYFMVGLVTYQGACAPLrdlDKNALFRELDAV------IDLNRIIrardegrtseveETGEELHMS 580 
EDW31127      560 LIFCVFSFITMVGVFYFMIGLVTYEGACAPTtqdEKYELFRQLDAV------IDMNRYLrptn----pgdeWVMPPLHMS 629 
EDW32791      498 MIFCVFSFITLVGLFYLIIGLITYTSACAPLkndQN--IFRYLDPV------IDINRYMsgst-----evrEPFSTLPVS 564 
XP_002016054  560 LIFCVFSFITLVGLFYLMIGLITYTSACAPLkdgQN--ILRHVDPV------IDLNRYMsgr-------sgDTQPTLPVS 624 
XP_001352734  559 LIFCMISFITLMGLVYFMIGLVTYQGACAPLrdvDKNGLFRQLDSM------VDLNRYLpradd---aeplKAAPPLRMS 629 
NP_001261352  541 LIFCVFSFIALVGLFYFMLGMVTYQGACAPLrdqENNTLFRQLDAS------IDLNHYLppse-----snkEVVQPLKMS 609 
XP_001957034  568 LIFCVFSFLTLIGLFYFIVGFVAYQGACAPLrdqENNAFFRQLDST------INLNDYApav-------gdDDRPPMRMS 634 
4_pfamImport  457 FSFLFAAPLILLVFATFLVGGNVQTLVCRSW---ESRELYEFVDTPgnlppsLNLSYLL------------GLKKDISIL 521 
XP_002068992  642 SAIKACEANQSIFDMLRTNKIYDINDISRISVMTsheSDDSDHGPIFNEDLSTVVLLTAEERNRLNKLRNGNLSTYHSSL 721 
XP_002046099  592 NAIRACQADQSIFKLLQENDLYDIDDLVRFKVIS-----ETPSVPISLANLDNFTILTEKDKRDLAELRGSNLSSYHSKV 666 
XP_002046100  581 KAIKACNQNQSIFDLLKHNNIYRVEDLTSISIMSe-sKEEDKKESIFEEDLSTVYLLTSDERIKLEKAHTGNLSGYHSVL 659 
EDW31127      630 EAVRSCRANESIFQLLRTNNIYDINDLANIILLP----DIPEEAPVFTEDLTKLEILTESEKILLNKVRNSNLSTYHSML 705 
EDW32791      565 EAIRACNANESVFQLLRAKNIYDIKKLLNLEVFV----DGFEDPPLFTGDLSNVELILEKEKLLLTDMREGNLSEYHSSL 640 
XP_002016054  625 DAIRACNANESIFDLLRAKKIYDINNLLNKEIFV----EDFEDPPVFTGDLTTLKLILEEEKVHLNKMRAGNLSEYHSIL 700 
XP_001352734  630 NALKMCEANQSVFDMLRANRLYDINELKRIKVMSs--EEDSDSTKIFDEDMSKTELLTKEEFGKLEAMRQGGAANYHSEL 707 
NP_001261352  610 SAIKACHANQTIFDMMRQHNIYDINDLTRIKVMSh-sQENTDSIKVFDEDLSTVVLLTKEERDELKTAGESKLAKYHSSL 688 
XP_001957034  635 GTIKACHANQTIFNVLRDHHVYDIRELARVKVLTe-pDDDSDSSKFFDEDLSNTVLLTDAERKDLNTVKETNLSAYHSAM 713 
4_pfamImport  522 MAYEQCKEGAALWSVLQLNNSYDLEKHLDISQYT---AQLQQELQSLGVDVHDLDLLSPAARRDLDALQSSGLEKIHYPG 598 
XP_002068992  722 YMEYLCKEFTPMDLRSLAQS-IDSMYNSLeyp-----tyaWAKIQFYNAVYSMRAFHDNFVIKLSGIVDKMRENLKKIDE 795 
XP_002046099  667 FTDVMCTQLTPVDLPTMANQ-LKELRASLwsqw---giydWARTSLYNEAYNLQRYHDEFVEKIKSIISKMTEKLLKIDE 742 
XP_002046100  660 YVENMCQALTP-SLPTISAA-LRKLQDDLyynsrwdsytrYGRIALLNEAYHFDMYNYEWTDKILKIMGKMKQKLLKIDD 737 
EDW31127      706 YDQNLCLKLSNNDLEVLANVlLEDLATDEavl------kiDGRVHSILHKYSALAYHKTFYLPVQRGIKKALKVVKEIDT 779 
EDW32791      641 YSEHLCTKFIHTDFSIIKSK-SMAFVYEIntky---lkgwSGVIAYYLAAVDLIRYGNYFLDPLTSAVKKLLEKVKEIDK 716 
XP_002016054  701 YSEHLCTKFTHTDYSILKTK-TRAFAYEIntry---lkgfPACLAYFLASSDLAKYDKYLVVPLTNAVNKALQKVNEIDS 776 
XP_001352734  708 F-KDLCSEFTPVNLNALGEK-MYALSNSLesp-----tfgWARVSFWNEGLNAKSYYQNFIPKLTTIVEKMKSNMKRIDE 780 
NP_001261352  689 YMPSLCTQFTPMNLNALSEQ-LYKLSNDLeyp-----aygWAKVSFWNEGLNTKAFYRNFVPKLTSLVEKMKANLKKIDE 762 
XP_001957034  714 YLMNLCNQFTPMNLNALAEQ-MYKLSNDLeyp-----tygWAKVSFWNEGLNTKAFHRNFVPKLNSIVEKMRHNLMKIDE 787 
4_pfamImport  599 FFAQIQEPVVKTSVEKLAQE-LEGLAQAQgn--------aSMGRQLQEELQALRRLYQDRVQPQQTLVAKLNGSVRVLAS 669 
XP_002068992  796 lilyENHDFNSSITILVAAVLRSEHFIQTRGKEYINLLGSNLTVELTEQIEDYVNMVITESNDNVGHCAPLSYIYYRGVD 875 
XP_002046099  743 lilyNGNAFGESIKKLHESTERSEVFLRANGEQYVSGLRANLTSYIKEQVVQYIEMVVDKCHGNVGKCAPLAQVYNRSVD 822 
XP_002046100  738 lilyENRNFTNSITVLANAVIRAENFLKGRGSHFINSLGQNLTDVVNEQVDEFIRGIMDECSRKVGRCAPLSYIYYRGVD 817 
EDW31127      780 lilyLNHDFGNSIEILLTAVINAENFVRKRGAEYVNNLGYNLTSAINEQVEEYINMVITEANNKVGLCQPLAYIYYEGVY 859 
EDW32791      717 lilyDNNNFGDSFKILMDAVERSENFIRNKGNDYINHLANNLSTSVNLQIQEYVERVIREAENNVGHCKPLAYIYHQGAS 796 
XP_002016054  777 lilyDNNNFGNSIGVLMDAVQRSEDFIRYKGNNYINNLAHNLSISVNLQLQEYIERVISEVNKNVGHCKPLAYIYSQSAY 856 
XP_001352734  781 lilyENRDFNNSIRLLLKAVRESQNFIQTKGTRYINELGKNLTSTISNMIDEYISMVIDESNENVGRCEPLAYIYHQGVD 860 
NP_001261352  763 lisyENHDFTNTIKILTATAINSEQFIQTRGKDYINALGGNLTNSIDQMIDDYIDMIIKEANESVGHCAPLSYIYYRGVD 842 
XP_001957034  788 lilyENQDFATTIKILTETAIASEKFIKTRGNDYINTIIDNMTESIHENYDKYVDMVINDAEYNVGHCAPLAYIYYRGVD 867 
4_pfamImport  670 ----SAPNLQLETKGILDQATYLKGELPAWATRILRNESECYLTREMGYFSQYVAWVREEVTQHIATCQPLSGALDNGRV 745 
XP_002068992  876 LICHRLVDPINGFWVGVLLCSLLFIPILFVAHRLMCLYK 914 
XP_002046099  823 LICHRLVDPMNGFWVGVLLCGVLFLPVLFVAHRLLCLYK 861 
XP_002046100  818 LVCYRLVDPINGFWMGILPAALLLLPLLYVAHKLMCLWK 856 
EDW31127      860 FVCSRLVDPINGFWLGLLLCSILLLPTLVVCHRLMCLYL 898 
EDW32791      797 LICERLVDPINAFWLATIFCCMLLLPVLLVAHCLMCLYS 835 
XP_002016054  857 LICERLVDPINAFAMATLLCCMFLLPVLPVAHRLMCMYL 895 
XP_001352734  861 LVCRSMVDPINGYWVGVLLCALLFLPILYVSHRLMCLYK 899 
NP_001261352  843 LICHRIVDPINGFWVGILLCALLFLPILFVAHRLMCLYK 881 
XP_001957034  868 HICHRIVDPINGFWVGILLCALLLLPILFVAHKLMCLYK 906 
4_pfamImport  746 ILCDMMADPWNAFWFCLAWCTFFLIPSIVFAVKTSKYFL 784 
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