Conserved Protein Domain Family
SIN1

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pfam05422: SIN1 
Stress-activated map kinase interacting protein 1 (SIN1)
SIN1 is the N-terminus of stress-activated map kinase interacting protein 1 (MAPKAP1 OR SIN1) sequences. This domain is likely to be the Ras-binding domain. The fission yeast Sty1/Spc1 mitogen-activated protein (MAP) kinase is a member of the eukaryotic stress-activated MAP kinase (SAPK) family. Sin1 interacts with Sty1/Spc1. Cells lacking Sin1 display many, but not all, of the phenotypes of cells lacking the Sty1/Spc1 MAP kinase including sterility, multiple stress sensitivity and a cell-cycle delay. Sin1 is phosphorylated after stress but this is not Sty1/Spc1-dependent. The separate CRIM and PH, pleckstrin-homology domains of the full-length SIN1 proteins have been separated into distinct families.
Statistics
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PSSM-Id: 398858
Aligned: 20 rows
Threshold Bit Score: 126.049
Threshold Setting Gi: 0
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_002005093         18 FISTDDT-GICETVMLSDDMP---KHYLRK-FQTA-----NpaMEAYrrshraA-QQRK-SQVPKTP-DTATP----MQR 80  Drosophi...
WGS:AAQB:GK21478-PA  18 FISTDDT-GMCETVMLSNDLP---KEYLRK-FQINfqsgrSagKTKS------AaLAKS-DRIIRNP-DAPLQ------- 77  Drosophi...
Q7PWV9               18 FISTDDT-GVSETVMVMEDIPlqlAKRFRE-SQAR-----VaeTTNQ------P-QPQP-ETTAPDE-DSDGPgidpIKQ 81  Anophele...
EDS32600             18 FISTDDT-GLSETVMLLEDLP---HQYVKL-HKQA-----V-----R------E-RELG-GDDGQQM-GSGKS----FE- 68  southern...
Q0IG33               18 FISTDDT-GLSETVMLLEDIP---HQYAQL-HRQA-----LreHSA----------GGV-QDVGRED-GLGMK----QKN 71  yellow f...
XP_028033489         18 FIATDDT-GLCEIVMAGEDFS---KIFQIKgLEEK-----KriKEAR------A-LQPGtSKIREGG-DSCED----FER 76  wild sil...
OWR44096             18 FIATDDT-GLCEIVMAGEDFS---KIYQNK-AIEE-----KkrDRDK------V-LYQP-STSRGKE-SETDD----EDE 74  Danaus p...
Q9NA80               18 RLEDDDGpGLCSRLLLNPDR------------------------------------------KCRAG-GLPLD----FRL 50  Caenorha...
EDX07086             18 FISTDDT-GMCETVMLSDDMP---KHYLRK-FGNS-----GagGDHY------H-WRRA-HKTPPTG-GGTTP----DRN 74  Drosophi...
XP_001960733         18 FISTDET-GICETVMLSDDMP---KHYLRK-FGNA-----GagGDLQ------S-QRRR-GQKPPPTaTPERN----IRN 75  Drosophi...
XP_002005093         81 SAplqhmvppriadpplqeVDFVCYPGLDLSDDEDlD-MSTHSFDIQMYPEVGAHRfRSNTAQKLEKLD------IAKRK 153 Drosophi...
WGS:AAQB:GK21478-PA  78 -E-----------------CDFVCYPGLDLSDDEDlD-TSTHSFDIQMYPEVGAHRfRSNTAQKLEKLD------IAKRK 132 Drosophi...
Q7PWV9               82 -Qmqarf--------gvdyEYFFSYPGLDDTDEED-AdTLSQSYEIQMDQESGFHRqRSNTAQKLEKLE------IARRK 145 Anophele...
EDS32600             69 --------------------SFYCYPGLDESDEEE-MdSLSQSYEIQMDQDIGFHRqRSNTAQKLERLE------IARRK 121 southern...
Q0IG33               72 FE------------------DFYCYPGLDDSDDEEmD-TLSQSYEIQMDQDIGFHRqRSNTAQKLERMD------IARRK 126 yellow f...
XP_028033489         77 EIi----------------TQFEPYPDIDESEDED-P-LGSSY---VRYEEFGGYRqRSNTSQWLDKKE------QALKK 129 wild sil...
OWR44096             75 KE-----------------VVTQFDPYPDMEDSDE-D-EPCPSYP--RFTDEMVHRqRSNTAQWLDKKE------LALKK 127 Danaus p...
Q9NA80               51 KN-------------------------GDLMDDGD-A-GFDDIYEIPLYEE-PIHT------------RtlindsLALRT 90  Caenorha...
EDX07086             75 TRhpda---------plqeVDFICYPGLDLSDDEE-D-MSTHSFDIQMYPEVGAHRfRSNTAQKLEKLD------IAKRR 137 Drosophi...
XP_001960733         76 PDall------------ldVDYICYPGLDLSDDEE-D-MSTHSFDIQMYPEVGAHRfRSNTAQKLEKLD------IAKRR 135 Drosophi...
XP_002005093        154 AARIKSVNYNE---EVVPPDRKDFFKRKVL 180 Drosophila mojavensis
WGS:AAQB:GK21478-PA 133 AARIKSINYNE---EAQPPENNDFFKRKEV 159 Drosophila willistoni
Q7PWV9              146 ASQIRSVKLDDs-sVLQPEEEE-----DEI 169 Anopheles gambiae str. PEST
EDS32600            122 ASKVKNIKYESavqRSEGGEDDELFVRKDV 151 southern house mosquito
Q0IG33              127 AAKVKNIKYECa-vQRSDEKDDELFVRKDV 155 yellow fever mosquito
XP_028033489        130 AAKIKVIKWEDs-sPLSKEQCMELFPTVEV 158 wild silkworm
OWR44096            128 AAKIKVIKWEDppaTLTAEQMSEVFSKVNI 157 Danaus plexippus plexippus
Q9NA80               91 AEKIKEEGRRD---NFYTGPLDELFVKQEV 117 Caenorhabditis elegans
EDX07086            138 AARIKSVNYQE---EVQPPDRDDFFQRKVL 164 Drosophila simulans
XP_001960733        136 AARIKSINYQE---EVQPPDSEDFFRRKEV 162 Drosophila ananassae
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