Conserved Protein Domain Family
BSP_II

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pfam05432: BSP_II (This model is not part of the current CDD release)
Bone sialoprotein II (BSP-II)
Bone sialoprotein (BSP) is a major structural protein of the bone matrix that is specifically expressed by fully-differentiated osteoblasts. The expression of bone sialoprotein (BSP) is normally restricted to mineralised connective tissues of bones and teeth where it has been associated with mineral crystal formation. However, it has been found that ectopic expression of BSP occurs in various lesions, including oral and extraoral carcinomas, in which it has been associated with the formation of microcrystalline deposits and the metastasis of cancer cells to bone.
Statistics
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PSSM-Id: 516817
Aligned: 14 rows
Threshold Bit Score: 157.341
Created: 14-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_003773007  17 FSVKNLYRRAKLGDSEENGVLNHRHRYYIYKYSYLYPPLKRIPVQRNGDSSEE-GDGESSEEEEEEEENSNEEEETES-- 93 
XP_003221343  17 FSVKSFRRRFKADDSEENAVFKNRFWPFFYRQPYLYPPMKR--QQFNSDSSEEgYGGNSSEEEEEEEAG----PSNEE-- 88 
ELK13677       1 --MKNFHRRAKLEDSEENGVFKYRPRYYLYKHAYFYPPLKRFPVQ-SSDSSEEnEDGDSSDEEEEEEETSNEEANNEEs- 76 
Q28862        17 LSMKNLNRRAKLEDSEENGVFKYRPQYYVYKHGYFYPALKRFAVQSSSDSSEEnGNGDSSEEEEEEEETSNEEGNNGGne 96  domestic cattle
P31936         1 FSMKNFHRRAKLEDPEENGVFKYRPRYYLYKHAYFYPPLKRFPVQSSSDSSEEnGNGDSSEEEEEEEENSNEEENNEEne 80  pig
2_pfamImport   1 FSMKNLHRRVKPEDSEENGVFKYRPRYYLYKHAYFYPALKRFPVQSSSDSSEEnEDGDSSEEEEEEEETSNEEEKDENs- 79 
3_pfamImport   1 LSMKNLHRRIKLEDSEENGVFKFRPRYYLYKHAYFYPPLKRFPVQGSSDSSEEnGDGDSSDEEEEEETS-NEEENNEDs- 78 
XP_054341702  17 FSMKNLHRRVKIEDSEENGVFKYRPRYYLYKHAYFYPHLKRFPVQGSSDSSEEnGD-DSSEEEEEEEETSNEGENNEE-- 93 
XP_021104440  17 LSMKNLHRRFKLEDSEENGVFKYRPRYYLYKHGYFYPPLKQFAVQGNSDSSEEnGNGDSSEEEEEEDETSNEEENNEDs- 95 
XP_008265839  17 FSMKNLHRRVKLQDSEENGVFKFRPQYYLYKHAYFYPPLKRFPVP-SSDSSEEnGEGDSSDEEEEGEETSNEEENNEDs- 94 
XP_003773007  94 --NGSE------ESTTLSATTLGYGEENTTASGDIG-LAAIQNPK------------------K---EEK-NNQVTKKEE 142
XP_003221343  89 --NEGEqek---eeaTKAPSEPATGDKK-------G-VSDSKPPKqvpvkkeplgkpgkeggaKkaeKDKaPEKGGKEEE 155
ELK13677      77 --DENEdeeseaENSTLSATTPGYGEETTPEAGNIG-LAAIQLPK------------------K---TGDtGKKATKKEE 132
Q28862        97 dsDENEdeeseaENTTLSTTTLGYGE-ITPGTGDIG-LAAIWLPR------------------K---AGAtGKKATKEDE 153 domestic cattle
P31936        81 dsDGNEdedseaENITLSTTTLGYGGDVTPGTASIG-LAALQLPK------------------K---AGDiGKKSAKEEE 138 pig
2_pfamImport  80 --NGGRyltrefKALEKSATM-GEGVLQVQGHGRMGsELSFCFSF------------------Q---AGDmRKQATKKEE 135
3_pfamImport  79 --NGNEdeeseaENTTLSATTPGYGEEVTPGTGNMG-LAAIQLPK------------------K---VGDlGNKATKKKE 134
XP_054341702  94 ---SNEdedseaENTTLSATTLGYGEDATLATGYPG-LAAIQLPK------------------K---AGDiTSKATKEEE 148
XP_021104440  96 --NGNEdedseaENTTLSTITPGYGEETTPGTDYIG-LAAIQLPK------------------K---AGDiGNKATKKEE 151
XP_008265839  95 --NGNEdeeseaENSTLSFTTPDYGE-ITRGTGYIG-LAGIKLPK------------------K---AGAiENKATEEEE 149
XP_003773007 143 SDEEEEEEE--------ENEESEAEVDENKEGGNSTNHENAEGDHGNGNGG----KEEGEEEEEVEN---GTEATENEAS 207
XP_003221343 156 EDSDENEEEene---eeENEEQE-KVDENGNGVNGTSTNSTAEENGNGGKG-----EEEEEEEENEA------------- 213
ELK13677     133 SDEEEEEEEeeeeeeenENEENEAEVDENGQGVNGTSTNSTEVENGNGSSGgd-nEEEREEESVPDAnaeGNTVAGEQD- 210
Q28862       154 SDEEEEEEE---------EEENEAEVDDNEQGINGTSSNSTEVDNGHGSSGgdngEEDGEEESVTEAnteGITVAGE--- 221 domestic cattle
P31936       139 SDEDEEEEE--------ENEENEAEVDDNEQGTNGTSTNSTEVDSGNGHSGgd-nGEEGDQESVTEAq--GTTVAGEQDN 207 pig
2_pfamImport 136 SDEEEEEEEee----enENEENEAEVDENDQGVNGTSTNSTETENGNGSSGgd-aGEGGEGDSVT-----------GETA 199
3_pfamImport 135 SDEEEEEEE--------ENEENEAEVDENEQGINGTSTNSTEVENGNGSSGgdnrEEEGGQESVTRAnvrGTT---QQNN 203
XP_054341702 149 SDEEEEEEEee-----nENEESEAEVDENEQGINGTSTNSTEAENGNGSSGgd-nGEEGEEESVTGAnaeGTTATGGQGK 222
XP_021104440 152 SDEEEEEEEn-------ENENNEAEVDGNEQAVNGTSTNSTEVENGNGSSGad-nGEEGDKESVTEAntpGTTMSAGQST 223
XP_008265839 150 SDEEEEEEEe------nENEENEAEVDENEQSINGTSSNSTEAENGEAGEG----------ESVTATdaaGTATRGEWIS 213
XP_003773007 208 NSTEVTTSLNG-YE---FTTLLKGDFEVTS-PPYEESTSNLYdsGY----------EEPVTNEYDNGYEV---YE-NENR 268
XP_003221343 214 ----TTIVPTTlFTtvvPTTEYQDQYDTTTeEQWHAETTPEDqwQYdtttedpwvhDTTTTTGYENGYETqtdYYgSENG 289
ELK13677     211 ---------NGrLE---PTTPPQEVYGATT-PTLEKTTTTEYegEY----------EQTGTNEYDNGYEV---YE-NENG 263
Q28862       222 ----TTTSPNGgFK---PTTPHQEVYGTTP-PPFGKITTPg---EY----------EQTGTNEYDNGYEI---YE-SENG 276 domestic cattle
P31936       208 GGAKTTTSPNGgLE---PTPPPQDISGTTL-PPSGKTTTPEYegEY----------EQTGAHEYDNGYEI---YE-SENG 269 pig
2_pfamImport 200 GTRGQTTSPNGgFQ---PTTPPPEVYGTPS-PPSGKTTTFEYeeEY----------EQTGTNEYDNGYEV---YD-SENG 261
3_pfamImport 204 GGYKTTTPQNGgFQ---PTTPPPEVYGTTS-PPFGRTTTVEYegEY----------EQMGTNEYGHDYEV---YD-NENG 265
XP_054341702 223 GSSKTTTSPNGgFE---PTTPPQ-VYRTTS-PPFGKTTTVEYegEY----------EYTGANEYDNGYEI---YE-SENG 283
XP_021104440 224 GSSKTTPSPNGvFE---PTTPAPEVYGSTP-PPYGKTTTAEYgaEY----------EQTGANEYDPGYEV---YD-NENG 285
XP_008265839 214 RAAETTTAPSGgFE---PTTPPPEAYGTTS-PPFGKTTAAEYggEY----------EQTGNHGYDDGYEI---YE-NENG 275
XP_003773007 269 EPRGDNYRAYEDEYSYYKGHAYNGYGGQDYY 299
XP_003221343 290 YPRGDTFRAYEDEYSYYKGHGYDVY-GQDYY 319
ELK13677     264 EPRGDNFRAYEDEYSYYKGHSYDGYDGQNYY 294
Q28862       277 DPRGDNYRAYEDEYSYYKGRGYDSYDGQDYY 307 domestic cattle
P31936       270 EPRGDSYRAYEDEYSYYKGRSYNSYGGHDYY 300 pig
2_pfamImport 262 EPRGDTYRAYEDEYSYYKGQSYDGYEGY-YY 291
3_pfamImport 266 EPRGDTYRAYEDEYSYYKGQGYGGYDSQNYY 296
XP_054341702 284 EPRGDNYRAYEDEYSYFKGQGYDGYDGQNYY 314
XP_021104440 286 GPRGDNYRAYEDEYSYYKGRGYDGYDGQDYY 316
XP_008265839 276 DPRGDNYRAYEDEYSYYKGRGYEGYEGQDYY 306
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