1DU9,1ACW


Conserved Protein Domain Family
Toxin_6

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pfam05453: Toxin_6 
BmTXKS1/BmP02 toxin family
This family consists of toxin-like peptides that are isolated from the venom of Buthus martensii Karsch scorpion. The precursor consists of 60 amino acid residues, with a putative signal peptide of 28 residues and an extra residue, and a mature peptide of 31 residues with an amidated C-terminal. The peptides share close homology with other scorpion K+ channel toxins and should present a common three-dimensional fold - the Cysteine -stabilized alphabeta (CSalphabeta) motif. This family acts by blocking small conductance calcium activated potassium ion channels in their victim.
Statistics
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PSSM-Id: 398878
View PSSM: pfam05453
Aligned: 7 rows
Threshold Bit Score: 32.1237
Threshold Setting Gi: 1711349
Created: 11-May-2020
Updated: 6-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1DU9_A  1 VGCEECPMHCKGKNAKPTCDDG--VCNCNV 28 
P15230  1 VGCEEDPMHCKGKQAKPTCCNG--VCNCNV 28  Mesobuthus tamulus sindicus
P83406  1 VGCEECPAHCKGKNAIPTCDDG--VCNCNV 28  Hottentotta judaicus
P60209  1 VGCAECPMHCKGKMAKPTCENE--VCKCNI 28  Indian red scorpion
P80671  1 VSCEDCPDHCSTQKARAKCDND--KCVCEP 28  Leiurus quinquestriatus hebraeus
Q95P89 30 IVCKVCKIICGMQGKKVNICKApiKCKCKK 59  Chinese scorpion
1ACW_A  1 VSCEDCPEHCSTQKAQAKCDND--KCVCEP 28 
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