Conserved Protein Domain Family
Peptidase_C37
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pfam05416: Peptidase_C37 
Southampton virus-type processing peptidase
Corresponds to Merops family C37. Norwalk-like viruses (NLVs), including the Southampton virus, cause acute non-bacterial gastroenteritis in humans. The NLV genome encodes three open reading frames (ORFs). ORF1 encodes a polyprotein, which is processed by the viral protease into six proteins.
Links
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Statistics
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PSSM-Id: 487747
Aligned: 5 rows
Threshold Bit Score: 876.106
Created: 14-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q04544  707 KLDFSHLKMELAPQGGFDNQGNTPFGKGTMKPTTINRLLIQAVALTMERQDEFQLQGK---MYDFDDDRVSAFTTMARDN 783  Southampton virus (...
Q9YQ23  628 KKDFSHLQLQLAPQGGFDCMGNTPYGKGAMSKTSLSRLLASATALALERLEDFQLQAP---EYDFDKNRVTAFTRMASDN 704  Bovine calicivirus
Q80J95  650 RPDYSHINFILAPQGGFDRQGNTPYGKGVTKIIGATALCARAVALVHERHDDFGLQNK---VYDFDAGKITAFKAMAADA 726  Murine norovirus 1
Q8JJL0  645 KQDFSHIKLTLAPQGGFDKNGNTPHGKGTMRSLTQGSLTARVAGLVHERKDEFQLQGNdlqTYNFDTNRVSAFRKLAADN 724  Norwalk-like virus
Q80RD7  641 SPDFSHIKLMLAPQGGFDKNGNTPHGKGVMKTLTTGSLIARASGLLHERLDEFELQGPnltTFNFDRNKIQAFRQLAAEN 720  Snow Mountain virus

Q04544  784 GLGILSMAGLGKKLRGVTTMEGLKNALKGYKISACTIKWQAKVYSLESDGN-SVNIKEernilTQQQQSVCTASVALTRL 862  Southampton virus (...
Q9YQ23  705 GLGVMAAMRLGNRLKNVTTITELESALFGHTIAPCQIVWRGARYSMHTDGK-NMSIQQ-----VTTPAPVEEVNYALKRL 778  Bovine calicivirus
Q80J95  727 GIPWYKMAAIGCKAMGCTCVEEAMHLLKDYEVAPCQVIYNGATYNVSCI-KgAPMVEK-----VKEPELPKTLVNCVRRI 800  Murine norovirus 1
Q8JJL0  725 KYGIVETMRVGAALKNVKTLEDLKVALRDVKFNECEIIYRNSKYRVSSNGKgSVSVDKv---eDHTSQTANEVSSALLRL 801  Norwalk-like virus
Q80RD7  721 KYGLVDTMRVGGQLKGVRTIPELKQALKNILIKRCQIVYGGSTYTLESDGKgNVKVEKv---qNTNIQINNELAGALHHL 797  Snow Mountain virus

Q04544  863 RAARAVAYASCIQSAITSILQIAGSALVVNRAVKRMfgtrtatlslegpprehkcrvhmA-----KAAGKGPIGHDDVVE 937  Southampton virus (...
Q9YQ23  779 AAARAVTYWSLAANLVTTTIQAAASALVVHRAVQRIrssptqle-------shncryhrAerenrEVDGAKVTGHLGMVD 851  Bovine calicivirus
Q80J95  801 KEARLRCYCRMAADVITSILQAAGTAFSIYHQIEKR--------------------------------SRPSFYWDRGYT 848  Murine norovirus 1
Q8JJL0  802 RQARARYYISCFQDLVYTLIQVAGASFVVNRISKRFc---------------------------wERWVKPT-----ETQ 849  Norwalk-like virus
Q80RD7  798 RCARIRYYVKCVQEALYSIIQIAGAAFVTTRIVKRMni--------------------------qNLWSRPPVGDAEEVT 851  Snow Mountain virus

Q04544  938 KYGLCET----EEDEEVAHTEIPSATMEGkNKGKNKKGRGRRnnYNAFSRRGLNDEEYEEYKKIREEKGGNYSIQEYLED 1013 Southampton virus (...
Q9YQ23  852 RYGLCES----EEEEVTPTPPPQKKKAAPiMKTQLESKKGKKgkSNAFSRRGLSDEEYDEYKKIREDRGGNYSIQEYLED 927  Bovine calicivirus
Q80J95  849 YRDGPGSfdifEDDDDGWY------HSEG-KKGKNKKGRGRP---GVFRTRGLTDEEYDEFKKRRESRGGKYSIDDYLAD 918  Murine norovirus 1
Q8JJL0  850 EASEPEK----EVAQGRWEIEPKDAEPEG-KKGKNKKGRGKK--HTAFSSKGLSDEEYDEFKRIREERNGKYSIEEYLQD 922  Norwalk-like virus
Q80RD7  852 SQDGCPK----PKDDEEFVISSSDITPEG-KKGKNKTGRGKK--HTAFSSKGLSDEEYDEYKRIREERNGKYSIEEYLQD 924  Snow Mountain virus

Q04544 1014 RQRYEEELAEVQAGGDGGIGEtemEIRHRVFYKSKSRKHhqeerrqlglvtgsdirKRKPIDWTPPKSAWADDEREVDYN 1093 Southampton virus (...
Q9YQ23  928 RERFERDLAERQADDADYDVG---AIRQKYFGRGKAAKA-----------------QRKRIDWNPTGPLWADDDRQVDYD 987  Bovine calicivirus
Q80J95  919 RER-EEELLERDEEEAIFGDG---------FGLKATRRSrkaeraklglvsggdirARKPIDWNVVGPSWADDDRQVDYG 988  Murine norovirus 1
Q8JJL0  923 RDRYYEEVAVARATEEDFCEEeeaKIRQRIF--RPTRKQrkeergvlglvtgsdirKRRPDDFQPKGNLWADDTRSVDYN 1000 Norwalk-like virus
Q80RD7  925 RDKYYEEVAIARATEEDFCEEeeaKIRQRIF--RPTRKQrkeeraslglvtgseirKRNPDDFKPKGKLWADDERVVDYN 1002 Snow Mountain virus

Q04544 1094 EKISFEAPPTLWSRVTKFGSGWGFWVSPTVFITTTHVIPTSAKEFFGEPLTSIAIHRAGEFTLFRFSKKIRPDLTGMILE 1173 Southampton virus (...
Q9YQ23  988 EVIDFQAPPSIWSRIQKFGSGWGCWVSPTLFITSSHVIPDGCSEAFGVPIAEVAVTSSGEFTQFRFPKPIRPDVSGLILE 1067 Bovine calicivirus
Q80J95  989 EKINFEAPVSIWSRVVQFGTGWGFWVSGHVFITAKHVAPPKGTEIFGRKPGDFTVTSSGDFLKYYFTSAVRPDIPAMVLE 1068 Murine norovirus 1
Q8JJL0 1001 ERLDFEAPPSVWSRIVPLGTGWGFWVSSNLLITTTHVLPKGVKELFGVEIKQIQIHKSGEFCRFRFPRPIRPDVTGLVLE 1080 Norwalk-like virus
Q80RD7 1003 EKLSFEAPPSIWSRIVNFGSGWGFWVSPSLFITSTHVIPQGTQEFFGVPIKQIQIHKSGEFCRLRFPKSIRTAVTGMILE 1082 Snow Mountain virus

Q04544 1174 EGCPEGTVCSVLIKRDSGELLPLAVRMGAIASMRIQGRLVHGQSGMLLTGANAKGMDLGTIPGDCGAPYVYKRANDWVVC 1253 Southampton virus (...
Q9YQ23 1068 EGAPEGTVATVLIKRASGELVPLAVRMSTTTSTKVQGKVINGQTGMLLTGANAKGMDLGTFPGDCGCPYFYKRGNDWIVF 1147 Bovine calicivirus
Q80J95 1069 NGCQEGVVASVLVKRASGEMLALAVRMGSQAAIKIGSAVVHGQTGMLLTGSNAKAQDLGTIPGDCGCPYVYKKGNTWVVI 1148 Murine norovirus 1
Q8JJL0 1081 EGAPEGTVCSILIKRPTGEMIPLAVRMGTHASMKIQGRTVGGQMGMLLTGANAKNMDLGTGPGDCGCPYIYKRGNDIVVA 1160 Norwalk-like virus
Q80RD7 1083 EGAPEGTVVSLLIKRPTGELMPLAARMGTHATMKIQGRTVGGQMGMLLTGSNAKSMDLGTTPGDCGCPYIYKRGNDYVVI 1162 Snow Mountain virus

Q04544 1254 GVHAAATKSGNTVVC 1268 Southampton virus (serotype 3)
Q9YQ23 1148 GVHAAATKSGNTVIC 1162 Bovine calicivirus
Q80J95 1149 GVHVAATRSGNTVIA 1163 Murine norovirus 1
Q8JJL0 1161 GVHTAAARGGNTVIC 1175 Norwalk-like virus
Q80RD7 1163 GVHTAAARGGNTVIC 1177 Snow Mountain virus
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