Conserved Protein Domain Family
TRH

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pfam05438: TRH (This model is not part of the current CDD release)
Thyrotropin-releasing hormone (TRH)
This family consists of several thyrotropin-releasing hormone (TRH) proteins. Thyrotropin-Releasing Hormone (TRH; pyroGlu-His-Pro-NH2), originally isolated as a hypothalamic neuropeptide hormone, most likely acts also as a neuromodulator and/or neurotransmitter in the central nervous system (CNS). This interpretation is supported by the identification of a peptidase localised on the surface of neuronal cells which has been termed TRH-degrading ectoenzyme (TRH-DE) since it selectively inactivates TRH. TRH has been used clinically for the treatment of spinocerebellar degeneration and disturbance of consciousness in humans.
Statistics
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PSSM-Id: 516819
Aligned: 13 rows
Threshold Bit Score: 149.954
Created: 14-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_003439044   6 LLILASLTVCNLMVSGGQSMSAEDETDRK------TIDDIiLERAET-LLLRSILKKLQDEDGRNDGYYS--QPEWVTKR 76 
XP_005805715   6 LLVLASFVICNLAVCDGQGLPAEDEMDRSt-----TIDNLmLQRAQS-LLLRSILKKLQDGDVRNDGIFS--QPEWVTKR 77 
Q1T735         6 LLILASLAICNFTVSDAQSISAEDETDRTt-----TTDDIiLRRAES-LLLRSLLKKMQDEDDINDGVYA--QQDWMAKR 77  Japanese medaka
XP_003963468   6 LLILASVVVCNLIVCGGQGIPDEDELDRM------AIDDIiLQRAEG-LLLQSILRKMQSEDGRS-GESS--QIDWVTKR 75 
XP_023475693   6 SLLAMALTLTLTGVPGGRSQPEAAQQEAAmgaehpGLDDL-LRQAERlLLLREDLQRLREDQGERESESQifQPNWLSKR 84 
2_pfamImport   1 LLLALALTLTLTGVPGGRAQLEVDQQEAAmaaehpALRDL-LRQAGHlLLLREDLQRLQGDQGNRESGS-----NGLSKR 74 
5_pfamImport   1 FLLAMALTLTLTSVPGGRAQLDVVQQDVDlse-qqGLEDL-LRQAERlLLLREDLQRLREDQDDSASESQifQPDWFSKR 78 
1_pfamImport   1 -LLLLCLTLCGVCFNGGHLLPEESKNMGKs-----PLDDI-LQRSES-FILQSVLKKAEKEEEINKESNAp-LLQWLSKR 71 
XP_021122866   7 pLLLLCLTLSGVCLNGGQPLPEASENMGRr-----PLDNI-LQRSES-FILQSVLKKAEKKEEMNKELNAp-LPEWLSKR 78 
XP_031411491   7 pVLLLCLTLSGVCLNGRQSPPEVREKMGRs-----SLDDI-LQRSGS-HMLQSAVKKLEKKEEMNKELNVp-LPQWLSKR 78 
4_pfamImport   1 LILLVSLTVCNLTVNLGQNIPDESDKEERv-----PLDDI-LQRAQN-IIFRSLLKKIEDEDKLNDQVSS--QQEWLSKR 71 
ALD51569       6 LLALALLVVCNFTVSGGQSIPAEDETGGR------TIDDIiLQRAES-LLLRSILKKIQDEDGGDEGFPP--QAEWMTKR 76 
XP_064422526  39 llllvslglssMTAVLGQHAPEGVESEESv-----PMDDL-LQQAES-ILLRSILKKMEEEKDLHDPTAS--QVEWISKR 109 coelacanth
XP_003439044  77 QHPGKRYSDDLEKRQHPGRREEDE-DEQYFDVQKRQHPGKREDE--THS---------------------------FLEP 126
XP_005805715  78 QHPGKRHFEDLEKRQHPGRREVVD-DEQFWDMQKRQHPGKREDE--MHS---------------------------FTEF 127
Q1T735        78 QHPGKRYREDLEKRQHPGRREEDE-DEEYLNAQKRQHPGKREDE--IQS---------------------------SMGL 127 Japanese medaka
XP_003963468  76 QHPGKRYMEDLEKRQHPGRREESE-DD--LDVQKRQHPGKRDDE--MHS---------------------------LVEI 123
XP_023475693  85 QHPGKR-EEEAEE----RVEEEEA-EEGAVGRHKRQHPGRREDEaaWSA---------------------------DATQ 131
2_pfamImport  75 QHPGKR-EEEAEE----GVEDEEE-EGGAVGPHKRQHPGPWENAaaWSV---------------------------DVTP 121
5_pfamImport  79 QHPGKREEEEADE----GVEGEEE-EGGAVGLRKRQHPGRRDDVaaWAV---------------------------DAGQ 126
1_pfamImport  72 QHPGKKYLSNLEKRQHPGKRDVEE-ETSYGDIQKRQHPGKREMEddPDV---------------------------YLEL 123
XP_021122866  79 QHPGKRYISDLEKRQHPGKRDVKE-EASYGDIQKRQHPGKREVEddLAS---------------------------YLEL 130
XP_031411491  79 QHPGKRYISDLEKRQHPGRRDVEE-AASFGDIQKRQNLGKTEGY--LAN---------------------------YLEL 128
4_pfamImport  72 QHPGKRYQEDIEKRQHPGRREEDEdDDDYFEEQKRQHPGKREDE--TDD---------------------------YVEL 122
ALD51569      77 QHPGKRYGEDLEKRQHPGRREADV-DEPYLDVQRRQHPGKREDE--MRP---------------------------FTEL 126
XP_064422526 110 QHPGK--------------RDEDE-EIAYIEAQKRQHPGKRGGEe-ENDnlqaqkrqhpgkrddaedddgdegldeYTEV 173 coelacanth
XP_003439044 127 QKRQHPGKRSTAGHSSDNP---ILLLSELSKRQHPGKRYLvlHSKRQHPGKRLLEDEDgdrd--wdaDADGEEDLAEMEK 201
XP_005805715 128 QKRQHPGKRSTTGHIPDSP---VALLSELSKRQHPGKRYLvlHSKRQHPGKRLLEDEDdea----dwTEDGEEDMSELEK 200
Q1T735       128 QKRQHPGKRFLTGHISDNP---IIMLGELSKRQHPGKRYLvlQSKRQHPGKRYQDDEDsdg----dwEAAEEVDLPELEK 200 Japanese medaka
XP_003963468 124 QRRQHPGKRTMMGHVTENP---VLLFSELSKRQHPGKRYLvlHTKRQHPGKRHFEEEDidgewdadaNADDVEDLAEPEK 200
XP_023475693 132 QKRQHPGRRSs----------wLGY--TFTKRQHPGRRLV------DPQAQRSWEDEE----------EEREEGELMPEK 183
2_pfamImport 122 QKRQHPGRRSf----------wLGY--TFTKRQHPGRRLV------DPKAQRSWEEEE---------EEEEEEGELMPEK 174
5_pfamImport 127 QKRQHPGRRAs----------wLGY--AVTKRQHPGRRLV------DPRPQRSWEEAG---------EDEDEGGELMSEK 179
1_pfamImport 124 IRQQPPRRKSLLDQFANSPraqLTYANKLSTREHPGRRYP--MYKHQRPSKRGWNY------------EVDLYS----EK 185
XP_021122866 131 KKRQHPGRRSLWDQHVDIPsarLTYLNVLSKRQHPGRGYL--MHKHQHPSKRGWND------------ELDISD-HDGEK 195
XP_031411491 129 KKRQHPGRRSLWDQSTDISnsqLTYLNELSKRQHPGRRYL--MYKHQHPSKRSWND------------ELDLGD-QNWEK 193
4_pfamImport 123 QRRQHPGKRSLMDQYSDATdsqMGYQSDMSKRQHPGKRYLs-YNKRQHPGRRELEN------------ELDAGDLQDLEK 189
ALD51569     127 QKRQNPGKRFAAGRVSENP---AVL--ELSKRQHPGKRYLvvQTKRQHPGKR---DGDddvd-wdadGEGGEEDLVEMEK 197
XP_064422526 174 QKRQHPGRRSTLDQFTDSPntqLAFLSELSKRQHPGKRYLl-YNKRQHPGKRGWDK------------ELDYEDLQELEK 240 coelacanth
XP_003439044 202 RQHPGKRFWDNSSADLgtNSPCDVLDPASCSKTS 235
XP_005805715 201 RQHPGKRFWDNSSPELstSSPCDVLDSDSCSKTS 234
Q1T735       201 RQHPGKRFWDNSNPEL--GNPCDALEPDNCSKTN 232 Japanese medaka
XP_003963468 201 RQHPGKRFWDNSNPDLgtNNPCDVLDHTSCSKTS 234
XP_023475693 184 RQHPGKRAL---------GSPCGPRGA--CGQAS 206
2_pfamImport 175 RQHPGKRAL---------GGPCGLQGD--CGQAS 197
5_pfamImport 180 RQHPGKRAL---------GSPCGPRGP--CGQAS 202
1_pfamImport 186 LQHPGKRHWNSGSSGD--TGPCNFQESFTCHKG- 216
XP_021122866 196 RQHPGKRHWDTDNPDY--AGPCDLQESSTCNTGs 227
XP_031411491 194 HQNFGKRNRDSDSPDY--AGPCDLQQSAICNKgs 225
4_pfamImport 190 RQHPGKRYWDIKSPDYinNLPCDIKDPVKCNKAS 223
ALD51569     198 RQHPGKRFWDTSSPDLgtNSPCDVLDPTSCRKTS 231
XP_064422526 241 RQHPGKRQLPPESPDY--GLPCDILDPINCSKTS 272 coelacanth
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