Conserved Protein Domain Family
ApoL

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pfam05461: ApoL 
Apolipoprotein L
Apo L belongs to the high density lipoprotein family that plays a central role in cholesterol transport. The cholesterol content of membranes is important in cellular processes such as modulating gene transcription and signal transduction both in the adult brain and during neurodevelopment. There are six apo L genes located in close proximity to each other on chromosome 22q12 in humans. 22q12 is a confirmed high-susceptibility locus for schizophrenia and close to the region associated with velocardiofacial syndrome that includes symptoms of schizophrenia.
Statistics
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PSSM-Id: 487776
Aligned: 30 rows
Threshold Bit Score: 381.225
Created: 14-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_007503451  171 LSEDEAWERFFADSSSMREKATQLSETLYGLFGDKVLDDTNGqDGSLSDEDKIFLKEFPKKKMELEERIQDLHAIADQVD 250
Q9BWW9         51 VNLCQSWKINNLMSTVHSDEAGMLSYFL--FEELMRCDKDSMpDGNLSEEEKLFLSYFPLHKFELEQNIKELNTLADQVD 128 human
1_pfamImport    1 LFDAKAWEMLVQRSGLDRDEANILYHML--MEELMQNKEASM-LENLSEEEKIFLFWFPLQKNNLKKNIRELHALADQVD 77 
Q5U1W1         31 LTKDEAWKVFVAEAELSRDEEASLHEALKLLLKLPTWEDKVR-LQKELQDRKKFVEAFPQLKRKLQENIRKLRALADHLD 109 Norway rat
Q8VDU3         11 VAEDGVWQAFVSKAKLSRERAVALHKALRELTALLAIADRGR-LQKGLKGREKFLKVFPRLKAELVEHISQLHALADHAE 89  house mouse
Q5XIB6         11 LTAEGAWEEFVSKAKLPRDRAVALHKALRDLTALLAIAERGR-SRKGWKGKEKFVKAFPCLKADLEEHISQLYALADHAE 89  Norway rat
XP_013008670   33 LTDDVAWEIIVETTDLTRKEADAVREALTDLQADC---------DEDFQARKRFLNEFPNVKKEMQEHIAKLYALAERID 103
EHB14171       33 LTHSGAWEVFVEMAKLTREEADALREALNVCTADT---------DEDLRARERYLKEFSEMKMELQKQIAQLHALADRID 103
2_pfamImport    1 LTEDKPWENFVTEANLSREQADVLREYLTKVQTVLAGEDQDR-LQKYQQKKERFLKEFPQVKEELKESIKKLHELADNVD 79 
10_pfamImport   1 LTEEKPWEHFVTEADLSREEADGLREYLIKVQTVLAGEDQDRlLQKYQQEKERFLKEFPQVKQELKENIKKLRELADSVD 80 
XP_007503451  251 KTHKKCIITNVVAGSTSIISSIVTIMGLALAPVTAGGSLILSASGFGLGALAAITSLSSSVIERVGNLTAKERVSNHKGT 330
Q9BWW9        129 TTHELLTKTSLVASSSGAVSGVMNILGLALAPVTAGGSLMLSATGTGLGAAAAITNIVTNVLENRSNSAARDKASRLGPL 208 human
1_pfamImport   78 AKHKMLTKTSLVASSSGTVSGVMSILGFALAPVTVGGSLMLSAAGLGLGVAAVATNTLTSILERNSNSAARDRASRLVPV 157
Q5U1W1        110 QVHKGCTISNVVTNSTSAASGVLSILGLALAPVTAGGSLLLSATGLGLGTVATVTGAATEIVEQTNKWLDEAEARRLLSD 189 Norway rat
Q8VDU3         90 KLHRGCTISNVVADSFSAASDILSLLGLFLAPVTAEGSLVLSATGLGLGVAATVTDVATSIVEETSRVLDEVEAA---PT 166 house mouse
Q5XIB6         90 ELHRGCTVSNMVADSFSVASDILNLFGLFLAPESAEGSLVLSAAGLGLGVAATVTNVATSIMKETSRVLDGVEAGHHGST 169 Norway rat
XP_013008670  104 KVHKGCTITNVVASTGGAVSGILTMLGFALAPVTAGGSLVLSATGMGLGTAAAVTGVSASIVDHSNKVSAQAEARQLLTS 183
EHB14171      104 RIHRNCTVSNMVSSSAGAASGVLTILGLALAPVTAGSSLLLSATGMGLGAVSAMTSAAAAIVEQSSVSSAKAEARCLVTN 183
2_pfamImport   80 KVHRDCTISNVVASSTGIASGTLSILGLVLAPFTGGLSLGLSAAGIGLGAASAVTGISTMVVENVNLSSAETQAGHI--- 156
10_pfamImport  81 KVHRDCTISNVVASSTGIASGALSILGLFLAPFTAGLSLGLSAAGIGLGAASAVTGLSTMVVENVNTSSAESQASSL--- 157
XP_007503451  331 ---KGQVAMVVLCKEAPQVVSVAQRCVslgnQVLEEINKNIRAFRLAKANTRLTTSAKTLMTTGSLSTRSARKVEKAFGG 407
Q9BWW9        209 -----TTSHEAFGGINWSEIEAAGFCVnkcvKAIQGI-KDLHAYQMAKSNSGFMAMVKNFVAKRHIPFWTARGVQRAFEG 282 human
1_pfamImport  158 ---PAMTVHDSSEERGCSEISAALLCIdkcvRAFKNL-KELRAYQMAKANSGFMAKVNKFMAMGHIPFWRTGGLQRAVGA 233
Q5U1W1        190 tmdTLNTAL-VLGQKALKLSKKAYDVI----KQLKSLGQHIRAIRVARANPRLLADAKRLMTSGRLSAPRASQVQNAFEG 264 Norway rat
Q8VDU3        167 gthVLGEAGTSVDRIASKVPQATRDIT----RDLEALEQHMNALRLVRANPRLEEDARILATTGSISAQRAMQVRASLKG 242 house mouse
Q5XIB6        170 amdILEEAGTSVARIASEIPQATRDIT----RDLEALEQHMNALSLVRANPRLEEDARALINAGSIPAQRAKQVRASLKG 245 Norway rat
XP_013008670  184 rldTGKEVLQVVGQATPKVVAASKKCV----QTFQSIEKNLYALKVAQSNPRLLARANRFIKTGKISARSGKQVQKAFGG 259
EHB14171      184 skdTAKELAQSVGQVELDVVLKSVQGI----SVLKGMKKSIHALKLARADARLLANANRFTGTWKIPFRKGERVQKAFGG 259
2_pfamImport  157 --------------NTAEIKCYVNDLY----QV-KDFGRHIRAIRVARGNPELLPTAQHCITTGQVLVQSAQQVSTHFRG 217
10_pfamImport 158 --------------NTDKVKCCLSDLY----QV-KDLRRHIHAIREARRNPQLVATAQSHIETWQLSDPAPQEVSTHFGG 218
XP_007503451  408 TALAMTKGSRMMSAMTTGAFVLVDMITVIHDLNHLLEGAKAEMAGELREQAQELEGKLEELSQ 470
Q9BWW9        283 TTLAMTNGAWVMGAAGAGFLLMKDMSSFLQSWKHLEDGARTETAEELRALAKKLEQELDRLTQ 345 human
1_pfamImport  234 SVMPMTKVARLLGAAGAGLSLMQDLRSLQQSWTHLEEGAKAETAEELRAVAGALEQELDQLTQ 296
Q5U1W1        265 TALAMTKKARIRGVATAGVFLAMDVYFLVRDSMDLCDGAKSESGNKLRALAQELEEKLKEVAQ 327 Norway rat
Q8VDU3        243 TPLAMSNEARIQRATAAGAALWSDVDSLVKESKHLYEGSASESAEALRKLARELEEKLEGLME 305 house mouse
Q5XIB6        246 TPLAMSKEDRIRSATTTGVTLLRDVGSLVNESKQLYEGSASESAAALRKLAQELEEKLGELMK 308 Norway rat
XP_013008670  260 TTLAMTKGTRLMGAATAGLFALVDVYSLVQDSVHLHNGAKTESAAELRQEAQVLEEKLEELTE 322
EHB14171      260 TAQAMSKGARMMGAAVAAVFLLVDVYSLVQTSKHLQKGAKAESAEELRQQAQVLERKLEELIG 322
2_pfamImport  218 TALAATRGARIGGGVLSALSMGLDVYSLVKDAQELQEGAKTASAENMRQKAQELEKELEKLTW 280
10_pfamImport 219 TPLAMTRAARIGSGVLSGVFIGLDVYSLVKDAQDLQEGAKTASAENMRQKAQELEKKLEELTW 281
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