Conserved Protein Domain Family
Duffy_binding

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pfam05424: Duffy_binding 
Duffy binding domain
This domain is found in Plasmodium Duffy binding proteins. Plasmodium vivax and Plasmodium knowlesi merozoites invade human erythrocytes that express Duffy blood group surface determinants. The Duffy receptor family is localized in micronemes, an organelle found in all organisms of the phylum Apicomplexa. This family is closely associated on PfEMP1 proteins with PFEMP, pfam03011.
Statistics
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PSSM-Id: 398859
Aligned: 90 rows
Threshold Bit Score: 129.747
Threshold Setting Gi: 74863467
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q8IIZ6     906 ICVPPRRRRLYIQKLHDWatavspqasgdkatqaaepqasdkaaqvteasasssssesnSvqttpastSSpsnsrdvdLV 985  Plasmodium falci...
Q8I098    1758 ACMPPRRIKLCVINLQYLnek--------------------------------------------kspEE--------LR 1785 Plasmodium falci...
Q8IAK2    1289 ECMPPRRQKLCLYFLAHK-----------------------------------------IetpnlntqED--------LR 1319 Plasmodium falci...
Q8IBX0    1252 VCMPPRRQNLCVHYLTQLddk--------------------------------------------ddeNK--------LR 1279 Plasmodium falci...
Q8IEU9    1257 ACMPPRRQKLCVYFFANP-----------------------------------------SqigsinkqDN--------LR 1287 Plasmodium falci...
Q8I220     903 VCMPPRRQKLCLYYIAHE-----------------------------------------SetknietqDD--------LR 933  Plasmodium falci...
Q8I218    1243 ACVPPRREKFCVSLLAKEgifk-------------------------------------------nkgED--------IR 1271 Plasmodium falci...
Q8IAK3    1247 ACMPPRRQKLCVSGLTQGgki--------------------------------------------ttiED--------IR 1274 Plasmodium falci...
Q8I640    1285 ACMPPRRIKLCIYYLENH-----------------------------------------TqkgnikkeFQ--------LR 1315 Plasmodium falci...
XP_966305 1361 ACMPPRRQSLCIHNLKESnet--------------------------------------------gteQQ--------LR 1388 Plasmodium falci...
Q8IIZ6     986 KAFVESAAVETFFLWDRYKKENtkrqgggagglggvpgvelpelpvsnsvektPQTQLas-gdIPTPFLRQMFYTLGDYR 1064 Plasmodium falci...
Q8I098    1786 KAFIQCAAIETYWLWQKYKKDKng---------------------------gvAQAKLns-gtIPDDFKRQMFYTFGDYR 1837 Plasmodium falci...
Q8IAK2    1320 KAFIKCAAAETFFSWYYFKKINdkl--------------------------nkLDEKLke-geIPPQFLRSMFYTFGDYK 1372 Plasmodium falci...
Q8IBX0    1280 EAFIKSAAAETFVLWQNYNSKNd------------------------------NDAQLldsgiIPPEFLRSMFYTFGDYR 1329 Plasmodium falci...
Q8IEU9    1288 KAFIISAAAETFRSWQYYKSKNgg---------------------------enLQTQLkd-gtIPDDFKRQMFYTYGDYR 1339 Plasmodium falci...
Q8I220     934 DAFIRTAAAETFLSWQYYKIKNga-----------------------------dAKQLdn-gtIPEEFLRSMYFTYGDYR 983  Plasmodium falci...
Q8I218    1272 ETFVKSAALETYFAWKRYNDDNk-----------------------------kAEEELks-gtIPENFKRQMYYTFADYR 1321 Plasmodium falci...
Q8IAK3    1275 TQFITCAAIETHFAWHKYKKDNv-----------------------------nAERELns-giIPHEFKRQMYYTFGDYR 1324 Plasmodium falci...
Q8I640    1316 EAFIKCAGAEIFLLWQKYKTDNnsd--------------------------tkLQTQLes-gqIPEEFKRQMFYTFGDFR 1368 Plasmodium falci...
XP_966305 1389 EAFINCAAIETFWLWYKYKKDKnv----------------------------dAEKKLeq-geIPSEFLRSMIYTFGDYR 1439 Plasmodium falci...
Q8IIZ6    1065 DILVRGgntsdsGNtngsnnnnivllasenKQEMENIQEQLKVFFSNSGNQSSTvgrnpsQSRVTPASLWGDFAQYIWNG 1144 Plasmodium falci...
Q8I098    1838 DLCLDT------DIssk----------adtSTGVGKVKINIDSVFQKIDITNVE----------QRKPWWGKNAEAIWDG 1891 Plasmodium falci...
Q8IAK2    1373 DICLDT------DIslk-----------teNGDITKAKSNIDRIIPKKSAKNPD---------EERKIWWDGIKEDVWEG 1426 Plasmodium falci...
Q8IBX0    1330 DICLDT------DIsak-----------tpDGDLEQAKENIGKVFQKIGPKTANhk---pPRGITREDWWKEYGSQIWKG 1389 Plasmodium falci...
Q8IEU9    1340 DFLFGT------DIsk-------------gLGEGTALEKQINILFPNGVRKIPN--------EKTREKWWTDHGPEIWKG 1392 Plasmodium falci...
Q8I220     984 DICLNT------DIsk-------------tVNDVAKAKDKIGKFFSKDGSKSPS-------GTTTPQDWWQTYGKDIWKG 1037 Plasmodium falci...
Q8I218    1322 DIFFGT------DIt--------------sHDHILDVSKNAKNKLKEKNGEQKSvi--iiDDEKLLADWWKEHGHEIWEG 1379 Plasmodium falci...
Q8IAK3    1325 DIFFGT------DIs--------------tHNHIPEVSQKVITILEKENLTKSEvk--qkYKNELLDDWWNEHGKEIWDG 1382 Plasmodium falci...
Q8I640    1369 DLCLGN------DIg--------------kADNTKDISTTVNRILSVTNGETQT----------TAENWWEKNAESIWQG 1418 Plasmodium falci...
XP_966305 1440 DLCLNT------DIsa-------------kKDPIKIVKNNIQKVFNRNNGPHKE------GDKEKRKKFWETNKNDIWQG 1494 Plasmodium falci...
Q8IIZ6    1145 MICALTYeekTSGSddkgvkieqn------------eglkealledKTNEPKKPQ 1187 Plasmodium falciparum 3D7
Q8I098    1892 MLCALSYn--TTNKnmdynahtklnpt-------ygynaikseledFVNRPQFLR 1937 Plasmodium falciparum 3D7
Q8IAK2    1427 MLCGLSHavsNNDKatvqktlttktiyd----ydtvtfdgttkledFSKRPQFLR 1477 Plasmodium falciparum 3D7
Q8IBX0    1390 MLCALSYd--NETRimnervrkqlmds------iynyhilknhlenFAERHPFFR 1436 Plasmodium falciparum 3D7
Q8IEU9    1393 MLCALTNglsESEKktkifddyshdkv-------nqskngnpsledFAKKPQFFR 1440 Plasmodium falciparum 3D7
Q8I220    1038 MICALTHgvtNTEKktkikndysydkv-------nqsqngnpsledFAKKPQFLR 1085 Plasmodium falciparum 3D7
Q8I218    1380 MLCALTHe-iDEEEknkikstysydql-------kkttngttplekFAERPQFLR 1426 Plasmodium falciparum 3D7
Q8IAK3    1383 MVCALCYdtkTKEFknevrtqltgpnskyqygtvsfgdkqntilskFAERPPFLR 1437 Plasmodium falciparum 3D7
Q8I640    1419 MLCGLSHavsARDKetvqktltnnpsykyd-lvkfsgsdnpptlekFAQTPQFLR 1472 Plasmodium falciparum 3D7
XP_966305 1495 MLCALEKi--ANNKktltetynyslv--------kfsgnnsttledFAKTPQFLR 1539 Plasmodium falciparum 3D7
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