Conserved Protein Domain Family
Med15_fungi
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pfam05397: Med15_fungi 
Mediator complex subunit 15
GAL11 or MED15 is one of the up to 32 or subunits of the Mediator complex which is found from fungi to humans. The Mediator complex interacts with RNA polymerase II and other general transcription factors to form the RNA polymerase II holoenzyme, thereby affecting transcription through targetting of activators and repressors. This family is found in fungi and the small metazoan starlet anemone.
Links
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Statistics
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PSSM-Id: 398846
Aligned: 46 rows
Threshold Bit Score: 84.9091
Threshold Setting Gi: 366996589
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
EPS27754     1009 TNLSPELLEFYKEVARTAPVTNVQD--ISPESKEKMVNMIQKSLECLCRLDILaIHALANA-----PNTERNMRNLFAMR 1081 Penicillium o...
EIE85784       86 SNVVFLVKQLDENVRKNKVNGPFIEd-LSEQDKMTIKTYTQQMKLMYDKLDHL-LPMFLLT-----TSNFEATRRIVLMK 158  Rhizopus dele...
EIM23832      594 AQASQLVQSIKQSIMQQRPPVNSQPn-LSPQEQHQIAQVCAEIKPMLISLENI-LPIFLCLndpiePGKIEAVKKISLMT 671  Wallemia mell...
GAC98402      963 EQARAAMQKIDQELATQRPRLPIIQn-IADDERDQILDQVQKLAPIQATVTAL-LPAFYAM-----NGNLEPAKRLKIMA 1035 Pseudozyma hu...
EDP42528      610 EEARSLLNKIDLSLSMSRPKLPIIEs-IQEEEKAMIFQQVQSLVPLKATVLAL-LPVFLAM-----TKNVEPAKRVKIMI 682  Malassezia gl...
XP_007376961  514 EEAKLQLKQLFTEVASKEVMLKDVTnmLTPEQKERVRTLLNEIQIQFPNIDAV-ISYVYVL-----TRNIEVTKRLIQMK 587  Spathaspora p...
XP_002619007  659 DEMKMKLRSLFEEVSRNNVQLKDVTmlLSEKDKAQVKETMARISQQYANVDSV-LSYFYVL-----TRNLEGTKRLIQMK 732  Clavispora lu...
XP_004200207  573 EEMKLQLRQLIEEVSKTNVALKDMTmlLSQQEKNSVKESIVRISQQYANIDSV-ISYFFIL-----TRNIEGTKRLIQMK 646  Pichia farino...
Q6BMM9        582 DEMKLQLRQLIEEVSRNNVALKDVTmlLSQQDKNAVRDTVVRISQQYANVDSI-ISYFYII-----TRNVEGTKRLIQMK 655  Debaryomyces ...
EDK37188      502 DEMKMKLRQLVEEVARNSIALKDVTmsLTGPQKDAVRDAVMRISQSYSNVDSI-ISYFYIL-----TRNAEGTKRLIQMK 575  Meyerozyma gu...

EPS27754     1082 HQVWRQFTNTHDwtitDHFTVTPDYLSGAILYIRKLFHMMLSR 1124 Penicillium oxalicum 114-2
EIE85784      159 HMLEDQYNFLSQ----DKYIFNLENIFKLRDQFNGYFNWVKNT 197  Rhizopus delemar RA 99-880
EIM23832      672 VMYYQQTIMLPQ----RQFCFNLEDMSRLRIQLARCFMYVKSQ 710  Wallemia mellicola CBS 633.66
GAC98402     1036 FMYKDQFDLLPK----KQCILRLADLDKLKMQMSRCISFVRSS 1074 Pseudozyma hubeiensis SY62
EDP42528      683 CIFEDQLALLPQ----KQCILKMADLEKLKVQMTRCIGFVRLn 721  Malassezia globosa CBS 7966
XP_007376961  588 FTIKKILDNLRS----GIYITNPEMLTKLSMQLAKYFGYVRDQ 626  Spathaspora passalidarum NRRL Y-27907
XP_002619007  733 HMTKSIMENLQR----GIYLAGPDLLEKLRSQYQRYFEYVKEQ 771  Clavispora lusitaniae ATCC 42720
XP_004200207  647 YMTKNIMQKLQQ----GVILATPDLVEKLRSQYQKYFEFVKEQ 685  Pichia farinosa CBS 7064
Q6BMM9        656 YMTKNIIENVQR----GIYLAAPDLLEKLRSQYQKYFEYVKEQ 694  Debaryomyces hansenii
EDK37188      576 YMTKNIMESLQK----GVYLAGPDLLEKLKLQYQKYFEYVKEQ 614  Meyerozyma guilliermondii ATCC 6260
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