Conserved Protein Domain Family
DARPP-32

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pfam05395: DARPP-32 
Protein phosphatase inhibitor 1/DARPP-32
This family consists of several mammalian protein phosphatase inhibitor 1 (IPP-1) and dopamine- and cAMP-regulated neuronal phosphoprotein (DARPP-32) proteins. Protein phosphatase inhibitor-1 is involved in signal transduction and is an endogenous inhibitor of protein phosphatase-1. It has been demonstrated that DARPP-32, if phosphorylated, can inhibit protein-phosphatase-1. DARPP-32 has a key role in many neurotransmitter pathways throughout the brain and has been shown to be involved in controlling receptors, ion channels and other physiological factors including the brain's response to drugs of abuse, such as cocaine, opiates and nicotine. DARPP-32 is reciprocally regulated by the two neurotransmitters that are most often implicated in schizophrenia - dopamine and glutamate. Dopamine activates DARPP-32 through the D1 receptor pathway and disables DARPP-32 through the D2 receptor. Glutamate, acting through the N-methyl-d-aspartate receptor, renders DARPP-32 inactive. A mutant form of DARPP-32 has been linked with gastric cancers.
Statistics
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PSSM-Id: 428454
Aligned: 8 rows
Threshold Bit Score: 148.837
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

pfam05395 is the only member of the superfamily cl05121
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
AAI70624       2 EANSPRKIQFTVPLL-EPHLDPEAAEQIRRRRPTPATLVLSSDQSSPEiDEERVPNPLQKSSLSMSPHQRKKMSRTTPTM 80 
NP_001268852  12 EPKERRKIQFAVPATePTQLDPRQVEMIRRRRPTPATLFKVADQTSPE-DDITSHQWVVGENGILKPKRINPNIYQPPSL 90 
XP_019213254  12 EPKERKKIQFAVPANaPTNLDPRQVEMIRRRRPTPATLFRVADQSSPE-DDQSTHQWVVGENGVLKPKRVNPNVYQPPSL 90 
XP_015217647  11 EPKERRKIQFSVPAPmPSQLDPRQVEMIRRRRPTPATLFRVSDNPSPE-EEHISHQWVVGENGILKPKRSNPCVYHPPSL 89 
1_pfamImport   1 EPKERRKIQFSVPAPmPSQLDPRQVEMIRRRRPTPATLFRVSDNPSPE-EEHISHQWVVGENGILKPKRSNPCVYHPPSL 79 
XP_001370926   2 DPKDRKKIQFSVPAP-PSQLDPRQVEMIRRRRPTPAMLFRVSEHSSPE-EEASPYQRSSGEGHHLKTKRPNPCAYTPPSL 79 
XP_002827694   2 DPKDRKKIQFSVPAP-PSQLDPRQVEMIRRRRPTPAMLFRLSEHSSPE-EEASPHQRASGEGHHLKSKRPNPCAYTPPSL 79 
NP_001002538   2 EPNSPKKIQFAVPLF-QSQLDPQAAEHIRKRRPTPATLVIYNEPSASGdDKQSTGHQTEAQNAQLSPAQRKQSVYTPPTM 80  zebrafish
AAI70624      81 KELQLLAEHHLCKQGSEEekiphlqnNLDDRPDlgccchgntastqeshipcscftqdGQQENNSLGRRHASq-----ED 155
NP_001268852  91 KAVQQMAEAQMQKLGVYP--------HVEEEGEepvhrgg-----------aelcsscTTESQEQRSTPEKQsgmrktEA 151
XP_019213254  91 KAVQKMAEAHMQKLGVYP--------PLEDPCE-------------------------GEEDEDYLKGEEG-------ED 130
XP_015217647  90 RAVQRMAQAHMQALGASP--------PLEDPPE-------------------------GVESEDGPPEAEMC------ED 130
1_pfamImport  80 RAVQRMAQAHMQALGASP--------PLEDPPE-------------------------GVESEDGPPEAEMC------ED 120
XP_001370926  80 KAVQRIAESHLQSIS-----------NLSENQP-------------------------SDEEEEEEGE----------QG 113
XP_002827694  80 KAVQRIAESHLQSIS-----------NLNENQ--------------------------ASEEEDELGELR--------EL 114
NP_001002538  81 RELQLVVEQHFQRQEQQEa-------GLSDSPDtpspitt------------qhfatgAQWANHNSSEPNGNqsyvstEG 141 zebrafish
AAI70624     156 SLDSLVSDGNTQTCEPK 172
NP_001268852 152 TAPTDEEEEEEEEEEEE 168
XP_019213254 131 AAPTKAADRQETAATEQ 147
XP_015217647 131 SPCTPAESPEETKSDPE 147
1_pfamImport 121 SPCTPAESPEDGQRSPQ 137
XP_001370926 114 SRGCQGEEEEEEEEEEE 130
XP_002827694 115 GYPREEDEEEEEDDEEE 131
NP_001002538 142 QPGSSGAGGNTAESSGS 158 zebrafish
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