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Salmonella type III secretion SopE effector N-terminus Salmonella typhimurium employs a type III secretion system to inject bacterial toxins into the host cell cytosol. These toxins transiently activate Rho family GTP-binding protein-dependent signaling cascades to induce cytoskeletal rearrangements. SopE, one of these toxins, can activate Cdc42 in a Dbl-like fashion via its C-terminal GEP domain pfam07487. This family represents the N-terminal region of SopE. The function of this domain is unknown. |
Jiyao W et al.(2023). "The conserved domain database in 2023.",