8RCH


Conserved Protein Domain Family
eIF_4EBP
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pfam05456: eIF_4EBP (This model is not part of the current CDD release)
Eukaryotic translation initiation factor 4E binding protein (EIF4EBP)
This family consists of several eukaryotic translation initiation factor 4E binding proteins (EIF4EBP1 ,2 and 3). Translation initiation in eukaryotes is mediated by the cap structure (m7GpppN, where N is any nucleotide) present at the 5' end of all cellular mRNAs, except organellar. The cap is recognised by eukaryotic initiation factor 4F (eIF4F), which consists of three polypeptides, including eIF4E, the cap-binding protein subunit. The interaction of the cap with eIF4E facilitates the binding of the ribosome to the mRNA. eIF4E activity is regulated in part by translational repressors, 4E-BP1, 4E-BP2 and 4E-BP3 which bind to it and prevent its assembly into eIF4F.
Links
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Statistics
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PSSM-Id: 516825
Aligned: 40 rows
Threshold Bit Score: 119.669
Created: 14-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
8RCH_Z          2 SGGSSCs---qTPSRAIPa-tRRVVLGDGVQLPPgDYSTTPGGTLFSTTPG---------GTRIIYDRKFLMECRNSPVT 68  human
ETN61553        2 SASPIArqacaSITQAIPs--KRVLIHDASELPD-LYSSTPGGTLYSTTPGasrpssggpSTRIVYERAFLMNLKNSPLA 78 
1_pfamImport    1 SASPIArq----aAMTIPs--RKVLIHDASDLPD-LYSSTPGGTLYSTTPG---------GTRIVYERAFLMNLKNSPLA 64 
Q17JZ5          2 SASPIArq-acSQTQAIPs--KRVLIHDASELPD-LYSSTPGGTLYSTTPG---------GTRIVYERAFLMNLKNSPLA 68  yellow fever m...
Q7PN41          2 SASPIArqacaSISQAIPs--KRVLIHDASELPD-LYSSTPGGTLYSTTPG---------GTRIVYERAFLMNLKNSPLA 69  Anopheles gamb...
11_pfamImport   1 SASPVArq--aTMSQSIPs--KRILISDSSQLPI-DYSTTPGGTLYSTTPG---------GTRIVYERSTLMFLRNSPLS 66 
6_pfamImport    1 SASPIArq--aTQSQSIPs--KRIVIHDPNQLPV-DYSSTPGGTLYSTTPG---------GTRIVYERAFLMNLRNSPIS 66 
XP_001604271    2 SASPIArq--aTQTQSIPa--KKVVIHDANQLPA-DYSSTPGGTLYSTTPG---------GTRIVYERAFLMNLRNSPIS 67 
XP_018652879    2 ER---------QPTEPIPv--KRVTVKDLSQIPS-NHGTTPGGTLFSTTPG---------GTRIIYERDFILSCRNSPIA 60 
Q9XZ56          2 SASPTAr---qAITQALPmitRKVVISDPIQMPE-VYSSTPGGTLYSTTPG---------GTKLIYERAFMKNLRGSPLS 68  fruit fly

8RCH_Z         69 KTPPRDLPT----------------IPGVTSP-------------------SS--DEPPMEASQSHLRNSPEDKRAGGEE 111 human
ETN61553       79 RTPPNN-------------------VPLNLLRangsptggasakplstlslSKpnQQKPARNSPP---------KYDEHQ 130
1_pfamImport   65 RTPPTNLNN----------------LPHNILR-------------------NSptANRQQQHVPQAKKQPNAQPKFDEHQ 109
Q17JZ5         69 RTPPSNLNN----------------LPHNILRngtt------------gvtSKpkPQQQPQNSPP---------KFDEHQ 111 yellow fever m...
Q7PN41         70 RTPPNN-------------------VPMNLLRtgvvspntk------pmttlsvkQQKPARNSPP---------KYDEHQ 115 Anopheles gamb...
11_pfamImport  67 QTPPN--------------------IPDCCKRg---------------------nDIKSNRENGLRRNPLKKTHENDDCN 105
6_pfamImport   67 RTPPRNPLT----------------IPSELLK-----------------------GNTPVITKDPAKNTNKDSLMIEESA 107
XP_001604271   68 QTPPKNMPT----------------IPASLLKg---------------------aAPTVTAPNKIPSPPAKDAAVLDESA 110
XP_018652879   61 QTPPSDMIY----------------LPELTPSslhnd----------ktihPCngHKVKDSLNVSESTSNDHSKLSKGED 114
Q9XZ56         69 QTPPSNVPScllrgtprtpfrkcvpVPTELIK--------------------------------------QTKSLKIEDQ 110 fruit fly

8RCH_Z        112 SQFEMDI 118 human
ETN61553      131 EQFDMDL 137
1_pfamImport  110 EQFDMDL 116
Q17JZ5        112 EQFDMDL 118 yellow fever mosquito
Q7PN41        116 EQFDMDL 122 Anopheles gambiae str. PEST
11_pfamImport 106 EQFQIDI 112
6_pfamImport  108 EQFEMDM 114
XP_001604271  111 EQFEMDM 117
XP_018652879  115 APFEMDV 121
Q9XZ56        111 EQFQLDL 117 fruit fly
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